JP3113705B2 - External preparation - Google Patents
External preparationInfo
- Publication number
- JP3113705B2 JP3113705B2 JP03196708A JP19670891A JP3113705B2 JP 3113705 B2 JP3113705 B2 JP 3113705B2 JP 03196708 A JP03196708 A JP 03196708A JP 19670891 A JP19670891 A JP 19670891A JP 3113705 B2 JP3113705 B2 JP 3113705B2
- Authority
- JP
- Japan
- Prior art keywords
- shea
- skin
- blood circulation
- skin temperature
- shea butter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Description
【0001】[0001]
【産業上の利用分野】本発明は外用剤に関し、更に詳細
には皮膚に塗布することにより当該皮膚の血行を促進
し、皮膚温を上昇・保持する作用を有する外用薬剤に関
する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation, and more particularly, to an external preparation having an action of promoting blood circulation of the skin by applying to the skin and increasing / maintaining the skin temperature.
【0002】[0002]
【従来の技術】皮膚の血行不良に起因する疾患として、
肌あれ、シモヤケ、冷え症等がある。これらの疾患の治
療剤としては、種々の油剤、保湿剤等を配合した軟膏
剤、クリーム等が広く用いられている。2. Description of the Related Art As diseases caused by poor circulation of the skin,
There are rough skin, shimoyake, and chills. Ointments and creams containing various oils, moisturizers and the like are widely used as therapeutic agents for these diseases.
【0003】[0003]
【発明が解決しようとする課題】しかしながら、従来の
軟膏剤やクリームは、単に油剤や保湿剤を皮膚に供給す
ることにより皮膚の自然治癒作用を促すものが多く、そ
の根本原因である皮膚の血行不良を改善する作用を有す
るものはほとんどなかった。一方、皮膚の血行を促進す
る作用を有する物質は、数多く知られているが、外用で
の有効性及び安全性の面から、外用剤に適用できるもの
はほとんどなかった。従って、本発明の目的は、安全性
が高く、外用で有効な血行促進剤を提供することにあ
る。However, many of the conventional ointments and creams promote the natural healing action of the skin simply by supplying an oil or a moisturizer to the skin. There was almost no effect of improving the defect. On the other hand, many substances having an action of promoting blood circulation of the skin are known, but from the viewpoint of efficacy and safety in external use, few substances can be applied to external preparations. Therefore, an object of the present invention is to provide a highly safe and effective external use blood circulation promoter.
【0004】[0004]
【課題を解決するための手段】かかる実情において本発
明者らは安全性の高い各種の植物性油脂についてその薬
理作用を検討した結果、シアの種子より得られる油脂を
皮膚に塗布すれば、血行促進に基づく、優れた皮膚温上
昇・保持効果が得られることを見出し、本発明を完成し
た。Under such circumstances, the present inventors have studied the pharmacological action of various highly safe vegetable oils and fats, and found that if oils and fats obtained from shea seeds were applied to the skin, blood circulation would be reduced. The present inventors have found that an excellent skin temperature increasing / holding effect based on the promotion can be obtained, and completed the present invention.
【0005】すなわち、本発明はシアの種子より得られ
る油脂を有効成分とする外用血行促進剤を提供するもの
である。[0005] That is, the present invention provides an external blood circulation promoter containing an oil or fat obtained from shea seed as an active ingredient.
【0006】本発明の血行促進剤の有効成分であるシア
の種子より得られる油脂は、主に中央アフリカに分布す
るシアの木(Butyrospermum Parki
i)の種子から抽出される植物性油脂である。The oil and fat obtained from shea seeds, which is an active ingredient of the blood circulation promoting agent of the present invention, is mainly a shea tree (Butyrospermum Parki) distributed in Central Africa.
It is a vegetable fat extracted from the seed of i).
【0007】従来、シアの種子より得られる油脂につい
ては、食品、化粧品基剤としての用途〔Perfume
s. Cosmet. Aromes., 58 p6
5〜66(1984)〕、紫外線吸収作用、日焼防止剤
としての用途〔NATO ASI Ser., 181
p267〜276(1990),特公昭58−433
63号〕、鼻粘膜の充血除去作用〔Br. J. Cl
in. Pharmacol., 7(5) p495
〜497(1979)〕等についての報告があるが、血
行促進作用があることは全く知られていない。Conventionally, oils and fats obtained from shea seeds have been used as food and cosmetic bases [Perfume].
s. Cosmet. Aromes. , 58 p6
5-66 (1984)], an ultraviolet absorbing effect, and use as a sunscreen inhibitor [NATO ASI Ser. , 181
267-276 (1990), Japanese Patent Publication No. 58-433
No. 63], decongestion of nasal mucosa [Br. J. Cl
in. Pharmacol. , 7 (5) p495
497 (1979)], however, it is not known at all that it has a blood circulation promoting effect.
【0008】シアの種子より油脂(以下、「シア脂」と
略す)を抽出するには、自体公知の手段、例えば、シア
の種子を温時圧搾する、水を加えて煮つめる等の方法を
採用すればよい。なお、このシア脂は、シアバター(S
hea Butter)及びシアバターコンク(She
a Unsaponifiable)のグレードのもの
が、例えばビオデルマSX−19、ビオデルマSX−2
0(いずれもセデルマ社)、シアバター45デオ(ヘン
ケル社)等として市販されている。また、これら市販の
シア脂を更に活性炭処理することにより、無着色、無臭
化したものを用いるのが好ましい。本発明に用いるシア
脂の性状は、例えば以下の如くであり、その組成につい
ては、J. Assoc. Off. Anal. C
hem., 50(6)p1335〜1338に記載さ
れている。 比重(d) 0.91〜0.98 屈折率(n) 1.450〜1.480 融点(℃) 25〜45 ケン化価 140〜190 ヨウ素価 50〜85 不ケン化物(%) 4以上In order to extract oils and fats (hereinafter referred to as "shear fat") from shea seeds, a method known per se, for example, a method of squeezing a shea seed at a warm temperature, adding water and boiling down, is used. do it. The shea butter is made of shea butter (S
hea Butter) and Shea Butter Conch (She
a Unsaponifiable) grades such as Bioderma SX-19, Bioderma SX-2
0 (both by Sederma), Shea Butter 45 Deo (Henkel) and the like. Further, it is preferable to use those commercially available shea butters which are not colored and deodorized by further treating with activated carbon. The properties of the shea butter used in the present invention are, for example, as follows. Assoc. Off. Anal. C
hem. , 50 (6) pages 1335-1338. Specific gravity (d) 0.91 to 0.98 Refractive index (n) 1.450 to 1.480 Melting point (° C) 25 to 45 Saponification value 140 to 190 Iodine value 50 to 85 Unsaponifiable substance (%) 4 or more
【0009】本発明外用血行促進剤へのシア脂の配合量
は、特に限定されないが、0.1〜9.5重量%が好ま
しい。The amount of the shea butter to be added to the external blood circulation promoter of the present invention is not particularly limited, but is preferably 0.1 to 9.5% by weight.
【0010】また、本発明外用血行促進剤には、シア脂
以外に通常外用医薬品、医薬部外品、化粧料等に使用さ
れる他の成分を発明の効果を損なわない範囲で配合する
ことができる。かかる成分としては、例えば水、他の薬
効成分、他の油剤、保湿剤、界面活性剤、紫外線吸収
剤、吸収促進剤、香料、色素、保存剤等を挙げることが
できる。ここで他の薬効成分としては、消炎鎮痛剤、抗
ヒスタミン剤、止痒剤、殺菌剤、ビタミン剤、ホルモン
剤等が挙げられる。[0010] In addition, in addition to the shea butter, other components commonly used in topical medicines, quasi-drugs, cosmetics, etc., may be added to the topical blood circulation enhancer of the present invention as long as the effects of the invention are not impaired. it can. Examples of such components include water, other medicinal components, other oils, humectants, surfactants, ultraviolet absorbers, absorption promoters, fragrances, dyes, preservatives, and the like. Here, the other medicinal components include antiphlogistic analgesics, antihistamines, antipruritics, bactericides, vitamins, hormones and the like.
【0011】本発明外用血行促進剤は、常法によりシア
脂と他の成分を混合して調製することができ、その剤型
としては軟膏剤、クリーム剤、ゲル、ローション等が挙
げられる。The topical blood circulation promoter of the present invention can be prepared by mixing shea butter and other components by a conventional method, and examples of the dosage form include ointments, creams, gels, lotions and the like.
【0012】[0012]
【発明の効果】本発明によれば、皮膚に塗布することに
より、当該塗布部位の皮膚の血行が促進される結果、皮
膚温が上昇し、かつその作用が持続するため、肌あれ、
シモヤケ、冷え症等を容易に治療することができる。According to the present invention, by applying the composition to the skin, the blood circulation of the skin at the application site is promoted. As a result, the skin temperature rises and its action is maintained.
Shimoyake, chills, etc. can be easily treated.
【0013】[0013]
【実施例】次に実施例を挙げて本発明を詳細に説明する
が、本発明はこれに限定されるものではない。Next, the present invention will be described in detail with reference to examples, but the present invention is not limited to these examples.
【0014】試験例1 (方法)室温23℃の測定室に被験者を30分以上安静
に保たせた後、医用サーモグラフィー装置(日本光電、
INFRA−EYE 180型)により両手の甲の皮膚
温を測定しカラービデオプリンターにより記録した。両
手甲の皮膚温がほぼ同じで安定した被験者5名に対し、
一方の甲にシア脂(ヘンケル社製)を、他方には日本薬
局方オリーブ油を、それぞれ約0.5g塗布し全体にの
ばし軽く擦り込んだ。この際被験者には塗布薬剤を知ら
せなかった。 (1)塗布後60分まで経時的に皮膚温を測定、記録し
た。次に、60分後の観察終了後直ちに16℃の水中に
10秒間両手を浸した。 (2)水を拭き取った後経時的に皮膚温を測定、記録し
た。 (結果) (1)塗布後30〜60分において、シア脂塗布側が、
5例中4例において高い皮膚温を示した。 (2)水冷後の皮膚温は両手とも著しく低下したが、5
〜30分にわたる回復過程においてもシア脂塗布側の皮
膚温が、5例中4例において高値を示した。Test Example 1 (Method) After a subject was kept at rest in a measuring room at room temperature of 23 ° C. for 30 minutes or more, a medical thermography apparatus (Nihon Kohden,
INFRA-EYE type 180), the skin temperature of the back of both hands was measured and recorded by a color video printer. For five subjects with stable skin temperature on both backs,
About 0.5 g of shea butter (manufactured by Henkel) and olive oil of the Japanese Pharmacopoeia were each applied to one upper, and the whole was spread and lightly rubbed. At this time, the subject was not notified of the applied drug. (1) The skin temperature was measured and recorded over time up to 60 minutes after application. Next, immediately after the observation was completed 60 minutes later, both hands were immersed in water at 16 ° C. for 10 seconds. (2) The skin temperature was measured and recorded over time after wiping off the water. (Results) (1) 30 to 60 minutes after application, the shea fat application side
High skin temperature was shown in 4 out of 5 cases. (2) The skin temperature after water cooling decreased significantly in both hands,
Even in the recovery process for 〜30 minutes, the skin temperature on the shea fat application side showed a high value in 4 out of 5 cases.
【0015】試験例2 試験例1と同様の条件下で左手甲に対照としてオリーブ
油を、右手甲にシア脂(ヘンケル社製)をそれぞれ約
0.5g塗布し、16℃の水道水により10秒間冷却
し、その後室温で放置して、医用サーモグラフィー装置
により皮膚温を測定した。その結果、図1及び図2に示
すようにシア脂を塗布した右手は、オリーブ油を塗布し
た左手に比べ明らかに皮膚温が上昇していた。Test Example 2 Under the same conditions as in Test Example 1, about 0.5 g of olive oil was applied to the left back as a control and about 0.5 g of shea butter (manufactured by Henkel Co.) was applied to the right back, and the tap water at 16 ° C. was applied for 10 seconds. After cooling, it was left at room temperature, and the skin temperature was measured by a medical thermography device. As a result, as shown in FIGS. 1 and 2, the right hand to which shea fat was applied clearly had a higher skin temperature than the left hand to which olive oil was applied.
【0016】実施例1(クリーム) (組成) (重量%) a)グリセリンモノステアリル 1.5 オリーブ油 5.0 シアバター(ヘンケル社製) 5.0 スクワラン 4.0 b)ステアリン酸 9.0 グリセリン 10.0 水酸化ナトリウム 0.25 精製水 65.25 成分a)及びb)をそれぞれ80℃に加温する。撹拌し
ながら成分a)に成分b)を添加した後、室温まで冷却
し、クリーム剤とする。Example 1 (Cream) (Composition) (% by weight) a) Glycerin monostearyl 1.5 Olive oil 5.0 Shea butter (manufactured by Henkel) 5.0 Squalane 4.0 b) Stearic acid 9.0 Glycerin 10.0 Sodium hydroxide 0.25 Purified water 65.25 Components a) and b) are each heated to 80 ° C. After the addition of component b) to component a) with stirring, the mixture is cooled to room temperature to give a cream.
【0017】実施例2(軟膏) (組成) (重量%) a)白色ワセリン 20.0 シアバター(セデルマ社製) 10.0 流動パラフィン 8.0 セタノール 2.0 ポリオキシエチレンセチルエーテル 2.5 b)プロピレングリコール 5.0 精製水 52.5 成分a)及びb)をそれぞれ80℃に加温する。撹拌し
ながら成分a)に成分b)を添加した後、室温まで冷却
し、軟膏を製造する。Example 2 (Ointment) (Composition) (% by weight) a) White petrolatum 20.0 Shea butter (manufactured by Cedema) 10.0 Liquid paraffin 8.0 Cetanol 2.0 Polyoxyethylene cetyl ether 2.5 b) Propylene glycol 5.0 Purified water 52.5 Components a) and b) are each heated to 80 ° C. After the addition of component b) to component a) with stirring, the mixture is cooled to room temperature to produce an ointment.
【0018】実施例3(ゲル) (組成) (重量%) a)プロピレングリコール 12.0 エタノール 20.0 シアバター(セデルマ社製) 0.6 b)カーボポール934 1.0 ジイソプロパノールアミン 0.5 エタノール 30.0 精製水 35.9 カーボポール934をエタノールに分散した後、撹拌し
ながら精製水に溶かしたジイソプロパノールアミンを少
量ずつ添加し、全体を均一に懸濁させる。この液に、撹
拌しながら成分a)を添加し、全体を均一なゲルとす
る。Example 3 (Gel) (Composition) (% by weight) a) Propylene glycol 12.0 Ethanol 20.0 Shea butter (manufactured by Sederma) 0.6 b) Carbopol 934 1.0 Diisopropanolamine 5 Ethanol 30.0 Purified water 35.9 After dispersing Carbopol 934 in ethanol, diisopropanolamine dissolved in purified water is added little by little while stirring, and the whole is uniformly suspended. The component a) is added to this liquid with stirring, and the whole becomes a uniform gel.
【0019】実施例4(リップクリーム) (組成) (重量%) キャンデリラロウ 20.0 カルナバロウ 2.0 シアバター(ヘンケル社製) 7.0 硬化ヒマシ油 2.0 マイクロクリスタリンワックス 1.0 ヒマシ油 68.0 各成分を80℃で加温溶融した後に型に入れ、室温まで
冷却する。Example 4 (Lip cream) (Composition) (% by weight) Candelilla wax 20.0 Carnauba wax 2.0 Shea butter (Henkel) 7.0 Hardened castor oil 2.0 Microcrystalline wax 1.0 Castor Oil 68.0 Each component is heated and melted at 80 ° C., placed in a mold, and cooled to room temperature.
【図面の簡単な説明】[Brief description of the drawings]
【図1】水冷1分後の皮膚温分布を示す図である。FIG. 1 is a diagram showing a skin temperature distribution one minute after water cooling.
【図2】水冷20分後の皮膚温分布を示す図である。FIG. 2 is a diagram showing a skin temperature distribution after 20 minutes of water cooling.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 FI A61P 17/00 A61P 17/00 (58)調査した分野(Int.Cl.7,DB名) A61K 35/78 A61K 7/00 A61K 9/06 A61P 9/00 A61P 17/00 BIOSIS(DIALOG) CA(STN)──────────────────────────────────────────────────の Continuation of the front page (51) Int.Cl. 7 identification code FI A61P 17/00 A61P 17/00 (58) Field surveyed (Int.Cl. 7 , DB name) A61K 35/78 A61K 7/00 A61K 9/06 A61P 9/00 A61P 17/00 BIOSIS (DIALOG) CA (STN)
Claims (2)
とする外用血行促進剤。1. An external blood circulation promoter comprising an oil or fat obtained from shea seeds as an active ingredient.
とする外用皮膚温上昇・保持剤。2. An external skin temperature increasing / retaining agent comprising an oil or fat obtained from shea seeds as an active ingredient.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP03196708A JP3113705B2 (en) | 1991-08-06 | 1991-08-06 | External preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP03196708A JP3113705B2 (en) | 1991-08-06 | 1991-08-06 | External preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH0539225A JPH0539225A (en) | 1993-02-19 |
JP3113705B2 true JP3113705B2 (en) | 2000-12-04 |
Family
ID=16362270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP03196708A Expired - Fee Related JP3113705B2 (en) | 1991-08-06 | 1991-08-06 | External preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP3113705B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003099240A1 (en) * | 2002-05-27 | 2003-12-04 | Karlshamns Ab | Lanolin substitute based on shea butter |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4426148A1 (en) * | 1994-07-22 | 1996-01-25 | Henkel Kgaa | Cosmetic and / or pharmaceutical preparations |
EP0914817A1 (en) * | 1997-10-20 | 1999-05-12 | Chemisch Adviesbureau Drs. J.C.P. Schreuder B.V. | Nipple ointment composition |
EP1609460A1 (en) * | 2004-06-24 | 2005-12-28 | The Procter & Gamble Company | Skin care compositions comprising fatty material having a melting temperature range of 21-40 C |
EP2739155A4 (en) * | 2011-08-05 | 2015-10-07 | Stemtech International Inc | Skin care compositions containing combinations of natural ingredients |
-
1991
- 1991-08-06 JP JP03196708A patent/JP3113705B2/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003099240A1 (en) * | 2002-05-27 | 2003-12-04 | Karlshamns Ab | Lanolin substitute based on shea butter |
Also Published As
Publication number | Publication date |
---|---|
JPH0539225A (en) | 1993-02-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP3112436B2 (en) | In particular, the use of honey as a keratolytic agent to improve the brightness of the skin facial and treat wrinkles | |
Sahu et al. | Skin cream as topical drug delivery system: a review | |
CA2132369C (en) | Use for the treatment of mixed skins, of an effective quantity of active substances | |
US5853732A (en) | Pharmaceutical compositions containing kukui nut oil | |
JP2000319187A (en) | Carbon dioxide transcutaneous and transmucosal absorption composition | |
JP2003528821A (en) | Pharmaceutical and cosmetic carriers or compositions for topical application | |
JP2000119131A (en) | Emulsion containing hydrophilic thickening compound and thickening copolymer and composition containing the same emulsion and its use | |
JPH0834708A (en) | Method for solubilization of salicylic acid derivative and make-up and/or medicinal scientific composition containing its derivative | |
KR20000052678A (en) | Antiherpetic pharmaceutical compositions containing acyclovir for topical applicators | |
JPH07258064A (en) | Composition for make-up goods, composition for skin and antiaging beauty method | |
PT1853303E (en) | Stabilized compositions for topical administration and methods of making same | |
KR930001805B1 (en) | Tretinoin emulsified cream formulations of improved stability | |
US20070092475A1 (en) | Methods for enhancing the morphology, tone, texture and/or appearance of skin using a Meadowestolide | |
HU218921B (en) | Topical use of anorganic salt of stroncium (ii) for producing pharmaceutical compositions for treating neurogen skin-diseases | |
JP2011088930A (en) | Carbon dioxide percutaneous and transmucosal absorption composition | |
JP5643872B2 (en) | Carbon dioxide transdermal / mucosal absorption composition | |
JPH05255115A (en) | Lip treatment composition | |
CN105770237A (en) | Foaming agent with itching-relieving and inflammation-diminishing effects and preparation method of foaming agent | |
JP3113705B2 (en) | External preparation | |
JP4256125B2 (en) | Composition for external use | |
JPH0774152B2 (en) | Liquid for external use on skin | |
JP5164438B2 (en) | Carbon dioxide transdermal / mucosal absorption composition | |
JP5699184B2 (en) | Carbon dioxide transdermal / mucosal absorption composition | |
CN110025508A (en) | A kind of essence cream and preparation method thereof preventing striae of pregnancy generation | |
Lu et al. | Cutaneous and Transdermal Delivery—Processes and Systems of Delivery |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090922 Year of fee payment: 9 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090922 Year of fee payment: 9 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100922 Year of fee payment: 10 |
|
LAPS | Cancellation because of no payment of annual fees |