JPH0539225A - Medicine for external use - Google Patents

Abstract

PURPOSE:To obtain a blood circulation promoter for external use containing fats and oils obtained from shea seeds as an active ingredient. CONSTITUTION:This medicine for external use is applied to the skin to promote blood circulation in the skin of the coated part. As a result, the skin temperature is raised to sustain the action of the medicine. Thereby, skin roughening, chilblains, oversensitiveness to cold, etc., can readily be treated.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation, and more particularly to an external preparation having the action of promoting blood circulation in the skin and increasing / maintaining the skin temperature when applied to the skin.

[0002]

2. Description of the Related Art As a disease caused by poor blood circulation in the skin,
There are rough skin, frostiness, and chills. As therapeutic agents for these diseases, ointments and creams containing various oils, humectants and the like are widely used.

[0003]

However, many of the conventional ointments and creams promote the natural healing action of the skin by simply supplying an oil or moisturizer to the skin, and the blood circulation of the skin which is the root cause thereof. Almost no one had the effect of improving defects. On the other hand, many substances having an action of promoting blood circulation in the skin are known, but from the viewpoint of effectiveness and safety for external use, almost none of them can be applied to external preparations. Therefore, an object of the present invention is to provide a blood circulation promoter having high safety and being effective for external use.

[0004]

Under the circumstances, the present inventors have studied the pharmacological action of various highly safe vegetable oils and fats, and as a result, when the oils and fats obtained from seeds of shea are applied to the skin, blood circulation is improved. The present invention has been completed by finding that an excellent effect of raising and maintaining skin temperature based on promotion can be obtained.

That is, the present invention provides an external blood circulation promoting agent containing oil and fat obtained from shea seeds as an active ingredient.

The oil and fat obtained from the seeds of shea, which is an active ingredient of the blood circulation promoting agent of the present invention, is a shea tree (Butyrospermum Parki) mainly distributed in Central Africa.
It is a vegetable oil or fat extracted from the seed of i).

Conventionally, oils and fats obtained from shea seeds have been used as food and cosmetic bases [Perfume.
s. Cosmet. Aromes. , 58 p6
5 to 66 (1984)], an ultraviolet absorbing effect, and use as a sunscreen agent [NATO ASI Ser. , 181
p267-276 (1990), Japanese Patent Publication No. 58-433
63], decongesting action of nasal mucosa [Br. J. Cl
in. Pharmacol. , 7 (5) p495
~ 497 (1979)] and the like, but it is not known at all that it has a blood circulation promoting action.

To extract oils and fats (hereinafter, abbreviated as "shea butter") from the seeds of shea, a method known per se, for example, a method of squeezing the seeds of warm at a warm time, adding water and boiling it, etc. is adopted. do it. The shea butter is shea butter (S
shea butter) and shea butter conc (She
a Unsaponifiable) grade, for example, Bioderma SX-19, Bioderma SX-2
No. 0 (both are manufactured by Sederma) and Shea Butter 45 Deo (Henkel) are commercially available. Further, it is preferable to use those which are uncolored and deodorized by further treating these commercially available shea fat with activated carbon. The properties of the shea fat used in the present invention are, for example, as follows. Assoc. Off. Anal. C
hem. , 50 (6) p1335-1338. Specific gravity (d) 0.91 to 0.98 Refractive index (n) 1.450 to 1.480 Melting point (° C) 25 to 45 Saponification value 140 to 190 Iodine value 50 to 85 Unsaponifiables (%) 4 or more

The blending amount of the shea fat in the external blood circulation promoting agent of the present invention is not particularly limited, but is preferably 0.1 to 9.5% by weight.

In addition to the shea butter, other components commonly used in external medicines, quasi drugs, cosmetics and the like may be added to the external blood circulation promoting agent of the present invention within a range that does not impair the effects of the invention. it can. Examples of such components include water, other medicinal components, other oils, moisturizers, surfactants, ultraviolet absorbers, absorption promoters, fragrances, dyes, preservatives and the like. Examples of other medicinal components include anti-inflammatory analgesics, antihistamines, antipruritics, bactericides, vitamins and hormones.

The external blood circulation promoting agent of the present invention can be prepared by mixing shea butter and other components by a conventional method, and its dosage form includes ointments, creams, gels, lotions and the like.

[0012]

EFFECTS OF THE INVENTION According to the present invention, by applying to the skin, the blood circulation of the application site is promoted, resulting in an increase in skin temperature and a continuous action thereof, and
It is possible to easily treat blemishes and chills.

[0013]

EXAMPLES The present invention will now be described in detail with reference to examples, but the present invention is not limited thereto.

Test Example 1 (Method) After a subject was kept at rest in a measuring room at room temperature of 23 ° C. for 30 minutes or more, a medical thermography device (Nihon Kohden,
The skin temperature of the backs of both hands was measured by INFRA-EYE 180 type) and recorded by a color video printer. For 5 subjects with stable skin temperature on both backs,
About 0.5 g of shea butter (manufactured by Henkel Co., Ltd.) was applied to one instep and about 0.5 g of Japanese Pharmacopoeia olive oil was applied to the other, and the whole was lightly rubbed. At this time, the test subject was not informed of the applied drug. (1) The skin temperature was measured and recorded over time up to 60 minutes after application. Then, immediately after the observation was completed after 60 minutes, both hands were immersed in 16 ° C. water for 10 seconds. (2) After the water was wiped off, the skin temperature was measured and recorded over time. (Results) (1) 30 to 60 minutes after coating,
High skin temperature was shown in 4 out of 5 cases. (2) The skin temperature after water cooling decreased significantly in both hands, but
The skin temperature on the shea fat application side showed a high value in 4 out of 5 cases even during the recovery process over ˜30 minutes.

Test Example 2 Under the same conditions as in Test Example 1, about 0.5 g of olive oil was applied to the left back as a control, and about 0.5 g of shea butter (made by Henkel) was applied to the right back, and tap water at 16 ° C. for 10 seconds. It was cooled and then left at room temperature and the skin temperature was measured by a medical thermography device. As a result, as shown in FIGS. 1 and 2, the skin temperature of the right hand coated with shea butter was clearly higher than that of the left hand coated with olive oil.

Example 1 (Cream) (Composition) (% by weight) a) Glycerin monostearyl 1.5 Olive oil 5.0 Shea butter (manufactured by Henkel) 5.0 Squalane 4.0 b) Stearic acid 9.0 Glycerin 10.0 Sodium hydroxide 0.25 Purified water 65.25 Components a) and b) are each heated to 80 ° C. After adding component b) to component a) with stirring, cool to room temperature to give a cream.

Example 2 (Ointment) (Composition) (wt%) a) White petrolatum 20.0 Shea butter (manufactured by Sederma) 10.0 Liquid paraffin 8.0 Cetanol 2.0 Polyoxyethylene cetyl ether 2.5 b) Propylene glycol 5.0 Purified water 52.5 Components a) and b) are each heated to 80 ° C. After adding the component b) to the component a) with stirring, the mixture is cooled to room temperature to produce an ointment.

Example 3 (Gel) (Composition) (wt%) a) Propylene glycol 12.0 Ethanol 20.0 Shea butter (manufactured by Sederma) 0.6 b) Carbopol 934 1.0 Diisopropanolamine 0. 5 Ethanol 30.0 Purified water 35.9 Carbopol 934 is dispersed in ethanol, and then diisopropanolamine dissolved in purified water is added little by little while stirring to uniformly suspend the whole. Component a) is added to this liquid with stirring to make a uniform gel.

Example 4 (Lip cream) (Composition) (% by weight) Candelilla wax 20.0 Carnauba wax 2.0 Shea butter (manufactured by Henkel) 7.0 Hardened castor oil 2.0 Microcrystalline wax 1.0 Castor Oil 68.0 Each component is heated and melted at 80 ° C., put into a mold, and cooled to room temperature.

[Brief description of drawings]

FIG. 1 is a diagram showing a skin temperature distribution after 1 minute of water cooling.

FIG. 2 is a diagram showing a skin temperature distribution after 20 minutes of water cooling.

Claims (2)

[Claims] 1. A blood circulation promoter for external use, which comprises an oil and fat obtained from seeds of Shea as an active ingredient. 2. An external skin temperature raising / holding agent comprising an oil / fat obtained from shea seeds as an active ingredient.