GB2209338A - Antiviral agents - Google Patents
Antiviral agentsInfo
- Publication number
- GB2209338A GB2209338A GB8821380A GB8821380A GB2209338A GB 2209338 A GB2209338 A GB 2209338A GB 8821380 A GB8821380 A GB 8821380A GB 8821380 A GB8821380 A GB 8821380A GB 2209338 A GB2209338 A GB 2209338A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- formula
- phosphonate
- salts
- azidomethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003443 antiviral agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 purine nucleoside phosphonate derivatives Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 230000000840 anti-viral effect Effects 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
- 125000004970 halomethyl group Chemical group 0.000 abstract 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical class N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- 229930024421 Adenine Natural products 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical group C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 abstract 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 229960000643 adenine Drugs 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 abstract 1
- 239000002212 purine nucleoside Substances 0.000 abstract 1
- 150000003212 purines Chemical class 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US547187A | 1987-01-20 | 1987-01-20 | |
| PCT/US1987/003446 WO1988005438A1 (en) | 1987-01-20 | 1987-12-23 | Antiviral agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB8821380D0 GB8821380D0 (en) | 1988-11-02 |
| GB2209338A true GB2209338A (en) | 1989-05-10 |
Family
ID=21716038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8821380A Pending GB2209338A (en) | 1987-01-20 | 1988-09-12 | Antiviral agents |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0309491A1 (enrdf_load_stackoverflow) |
| JP (1) | JPH01501864A (enrdf_load_stackoverflow) |
| DE (1) | DE3790883T1 (enrdf_load_stackoverflow) |
| GB (1) | GB2209338A (enrdf_load_stackoverflow) |
| NL (1) | NL8720745A (enrdf_load_stackoverflow) |
| SE (1) | SE8803309D0 (enrdf_load_stackoverflow) |
| WO (1) | WO1988005438A1 (enrdf_load_stackoverflow) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0335770B1 (en) * | 1988-04-01 | 1997-01-15 | Merrell Pharmaceuticals Inc. | Novel fluorophosphonate nucleotide derivatives |
| US5208221A (en) * | 1990-11-29 | 1993-05-04 | Bristol-Myers Squibb Company | Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives |
| WO1993006112A1 (en) * | 1991-09-24 | 1993-04-01 | The Wellcome Foundation Limited | Therapeutic nucleosides |
| US5532225A (en) * | 1992-07-31 | 1996-07-02 | Sri International | Acyclic purine phosphonate nucleotide analogs as antiviral agents, and related synthetic methods |
| US5798340A (en) * | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
| KR100386685B1 (ko) * | 1993-09-17 | 2003-12-31 | 길리애드 사이언시즈, 인코포레이티드 | 뉴클레오타이드동족체류 |
| US5717095A (en) * | 1995-12-29 | 1998-02-10 | Gilead Sciences, Inc. | Nucleotide analogs |
| US5877166A (en) * | 1996-04-29 | 1999-03-02 | Sri International | Enantiomerically pure 2-aminopurine phosphonate nucleotide analogs as antiviral agents |
| US5922695A (en) * | 1996-07-26 | 1999-07-13 | Gilead Sciences, Inc. | Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability |
| EP3025718A1 (en) | 2003-01-14 | 2016-06-01 | Gilead Sciences, Inc. | Compositions and methods for combination antiviral therapy |
| TWI375560B (en) | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
| TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1984004748A1 (en) * | 1983-05-24 | 1984-12-06 | Stanford Res Inst Int | Novel antiviral agents |
| EP0173624A2 (en) * | 1984-08-24 | 1986-03-05 | Merck & Co. Inc. | 4-(guanin-9-yl) butanals and antiviral compositions containing them |
-
1987
- 1987-12-23 WO PCT/US1987/003446 patent/WO1988005438A1/en not_active Application Discontinuation
- 1987-12-23 JP JP63501095A patent/JPH01501864A/ja active Pending
- 1987-12-23 NL NL8720745A patent/NL8720745A/nl not_active Application Discontinuation
- 1987-12-23 DE DE19873790883 patent/DE3790883T1/de not_active Withdrawn
- 1987-12-23 EP EP88900934A patent/EP0309491A1/en not_active Withdrawn
-
1988
- 1988-09-12 GB GB8821380A patent/GB2209338A/en active Pending
- 1988-09-19 SE SE8803309A patent/SE8803309D0/xx not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1984004748A1 (en) * | 1983-05-24 | 1984-12-06 | Stanford Res Inst Int | Novel antiviral agents |
| EP0173624A2 (en) * | 1984-08-24 | 1986-03-05 | Merck & Co. Inc. | 4-(guanin-9-yl) butanals and antiviral compositions containing them |
Non-Patent Citations (2)
| Title |
|---|
| Antiviral Research, volu * |
| Journal of Medicinal Che * |
Also Published As
| Publication number | Publication date |
|---|---|
| NL8720745A (nl) | 1988-12-01 |
| DE3790883T1 (enrdf_load_stackoverflow) | 1988-12-08 |
| GB8821380D0 (en) | 1988-11-02 |
| JPH01501864A (ja) | 1989-06-29 |
| EP0309491A1 (en) | 1989-04-05 |
| SE8803309L (sv) | 1988-09-19 |
| WO1988005438A1 (en) | 1988-07-28 |
| SE8803309D0 (sv) | 1988-09-19 |
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