GB2186486A - Antibacterial dressing - Google Patents

Antibacterial dressing Download PDF

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Publication number
GB2186486A
GB2186486A GB08603583A GB8603583A GB2186486A GB 2186486 A GB2186486 A GB 2186486A GB 08603583 A GB08603583 A GB 08603583A GB 8603583 A GB8603583 A GB 8603583A GB 2186486 A GB2186486 A GB 2186486A
Authority
GB
United Kingdom
Prior art keywords
ointment
dressing
chlorhexidine
phenoxetol
antibacterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB08603583A
Other versions
GB2186486B (en
GB8603583D0 (en
Inventor
Christopher David Roberts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith and Nephew PLC
Original Assignee
Smith and Nephew Associated Companies PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith and Nephew Associated Companies PLC filed Critical Smith and Nephew Associated Companies PLC
Priority to GB8603583A priority Critical patent/GB2186486B/en
Publication of GB8603583D0 publication Critical patent/GB8603583D0/en
Publication of GB2186486A publication Critical patent/GB2186486A/en
Application granted granted Critical
Publication of GB2186486B publication Critical patent/GB2186486B/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/206—Biguanides, e.g. chlorohexidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures

Abstract

The dressing has a support matrix bearing an ointment which contains a synergistic mixture of 0.8 to 3.2% by weight of phenoxetol and 0.2 to 1.4% by weight of chlorhexidine. The matrix is e.g. a gauze.

Description

SPECIFICATION Antibacterial dressing The present invention relates to a dressing which comprises a support matrix bearing an ointment which contains a synergistic mixture of phenoxetol and a chlorhexidine salt.
Tulle Gras dressings (sometimes called paraffin gauze dressings) consist essentially of an openwork support such as a gauze or other support matrix which carries an ointment. Such dressings have been produced which contain active principles. A dressing has now been discovered which offers a particularly effective prophylactic or curative antibacterial treatment.
Accordingly the present invention provides an antibacterial dressing which comprises a support matrix bearing an ointment which contains a synergistic mixture of 0.8 to 3.2% phenoxetol and 0.2 to 1 .4%ofa chlorhexidine salt.
(Herein % refers to w/w and chlorhexidine salts are expressed as chlorhexidine acetate equivalents).
Most suitably the ointment contains from 1.25 to 2.75 phenoxetol and 0.3 to 0.8% chlorhexidine salt.
Preferably the ointment contains from 1.75 to 2.25% phenoxetol and 0.4 to 0.6% chlorhexidine salt.
Aptly the ch lorhexidine salt em ployed isthe hydrochloride, acetate or glugonate.
Most aptly the chlorhexidine salt employed is the acetate.
Preferably the ointment contains 2% phenoxetol and 0.5% chlorhexidine acetate.
The supporting matrix is most suitably a gauze.
ltismostsuitablethattheointmentemployed isa hydrophobic ointment. Soft white paraffin has proved to be a favoured hydrophobic ointment.
The dressing is preferably provided in sterile form and is most preferably provided in sterile form sealed within a bacteria proof package.
Sterilization is most suitably achieved by gamma irradiation.
The amount of ointment is chosen to supply 40 to 15 gum~2 of active agent, more aptly5to 12 gm-2 and preferably about8 gm-2 ofthe combined antibacterial agent.
The dressing may be fabricated by spreading the ointment on the substrate in conventional manner.
Example An ointment was made by blending soft white paraffin (97.5%), phenoxetol (2%) and chlorhexidine acetate (0.5%). The ointment was spread on a 10cm wide ribbon of gauze to a weight per unit area of 200 gm-2. The ribbon was cut into 10cm x 10cm squares.
The squares where placed between protector papers (interleaves) and sealed into pouches. The pouches and contents were sterilized by gamma irradiation.
1. An antibacterial dressing which comprises a support matrix bearing an ointment which contains a synergistic mixture of 0.8 to 3.2% phenoxetol and 0.2 to 1.4% of a chlorhexidine salt.
2. An antibacterial dressing as claimed in claim 1 in which the ointment contains from 1.25 to 2.75% phenoxetol and 0.3 to 0.8% chlorhexidine salt.
3. An antibacterial dressing as claimed in claim 2 in which the ointment contains from 1.75 to 2.25% phenoxetol and 0.4to 0.6% chlorhexidine salt.
4. An antibacterial dressing as claimed in any one of claims 1 to 3 in which the chlorhexidine salt is the hydrochloride, acetate org luconate.
5. An antibacterial dressing as claimed in claim 4 in which the chlorhexidine salt is chlorhexidine acetate.
6. An antibacterial dressing as claimed in claim 5 in which the ointment comprises 2% phenoxetol and 0.5% chlorhexidine acetate.
7. An antibacterial dressing as claimed in any one of claims 1 to 6 in which the ointment is a hydrophobic ointment containing softwhite paraffin.
8. An antibacterial dressing as claimed in any one of claims 1 to 7 in which the supporting matrix is a gauze.
9. An antibacterial dressing as claimed in any one of claims 1 to 8 in which the ointment supplies from 4to 15 g m-2 of active agent.
10. An antibacterial dressing as claimed in any one of claims 1 to 9 in which the dressing is provided in sterile form and is sealed within a bacteria proof package.
**WARNING** end of DESC field may overlap start of CLMS **.

Claims (10)

**WARNING** start of CLMS field may overlap end of DESC **. SPECIFICATION Antibacterial dressing The present invention relates to a dressing which comprises a support matrix bearing an ointment which contains a synergistic mixture of phenoxetol and a chlorhexidine salt. Tulle Gras dressings (sometimes called paraffin gauze dressings) consist essentially of an openwork support such as a gauze or other support matrix which carries an ointment. Such dressings have been produced which contain active principles. A dressing has now been discovered which offers a particularly effective prophylactic or curative antibacterial treatment. Accordingly the present invention provides an antibacterial dressing which comprises a support matrix bearing an ointment which contains a synergistic mixture of 0.8 to 3.2% phenoxetol and 0.2 to 1 .4%ofa chlorhexidine salt. (Herein % refers to w/w and chlorhexidine salts are expressed as chlorhexidine acetate equivalents). Most suitably the ointment contains from 1.25 to 2.75 phenoxetol and 0.3 to 0.8% chlorhexidine salt. Preferably the ointment contains from 1.75 to 2.25% phenoxetol and 0.4 to 0.6% chlorhexidine salt. Aptly the ch lorhexidine salt em ployed isthe hydrochloride, acetate or glugonate. Most aptly the chlorhexidine salt employed is the acetate. Preferably the ointment contains 2% phenoxetol and 0.5% chlorhexidine acetate. The supporting matrix is most suitably a gauze. ltismostsuitablethattheointmentemployed isa hydrophobic ointment. Soft white paraffin has proved to be a favoured hydrophobic ointment. The dressing is preferably provided in sterile form and is most preferably provided in sterile form sealed within a bacteria proof package. Sterilization is most suitably achieved by gamma irradiation. The amount of ointment is chosen to supply 40 to 15 gum~2 of active agent, more aptly5to 12 gm-2 and preferably about8 gm-2 ofthe combined antibacterial agent. The dressing may be fabricated by spreading the ointment on the substrate in conventional manner. Example An ointment was made by blending soft white paraffin (97.5%), phenoxetol (2%) and chlorhexidine acetate (0.5%). The ointment was spread on a 10cm wide ribbon of gauze to a weight per unit area of 200 gm-2. The ribbon was cut into 10cm x 10cm squares. The squares where placed between protector papers (interleaves) and sealed into pouches. The pouches and contents were sterilized by gamma irradiation. CLAIMS
1. An antibacterial dressing which comprises a support matrix bearing an ointment which contains a synergistic mixture of 0.8 to 3.2% phenoxetol and 0.2 to 1.4% of a chlorhexidine salt.
2. An antibacterial dressing as claimed in claim 1 in which the ointment contains from 1.25 to 2.75% phenoxetol and 0.3 to 0.8% chlorhexidine salt.
3. An antibacterial dressing as claimed in claim 2 in which the ointment contains from 1.75 to 2.25% phenoxetol and 0.4to 0.6% chlorhexidine salt.
4. An antibacterial dressing as claimed in any one of claims 1 to 3 in which the chlorhexidine salt is the hydrochloride, acetate org luconate.
5. An antibacterial dressing as claimed in claim 4 in which the chlorhexidine salt is chlorhexidine acetate.
6. An antibacterial dressing as claimed in claim 5 in which the ointment comprises 2% phenoxetol and 0.5% chlorhexidine acetate.
7. An antibacterial dressing as claimed in any one of claims 1 to 6 in which the ointment is a hydrophobic ointment containing softwhite paraffin.
8. An antibacterial dressing as claimed in any one of claims 1 to 7 in which the supporting matrix is a gauze.
9. An antibacterial dressing as claimed in any one of claims 1 to 8 in which the ointment supplies from 4to 15 g m-2 of active agent.
10. An antibacterial dressing as claimed in any one of claims 1 to 9 in which the dressing is provided in sterile form and is sealed within a bacteria proof package.
GB8603583A 1986-02-13 1986-02-13 Antibacterial dressing Expired GB2186486B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB8603583A GB2186486B (en) 1986-02-13 1986-02-13 Antibacterial dressing

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8603583A GB2186486B (en) 1986-02-13 1986-02-13 Antibacterial dressing

Publications (3)

Publication Number Publication Date
GB8603583D0 GB8603583D0 (en) 1986-03-19
GB2186486A true GB2186486A (en) 1987-08-19
GB2186486B GB2186486B (en) 1989-11-08

Family

ID=10593011

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8603583A Expired GB2186486B (en) 1986-02-13 1986-02-13 Antibacterial dressing

Country Status (1)

Country Link
GB (1) GB2186486B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000118A1 (en) * 1991-06-21 1993-01-07 Smith & Nephew Plc Adhesive compositions and products
WO1997031533A1 (en) * 1996-02-29 1997-09-04 Laboratoires Anios S.A. Antimicrobial composition, particularly for antisepsis and/or disinfection
WO2003030953A1 (en) * 2001-10-02 2003-04-17 Kimberly-Clark Worldwide, Inc. Inhibition of exoprotein production using aromatic compositions
US7026354B2 (en) 2001-10-02 2006-04-11 Kimberly-Clark Worldwide, Inc. Aromatic compositions for the inhibition of exoprotein production from gram positive bacteria
US7258867B2 (en) 2001-10-02 2007-08-21 Kimberly-Clark Worldwide, Inc. Aromatic compositions as inhibitors of exoprotein production in non-absorbent articles
CN102371003A (en) * 2010-08-18 2012-03-14 张德华 Water-soluble fiber fabric wound dressing and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MARTINDALES EXTRA PHARMACOPOEIA 28TH EDITION (SEE PAGE 1288 UNDER PHENOXYETHANOL AND PAGES 554-555 UNDER CHLORHEXIDINE) *
MERCK INDEX-10TH EDITION AT NUMBERS 2057 (ON PAGE 293)AND 7135 (ON PAGE1046) *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000118A1 (en) * 1991-06-21 1993-01-07 Smith & Nephew Plc Adhesive compositions and products
GB2271510A (en) * 1991-06-21 1994-04-20 Smith & Nephew Adhesive compositions and products
GB2271510B (en) * 1991-06-21 1995-01-04 Smith & Nephew Chlorhexidine gluconate-containing adhesive compositions and products
US5717005A (en) * 1991-06-21 1998-02-10 Smith & Nephew Plc Adhesive compositions and products
WO1997031533A1 (en) * 1996-02-29 1997-09-04 Laboratoires Anios S.A. Antimicrobial composition, particularly for antisepsis and/or disinfection
FR2745497A1 (en) * 1996-02-29 1997-09-05 Anios Lab Sarl ANTI-MICROBIAL COMPOSITION, IN PARTICULAR FOR ANTISEPTY AND / OR DISINFECTION
WO2003030953A1 (en) * 2001-10-02 2003-04-17 Kimberly-Clark Worldwide, Inc. Inhibition of exoprotein production using aromatic compositions
JP2005523239A (en) * 2001-10-02 2005-08-04 キンバリー クラーク ワールドワイド インコーポレイテッド Suppression of exoprotein production using aromatic compounds
US7026354B2 (en) 2001-10-02 2006-04-11 Kimberly-Clark Worldwide, Inc. Aromatic compositions for the inhibition of exoprotein production from gram positive bacteria
US7258867B2 (en) 2001-10-02 2007-08-21 Kimberly-Clark Worldwide, Inc. Aromatic compositions as inhibitors of exoprotein production in non-absorbent articles
AU2002336472B2 (en) * 2001-10-02 2007-08-23 Kimberly-Clark Worldwide, Inc. Inhibition of exoprotein production using aromatic compositions
CN102371003A (en) * 2010-08-18 2012-03-14 张德华 Water-soluble fiber fabric wound dressing and preparation method thereof

Also Published As

Publication number Publication date
GB2186486B (en) 1989-11-08
GB8603583D0 (en) 1986-03-19

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19950213