JPH03500853A - Treatment material for covering wounds and skin lesions and its preparation method - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] Treatment materials for covering wounds and skin lesions and its preparation method The present invention relates to a therapeutic material for covering wounds and skin lesions and a method for its preparation.

Wounds with secretions and damaged skin surfaces should be covered with gauze tape/sheets. Known methods to protect and treat ■・ So, paraffin (Jelonel, Sm1th and Nepbev) Generally, gauze sheets impregnated or partially impregnated with It is used. If the wound must also be treated with biologically active substances. , the medicine is applied directly to the gauze or to the wound surface at the treatment site and at the time of treatment. and then bandage the thus covered wound with a bandage.

The disadvantages of such known methods include the following: when removing the bandage; The newly formed epithelial layer is damaged, and in many cases its surface is severely damaged. be done; Secretions dry on a conventional gauze layer, forming a solid surface that allows secretions to pass through and the amount of biologically active substance optionally used depends on the mode of application. sterility cannot be ensured in all cases. I can't.

In order to overcome the above-mentioned drawbacks, the object of the present invention is to provide a method for covering wounds and skin lesions. a treatment material that does not stick to the wound; After the procedure, it can be easily removed from the surface without any damage and trauma. can be done; permeable to secretions; With any biologically active substance, i.e. with water-soluble, oil-soluble or fat-soluble components can be mixed as desired, thus achieving optimal active ingredient levels. can be secured on the surface to be used; It can be stored sterile for long periods of time and is easy to use at any time. The goal is to provide protective treatment materials.

We have developed carriers suitable for covering wounds and skin lesions, especially those with high HLB values ( For example, in the presence of an 0/W type emulsifier with HLB > 10), different from a mixture of oxyethylene glycols and oil, optionally an effective amount of biological The resulting emulsion is layered or impregnated with active substances. It has been found that the desired purpose can be achieved if Furthermore, the above solution It also allows controlled dosing and release of the optionally used active ingredients. Ru.

The present invention therefore relates to therapeutic materials for covering wounds and skin lesions. . This material consists of: 1) a carrier made of fabric, paper, or synthetic fiber; Consists of the body, b) This carrier can be laminated with an emulsion having the following composition or impregnated with it. Propylene glycol 0-20% by weight polyoxyethylene Glycols: 5-95% by weight Oil: 10-25% by weight Emulsifier 5-20% by weight C) This emulsion contains antibiotics, preservatives, anti-infection agents, and anti-mycobacterial agents. biologically active ingredients selected from anti-inflammatory agents, biologically active plant extracts and dermatological agents; Optionally, an effective amount of the ingredients may be mixed together.

The therapeutic material for covering wounds and skin lesions according to the present invention contains the ingredients listed in b) above. to produce an emulsion by methods known per se and, if desired, the obtained emulsion. The emulsion is mixed with an effective amount of the biologically active substance described in C) above, and then The carrier described in item 1) is impregnated with this mixture, and the resulting product is then packaged. However, if desired, it can be prepared by sterilization.

As carrier 1), textile fabric materials of inoculated density formed from twisted yarns or single yarns can be used. (e.g. gauze or coarse fabrics) or non-woven fabrics (e.g. veils) fabric), paper sheets, viscose sheets that can be perforated or reticulated, and Foils formed from synthetic materials and/or synthetic materials can be used.

The polyethylene glycol in emulsion b) has various degrees of polymerization. (e.g. n=300-6000), a mixture of polyoxyethylene glycols use. High and low polymerization degree of polyoxyethylene glycol The ratio is (1:40) to (4o:1), preferably ci:1) to (20 :1).

In the emulsion b) according to the invention, the oil phase is the one commonly used for injection preparations. , any known oil, such as vegetable oil (e.g. sunflower oil, olive oil, peanut oil, linseed oil, castor oil), animal oils (e.g. fish oil), mineral oils (e.g. paraffin oil), synthetic oils (e.g. silicone oil, various types of MyrHol, Leyitol, etc.] Can be done.

In the emulsion b) according to the invention, high HLB values (for example HLB>1 0) with ionic or nonionic emulsifiers, such as ethoxylated fatty acids. Alcohol esters, esters produced from polyhydric alcohols and fatty acids, Tokimo dianhydride sorbitol-stearate, ethylene oxide adduct ( For example, fatty acid-polyethylene glycol esters, fatty alcohol-ethyl (ren oxide adduct), etc. can be used.

O/W type elastomer used in wound and skin lesion protection therapeutic materials according to the invention The emulsion may optionally contain biologically active substances of any kind, i.e. It can also be prepared by mixing oil-soluble, oil-soluble or fat-soluble substances with the above compositions; to the surface to be treated with the active substance in an optimal, predetermined amount. It can be easily administered and also allows the procedure to be carried out by a layman.

Products according to the invention can be formed into any desired size and shape and are For example, 13X8an.

5X6an and 8X15cm sheets can be prepared. Do it like this The resulting sheet is placed on a cardboard or polymer sheet and then wrapped in foil and then sterilized if desired. obtained in this way The product is sterilized and sealed to form an easy-to-handle unit.

The product according to the invention can be used to treat burns, ulcutus ulcers, suppurative For the treatment of superficial lesions and various exudative skin lesions, for wounds after plastic surgery. For cover-up, when the presence of wound care materials is required permanently and in case of first aid. For use in outpatient procedures in the military, on board ships or in trauma surgeons, for example. Suitable for such purposes.

The invention will be explained in detail by the following non-limiting examples.

The suitability of the therapeutic material according to the invention for application to the skin is demonstrated by the biological example below. This is proven.

This test was conducted on New Sealant rabbits. 5an2 part of the rabbit's back The hair was removed and each was impregnated with 0.5 g of the emulsion according to Examples 1 to 10 below. A gauze sheet was applied over it and secured with a bandage according to clinical practice.

The bandages were removed 24 and 48 hours after this treatment. −times Three animals were used per treatment and - test period.

After each use, the gauze sheets can be easily removed and they are left to dry. It was found that there was no irritation to the skin, and that it did not cause any irritation to the skin. .

Before the above skin irritation test, the sterility of the impregnated gauze sheet used was tested using the following method. Tested: A gauze sheet completely wrapped in PE foil was placed in a sterile tube under sterile conditions. Sterilize the bottom and then use sterile scissors and tweezers to remove approximately 1/2 an cut into 2 small pieces and then soak these gauze pieces in sterile liquid soy-casein and Incubated in Sabouraud medium. The resulting culture was incubated at 32°C and 26°C. Incubated for one week. Then, visually evaluate these and make sure that all gauze was found to be sterile.

2) Microbiological stability test In this experiment, two different strains of bacteria [Pseudomonas aeruginosa ( ? cudomona@aerugin*sa) and Staphylococcus aure Slaph (Slaph ococcusaureus) is used to cover wounds. Due to the presence of microorganisms in the applied material during the maximum possible period of 72 hours A test was conducted to see if it could be used as a culture medium.

The materials used for impregnation purposes (e.g. those of the emulsions described in Examples 1 to 10) 24 hours, 48 hours and 72 hours. After fermentation, the number of bacteria was determined.

It has been proven that no growth can be found in the case of either strain of the microorganism. , and the initial bacterial count (approximately 10-106/g) gradually decreased to 0-10/g. Was. These results indicate that the emulsion used for impregnation also contained some microorganisms. Example 1 shows that it also exhibits physical activity. composition: Propylene glycol 5% Polyoxyethylene glycol 400 59.5% [Lujrol ) 400] Polyoxyethylene glycol 40G 8. 0% [Radolol ( Lutrol) 400G] Mrritol 318 20.　 0% SolIllol O5157, 5% Example 2 composition: Paraffin oil 1% Propylene glycol 10% Radroll 400 75% Radroll 4000 10% Cremophor (Cremopbot) RH6G 4% Example 3 composition: Flaxseed oil 2% Propylene glycol 4% Radroll 300 80% Ladolor 6 (IH8% Cremophor RH6G 6% Example 4 composition: Propylene glycol 5% Radroll 300 40% Radroll 1540 35% Militor 31B 10% Cremophor EL 10% Example 5 composition: Luvilol EHO 13% Radolol 400 59.5% Radroll 4000 18% Cremophor A6 9.6% Example 6 composition: Silicone oil (300cp) 5% Radroll 400 70% Radroll 1540 10% Cremophor 89 15% Example 7 composition: Corn oil 15% Radroll 400 55% Radroll 4000 10% Tsurutoru HS15 20% Example 8 composition: Sesame oil 8% Propylene glycol 2% Radroll 400 70% Radroll 1540 5% Tsurutoru H31515% Example 9 composition: Peanut oil 5% Radroll 300 70% Radroll 4000 20% Polypropylene glycol 5% Tsurutoru H5155% Example 10 composition: Sunflower oil 6% Radroll 300 80% Radroll 6000 2% Tsurutoru HSI5 12% The emulsions described in Examples 1 to 10 above can be prepared by methods known per se, e.g. For example, various polyoxyethylene glycols are melted and the resulting melt is stirred. However, it can be prepared by mixing with other ingredients.

The chemical composition of the above material as specified by trade name is as follows: Myritol 3 1 8: Caprylic acid - Myritol phosphoric acid-triglyceride Solifol HS 15: Diethyl Ren glycol-monoethyl ether Cremophor R H60: Polyethylene (660)-12-hydroxy-stearate (60) Cremophor (C+en+ophot) E L: Polyoxyethylene glycerin Low root lyricin oleate (35) Cremophor (Cremopbot) A6: Ethoxylated fatty alcohol mixture with free fatty alcohol Cremopbor S 9: Polyethylene glycol (4 00)-stearate Preparation of wound dressing material Example 11 Coarsely woven on a 6 x 6 an sized polypropylene foil with holes. Place a sheet of gauze coated on the gauze sheet and then coat the gauze sheet with the emulsion described in Example 1. John is impregnated, then covered with metal foil, cut into small pieces and then exposed to irradiation. Therefore, it is sterilized.

Example 12 Following the method of Example 11, but adding an effective amount of gentamicin to the emulsion prior to impregnation. as the active ingredient.

Example 13 The method of Example 11 is followed, but synthetic materials (e.g. polypropylene, polymer using a perforated sheet made from lyamide, viscose, etc.).

Example 14 Following the method of Example 12, but using an effective amount of one of the following ingredients: Erythro Mycin, neomycin, sisomicin, tetrane, chlorhexidine glucone benzalkonium chloride, mcanozol (mtcsnozol) or is metronidaxole.

international search report 10-++°-A#Gang111PCTIHU 89100023A61K 9/7 0 360 7624-4CA 61 L 15/44 Nna Country 1074 Budapest, Rakokuzi Udo 62 Country 1111 Futapest, Ko Runo 1's Ny, 7A Country 1108 Budapest, Agiyaghueyut Ny, 2 0A country 1089 Fpest, Piro Lajos Ny, 29A country 1163 Budapé strike, farcasida, nee, 17

Claims (7)

[Claims] 1. Therapeutic materials for covering wounds and skin diseases, comprising: a) fabric or paper; is made of synthetic fibers, b) having a carrier impregnated or laminated with an emulsion having the following composition, Propylene glycol 0-2% by weight Polyoxyethylene glycols 5-95% by weight Oil 10-25% by weight Emulsifier (one or more types) 5 to 20% by weight This emulsion may optionally contain c) an effective amount of an antibiotic, preservative, anti-infective, anti-mycobacterial, biological agent; It is mixed with biologically active substances selected from biologically active plant extracts and dermatological drugs. may be, A therapeutic material characterized by: 2. Textile fabrics in which the support material a) has various densities and is formed from twisted yarns or single yarns Claims characterized in that it is a fabric, preferably gauze or coarse cotton fabric. The therapeutic material according to item 1. 3. The carrier a) is a perforated viscose sheet or a mesh formed from synthetic fibers. The therapeutic material according to claim 1, characterized in that: 4. emulsion b) as oil, vegetable oil, such as sunflower oil, olive oil; , corn oil, peanut oil, linseed oil, animal oils such as fish oil, synthetic oil, For example silicone oil (10-10000 cp) or mineral oil such as paraffin Therapeutic material according to claim 1, characterized in that it contains an oil. 5. The polyethoxyethylene glycol present in the emulsion b) has different weights. polyoxyethylene glycol having a specific degree (for example, n = 300 to 6000) This polyoxyethylene glycol has a high degree of polymerization. The ratio with the lower one is (1:40) to (40:1), preferably (1:1) to (2 0:1). 6. Gentamicin, erythromycin, neomycin, lisomycin, tetra Chlorohexidine Gluconate, Benzalkonium Chloride, Micanozo c), optionally a biologically active substance selected from Therapeutic material according to claim 1, characterized in that it contains. 7. A method for preparing a therapeutic material for covering wounds and skin diseases according to claim 1. A method in which emulsion b) is prepared by mixing the above ingredients and Optionally, the emulsion obtained is mixed with an effective amount of biologically active substance c); of emulsion is layered onto carrier a) or impregnated into carrier a) and then A method of preparation characterized in that the product obtained is packaged and then, if desired, sterilized. Law.