GB2150032A - Method of producing sterility in female animals - Google Patents
Method of producing sterility in female animals Download PDFInfo
- Publication number
- GB2150032A GB2150032A GB08419762A GB8419762A GB2150032A GB 2150032 A GB2150032 A GB 2150032A GB 08419762 A GB08419762 A GB 08419762A GB 8419762 A GB8419762 A GB 8419762A GB 2150032 A GB2150032 A GB 2150032A
- Authority
- GB
- United Kingdom
- Prior art keywords
- uterus
- female animal
- flowable material
- obturator
- sterility
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
- A61D1/06—Castrating appliances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/08—Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Surgery (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Materials For Medical Uses (AREA)
Abstract
A flowable material, such as a collagen compound or a silicone elastomer, is injected into the uterus U of a female animal, such as a heifer. The flowable material expands and is cured at body temperature in the uterus of a female animal to implant a permanent obturator in the uterus of the female animal. More particularly, the obturator is implanted in the cervical os C and one or more cornu R of the uterus of the female animal. <IMAGE>
Description
SPECIFICATION
Method of producing sterility in female animals
The present invention relates in general to a method of producing sterility in female animals. and more particularly to a method of producing sterility in female animals by an obturator implanted in the uterus of a female animal.
Cattle are customarily fattened before being slaughtered. Many different techniques have been employed such as controlling the intake of feed and controlling the type of feed consumed by the cattle.
Some cattle have been fed various drugs and chemicals to increase the weight thereof before being slaughtered. A melengestrol acetate and a progestogen have been fed to heifers to depress the estrus cycle and thereby cause a cessation of heat periods. As a consequence thereof, the body weight of the heifers is increased and the efficiency in food consumption fattens the heifers. However, this technique requires accurate dispensing of the drug on a daily basis and the heifer subjected to the drug cannot be slaughtered within 48 hours of the last administration of the drug.
Hormone implants have been used to fatten heifers for beef. The hormone implants can be discarded with the inedible parts of the carcass and thus obviate the need to feed daily a chemical or to withdraw the heifer prior to slaughter.
Dromostanolene propinate in pellet form has been implanted subcutaneously in a heifer to increase the weight thereof. The estrus cycle of the heifer is suppressed.
In an article entitled OPERATIVE CORREC
TION OF PARTIAL EPIPHYSEAL PLATE CLO
SURE BY OSSEOUS-BRIDGE RESECTION
AND SILICANE-RUBBER IMPLANT by Robert
W. Bright, appearing in The journal Of Bone
And Joint Surgery, American Volume, Volume 56-A, No. 4, June 1974, pp. 655-665, there is described an experimental study on dogs. A procedure is discussed in which silicone-rubber material is molded to fill an osseous defect. The material is applied and allowed to vulcanize.
Silicone elastomer has been used for sterilization of human females by injection into the fallopian tubes. The injected material is in a liquid state and subsequently vulcanizes to form a plug.
The U.S. patent to Dickinson, Ill, et al., No.
3,811,424, discloses a method of inserting a mechanical device, which clamps around the annulus of a cow's cervix. For this purpose, a clamping ring slides over and compresses against the projecting annulus of the cow's cervix. The method alters the cross-sectional configuration of the reproductive tract with subsequent stimulation and changing (or resetting) of the estrus cycle.
In the U.S. patent to Robinson, No.
3,916,898, there is disclosed a method of controlling estrus, ovulation and fertility in domestic animals by introducing into the vagina, and later removing, a sponge impregnated with a progestational compound. The
U.S. patent to Haller, No. 3,690,316, discloses a cervical obturator for humans, which is made of a compressed spermicidal powder in the shape of fusiform. The powder has a wide base to serve as an obturator. The powder dissolves upon use.
The U.S. patent to Vennard, et al., No.
3,779,241, discloses a preformed hollow body having thin, flexible walls which have the size and shape of the uterine cavity. A flexible, compressible, filler material fills the hollow body, whereby the walls of the hollow body will make contact with the walls of the uterine cavity. The filler material is polymerizable organosiloxane material. The U.S. patent to Bolduc, et al., No. 4,119,098, discloses a dispensing apparatus for placing settable material in the uterine cavity and moving the material from the uterine cavity into the Fallopian tubes. It seals the cervical entrance to the cavity and causes expansion to conform to the slope of the uterine cavity and force the dispensed materials into the canals of the
Fallopian tubes.
In the U.S. patent to Barrington, No.
4,1 60,446, there is disclosed a device to deliver a tubal-occluding polymer such as organosilicon rubber. The material is a foamable polymer that flows into the Fallopian tubes to occlude the tubes.
The U.S. patent to Erb, Reissue No.
29,345, discloses a method for the sterilization of humans, in which a removable tip is inserted into the uterus. The tip is aligned with the uterine end of the oviduct. A curable elastomeric composition is injected through the tip into the oviduct to fill the oviduct adjacent to the uterus. The elastomeric composition solidifies on the tip. The apparatus for inserting the tip in the uterus is removed and the tip is ejected by the apparatus to remain for blocking the oviduct. The apparatus is inserted through the cervical os into the uterus. The material used is silicon elastomers.
In the U.S. patent to Chvapil, No.
4,274,410, a collagen porous sponge is inserted in the upper vault of the vagina near the cervix. The sponge is preformed before it is inserted in the upper vault of the vagina near the cervix. In the U.S. patent to Chvapil,
No. 4,369,773, there is disclosed a preformed collagen sponge inserted into the upper vault of the vagina to cover the cervix.
The U.S. patent to Brundin, No.
4,365,621, discloses a device for blocking the oviduct which includes a body made of hydrogels. The body swells by absorbing body fluids. The body is introduced into a cavity in its normal state and enlarges upon the absorption of body fluid to block a passage or close a cavity.
In the U.S. patent to Vickery, No.
3,991,750, issued on November 16, 1976, for Dromostanolene Propinate Implant Pellet
Useful For Producing Weight Gains In Animals And Suppressing Estrus In Female Animals, there is described the implant of a pellet subcutaneously in a heifer. The pellet contains dromostanolene propinate and produces an increase in weight in the heifers and suppresses the estrus cycle in the heifers.
In the present invention, a flowable material is injected into the uterus of a female animal, which expands and is cured at body temperature to implant an obturator in the uterus of the female animal for producing sterility in the female animal.
An obturator made of a collagen compound or a silicone elastomer is used in the present invention as a progestogen to depress the estrus cycle in the female animal. This action causes a cessation of heat periods and results in improved body weight gains and results in more efficient utilization of feed consumed by the female animal. Thus, the female animal is fattened for slaughter in the production of beef.
An object of the present invention is to produce sterility in a heifer by intrauterine injection of flow material, such as silicone elastomer or a collagen compound for implanting in the cervical os of the uterus of the heifer a permanent obturator. The flowable material is expanded and cured by the body heat of the heifer. The implant of the obturator in the cervical os of the uterus of the heifer serves to maintain through the course of the feed lot period for the heifer a weight gain, which is greater than average weight gain heretofore realized during the feed lot period.
By virtue of an intrauterine injection of flowable material, the problem of proper me chanical size for the obturator is obviated. A mechanical obturator of a wrong size for the female animal may require further instruments. Mechanical obturators are difficult to install.
Implanting or manipulating the reproductive organs of a female animal other than the uterus may require operative procedures with all attendant risks. This problem has also been obviated by the present invention since the flowable material is injected through the vagina into the uterus.
Reference is now made to the accompanying drawings wherein:
Figure 1 is a fragmentary, diagrammatic illustration of an obturator made of a silicone elastomer or a collagen compound implanted in the uterus of a heifer in accordance with the present invention.
Figure 2 is a fragmentary, diagrammatic axial sectional view of a material injecting device employed in the present invention for
implanting an obturator in the uterus of a heifer.
DESCRIPTION OF THE PREFERRED EMBODI
MENTS.
Illustrated in Figure 1 is a diagrammatic sectional view of reproductive organs of a
heifer, which includes a vagina V, a cervical os C of a uterus U, and a cornu R of the uterus U. Implanted in the cervical os C of the uterus U and in at least one cornu R of the uterus U is an obturator 10 made of a silicone elastomer or a collagen compound. The obtu
rator 10 is permanently implanted in the uterus U.
For implanting the obturator 10 in the uterus U, a suitable material injecting device 20 (Figure 2) is employed The material injecting device 20, in the exemplary embodiment, comprises a cylinder 25. Disposed within the cylinder 25 for reciprocating movement is a piston rod 30. Adjacent one end of the piston rod 30 is a thin disc 35 made of rubber. At the other end of the piston rod 30 is a suitable handle 36.
Fixed to the piston rod 30 adjacent to the disc 35 is a plunger 40. The disc 35 is axially aligned with the plunger 40. The plunger 40 is formed with a plurality of axially disposed apertures 45 that extend therethrough. Disposed within the apertures 45 of the plunger 40 is a prescribed or metered amount of a catalyst of the flow material hardening into the obturator 10. A suitable parting material is disposed in the apertures 45 of the plunger 40 at the end thereof toward the handle 36.
At one end of the cylinder 25 is a discharge opening 50, which communicates with a suitable discharge tube 55. The tube 55 may be made of flexible rubber or plastic material. It may also be made of stainless steel. A stopcock 60 disposed in the tube 55 opens and closes the axial opening of the tube 55 in a conventional manner.
At the other end of the cylinder 25 is a suitable removable cap 65 within which is disposed a gasket 70. The cap 65, when mounted on the cylinder 25, provides a sealed end therefor. Initially, the stop-cock 60 is in the closed position and the cap 65 is removed from the cylinder 25. Initially, the piston 35 and the plunger 40 are disposed at the end of the cylinder 25 adjacent the discharge opening 50. The plunger 40 has previously been filled with a predetermined quantity of a catalyst and also with the parting material. A base of the flowable material that is cured by body heat to form the obturator 10 is deposited in the cylinder 25 through an opening 75. The base of the flowable material is disposed between the plunger 40 and the opening 75. Now, the cap 65 with the gasket 70 is securely attached to the cylinder 25 to form a seal.
The piston rod 30 is actuated to move the
plunger 40 and the disc 35 toward the cap
65. The plunger 40 during this operation is
pulled through the base of the flexible material, and the base of the flowable material is thereby mixed with the catalyst and parting
material in the cylinder 25. The disc 35 is
displaced away from the apertures 45 at the
adjacent end of the plunger 40 during the mixing operation in the cylinder 25 to open or
unseal the ends of the apertures 45 at the end of the plunger 40 facing the discharge opening 50. The plunger 40 at the end of the
mixing operation is adjacent the gasket 70.
Now the stop-cock 60 is opened and the
piston rod 30 is now actuated to move toward the discharge opening 50. The flowable material is ejected by the plunger 40 from the cylinder 25 through the free end of the tube
55. The disc 35 is moved away from the apertures 45 and assumes a concave-convex configuration to unseal the same at the adjacent end of the plunger 40 during the mixing of the base of the flowable material and the catalyst. While the flowable material is being ejected from the cylinder 25 by the plunger 40, the disc 35 forms a seal for the apertures 45 by engaging the adjacent end of the plunger 40 to enable the flowable material to be ejected by the plunger 40 from the cylinder 25.
For injecting the flowable material into the uterus U of a cow or a heifer, the cow or heifer is manipulated transvaginally. The tube 55 is passed through the vagina V and inserted into the os of the cervix C of the uterus
U. The flowable material passes into the cervix C of the uterus U and optionally may also pass into one or more cornu of the uterus U.
If desired, the flowable material may additionally pass into the corpus of the uterus U.
Thus, an intrauterine injection of flowable material is performed and the tube 55 passes into the cervix C of the uterus U. The intrauterine injection of the flowable material should be performed while the cow or heifer is confined by a squeeze gate or chute for cattle.
The flowable material may be in a liquid or in a foam state. One suitable flowable material is an elastomer of silicone material, which vulcanizes or cures at the body temperature of a cow or heifer. Such a silicone elastomer is sold by Dow Corning Corporation as Silastic 382 Medical Grade Elastomer. The Silastic 382 Medical Grade Elastomer comprises an elastomer base of polydimethylsiloxane and silica filler as one liquid and a liquid catalyst of stannous octoate. The liquid catalyst of stannous octoate is sold by Dow Corning
Corporation as Dow Corning Catalyst M. A suitable bonding agent or adhesive employed with the flowable material of silicone elastomer is a Dow Corporation Silastic Medical
Adhesive Silicone A.
The catalyst and the bonding agent are
disposed in the holes 45 of the plunger 40.
The elastomer base of polydimethylsiloxane
and silicone filler are disposed in the cylinder
25 between the plunger 40 and the opening
70. The flowable material comprises 0.5 parts of the catalyst to 100 parts of the elastomer
base by volume. The flowable material is expanded and cured in the uterus U at the body temperature of the cow or heifer to implant the obturator 10 in the uterus U. The implant of the obturator 10 is in the cervical canal or os C of the uterus U and also in one or more cornu R of the uterus U. The minimum time required for the curing of the flowable material to implant the obturator 10 in the uterus U is 5 minutes. To implant the obturator 10 in a heifer between 1 Occ and 30cc of flowable material is used.
Another suitable flow material is a silicone foam elastomer which vulcanizes or cures at the body temperature of a cow or heifer. Such a silicone foam elastomer is sold by Dow
Corning Corporation as Dow Corning DT4290 Prosthetic Foam. The Dow Corning DT4290 Prosthetic Foam comprises a silicone foam elastomer base mixture of polydimethylsiloxane and polymethylhydrogensiloxane. The catalyst used with the silicone foam elastomer is stannous octoate, which is sold by Dow
Corning Corporation as Dow Corning Q74290 catalyst. The flow material is produced by six parts of Dow Corning 07-4290 catalyst with 100 parts of Dow Corning silicone foam elastomer base by weight.
The catalyst is disposed in the holes 45 of the plunger 40. The silicone foam elastomer is disposed in the cylinder 25 between the plunger 40 and the opening 70. The flowable material is expanded and cured in the uterus
U at the body temperature of the cow or heifer to implant the obturator 10 in the uterus U. The implant of the obturator 10 is in the cervical canal or os C of the uterus U and also in one or more cornu R of the uterus
U.
The minimum time required for the curing of the flowable material to implant the obturator 10 in the uterus U is 2 minutes.
To implant the obturator 10 in a heifer between 5cc and 1 0cc of flowable material is used.
Another suitable flow material is a collagen material of the type used in plastic surgery and by dermatologists. Such collagen material has been supplied by Collagen Corporation of
Palo Alto, California, U.S.A. For example,
Collagen Corporation supplies a ZYDERM col lagen composed of highly purified bovine dermal collagen in physiological saline or a highly purified form of collage made from calf hide in physiological saline. Between 20cc and 30cc of the collagen material which was buffered with a saline dilutant is injected into the uterus U of a heifer. The collagen material expands and cures at the body temperature of a heifer. Fifty-five minutes after the injection of the collagen material into a heifer, the collagen material solidifies sufficiently to implant in the uterus U of a heifer the obturator 10. The obturator 10 is implanted in the cervical canal or os C of the uterus U, the cornu R of the uterus U and in the corpus of the uterus U. The injection of the collagen material in the uterus U of a heifer can be carried out with the same material injecting device as used for the silicone elastomer.
Claims (11)
1. A method of producing sterility in a female animal comprising the steps of:
(a) injecting flowable material into the uterus of a female animal; (b) said flowable material having a property of curing at the body temperature of the female animal to implant in the uterus of the female animal an obturator.
2. A method of producing sterility in a female animal as claimed in Claim 1 wherein said obturator is implanted in the cervix of the uterus of the female animal to permanently block the cervical os of the uterus of the female animal.
3. A method of producing sterility in a female animal as claimed in Claim 2 wherein said flowable material has a property of expanding while being cured.
4. A method of producing sterility in a female animal as claimed in Claim 3 wherein said obturator has a rubber-like property.
5. A method of producing sterility in a female animal as claimed in Claim 2 wherein said flowable material comprises an elastomer of silicone material.
6. A method of producing sterility in a female animal as claimed in Claim 5 wherein said flowable material comprises a catalyst.
7. A method of producing sterility in a female animal as claimed in Claim 6 wherein said flowable material comprises a bonding agent.
8. A method of producing sterility in a female animal as claimed in Claim 2 wherein said flowable material comprises an elastomer of silicone foam material.
9. A method of producing sterility in a female animal as claimed in Claim 8 wherein said flowable material comprises a catalyst.
10. A method of producing sterility in a female animal as claimed in Claim 10 wherein said flowable material comprises a dilutant for buffering said collagen material.
11. A method of producing sterility in a female animal substantially as hereinbefore described with reference to the accompanying drawings
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55506383A | 1983-11-23 | 1983-11-23 |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8419762D0 GB8419762D0 (en) | 1984-09-05 |
GB2150032A true GB2150032A (en) | 1985-06-26 |
GB2150032B GB2150032B (en) | 1988-01-06 |
Family
ID=24215828
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB08419762A Expired GB2150032B (en) | 1983-11-25 | 1984-08-02 | Method of producing sterility in female animals |
Country Status (4)
Country | Link |
---|---|
AU (1) | AU566079B2 (en) |
CA (1) | CA1220102A (en) |
GB (1) | GB2150032B (en) |
ZA (1) | ZA847105B (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1430045A (en) * | 1973-02-26 | 1976-03-31 | Franklin Institute | Contraceptive apparatus and method |
GB1470573A (en) * | 1973-03-09 | 1977-04-14 | Population Res Inc | Method of dispensing fluid material into the fallopian tubes of a female body |
GB2021956A (en) * | 1978-06-06 | 1979-12-12 | Rsp Co | Apparatus and method for the hysteroscopic non-surgical sterilisation of females |
-
1984
- 1984-08-02 GB GB08419762A patent/GB2150032B/en not_active Expired
- 1984-09-10 ZA ZA847105A patent/ZA847105B/en unknown
- 1984-09-17 CA CA000463363A patent/CA1220102A/en not_active Expired
- 1984-10-25 AU AU34682/84A patent/AU566079B2/en not_active Ceased
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1430045A (en) * | 1973-02-26 | 1976-03-31 | Franklin Institute | Contraceptive apparatus and method |
GB1470573A (en) * | 1973-03-09 | 1977-04-14 | Population Res Inc | Method of dispensing fluid material into the fallopian tubes of a female body |
GB2021956A (en) * | 1978-06-06 | 1979-12-12 | Rsp Co | Apparatus and method for the hysteroscopic non-surgical sterilisation of females |
Also Published As
Publication number | Publication date |
---|---|
ZA847105B (en) | 1985-04-24 |
GB8419762D0 (en) | 1984-09-05 |
AU566079B2 (en) | 1987-10-08 |
AU3468284A (en) | 1985-05-30 |
GB2150032B (en) | 1988-01-06 |
CA1220102A (en) | 1987-04-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |