GB2149660A - Wound healing agents - Google Patents
Wound healing agents Download PDFInfo
- Publication number
- GB2149660A GB2149660A GB08330712A GB8330712A GB2149660A GB 2149660 A GB2149660 A GB 2149660A GB 08330712 A GB08330712 A GB 08330712A GB 8330712 A GB8330712 A GB 8330712A GB 2149660 A GB2149660 A GB 2149660A
- Authority
- GB
- United Kingdom
- Prior art keywords
- wound healing
- cephalopod
- formulation
- finely divided
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
Abstract
Wound healing agents comprise finely divided cephalopod skeletal material, e.g. from cuttlefish and squid. The compositions include the material in a compatible carrier or the agent can be the finely divided cephalopod material per se, which can be applied directly to a wound to be treated.
Description
SPECIFICATION
Wound Healing Agents and Compositions
This invention relates to wound healing agents and compositions.
Some agents which promote the healing of wounds in mammalian bodies are known. Thus,
Prudden, J. F. and Allen, J. (J. Am. Med. Assn., Vol.
192, pp.352-356; (1965) have shown that modified animal cartilage promotes the healing of wounds in humans. Also, Carlozzi et al. (U.S. Patent 3,232,836; 1966) have shown that N-acetyl glucosamine and related compounds facilitate the healing of body wounds in humans and animals. Moreover, Balassa (U.S. Patent 3,632,754; 1972) has shown that finely divided chitin, partially depolymerized chitin, and chitin derivatives promote the healing of wounds.
As the prior art shows that improved rates of wound healing are obtainable, the search for agents with improved wound healing properties has continued, particularly in view of certain limitations and objectionable features associated with known agents; for example, each requires considerable chemical processing, enzymatic digestion or other manipulation, and the products are artifacts, rather than natural substances.
According to one aspect of the present invention, there is provided a wound healing composition comprising finely divided cephalopod skeleton in a compatible topical carrier.
According to another aspect of the present invention there is provided a wound healing agent comprising a cephalopod skeletal material in finely divided form, for use in wound healing.
The present invention is based on the discovery that finely divided cephalopod skeletons, when topically applied, e.g. applied externally especially in a compatible carrier, to mammilian wounds, show improved effectiveness in promoting the healing of the wounds. By "promoting the healing" is meant that the treated wound is healed more rapidly andlor that the healed bond has greater resistance to physical rupture than an otherwise similar but untreated wound. Other features noted at times with the use of the compositions of the present invention are the alleviation of pain, itching or other irritation. The products of the invention are applicable to abrasions, scratches, chapped skin, bed sores, cuts, burns, and haemorrhoids.
While all cephalopod skeletons are believed operable in the composition of the present invention, the most readily available, and therefore preferred, are those from cuttlefish (cuttlebone) and squid (squid pen). Of these, cuttlebone is commercially available as a bird feed and squid pen can be readily isolated and purified from wastes in processing squid for food.
One method of isolating cephalopod skeletons involves boiling the wastes in water, mechanically separating the skeleton structures and then treating them by scrubbing, by ultrasonic vibration, or with detergents to remove adventitious protein. The dried skeletons are then ground to a fine powder.
Cephalopod skeletons, particularly cuttlebone, differ from crustacean shells in that they are
substantially less calcified and much easier to grind.
The ground cephalopod skeletal material may be
dusted directly on the wound or may be applied in a
compatible carrier. The carrier in which the ground
cephalopod skeletal material may be applied to a
wound may comprise any of the means commonly
used to maintain a medicament in contact with the
wound. The carrier may be a gas, liquid or solid. For
example, the ground cephalopod skeletal powder
may be dusted between the fibres of a gauze pad
and applied as a dressing to a wound. Also, the
powder may be suspended in a liquid or wax or fatty
carrier and applied to the wound as an ointment or
salve.
In the examples which follow and which are given
merely for illustrative purposes, six representative
formulations containing cephalopod skeleton
powders were employed.
Formulation 1
Commercial cuttlebone (Geisler Pet Products, Inc.,
Fairfield, New Jersey 07006, U.S.A.) ground to 120
mesh (125 microns) was placed in a high-torque
mechanical stirrer with five times its weight of a
commercial skin dressing containing water, cetyl
alcohol, glyceryl stearate, mineral oil, glycerine,
stearic acid, triethanolamine, dimethicone FEG-40
(dimethyl polysiloxane), sorbitan lanolate, methyl
paraben, Quaternium 15 and propyl paraben
(marketed as "Rose Milk" by Century Creations, Inc.,
Venice, California 90271). The mixture was stirred at
high speed until homogenized. The paste-like
product was stored in salve jars for use. Paraben is parahydroxybenzoic acid.
Formulation 2
The procedure of Formulation 1 was repeated
except that the commercial skin dressing contained
water, mineral oil, potassium stearate, sodium
stearate, cholesterol, cetyl palmitate, butyl paraben, sodium carbomer, potassium carbomer 934, propyl
paraben, methyl paraben, sodium laurate,
potassium laurate, castor oil, sodium myristate,
potassium myristate, myristyl alcohol, cetyl alcohol,
sodium palmitate, potassium palmitate, stearyl
alcohol, fragrance, and FD & C Red No.4 (marketed
as "Oil or Olay" by Olay Co., Inc., Wilten, CT 06897).
The mixture was thixotropic. When diluted with a small amount of water, it gave a stable dispersion.
Formulation 3
Squid was collected in Delaware Bay, the pen
cleaned of adventitious protein, dried and ground to
120 mesh (125 microns). This powder was used in the procedure of Formulation 1 in place of the
commercial cuttlebone. A small amount of calamine-phenol was incorporated into the resulting salve.
Formulation 4
The procedure of Formulation 1 was repeated except that the commercial skin dressing contained water, mineral oil, cocoa butter, stearic acid, oat flour, cetyl alcohol, sodium lauryl sulphate, dimethicone, PEG-15 cocamine, triethanol amine, fragrance, Quaternium-15, carbomer-934, lanolin alcohol, propyl paraben, methyl paraben, stearic hydrazide, FD & C yellow No. 5, and D & C Red No.
19 (marketed as "Balm Barr" by Balm Barr, Inc., a subsidiary of the Mennen Co., Morristown, New
Jersey 07960). The product was a smooth thick cream.
Formulation 5 Asoft unguentwas prepared by melting together 5 parts of cocoa butter, 4 parts of vegetable oil, 1 part of bacitracin ointment and dispersing therein 5 parts of finely powdered cuttlebone. The stirred mixture thickened as it cooled and, while still molten, it was transferred to appropriate containers.
The prepared unguent was useful for treating haemorrhoids.
Formulation 6
The procedure of Formulation 1 was repeated except that the commercial skin dressing contained live yeast cell derivatives, supplying 2000 units Skin
Respiratory Factor per ounce of ointment, shark liver oil (3%), and phenylemercuric nitrate 1:10,000 in a specially prepared rectal ointment base (marketed as "Preparation H" by Whitehall
Laboratories, Inc., New York, New York 10017). The product speeds the healing of haemorrhoidal bleeding.
EXAMPLE 1
A man in his late 60's suffered each winter with the skin on the tip of his index finger and thumb cracking open and becoming sore. His doctor prescribed the use of "Synalar" Cream 0.025% (a cortico-steroid) twice a day. The cream made the fingers less sore and seemed to speed up the healing but did not prevent the skin from recracking.
When Formulation 1 was substituted, the effect was the same as with "Synalar". However, when the two agents were applied concurrently, the cracking cleared up and did not reappear.
EXAMPLE 2
A women, age 73, received a first degree burn of about 1/4 inch on a finger. The burn was white
initially and there was no breakage of the skin. It was
promptly treated with Metholatum and then ice for
about 20 minutes. Formulation 2 was then applied.
An hour and a half later, the burn was sore and
sensitive to warm water used for dishwashing.
Formulation 2 was again applied. Two hours later the burn was essentially cured. There was no pain from warm water. The burn spot was slightly wrinkled as if calloused, but one had to hunt for the
spot, as it was not very evident.
EXAMPLE 3
A senior citizen (male, age 73) was exposed to the sun without a hat for 4--5 hours and appreciably sunburned on the forehead. The burn was treated with Mentholatum the same day, but this applicaion was not very effective. The following day the burn was treated with Formulation 3. The day after that the soreness had gone on the treated area, but not back of the hairline, which had been missed with the preparation. This area was treated with Formulation 3 and within a day the soreness had completely gone.
EXAMPLE 4
A large spaniel dog had had a yeast burn on its leg that had been open for a year or so. It had been treated by a veterinarian by removal of the material (like proud flesh), along with shots, etc. However, the sore was not cured. Formulation 3 was applied and the leg bandaged. In a month the sore was essentially cured. The sore came back part way; it was red but not raw. The treatment for Formulation 3 was repeated and after 3 months the wound was cured.
EXAMPLE 5
A girl aged 13 was scratched by a cat on several fingers and knuckles, there were 6 scratches or skinned spots. There was bleeding and later, reddening, probably from an allergic reaction prevalent in her family. Formulation 1 was applied on the second day. The third day there was much less redness, no open bleeding and wounds were nearly cured. Formulation 4 was applied in continuing treatment. The fourth and fifth days, the scratches were still evident, but no longer bothered and some scabs were gone. Treatment continued.
By the 7th day there were no scabs and no scars.
Claims (7)
1. A wound healing composition comprising finely divided cephalopod skeleton in a compatible topical carrier.
2. A wound healing composition according to claim 1,wherein the cephalopod skeleton is cuttlebone.
3. A wound healing composition according to claim 1, wherein the cephalopod skeleton is squid
pen.
4. Awound healing composition according to claim 1,2 or 3, wherein the finely divided cephalopod skeleton is in the form of a dust.
5. A wound healing composition according to claim 1, substantially as described in any one of the foregoing Formulations 1 to 6.
6. For use as an agent in wound healing, a cephaloped skeletal material in finely divided form.
7. For use as an agent in wound healing, a cephalopod skeletal material in finely divided form, the material being cuttlebone or squid pen.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB08330712A GB2149660B (en) | 1983-11-17 | 1983-11-17 | Wound healing agents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB08330712A GB2149660B (en) | 1983-11-17 | 1983-11-17 | Wound healing agents |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8330712D0 GB8330712D0 (en) | 1983-12-29 |
GB2149660A true GB2149660A (en) | 1985-06-19 |
GB2149660B GB2149660B (en) | 1986-10-29 |
Family
ID=10551923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB08330712A Expired GB2149660B (en) | 1983-11-17 | 1983-11-17 | Wound healing agents |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB2149660B (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1041172A (en) * | 1962-02-28 | 1966-09-01 | Balassa Leslie L | Wound healing compositions and methods |
-
1983
- 1983-11-17 GB GB08330712A patent/GB2149660B/en not_active Expired
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1041172A (en) * | 1962-02-28 | 1966-09-01 | Balassa Leslie L | Wound healing compositions and methods |
Non-Patent Citations (1)
Title |
---|
MERCK INDEX 9TH EDITION NO.8204 ON PAGE 8211. * |
Also Published As
Publication number | Publication date |
---|---|
GB8330712D0 (en) | 1983-12-29 |
GB2149660B (en) | 1986-10-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19921117 |