GB1041172A - Wound healing compositions and methods - Google Patents
Wound healing compositions and methodsInfo
- Publication number
- GB1041172A GB1041172A GB8158/63A GB815863A GB1041172A GB 1041172 A GB1041172 A GB 1041172A GB 8158/63 A GB8158/63 A GB 8158/63A GB 815863 A GB815863 A GB 815863A GB 1041172 A GB1041172 A GB 1041172A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cartilage
- aqueous
- product
- proteolytic treatment
- dextran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
Abstract
Cartilage preparations for use in healing wounds are obtained by subjecting cartilage to a proteolytic treatment and grinding the cartilage, before or after the proteolytic treatment, in the substantial absence of oxygen or in the presence of an antioxidant to a finely divided state. Preferably, the cartilage is defatted before the grinding step. The cartilage is preferably obtained from animals not over six months old, the most effective source generally being foetal skeletons. The proteolytic treatment can be effected with a proteolytic enzyme such as an acid-pepsin solution. The final product generally has a particle size not exceeding 40 microns. Active woundhealing extracts may be obtained from the cartilage product by treating the latter with aqueous solutions of ammonia, urea or various salts having a pH of 6.5 to 10, preferably in the absence of oxygen or in the presence of an antioxidant. The aqueous extracts may be concentrated in vacuum or spray-dried or freeze-dried. The activity of the prepared cartilage is increased by exposing it to irradiation of wavelength not greater than 4000 , e.g. UV light. A synergistic effect is obtained by admixing the cartilage product with growth hormone or tung oil. The product may be administered in the form of tablets, capsules, suppositories, ointments, salves (based on aqueous gels, for example, of aluminium hydroxide, kaolin, silica, methylcellulose, alginates, gum tragacanth, gelatin, gluten, casein, polyvinyl pyrrolidone or dextran), solutions, aqueous suspensions, oily suspensions, emulsions, sprays or incorporated with surgical gauze. Blood, blood plasma or a plasma substitute, e.g. polyvinylpyrrolidone or dextran, may be used as an extending agent. In one Example (No. 14), pepsin-treated, ground cartilage is held, in powder form, between layers of surgical gauze and held through bandages to an unsutured wound. In another Example (No. 22), the cartilage is put into the form of enterically coated tablets.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17644362A | 1962-02-28 | 1962-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1041172A true GB1041172A (en) | 1966-09-01 |
Family
ID=22644370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8158/63A Expired GB1041172A (en) | 1962-02-28 | 1963-02-28 | Wound healing compositions and methods |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE650626A (en) |
| DE (1) | DE1302401C2 (en) |
| FR (1) | FR3186M (en) |
| GB (1) | GB1041172A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2149660A (en) * | 1983-11-17 | 1985-06-19 | Univ Delaware | Wound healing agents |
| US5529786A (en) * | 1994-02-28 | 1996-06-25 | Moore; Eugene R. | Process and product for treatment of rheumatoid arthritis |
| ES2403804A1 (en) * | 2011-09-21 | 2013-05-21 | Bioibérica, S.A. | Cartilage product. (Machine-translation by Google Translate, not legally binding) |
| US9347081B2 (en) | 2011-04-19 | 2016-05-24 | Bioiberica, S.A. | Cartilage product |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2413912A1 (en) * | 1978-01-10 | 1979-08-03 | Bontemps Raymond | Frozen biogenic foetal material in normal saline - for regeneration and re-organisation of cells |
| US4350682A (en) * | 1979-05-11 | 1982-09-21 | Lescarden Ltd. | Cartilage extraction processes and products |
| FR2530955B1 (en) * | 1982-07-30 | 1987-11-13 | Hecmati Michel | ANTI-WRINKLE IMPLANT AND ITS MANUFACTURING METHOD |
| DE3626414C2 (en) * | 1986-08-05 | 1994-11-10 | Robapharm Ag | A preparation for stimulating chondrocytes and osteoblasts (ossein-hydroxyapatite complex), process for its preparation and medicament containing the same |
-
0
- BE BE650626D patent/BE650626A/nl unknown
-
1963
- 1963-02-27 DE DE1963B0070901 patent/DE1302401C2/en not_active Expired
- 1963-02-28 GB GB8158/63A patent/GB1041172A/en not_active Expired
- 1963-05-24 FR FR935842A patent/FR3186M/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2149660A (en) * | 1983-11-17 | 1985-06-19 | Univ Delaware | Wound healing agents |
| US5529786A (en) * | 1994-02-28 | 1996-06-25 | Moore; Eugene R. | Process and product for treatment of rheumatoid arthritis |
| US9347081B2 (en) | 2011-04-19 | 2016-05-24 | Bioiberica, S.A. | Cartilage product |
| US9687525B2 (en) | 2011-04-19 | 2017-06-27 | Bioiberica, S.A. | Cartilage product |
| ES2403804A1 (en) * | 2011-09-21 | 2013-05-21 | Bioibérica, S.A. | Cartilage product. (Machine-translation by Google Translate, not legally binding) |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1302401B (en) | 1978-02-09 |
| BE650626A (en) | 1900-01-01 |
| DE1302401C2 (en) | 1978-02-09 |
| FR3186M (en) | 1965-03-15 |
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