GB2143232B - Chemical compounds - Google Patents

Chemical compounds

Info

Publication number
GB2143232B
GB2143232B GB08416682A GB8416682A GB2143232B GB 2143232 B GB2143232 B GB 2143232B GB 08416682 A GB08416682 A GB 08416682A GB 8416682 A GB8416682 A GB 8416682A GB 2143232 B GB2143232 B GB 2143232B
Authority
GB
United Kingdom
Prior art keywords
group
thiomorpholino
piperidino
morpholino
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08416682A
Other versions
GB2143232A (en
GB8416682D0 (en
Inventor
Josef Roch
Josef Nickl
Erich Muller
Berthold Narr
Johannes Weisenberger
Rainer Zimmerman
Walter Haarmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of GB8416682D0 publication Critical patent/GB8416682D0/en
Publication of GB2143232A publication Critical patent/GB2143232A/en
Application granted granted Critical
Publication of GB2143232B publication Critical patent/GB2143232B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)

Abstract

New 2-piperazino-pteridines of general formula <IMAGE> are described wherein R1 represents a phenylalkylamino, alkylamino or dialkylamino group, a piperidino, morpholino, thiomorpholino, or 1-oxidothiomorpholino group, R2 represents a dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxidothiomorpholino group and R3 represents a halogen atom, an alkoxy, alkylthio, phenylalkoxy or phenylalkylthio group, wherein the alkyl moiety may contain from 1 to 3 carbon atoms, and the acid addition salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable pharmacological properties, particularly antithrombotic and metastasis-inhibiting effects. Processes for preparing the compounds of formula (I) are also described.
GB08416682A 1983-07-02 1984-06-29 Chemical compounds Expired GB2143232B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833323932 DE3323932A1 (en) 1983-07-02 1983-07-02 NEW 2-PIPERAZINO-PTERIDINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THIS COMPOUND

Publications (3)

Publication Number Publication Date
GB8416682D0 GB8416682D0 (en) 1984-08-01
GB2143232A GB2143232A (en) 1985-02-06
GB2143232B true GB2143232B (en) 1986-11-05

Family

ID=6203017

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08416682A Expired GB2143232B (en) 1983-07-02 1984-06-29 Chemical compounds

Country Status (17)

Country Link
EP (1) EP0134922B1 (en)
JP (1) JPS6025991A (en)
AT (1) ATE39253T1 (en)
AU (1) AU565105B2 (en)
CA (1) CA1233179A (en)
DD (1) DD229990A5 (en)
DE (2) DE3323932A1 (en)
DK (1) DK159113C (en)
ES (2) ES8503352A1 (en)
FI (1) FI80454C (en)
GB (1) GB2143232B (en)
HU (1) HU190932B (en)
IL (1) IL72265A (en)
NO (1) NO160920C (en)
NZ (1) NZ208725A (en)
PH (1) PH22493A (en)
ZA (1) ZA844968B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445298A1 (en) * 1984-12-12 1986-06-12 Dr. Karl Thomae Gmbh, 7950 Biberach NEW PTERIDINE, METHOD FOR THE PRODUCTION AND USE THEREOF AS INTERMEDIATE PRODUCTS OR AS A MEDICINAL PRODUCT
DE3540952C2 (en) * 1985-11-19 1997-08-14 Thomae Gmbh Dr K 2-Piperazino-pteridines, process for their preparation and medicaments containing these compounds
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
DE10202468A1 (en) * 2002-01-23 2004-09-30 Faustus Forschungs Cie. Translational Cancer Research Gmbh Pteridine derivatives, process for their preparation and their use
ES2295897T3 (en) * 2003-08-29 2008-04-16 4 Aza Ip Nv IMMUNODEPRESSING EFFECTS OF PTERIDINE DERIVATIVES.
GB2407089A (en) * 2003-10-17 2005-04-20 4 Aza Bioscience Nv Pteridine derivatives
DE102004057595A1 (en) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted pteridines for the treatment of inflammatory diseases
DE102004057594A1 (en) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substitute pteridine for the treatment of inflammatory diseases
DE102004057618A1 (en) 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted pteridines for the treatment of inflammatory diseases
DE102004057645A1 (en) * 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg New substituted pteridine compounds, useful as phosphodiesterase 4 inhibitors for treating e.g. inflammatory diseases, cancer, asthma, ulcerative colitis, depression and schizophrenia
EP2029600B1 (en) * 2006-05-24 2012-03-14 Boehringer Ingelheim International GmbH Substituted pteridines substituted with a four-membered heterocycle
WO2007135026A2 (en) 2006-05-24 2007-11-29 Boehringer Ingelheim International Gmbh Substituted pteridines as therapeutic agents
WO2008003149A2 (en) * 2006-07-06 2008-01-10 Gilead Sciences , Inc. Substituted pteridines for the treatment and prevention of viral infections
WO2008009079A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
SI3097102T1 (en) 2015-03-04 2018-02-28 Gilead Sciences, Inc. Toll-like receptor modulating 4,6-diamino-pyrido(3,2-d)pyrimidine compounds
US10370342B2 (en) 2016-09-02 2019-08-06 Gilead Sciences, Inc. Toll like receptor modulator compounds
ES2826748T3 (en) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivatives of 4,6-diamino-pyrido [3,2-d] pyrimidine as modulators of Toll-like receptors
TWI751517B (en) 2019-04-17 2022-01-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TWI751516B (en) 2019-04-17 2022-01-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TW202115056A (en) 2019-06-28 2021-04-16 美商基利科學股份有限公司 Processes for preparing toll-like receptor modulator compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2940972A (en) * 1957-06-27 1960-06-14 Thomae Gmbh Dr K Tri-and tetra-substituted pteridine derivatives
FR1352111A (en) * 1962-01-25 1964-02-14 Lumiere Lab Triamino pteridines and their preparation

Also Published As

Publication number Publication date
PH22493A (en) 1988-09-12
ES8601205A1 (en) 1985-10-16
ES537785A0 (en) 1985-10-16
AU3009284A (en) 1985-01-03
DK316284D0 (en) 1984-06-28
DD229990A5 (en) 1985-11-20
JPS6025991A (en) 1985-02-08
AU565105B2 (en) 1987-09-03
NO160920B (en) 1989-03-06
ZA844968B (en) 1986-03-26
IL72265A0 (en) 1984-10-31
DK159113C (en) 1991-02-18
ES533298A0 (en) 1985-02-16
GB2143232A (en) 1985-02-06
ATE39253T1 (en) 1988-12-15
DK316284A (en) 1985-01-03
CA1233179A (en) 1988-02-23
DE3323932A1 (en) 1985-01-10
HU190932B (en) 1986-12-28
FI842622A (en) 1985-01-03
EP0134922B1 (en) 1988-12-14
IL72265A (en) 1987-08-31
DK159113B (en) 1990-09-03
NO160920C (en) 1989-06-14
GB8416682D0 (en) 1984-08-01
NO842631L (en) 1985-01-03
FI80454B (en) 1990-02-28
FI80454C (en) 1990-06-11
ES8503352A1 (en) 1985-02-16
NZ208725A (en) 1988-10-28
DE3475620D1 (en) 1989-01-19
FI842622A0 (en) 1984-06-29
EP0134922A1 (en) 1985-03-27
HUT34487A (en) 1985-03-28

Similar Documents

Publication Publication Date Title
GB2143232B (en) Chemical compounds
EP0163599A3 (en) Pyrimidopyrimidine derivatives, processes for producing them, pharmaceutical compositions containing them and their use as anti-allergic agents
ES8105005A1 (en) Process for the preparation of oxoalkylxanthines.
DE3061424D1 (en) 8-phenyl purines, their preparation and medicaments containing them
DE69230265D1 (en) Derivatives of galacturonic acid, process for their preparation and their use
PL243132A1 (en) Process for manufacturing novel muramyl peptides
ATE70837T1 (en) ALLYLMERCAPTOACETYL-SYDNONIMINE, PROCESS FOR THEIR PREPARATION AND USE.
ZA881383B (en) 2-(2,3-dihydro-2-oxo-3-benzofuranyl)acetic acid derivatives,processes for preparing them and the pharmaceutical compositions which contain them
IL77583A (en) N-sulphonyl-n&#39;-phosphonomethyl glycine derivatives,process for the preparation thereof and herbicidal compositions comprising the same
ATE5720T1 (en) 2-PYRIDYLOXYACETANILIDE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE.
EP0312245A3 (en) Polycyclic compounds and pharmaceutical compositions thereof
ATE75468T1 (en) SUBSTITUTED 3-AMINOSYDNONIMINES, PROCESSES FOR THEIR PREPARATION AND THEIR USE.
ZA881384B (en) Acetamides derived from 2,3-dihydro-3-phenyl-2-benzofuranone,processes for preparing them and the pharmaceutical compositions which contain them

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee