DK316284A - 2-PIPERAZINO-PTERIDINES, PROCEDURES FOR THEIR PREPARATION AND MEDICINALS CONTAINING THE COMPOUNDS - Google Patents

2-PIPERAZINO-PTERIDINES, PROCEDURES FOR THEIR PREPARATION AND MEDICINALS CONTAINING THE COMPOUNDS Download PDF

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Publication number
DK316284A
DK316284A DK316284A DK316284A DK316284A DK 316284 A DK316284 A DK 316284A DK 316284 A DK316284 A DK 316284A DK 316284 A DK316284 A DK 316284A DK 316284 A DK316284 A DK 316284A
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DK
Denmark
Prior art keywords
group
pteridines
piperazino
compounds
procedures
Prior art date
Application number
DK316284A
Other languages
Danish (da)
Other versions
DK159113C (en
DK316284D0 (en
DK159113B (en
Inventor
Josef Roch
Josef Nickl
Erich Mueller
Berthold Narr
Johannes Weisenberger
Rainer Zimmermann
Walter Haarmann
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of DK316284D0 publication Critical patent/DK316284D0/en
Publication of DK316284A publication Critical patent/DK316284A/en
Publication of DK159113B publication Critical patent/DK159113B/en
Application granted granted Critical
Publication of DK159113C publication Critical patent/DK159113C/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

New 2-piperazino-pteridines of general formula <IMAGE> are described wherein R1 represents a phenylalkylamino, alkylamino or dialkylamino group, a piperidino, morpholino, thiomorpholino, or 1-oxidothiomorpholino group, R2 represents a dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxidothiomorpholino group and R3 represents a halogen atom, an alkoxy, alkylthio, phenylalkoxy or phenylalkylthio group, wherein the alkyl moiety may contain from 1 to 3 carbon atoms, and the acid addition salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable pharmacological properties, particularly antithrombotic and metastasis-inhibiting effects. Processes for preparing the compounds of formula (I) are also described.
DK316284A 1983-07-02 1984-06-28 2-PIPERAZINO-PTERIDINES OR ACID ADDITIONAL SALTS THEREOF AND MEDICINALS CONTAINING THE COMPOUNDS DK159113C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3323932 1983-07-02
DE19833323932 DE3323932A1 (en) 1983-07-02 1983-07-02 NEW 2-PIPERAZINO-PTERIDINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THIS COMPOUND

Publications (4)

Publication Number Publication Date
DK316284D0 DK316284D0 (en) 1984-06-28
DK316284A true DK316284A (en) 1985-01-03
DK159113B DK159113B (en) 1990-09-03
DK159113C DK159113C (en) 1991-02-18

Family

ID=6203017

Family Applications (1)

Application Number Title Priority Date Filing Date
DK316284A DK159113C (en) 1983-07-02 1984-06-28 2-PIPERAZINO-PTERIDINES OR ACID ADDITIONAL SALTS THEREOF AND MEDICINALS CONTAINING THE COMPOUNDS

Country Status (17)

Country Link
EP (1) EP0134922B1 (en)
JP (1) JPS6025991A (en)
AT (1) ATE39253T1 (en)
AU (1) AU565105B2 (en)
CA (1) CA1233179A (en)
DD (1) DD229990A5 (en)
DE (2) DE3323932A1 (en)
DK (1) DK159113C (en)
ES (2) ES533298A0 (en)
FI (1) FI80454C (en)
GB (1) GB2143232B (en)
HU (1) HU190932B (en)
IL (1) IL72265A (en)
NO (1) NO160920C (en)
NZ (1) NZ208725A (en)
PH (1) PH22493A (en)
ZA (1) ZA844968B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445298A1 (en) * 1984-12-12 1986-06-12 Dr. Karl Thomae Gmbh, 7950 Biberach NEW PTERIDINE, METHOD FOR THE PRODUCTION AND USE THEREOF AS INTERMEDIATE PRODUCTS OR AS A MEDICINAL PRODUCT
DE3540952C2 (en) * 1985-11-19 1997-08-14 Thomae Gmbh Dr K 2-Piperazino-pteridines, process for their preparation and medicaments containing these compounds
WO2005021003A2 (en) * 2003-08-29 2005-03-10 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
DE10202468A1 (en) * 2002-01-23 2004-09-30 Faustus Forschungs Cie. Translational Cancer Research Gmbh Pteridine derivatives, process for their preparation and their use
GB2407089A (en) * 2003-10-17 2005-04-20 4 Aza Bioscience Nv Pteridine derivatives
DE102004057595A1 (en) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted pteridines for the treatment of inflammatory diseases
DE102004057645A1 (en) * 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg New substituted pteridine compounds, useful as phosphodiesterase 4 inhibitors for treating e.g. inflammatory diseases, cancer, asthma, ulcerative colitis, depression and schizophrenia
DE102004057594A1 (en) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substitute pteridine for the treatment of inflammatory diseases
DE102004057618A1 (en) * 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted pteridines for the treatment of inflammatory diseases
CA2652840C (en) 2006-05-24 2014-09-09 Boehringer Ingelheim International Gmbh 2-piperazino-6-chloro-pteridines as pde4-inhibitors for the treatment of inflammatory diseases
ATE549338T1 (en) * 2006-05-24 2012-03-15 Boehringer Ingelheim Int SUBSTITUTED PTERIDINES SUBSTITUTED WITH A FOUR-MEMBER HETEROCYCLE
US20090318456A1 (en) * 2006-07-06 2009-12-24 Gilead Sciences, Inc. Substituted pteridines for the treatment and prevention of viral infections
US10144736B2 (en) 2006-07-20 2018-12-04 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
PL3321265T3 (en) 2015-03-04 2020-11-16 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine compounds and their utilisation as modulators of toll-like receptors
WO2018045150A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
SI3507276T1 (en) 2016-09-02 2022-01-31 Gilead Sciences, Inc. Toll like receptor modulator compounds
TW202210480A (en) 2019-04-17 2022-03-16 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TW202212339A (en) 2019-04-17 2022-04-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TW202115056A (en) 2019-06-28 2021-04-16 美商基利科學股份有限公司 Processes for preparing toll-like receptor modulator compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2940972A (en) * 1957-06-27 1960-06-14 Thomae Gmbh Dr K Tri-and tetra-substituted pteridine derivatives
FR1352111A (en) * 1962-01-25 1964-02-14 Lumiere Lab Triamino pteridines and their preparation

Also Published As

Publication number Publication date
NO842631L (en) 1985-01-03
FI80454C (en) 1990-06-11
ES8503352A1 (en) 1985-02-16
JPS6025991A (en) 1985-02-08
HUT34487A (en) 1985-03-28
ES533298A0 (en) 1985-02-16
GB2143232B (en) 1986-11-05
NO160920C (en) 1989-06-14
ZA844968B (en) 1986-03-26
FI80454B (en) 1990-02-28
ES8601205A1 (en) 1985-10-16
AU565105B2 (en) 1987-09-03
DK159113C (en) 1991-02-18
IL72265A (en) 1987-08-31
EP0134922B1 (en) 1988-12-14
FI842622A0 (en) 1984-06-29
ES537785A0 (en) 1985-10-16
HU190932B (en) 1986-12-28
DD229990A5 (en) 1985-11-20
PH22493A (en) 1988-09-12
CA1233179A (en) 1988-02-23
ATE39253T1 (en) 1988-12-15
AU3009284A (en) 1985-01-03
GB2143232A (en) 1985-02-06
GB8416682D0 (en) 1984-08-01
EP0134922A1 (en) 1985-03-27
DE3323932A1 (en) 1985-01-10
DK316284D0 (en) 1984-06-28
DE3475620D1 (en) 1989-01-19
NO160920B (en) 1989-03-06
NZ208725A (en) 1988-10-28
IL72265A0 (en) 1984-10-31
DK159113B (en) 1990-09-03
FI842622A (en) 1985-01-03

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