GB2102291A - Method for purifying polyosides of streptococcus pneumoniae and vaccine based on polyosides thus purified - Google Patents

Method for purifying polyosides of streptococcus pneumoniae and vaccine based on polyosides thus purified

Info

Publication number
GB2102291A
GB2102291A GB08223061A GB8223061A GB2102291A GB 2102291 A GB2102291 A GB 2102291A GB 08223061 A GB08223061 A GB 08223061A GB 8223061 A GB8223061 A GB 8223061A GB 2102291 A GB2102291 A GB 2102291A
Authority
GB
United Kingdom
Prior art keywords
polyosides
streptococcus pneumoniae
purifying
purified
vaccine based
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB08223061A
Other versions
GB2102291B (en
Inventor
Francois Arminjon
Robert Donikian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Merieux SA
Original Assignee
Institut Merieux SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Merieux SA filed Critical Institut Merieux SA
Publication of GB2102291A publication Critical patent/GB2102291A/en
Application granted granted Critical
Publication of GB2102291B publication Critical patent/GB2102291B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The method is characterized by the fact that the starting protein is an aqueous solution of said polyosides, containing protein impurities, obtained by lysis of a culture of Streptococcus pneumoniae, clarification and concentration of the polyoside, that, with the aim to reduce the protein content, there are added 5 to 50% of phenol by volume, at a temperature comprised between 5 and 30`C approximately, that the aqueous phase is first stirred, and then separated and collected, and that the phenol treatment, if necessary, is repeated until the protein content of the aqueous phase is lower than a predetermined threshold.
GB08223061A 1980-12-11 1981-12-11 Method for purifying polyosides of streptococcus pneumoniae and vaccine based on polyosides thus purified Expired GB2102291B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8026320A FR2495939B1 (en) 1980-12-11 1980-12-11 PROCESS FOR THE PURIFICATION OF STREPTOCOCCUS PNEUMONIAE POLYOSIDES AND VACCINE BASED ON THE PURIFIED POLYOSIDES

Publications (2)

Publication Number Publication Date
GB2102291A true GB2102291A (en) 1983-02-02
GB2102291B GB2102291B (en) 1985-07-24

Family

ID=9248957

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08223061A Expired GB2102291B (en) 1980-12-11 1981-12-11 Method for purifying polyosides of streptococcus pneumoniae and vaccine based on polyosides thus purified

Country Status (7)

Country Link
BE (1) BE891444A (en)
CH (1) CH662056A5 (en)
DE (1) DE3152621T1 (en)
FR (1) FR2495939B1 (en)
GB (1) GB2102291B (en)
NL (1) NL8120466A (en)
WO (1) WO1982001995A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5623057A (en) * 1991-01-28 1997-04-22 Merck & Co., Inc. Pneumococcal polysaccharide conjugate vaccine
US5847112A (en) * 1991-01-28 1998-12-08 Merck & Co., Inc. Process for making capsular polysaccharides from Streptococcus pneumoniae

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3466982T3 (en) * 2005-04-08 2020-08-03 Wyeth Llc SEPARATION OF POLLUTING CONTAMINANTS FROM STREPTOCOCCUS PNEUMONIAE POLYSACCHARID BY PH MANIPULATION
CA2681570C (en) * 2007-03-23 2016-05-03 Wyeth Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides
HUE046859T2 (en) 2008-12-18 2020-03-30 Wyeth Llc Method for controlling streptococcus pneumoniae polysaccharide molecular weight using carbon
WO2010080486A2 (en) 2008-12-18 2010-07-15 Wyeth Llc Method for controlling streptococcus pneumoniae serotype 19a polysaccharide molecular weight
WO2011151841A1 (en) * 2010-05-31 2011-12-08 Panacea Biotec Limited Fermentation process for streptococcus pneumoniae
CN106460062A (en) 2014-05-05 2017-02-22 美敦力公司 Methods and compositions for SCD, CRT, CRT-D, or SCA therapy identification and/or selection
GB202016165D0 (en) 2020-10-12 2020-11-25 Optivalent Ltd Vaccine
GB2614916A (en) 2022-01-25 2023-07-26 Optivalent Ltd Intradermal vaccine complement

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2388563A1 (en) * 1977-04-29 1978-11-24 Fabre Sa Pierre ADVANCED ACELLULAR VACCINES CONTAINING CAPSULAR POLYSACCHARIDES

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5623057A (en) * 1991-01-28 1997-04-22 Merck & Co., Inc. Pneumococcal polysaccharide conjugate vaccine
US5847112A (en) * 1991-01-28 1998-12-08 Merck & Co., Inc. Process for making capsular polysaccharides from Streptococcus pneumoniae

Also Published As

Publication number Publication date
GB2102291B (en) 1985-07-24
BE891444A (en) 1982-06-11
FR2495939A1 (en) 1982-06-18
WO1982001995A1 (en) 1982-06-24
FR2495939B1 (en) 1985-10-11
DE3152621C2 (en) 1988-05-11
CH662056A5 (en) 1987-09-15
DE3152621T1 (en) 1983-11-17
NL8120466A (en) 1982-11-01

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Effective date: 20011210