GB2094145B - Stabilized insulin preparations and method for their production - Google Patents
Stabilized insulin preparations and method for their productionInfo
- Publication number
- GB2094145B GB2094145B GB8206899A GB8206899A GB2094145B GB 2094145 B GB2094145 B GB 2094145B GB 8206899 A GB8206899 A GB 8206899A GB 8206899 A GB8206899 A GB 8206899A GB 2094145 B GB2094145 B GB 2094145B
- Authority
- GB
- United Kingdom
- Prior art keywords
- production
- insulin preparations
- insulin
- stabilized insulin
- preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 8
- 102000004877 Insulin Human genes 0.000 title abstract 4
- 108090001061 Insulin Proteins 0.000 title abstract 4
- 229940125396 insulin Drugs 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 159000000003 magnesium salts Chemical class 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8107423 | 1981-03-10 | ||
| DK414381 | 1981-09-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2094145A GB2094145A (en) | 1982-09-15 |
| GB2094145B true GB2094145B (en) | 1984-12-05 |
Family
ID=26067363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8206899A Expired GB2094145B (en) | 1981-03-10 | 1982-03-09 | Stabilized insulin preparations and method for their production |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4472385A (enExample) |
| EP (1) | EP0060141B1 (enExample) |
| AT (1) | ATE23269T1 (enExample) |
| AU (1) | AU550068B2 (enExample) |
| CA (1) | CA1170990A (enExample) |
| CH (1) | CH652031A5 (enExample) |
| DE (1) | DE3274064D1 (enExample) |
| ES (1) | ES510245A0 (enExample) |
| FI (1) | FI78838C (enExample) |
| FR (1) | FR2501507B1 (enExample) |
| GB (1) | GB2094145B (enExample) |
| IE (1) | IE52904B1 (enExample) |
| IT (1) | IT1150639B (enExample) |
| NO (1) | NO157843C (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7322066B2 (en) | 2003-07-16 | 2008-01-29 | Church & Dwight Co., Inc. | Electric toothbrushes having movable, intermittently movable, and fixed bristles |
| US7356866B2 (en) | 2002-06-11 | 2008-04-15 | Church & Dwight Co., Inc. | Modular electric toothbrushes |
| US7748070B2 (en) | 2003-09-09 | 2010-07-06 | The Procter & Gamble Company | Electric toothbrush comprising an electrically powered element |
| US7845039B2 (en) | 2003-09-09 | 2010-12-07 | The Procter & Gamble Company | Toothbrush with severable electrical connections |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985002544A1 (en) * | 1983-12-16 | 1985-06-20 | Thomas Takemi Aoki | Insulin delivery algorithm |
| PH23446A (en) * | 1986-10-20 | 1989-08-07 | Novo Industri As | Peptide preparations |
| ES2053723T3 (es) * | 1987-02-25 | 1994-08-01 | Novo Nordisk As | Nuevos derivados de insulina. |
| US4789660A (en) * | 1987-09-10 | 1988-12-06 | American Home Products Corporation | Insulin administration using methyl and propyl paraben |
| HU228094B1 (en) † | 1996-06-20 | 2012-10-29 | Novo Nordisk As | Insulin preparations containing nacl |
| AR012894A1 (es) * | 1997-06-13 | 2000-11-22 | Lilly Co Eli | Formulacion de insulina en solucion estable, su uso para preparar un medicamento y proceso para la preparacion de la misma. |
| DE69924232D1 (de) * | 1998-01-09 | 2005-04-21 | Novo Nordisk As | Stabilisierte insulin-zubereitungen |
| US20020156434A1 (en) * | 1998-03-13 | 2002-10-24 | Minimed Inc. | Stabilizing catheter for protein drug delivery |
| WO2003094956A1 (en) | 2002-05-07 | 2003-11-20 | Novo Nordisk A/S | Soluble formulations comprising monomeric insulin and acylated insulin |
| FR2896164B1 (fr) * | 2006-01-18 | 2008-07-04 | Flamel Technologies Sa | Formulation colloidale d'insuline longue action et sa preparation |
| FR2943538B1 (fr) * | 2009-03-27 | 2011-05-20 | Adocia | Formulation a action rapide d'insuline recombinante humaine |
| US9018190B2 (en) | 2009-03-27 | 2015-04-28 | Adocia | Functionalized oligosaccharides |
| US20130231281A1 (en) | 2011-11-02 | 2013-09-05 | Adocia | Rapid acting insulin formulation comprising an oligosaccharide |
| EP2919804B1 (fr) | 2012-11-13 | 2018-01-31 | Adocia | Formulation à action rapide d'insuline comprenant un composé anionique substitué |
| WO2015120457A1 (en) * | 2014-02-10 | 2015-08-13 | Biodel Inc. | Stabilized ultra-rapid-acting insulin formulations |
| US9795678B2 (en) | 2014-05-14 | 2017-10-24 | Adocia | Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound |
| FR3020947B1 (fr) | 2014-05-14 | 2018-08-31 | Adocia | Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations |
| FR3043557B1 (fr) | 2015-11-16 | 2019-05-31 | Adocia | Composition a action rapide d'insuline comprenant un citrate substitue |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR892194A (fr) * | 1938-06-29 | 1944-03-30 | Ig Farbenindustrie Ag | Procédé de fabrication de préparations à base d'insuline |
| US2474729A (en) * | 1945-01-03 | 1949-06-28 | Rhone Poulenc Sa | Insulin preparations |
| US3102077A (en) * | 1953-08-19 | 1963-08-27 | Christensen Henry Marinus | Preparation of insulin containing 2.75 to 8 percent zinc content |
| DK98342C (da) * | 1959-06-16 | 1964-03-31 | Henry Marinus Dr Christensen | Fremgangsmåde til fremstilling af et insulinpræparat til peroral applikation. |
| US4196196A (en) * | 1978-06-19 | 1980-04-01 | Tiholiz Ivan C | Divalen/monovalent bipolar cation therapy for enhancement of tissue perfusion and reperfusion in disease states |
-
1982
- 1982-03-04 AU AU81114/82A patent/AU550068B2/en not_active Ceased
- 1982-03-09 FI FI820808A patent/FI78838C/fi not_active IP Right Cessation
- 1982-03-09 CH CH1447/82A patent/CH652031A5/de not_active IP Right Cessation
- 1982-03-09 AT AT82301207T patent/ATE23269T1/de not_active IP Right Cessation
- 1982-03-09 EP EP82301207A patent/EP0060141B1/en not_active Expired
- 1982-03-09 GB GB8206899A patent/GB2094145B/en not_active Expired
- 1982-03-09 CA CA000397937A patent/CA1170990A/en not_active Expired
- 1982-03-09 IT IT8220038A patent/IT1150639B/it active
- 1982-03-09 NO NO820742A patent/NO157843C/no unknown
- 1982-03-09 DE DE8282301207T patent/DE3274064D1/de not_active Expired
- 1982-03-09 IE IE536/82A patent/IE52904B1/en not_active IP Right Cessation
- 1982-03-09 ES ES82510245A patent/ES510245A0/es active Granted
- 1982-03-09 FR FR8203942A patent/FR2501507B1/fr not_active Expired
- 1982-03-09 US US06/356,343 patent/US4472385A/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7356866B2 (en) | 2002-06-11 | 2008-04-15 | Church & Dwight Co., Inc. | Modular electric toothbrushes |
| US7322066B2 (en) | 2003-07-16 | 2008-01-29 | Church & Dwight Co., Inc. | Electric toothbrushes having movable, intermittently movable, and fixed bristles |
| US7748070B2 (en) | 2003-09-09 | 2010-07-06 | The Procter & Gamble Company | Electric toothbrush comprising an electrically powered element |
| US7845039B2 (en) | 2003-09-09 | 2010-12-07 | The Procter & Gamble Company | Toothbrush with severable electrical connections |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0060141A2 (en) | 1982-09-15 |
| FI820808L (fi) | 1982-09-11 |
| FI78838B (fi) | 1989-06-30 |
| NO820742L (no) | 1982-09-13 |
| ES8302462A1 (es) | 1983-01-16 |
| CH652031A5 (de) | 1985-10-31 |
| NO157843C (no) | 1988-06-01 |
| CA1170990A (en) | 1984-07-17 |
| FI78838C (fi) | 1989-10-10 |
| GB2094145A (en) | 1982-09-15 |
| US4472385A (en) | 1984-09-18 |
| AU550068B2 (en) | 1986-02-27 |
| NO157843B (no) | 1988-02-22 |
| AU8111482A (en) | 1982-09-16 |
| FR2501507B1 (enExample) | 1986-04-18 |
| ES510245A0 (es) | 1983-01-16 |
| ATE23269T1 (de) | 1986-11-15 |
| DE3274064D1 (en) | 1986-12-11 |
| IE820536L (en) | 1982-09-10 |
| EP0060141A3 (en) | 1983-08-24 |
| IT8220038A0 (it) | 1982-03-09 |
| IT1150639B (it) | 1986-12-17 |
| FR2501507A1 (enExample) | 1982-09-17 |
| EP0060141B1 (en) | 1986-11-05 |
| IE52904B1 (en) | 1988-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU550068B2 (en) | Zinc insulin stabilized with calcium or magnesium salts | |
| ES8500060A1 (es) | Un metodo de producir una solucion de insulina. | |
| AU528310B2 (en) | Composition of paracetamol and metoclopramide | |
| AU3502289A (en) | Method for administering the drug deprenyl so as to minimize the danger of side effects | |
| UA39174C2 (uk) | Асоціати депротонованої гіалуронової кислоти, спосіб одержання асоціатів депротонованої гіалуронової кислоти, фармацевтична композиція та спосіб одержання фармацевтичної композиції | |
| GR970300038T1 (en) | Filtration | |
| PT85949A (en) | Process for the preparation of insulin compositions containing magnesium ions | |
| AU3683484A (en) | The use of menthol to enhance transdermal drug delivery | |
| PT66789A (en) | Process for the preparation of pharmaceutical compositions having high rate of resorption,from heart glicosides,in se hardly resorptive,to be parenterically administered | |
| ES8303086A1 (es) | "un metodo para producir una forma de farmaco para administracion no parenteral a base de l-piroglutamil-l-histidil-l-prolinamida." | |
| NZ192108A (en) | Tablet containing analgesic medicament and metoclopramide | |
| DE3065473D1 (en) | Method of stabilizing interferon and composition containing it | |
| ES8705763A1 (es) | Procedimiento para preparar nuevas formulaciones de gel parafines terapeuticos y diagnosticos | |
| JPS57206608A (en) | Production of gamma-globulin for intravenous injection | |
| IT7829910A0 (it) | Derivati dell'acido fosfonoso, procedimenti per la loro preparazione e loro impiego per combattere microorganismi. | |
| HUT47600A (en) | Process for production of encephalinase glykopeptids, amin acid derivatives with hindering effect and medical compositions containing them | |
| IL84659A (en) | Pharmaceutical composition for delivery of azumolene directly to intestines | |
| JPS57116098A (en) | Novel 3-aminosteroid derivative, salt, manufacture, intermediate, use as drug and composition containing same | |
| JPS57183720A (en) | Health drug for fish farming | |
| DE3166925D1 (en) | Products prepared from the thymic series factor or from its analogues and derivatives, process for preparation thereof, these products for use as medicines, radioactive tracers obtained from these products and use of these radioactive tracers in dosage processes | |
| EP0239015A3 (en) | Process for producing 1-beta-d-arabinofuranosylcytosine-5'-stearylphosphate monosodium salt and monohydrate thereof, and pharmaceutical composition containing the latter | |
| ES8504166A1 (es) | Un metodo de preparar derivados de 6,11-dihidrodibenz(b,e) oxepina. | |
| SU1517173A1 (ru) | Антисептическое средство | |
| GB1449441A (en) | Agnets for lowering the lipid level in plasma | |
| JPS57188511A (en) | Stabilized electrolyte solution |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19990309 |