GB2085446B - Fractionation of protein mixtures by salt addition followed by dialysis treatment - Google Patents

Fractionation of protein mixtures by salt addition followed by dialysis treatment

Info

Publication number
GB2085446B
GB2085446B GB8110976A GB8110976A GB2085446B GB 2085446 B GB2085446 B GB 2085446B GB 8110976 A GB8110976 A GB 8110976A GB 8110976 A GB8110976 A GB 8110976A GB 2085446 B GB2085446 B GB 2085446B
Authority
GB
United Kingdom
Prior art keywords
fractionation
dialysis treatment
salt addition
protein mixtures
addition followed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8110976A
Other languages
English (en)
Other versions
GB2085446A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Veolia WTS Systems USA Inc
Original Assignee
Ionics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionics Inc filed Critical Ionics Inc
Publication of GB2085446A publication Critical patent/GB2085446A/en
Application granted granted Critical
Publication of GB2085446B publication Critical patent/GB2085446B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
    • A23C9/144—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by electrical means, e.g. electrodialysis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/06—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3482—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate by filtrating the filtrate using another cross-flow filter, e.g. a membrane filter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
    • B01D61/44—Ion-selective electrodialysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/303—Extraction; Separation; Purification by precipitation by salting out
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/22—Blood coagulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Water Supply & Treatment (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
GB8110976A 1980-10-16 1981-04-08 Fractionation of protein mixtures by salt addition followed by dialysis treatment Expired GB2085446B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/197,441 US4321192A (en) 1980-01-10 1980-10-16 Fractionation of protein mixtures by salt addition followed by dialysis treatment

Publications (2)

Publication Number Publication Date
GB2085446A GB2085446A (en) 1982-04-28
GB2085446B true GB2085446B (en) 1984-08-22

Family

ID=22729448

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8110976A Expired GB2085446B (en) 1980-10-16 1981-04-08 Fractionation of protein mixtures by salt addition followed by dialysis treatment

Country Status (7)

Country Link
US (1) US4321192A (OSRAM)
JP (1) JPS5772916A (OSRAM)
CA (1) CA1142175A (OSRAM)
DE (1) DE3112539A1 (OSRAM)
FR (1) FR2492270A2 (OSRAM)
GB (1) GB2085446B (OSRAM)
IT (1) IT1142464B (OSRAM)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4426323A (en) 1980-01-10 1984-01-17 Ionics, Incorporated Selected recovery of proteins from fermentation broths
US4435318A (en) 1981-05-22 1984-03-06 Ionics, Incorporated Electrodialysis preparation of purified AHF concentrate
JPS58155865A (ja) * 1982-03-12 1983-09-16 株式会社クラレ 血漿処理用中空糸膜
JPS6099266A (ja) * 1983-11-07 1985-06-03 テルモ株式会社 体液中の蛋白質除去法およびそれに使用する装置
JPS6099265A (ja) * 1983-11-07 1985-06-03 テルモ株式会社 体液中の蛋白質除去装置
SE8402861L (sv) * 1984-05-28 1985-11-29 Stefan Svenson Rening av biologiskt material
US4663049A (en) * 1984-07-05 1987-05-05 University Of Utah Process for therapeutic dissociation of immune complexes and removal of antigens
JPS6164259A (ja) * 1984-09-07 1986-04-02 テルモ株式会社 血漿蛋白質分画分離剤および装置
US4678566A (en) * 1984-07-20 1987-07-07 Terumo Kabushiki Kaisha Apparatus for separating proteins from blood plasma
JPH06104122B2 (ja) * 1985-09-19 1994-12-21 東レ株式会社 β▲下２▼−ミクログロブリン除去カラム
US4877608A (en) * 1987-11-09 1989-10-31 Rorer Pharmaceutical Corporation Pharmaceutical plasma protein formulations in low ionic strength media
CA1308023C (en) * 1988-07-29 1992-09-29 William Austin James Mcauley Immunoglobulin extraction utilizing properties of colloidal solutions
EP0396402A3 (en) * 1989-05-02 1991-06-19 Alliance Pharmaceutical Corporation Cell growth activators
US5217618A (en) * 1991-08-26 1993-06-08 Terumo Kabushiki Kaisha Plasma purification treatment
US5804079A (en) * 1991-12-23 1998-09-08 Baxter International Inc. Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes
US5549834A (en) * 1991-12-23 1996-08-27 Baxter International Inc. Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes
US5643193A (en) * 1995-12-13 1997-07-01 Haemonetics Corporation Apparatus for collection washing and reinfusion of shed blood
US20060076295A1 (en) * 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
ATE510605T1 (de) * 2003-03-14 2011-06-15 Univ Columbia Systeme und verfahren für auf blut basierende therapien mit einer membranlosen mikrofluid- austauschvorrichtung
US7959780B2 (en) 2004-07-26 2011-06-14 Emporia Capital Funding Llc Textured ion exchange membranes
US7780833B2 (en) * 2005-07-26 2010-08-24 John Hawkins Electrochemical ion exchange with textured membranes and cartridge
US7879332B2 (en) * 2005-09-01 2011-02-01 Plasma Technologies, Llc Ultra-high yield intravenous immune globulin preparation
US20070049732A1 (en) * 2005-09-01 2007-03-01 Zurlo Eugene J Ultra-high yield intravenous immune globulin preparation
US8293242B2 (en) * 2005-09-01 2012-10-23 Plasma Technologies, Llc Ultra-high yield of alpha-1-anti-trypsin
CN101316794B (zh) 2005-10-06 2016-01-06 派克逖克斯公司 流体的电化学离子交换处理
US7727399B2 (en) * 2006-05-22 2010-06-01 The Trustees Of Columbia University In The City Of New York Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams
CA2714594A1 (en) * 2008-02-04 2009-08-13 Edward F. Leonard Fluid separation devices, systems and methods
TW201041899A (en) * 2009-04-13 2010-12-01 Bristol Myers Squibb Co Protein purification by citrate precipitation
WO2010129724A2 (en) * 2009-05-05 2010-11-11 Anne Schwartz Efficient biomass fractionating system for an energy pulse crop
EP3204062B1 (en) 2014-10-07 2021-01-20 Haemonetics Corporation System and method for washing shed blood
WO2017223318A1 (en) 2016-06-24 2017-12-28 Dominique Uhlmann System and Method for Continuous Flow Red Blood Cell Washing
US10815270B1 (en) * 2019-09-20 2020-10-27 Plasma Technologies, Llc Compositions and methods for high efficiency protein precipitation
WO2021054999A1 (en) * 2019-09-20 2021-03-25 Plasma Technologies, Llc Therapeutic protein compositions and methods

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Publication number Priority date Publication date Assignee Title
US1600161A (en) * 1926-04-15 1926-09-14 Government Process of separating proteins and other matter from whey in soluble form
US1718282A (en) * 1927-02-16 1929-06-25 Firm Elektro Osmose Ag Graf Sc Medical serum
US2461505A (en) * 1944-12-02 1949-02-15 Sun Chemical Corp Removal or replacement of electrolytes in physiologically active materials
US2692854A (en) * 1951-01-08 1954-10-26 American Instr Co Inc Mechanical dialyzer
US2726235A (en) * 1953-03-02 1955-12-06 Rane Leo Method for the separation of proteins
US2790790A (en) * 1954-11-10 1957-04-30 Swift & Co Protein fractionation
US3038838A (en) * 1958-11-20 1962-06-12 Merck & Co Inc Method of producing purified properdin
US3234199A (en) * 1958-12-18 1966-02-08 Allen F Reid Ion exchange process for separating proteins
US3203865A (en) * 1962-11-30 1965-08-31 Dow Chemical Co Hog serum antibody concentrate
DK100842C (da) * 1962-12-10 1965-01-25 Novo Terapeutisk Labor As Fremgangsmåde ved udvinding af plasminogen ud fra blodserum.
US3429867A (en) * 1965-04-30 1969-02-25 Microbiological Ass Inc Serum substantially free from gamma globulin and method of preparing same
BE759625A (fr) * 1969-12-10 1971-04-30 Molkereigenossenschaft Dahlenb Procede et dispositif pour la dialyse du lait, en particulier pour l'obtention de l'albumine du lait et du petit-lait
US3706631A (en) * 1970-10-08 1972-12-19 John D Falk Sterilization of protein-containing fluids
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Also Published As

Publication number Publication date
US4321192A (en) 1982-03-23
GB2085446A (en) 1982-04-28
FR2492270B2 (OSRAM) 1984-03-16
IT8148007A0 (it) 1981-03-12
JPS5772916A (en) 1982-05-07
IT1142464B (it) 1986-10-08
FR2492270A2 (fr) 1982-04-23
CA1142175A (en) 1983-03-01
DE3112539A1 (de) 1982-05-27

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee