GB2081090B - Coagulant compositions containing thrombin - Google Patents

Coagulant compositions containing thrombin

Info

Publication number
GB2081090B
GB2081090B GB8119421A GB8119421A GB2081090B GB 2081090 B GB2081090 B GB 2081090B GB 8119421 A GB8119421 A GB 8119421A GB 8119421 A GB8119421 A GB 8119421A GB 2081090 B GB2081090 B GB 2081090B
Authority
GB
United Kingdom
Prior art keywords
compositions containing
containing thrombin
coagulant compositions
coagulant
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8119421A
Other languages
English (en)
Other versions
GB2081090A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Medical Devices Inc
Original Assignee
Applied Medical Devices Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Medical Devices Inc filed Critical Applied Medical Devices Inc
Publication of GB2081090A publication Critical patent/GB2081090A/en
Application granted granted Critical
Publication of GB2081090B publication Critical patent/GB2081090B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
GB8119421A 1980-06-30 1981-06-24 Coagulant compositions containing thrombin Expired GB2081090B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16482180A 1980-06-30 1980-06-30
US06/255,953 US4363319A (en) 1980-06-30 1981-04-20 Ready-to-use bandage incorporating a coagulant composition and method of preparing same

Publications (2)

Publication Number Publication Date
GB2081090A GB2081090A (en) 1982-02-17
GB2081090B true GB2081090B (en) 1984-06-20

Family

ID=26860878

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8119421A Expired GB2081090B (en) 1980-06-30 1981-06-24 Coagulant compositions containing thrombin

Country Status (4)

Country Link
US (1) US4363319A (cg-RX-API-DMAC7.html)
DE (1) DE3122926C2 (cg-RX-API-DMAC7.html)
FR (1) FR2485375A1 (cg-RX-API-DMAC7.html)
GB (1) GB2081090B (cg-RX-API-DMAC7.html)

Families Citing this family (69)

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US4605399A (en) * 1984-12-04 1986-08-12 Complex, Inc. Transdermal infusion device
US4696812A (en) * 1985-10-28 1987-09-29 Warner-Lambert Company Thrombin preparations
US4960413A (en) * 1985-11-09 1990-10-02 The Shirley Institute Wound dressing
US5180583A (en) * 1985-11-26 1993-01-19 Hedner Ulla K E Method for the treatment of bleeding disorders
ZA88227B (en) * 1987-01-28 1988-06-30 Warner-Lambert Company Thrombin preparations
US4965203A (en) * 1987-01-28 1990-10-23 Warner-Lambert Company Purified thrombin preparations
JPS6440433A (en) * 1987-08-05 1989-02-10 Green Cross Corp Aqueous liquid composition of thrombin
US5037429A (en) * 1987-08-26 1991-08-06 United States Surgical Corporation Method for improving the storage stability of a polymeric braided suture susceptible to hydrolytic degradation and resulting article
US5222978A (en) 1987-08-26 1993-06-29 United States Surgical Corporation Packaged synthetic absorbable surgical elements
US5306289A (en) * 1987-08-26 1994-04-26 United States Surgical Corporation Braided suture of improved characteristics
US5226912A (en) * 1987-08-26 1993-07-13 United States Surgical Corporation Combined surgical needle-braided suture device
US5366081A (en) 1987-08-26 1994-11-22 United States Surgical Corporation Packaged synthetic absorbable surgical elements
US5254301A (en) * 1988-03-29 1993-10-19 Ferris Mfg. Corp. Process for preparing a sheet of polymer-based foam
US5064653A (en) * 1988-03-29 1991-11-12 Ferris Mfg. Co. Hydrophilic foam compositions
US5065752A (en) * 1988-03-29 1991-11-19 Ferris Mfg. Co. Hydrophilic foam compositions
CA1330391C (en) * 1988-07-19 1994-06-28 Matthew E. Hermes Method for improving the storage stability of a polymeric article susceptible to hydrolic degradation and resulting article
DK223389D0 (da) * 1989-05-05 1989-05-05 Ferrosan As Saarsvamp
US5359831A (en) 1989-08-01 1994-11-01 United States Surgical Corporation Molded suture retainer
US5246104A (en) * 1989-08-01 1993-09-21 United States Surgical Corporation Molded suture retainer
IE73210B1 (en) * 1990-01-24 1997-05-07 Warner Lambert Co Process for the production of thrombin and high purity thrombin preparation thereby obtained
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
US5595735A (en) * 1990-05-23 1997-01-21 Johnson & Johnson Medical, Inc. Hemostatic thrombin paste composition
US5178277A (en) * 1991-01-04 1993-01-12 United States Surgical Corporation Breather pouch for surgical suture packages
US5220769A (en) * 1991-01-04 1993-06-22 United States Surgical Corporation Method for packaging surgical elements
US5217772A (en) * 1991-01-04 1993-06-08 United States Surgical Corporation Breather pouch for surgical suture packages
US5383891A (en) * 1991-04-08 1995-01-24 Walker; Marshall D. Nose bleed kid
US5259835A (en) * 1991-08-29 1993-11-09 Tri-Point Medical L.P. Wound closure means and method using flowable adhesive
DK83092D0 (da) * 1992-06-24 1992-06-24 Unes As Fremgangsmaade til udvinding af thrombin
US5795780A (en) * 1993-06-23 1998-08-18 Bristol-Myers Squibb Company Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes
US5409471A (en) * 1993-07-06 1995-04-25 Vernay Laboratories, Inc. Method of lubricating a medical coupling site
ATE273035T1 (de) * 1993-11-03 2004-08-15 Clarion Pharmaceuticals Inc Hämostatisches pflaster
US5411885A (en) * 1993-12-17 1995-05-02 New York Blood Center, Inc. Methods for tissue embedding and tissue culturing
DE19903693A1 (de) * 1998-04-24 1999-10-28 Centeon Pharma Gmbh Protease zur Aktivierung des Gerinnungsfaktors VII
WO2000062828A1 (en) 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
USD386609S (en) * 1996-05-06 1997-11-25 Green Vicki J Bladder control receptacle
EP0993311B1 (en) 1997-06-18 2012-11-14 Angiotech Pharmaceuticals (US), Inc. Compositions containing thrombin and microfibrillar collagen, and methods for preparation and use thereof
US6168788B1 (en) 1997-09-26 2001-01-02 Leon Wortham Fibrin glue without fibrinogen and biosealant compositions and methods
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
GB2340400A (en) * 1998-08-17 2000-02-23 William Foster Disposable styptic device
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
US20030228288A1 (en) 1999-10-15 2003-12-11 Scarborough Nelson L. Volume maintaining osteoinductive/osteoconductive compositions
US6187347B1 (en) 2000-02-09 2001-02-13 Ecosafe, Llc. Composition for arresting the flow of blood and method
DE10012732A1 (de) * 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
DE60117977D1 (de) 2000-06-05 2006-05-11 Boston Scient Ltd Vorrichtungen zur behandlung von harninkontinenz
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
US6447799B1 (en) * 2000-07-24 2002-09-10 Joseph M. Ullman Thromboplastic system
US7323193B2 (en) 2001-12-14 2008-01-29 Osteotech, Inc. Method of making demineralized bone particles
US7364541B2 (en) 2001-03-09 2008-04-29 Boston Scientific Scimed, Inc. Systems, methods and devices relating to delivery of medical implants
US8033983B2 (en) 2001-03-09 2011-10-11 Boston Scientific Scimed, Inc. Medical implant
US9149261B2 (en) 2001-03-09 2015-10-06 Boston Scientific Scimed, Inc. Systems, methods and devices relating to delivery of medical implants
US7235043B2 (en) 2001-03-09 2007-06-26 Boston Scientific Scimed Inc. System for implanting an implant and method thereof
JP4181410B2 (ja) * 2001-03-09 2008-11-12 ボストン サイエンティフィック リミテッド インプラントを移植するためのシステムおよびその方法
US8915927B2 (en) 2001-03-09 2014-12-23 Boston Scientific Scimed, Inc. Systems, methods and devices relating to delivery of medical implants
EP1434608B1 (en) 2001-10-12 2018-08-22 Warsaw Orthopedic, Inc. Improved bone graft
US7745192B2 (en) * 2002-04-03 2010-06-29 Venomics Pty Limited Prothrombin activating protein
EP1531737B1 (en) 2002-08-14 2008-12-17 Boston Scientific Limited Systems and devices relating to delivery of medical implants
AU2003259834A1 (en) 2002-12-17 2004-07-29 Boston Scientific Limited Spacer for sling delivery system
US20040243044A1 (en) * 2003-06-02 2004-12-02 Penegor Stephen A. Hemostatic wound dressing
WO2004110308A2 (en) 2003-06-11 2004-12-23 Osteotech, Inc. Osteoimplants and methods for their manufacture
US20050089551A1 (en) * 2003-10-22 2005-04-28 Recupero Elizabeth A. Clotting agent-containing window dressing
AU2005265251B2 (en) * 2004-06-22 2009-09-10 Baxter International Inc. Thrombin compositions
WO2006076712A2 (en) * 2005-01-14 2006-07-20 Osteotech, Inc. Expandable osteoimplant
US20060270015A1 (en) * 2005-05-26 2006-11-30 Dan Pawlak Thrombin purification
WO2007056671A1 (en) * 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
US20090308764A1 (en) * 2006-09-14 2009-12-17 Lee Kevin R Hemostatic bandage kit and method of use
GB2447012B (en) * 2007-02-21 2011-03-16 Pharmacure Health Care Ab Composition for combating epistaxis
KR20110086045A (ko) 2008-10-24 2011-07-27 오스테오테크, 인코포레이티드 뼈 형성 촉진용 조성물 및 뼈 형성 촉진방법
US20150238648A1 (en) * 2014-02-26 2015-08-27 Monif M. Matouk Silver-copper-zinc oxide wound care system
US10045885B2 (en) * 2015-09-24 2018-08-14 Medline Industries, Inc. Wound dressing materials and methods of making thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2433299A (en) * 1944-01-22 1947-12-23 Parke Davis & Co Blood coagulant and method of preserving same
US2442111A (en) * 1946-05-06 1948-05-25 Charles S Beardsley Bandage
GB704517A (en) * 1951-08-07 1954-02-24 Schering Ag Improvements relating to media for stopping the flow of blood
DE916461C (de) * 1951-12-08 1954-08-12 Angela Ziegelmayer Geb Gerdes Verfahren zur Herstellung blutstillender Mittel
US3317376A (en) * 1963-02-12 1967-05-02 Robert I Schattner Germicidal fabric
US3328259A (en) * 1964-01-08 1967-06-27 Parachem Corp Dressing for a wound containing a hemostatic agent and method of treating a wound
US3342183A (en) * 1964-08-13 1967-09-19 Johnson & Johnson Absorbent adhesive patch impregnated with a vasoconstrictor
US3731683A (en) * 1971-06-04 1973-05-08 Alza Corp Bandage for the controlled metering of topical drugs to the skin
US3937223A (en) * 1974-04-19 1976-02-10 American Cyanamid Company Compacted surgical hemostatic felt
US4022203A (en) * 1976-01-22 1977-05-10 Win Ackley Treated patch for minor cuts
JPS597693B2 (ja) * 1978-01-07 1984-02-20 株式会社ミドリ十字 抗トロンビン製剤及びその製法
US4265233A (en) * 1978-04-12 1981-05-05 Unitika Ltd. Material for wound healing

Also Published As

Publication number Publication date
US4363319A (en) 1982-12-14
FR2485375B1 (cg-RX-API-DMAC7.html) 1984-11-23
DE3122926C2 (de) 1985-12-12
DE3122926A1 (de) 1982-07-22
GB2081090A (en) 1982-02-17
FR2485375A1 (fr) 1981-12-31

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19920624