GB2079179A - Cosmetic Composition Based On an Aqueous Dispersion of Small Lipid Spheres - Google Patents
Cosmetic Composition Based On an Aqueous Dispersion of Small Lipid Spheres Download PDFInfo
- Publication number
- GB2079179A GB2079179A GB8120182A GB8120182A GB2079179A GB 2079179 A GB2079179 A GB 2079179A GB 8120182 A GB8120182 A GB 8120182A GB 8120182 A GB8120182 A GB 8120182A GB 2079179 A GB2079179 A GB 2079179A
- Authority
- GB
- United Kingdom
- Prior art keywords
- oil
- composition according
- fatty acid
- ionic amphiphilic
- amphiphilic lipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 59
- 239000006185 dispersion Substances 0.000 title claims abstract description 51
- 150000002632 lipids Chemical class 0.000 title claims abstract description 51
- 239000002537 cosmetic Substances 0.000 title claims abstract description 34
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 21
- -1 fatty acid ester Chemical class 0.000 claims abstract description 18
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 17
- 239000000194 fatty acid Substances 0.000 claims abstract description 17
- 229930195729 fatty acid Natural products 0.000 claims abstract description 17
- 239000008346 aqueous phase Substances 0.000 claims abstract description 14
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229920005862 polyol Polymers 0.000 claims abstract description 7
- 150000003077 polyols Chemical class 0.000 claims abstract description 6
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 5
- 150000002430 hydrocarbons Chemical group 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 239000003921 oil Substances 0.000 claims description 27
- 235000019198 oils Nutrition 0.000 claims description 26
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 12
- 239000002304 perfume Substances 0.000 claims description 12
- 239000012071 phase Substances 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 claims description 9
- 229940093541 dicetylphosphate Drugs 0.000 claims description 9
- 235000019486 Sunflower oil Nutrition 0.000 claims description 8
- 239000002600 sunflower oil Substances 0.000 claims description 8
- 239000003349 gelling agent Substances 0.000 claims description 7
- 235000012000 cholesterol Nutrition 0.000 claims description 6
- 229950005143 sitosterol Drugs 0.000 claims description 6
- 229930182558 Sterol Natural products 0.000 claims description 5
- 150000003432 sterols Chemical class 0.000 claims description 5
- 235000003702 sterols Nutrition 0.000 claims description 5
- 150000001412 amines Chemical class 0.000 claims description 4
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims description 3
- 239000004215 Carbon black (E152) Substances 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 241000196324 Embryophyta Species 0.000 claims description 3
- 239000004166 Lanolin Substances 0.000 claims description 3
- 206010040829 Skin discolouration Diseases 0.000 claims description 3
- 230000001166 anti-perspirative effect Effects 0.000 claims description 3
- 239000003213 antiperspirant Substances 0.000 claims description 3
- 235000005687 corn oil Nutrition 0.000 claims description 3
- 239000002781 deodorant agent Substances 0.000 claims description 3
- 230000002951 depilatory effect Effects 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 3
- 150000002191 fatty alcohols Chemical class 0.000 claims description 3
- 239000010503 gourd oil Substances 0.000 claims description 3
- 239000008169 grapeseed oil Substances 0.000 claims description 3
- 239000003906 humectant Substances 0.000 claims description 3
- 229930195733 hydrocarbon Natural products 0.000 claims description 3
- 229940119170 jojoba wax Drugs 0.000 claims description 3
- 239000003410 keratolytic agent Substances 0.000 claims description 3
- 229940039717 lanolin Drugs 0.000 claims description 3
- 235000019388 lanolin Nutrition 0.000 claims description 3
- 229920000223 polyglycerol Polymers 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 claims description 3
- 235000012424 soybean oil Nutrition 0.000 claims description 3
- 230000001256 tonic effect Effects 0.000 claims description 3
- 241000195493 Cryptophyta Species 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- MNQZXJOMYWMBOU-VKHMYHEASA-N D-glyceraldehyde Chemical compound OC[C@@H](O)C=O MNQZXJOMYWMBOU-VKHMYHEASA-N 0.000 claims description 2
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 229940120503 dihydroxyacetone Drugs 0.000 claims description 2
- 150000002009 diols Chemical class 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims description 2
- 229960000367 inositol Drugs 0.000 claims description 2
- 229920001206 natural gum Polymers 0.000 claims description 2
- 229940059574 pentaerithrityl Drugs 0.000 claims description 2
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 2
- 150000003014 phosphoric acid esters Chemical class 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 229960002920 sorbitol Drugs 0.000 claims description 2
- 229920001059 synthetic polymer Polymers 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 1
- UQPHVQVXLPRNCX-UHFFFAOYSA-N erythrulose Chemical compound OCC(O)C(=O)CO UQPHVQVXLPRNCX-UHFFFAOYSA-N 0.000 claims 1
- 244000068988 Glycine max Species 0.000 abstract description 3
- 235000010469 Glycine max Nutrition 0.000 abstract description 3
- 235000009852 Cucurbita pepo Nutrition 0.000 abstract 1
- 240000001980 Cucurbita pepo Species 0.000 abstract 1
- 244000020551 Helianthus annuus Species 0.000 abstract 1
- 235000003222 Helianthus annuus Nutrition 0.000 abstract 1
- 244000044822 Simmondsia californica Species 0.000 abstract 1
- 235000004433 Simmondsia californica Nutrition 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 abstract 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 1
- 229940087559 grape seed Drugs 0.000 abstract 1
- 235000009973 maize Nutrition 0.000 abstract 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 10
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 10
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 10
- 229960002216 methylparaben Drugs 0.000 description 10
- 210000003491 skin Anatomy 0.000 description 9
- 239000012530 fluid Substances 0.000 description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 7
- 239000002253 acid Substances 0.000 description 7
- 150000007513 acids Chemical class 0.000 description 7
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 6
- 238000013019 agitation Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 241000416162 Astragalus gummifer Species 0.000 description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
- 229920001615 Tragacanth Polymers 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000004150 EU approved colour Substances 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 206010042496 Sunburn Diseases 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000003212 astringent agent Substances 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- XRWMGCFJVKDVMD-UHFFFAOYSA-M didodecyl(dimethyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCC XRWMGCFJVKDVMD-UHFFFAOYSA-M 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 2
- 230000007480 spreading Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 235000015961 tonic Nutrition 0.000 description 2
- 229960000716 tonics Drugs 0.000 description 2
- 239000000196 tragacanth Substances 0.000 description 2
- 235000010487 tragacanth Nutrition 0.000 description 2
- 229940116362 tragacanth Drugs 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 229930186217 Glycolipid Natural products 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 244000025272 Persea americana Species 0.000 description 1
- 235000008673 Persea americana Nutrition 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001414 amino alcohols Chemical class 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229930183167 cerebroside Natural products 0.000 description 1
- 150000001784 cerebrosides Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 239000008278 cosmetic cream Substances 0.000 description 1
- 239000008341 cosmetic lotion Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 125000006353 oxyethylene group Chemical group 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229940068065 phytosterols Drugs 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 230000003019 stabilising effect Effects 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/42—Ethers, e.g. polyglycol ethers of alcohols or phenols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0084—Antioxidants; Free-radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D19/00—Degasification of liquids
- B01D19/02—Foam dispersion or prevention
- B01D19/04—Foam dispersion or prevention by addition of chemical substances
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
- C11D17/0026—Structured liquid compositions, e.g. liquid crystalline phases or network containing non-Newtonian phase
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M7/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made of other substances with subsequent freeing of the treated goods from the treating medium, e.g. swelling, e.g. polyolefins
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2201/00—Inorganic compounds or elements as ingredients in lubricant compositions
- C10M2201/02—Water
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2203/00—Organic non-macromolecular hydrocarbon compounds and hydrocarbon fractions as ingredients in lubricant compositions
- C10M2203/02—Well-defined aliphatic compounds
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2203/00—Organic non-macromolecular hydrocarbon compounds and hydrocarbon fractions as ingredients in lubricant compositions
- C10M2203/02—Well-defined aliphatic compounds
- C10M2203/022—Well-defined aliphatic compounds saturated
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2203/00—Organic non-macromolecular hydrocarbon compounds and hydrocarbon fractions as ingredients in lubricant compositions
- C10M2203/02—Well-defined aliphatic compounds
- C10M2203/024—Well-defined aliphatic compounds unsaturated
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2203/00—Organic non-macromolecular hydrocarbon compounds and hydrocarbon fractions as ingredients in lubricant compositions
- C10M2203/04—Well-defined cycloaliphatic compounds
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2215/00—Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant compositions
- C10M2215/02—Amines, e.g. polyalkylene polyamines; Quaternary amines
- C10M2215/04—Amines, e.g. polyalkylene polyamines; Quaternary amines having amino groups bound to acyclic or cycloaliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2215/00—Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant compositions
- C10M2215/26—Amines
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2223/00—Organic non-macromolecular compounds containing phosphorus as ingredients in lubricant compositions
- C10M2223/10—Phosphatides, e.g. lecithin, cephalin
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
- C10N2040/00—Specified use or application for which the lubricating composition is intended
- C10N2040/46—Textile oils
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2200/00—Functionality of the treatment composition and/or properties imparted to the textile material
- D06M2200/40—Reduced friction resistance, lubricant properties; Sizing compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Textile Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Cosmetics (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Colloid Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
A cosmetic composition is a radical of a fatty acid containing described which is in the form of an aqueous dispersion of small spheres composed of organised molecular layers between which an internal aqueous phase is encapsulated, these layers comprising at least one non- ionic amphiphilic lipid, the external aqueous phase containing at least one oil which is a fatty acid ester of a polyol, or a fatty acid ester of a branched alcohol, of the formula R- COOR', in which formula R represents a radical of a fatty acid containing from 8 to 20 carbon atoms and R' represents a branched hydrocarbon chain containing from 3 to 20 carbon atoms; the oil may be sunflower, maize, soya, gourd, grapeseed, jojoba or purcellin oil or glycerol tricaprocaprylate.
Description
SPECIFICATION
Cosmetic Composition Based on an Aqueous Dispersion of Small Lipid Spheres
The present invention relates to a cosmetic composition consisting of a dispersion of small lipid spheres. Aqueous dispersions of this type have already been described in French Patent 2,315,991 .
The small lipid spheres in these dispersions are in the form of roughly concentric laminae consisting of two or more lipid layers which are separated from one another by layers of aqueous phase. They can thus be used to encapsulate water-soluble active substances, for example pharmaceutical or cosmetic substances, in the aqueous compartments between the lipid layers, and to protect them from the exterior.
The abovementioned French patent also describes a new process for the preparation of an aqueous dispersion of small lipid spheres, which consists firstly in bringing the lipids which are to constitute the concentric laminae of the small spheres into contact with the aqueous solution to be encapsulated, the lipophilic/hydrophilic ratio of the chosen lipids being such that the latter swell in water or in the aqueous phase to be encapsulated, in order to form a plane lamellar phase, secondly in adding, to the lamellar phase, an aqueous solution which is to constitute the continuous external phase of the dispersion, and thirdly in subjecting the whole to vigorous agitation in order to obtain a dispersion of small spheres, between the concentric laminae of which the aqueous phase to be encapsulated is trapped.
In order to form the concentric laminae of the small spheres, it is possible, according to the teaching of this French patent, to use either ionic or non-ionic amphiphilic lipids. The following are preferred amongst the non-ionic amphiphilic lipids:
the linear or branched polyglycerol ethers of the formulae respectively: R~(OCH2~CHOH~CH2)n OH and
n being an integer from 1 to 6 and R being a saturated or unsaturated, linear or branched aliphatic chain containing 12 to 30 carbon atoms, a hydrocarbon radical of a lanolin alcohol or a 2-hydroxyalkyl radical of a long-chain a-diol; polyoxyethyleneated fatty alcohols;
oxyethyleneated or non-oxyethyleneated polyol esters and, in particular, polyoxyethyleneated sorbitol esters; and
glycolipids of natural or synthetic origin, for example cerebrosides.
Amongst the cosmetic active substances which can be encapsulated in the small lipid spheres, the above-mentioned French patent gives as examples substances for skin care, such as humectants, artificial tanning agents, skin-colouring agents, water-soluble sun filters, antiperspirants, deodorants, astringents, freshening-up products, tonics, cicatrising agents, keratolytic agents, depilatories, perfumed waters and extracts from animal or plant tissues.
It has been observed that the cosmetic compositions referred to above, in the form of an aqeuous dispersion of small lipid spheres, exhibit the advantage, compared with conventional preparations in the form of an oil and water emulsion, of having a less aggressive action and consequently of causing less irritation when they are applied to the skin.
The aim of the present invention is to provide a cosmetic composition based on an aqueous dispersion of small lipid spheres, which makes it possible to combine the advantages of the dispersions of small spheres with the advantages resulting from the presence of cosmetic oils.
The present invention thus provides a cosmetic composition consisting of an aqueous dispersion of small spheres composed of organised molecular layers between which an internal aqueous phase is encapsulated, these layers consisting of at least one non-ionic amphiphilic lipid, characterised in that at least one oil is dispersed in the external aqueous phase which surrounds the small spheres, the said oil being taken from the group comprising fatty acid esters of polyols, especially liquid triglycerides, and fatty acid esters of branched alcohols, of the formula R-C0OR', in which formula R represents the radical of a higher fatty acid containing from 8 to 20 carbon atoms and R' represents a branched hydrocarbon chain containing from 3 to 20 carbon atoms.
It has been observed, unexpectedly, that the small spheres of non-ionic amphiphilic substances make it possible to stabilise the oil-in-water dispersion without requiring the addition of a conventional emulsifying agent and without causing the destruction of the small spheres. It is known that the stability of an emulsion depends mainly on the presence of an emulsifier, the molecules of which are adsorbed onto the surface of the oil droplets to form a kind of continuous membrane which prevents direct contact between two adjacent droplets, for example during shock.Thus, in the present case, those skilled in the art might have expected that the non-ionic amphiphilic lipids in the small spheres would act as an emulsifier by being adsorbed onto the surface of the oil droplets, but they would also have expected that this stabilisation effect would also have the effect of causing the destruction of the concentric laminae of the small spheres. This has been found not to be the case at all and, surprisingly, the small spheres of non-ionic amphiphilic substances of the invention are capable of stabilising a dispersion of at least one vegetable oil, defined above, in an external aqueous phase by dispersing around the oil droplets, whilst retaining their integrity.
U.S. Patent 3,957,971 describes dispersions of small spheres of ionic amphiphilic substances or liposomes, which are used in cosmetic creams or lotions, that is to say of water-in-oil or oil-in-water emulsions. In the present invention, the small spheres are composed not of ionic amphiphilic substances but of non-ionic amphiphilic substances. Moreover, it can be shown that the liposomes do not make it possible to stabilise a dispersion, in water, of a vegetable oil as defined above, whereas, totally unexpectedly, the small spheres of non-ionic amphiphilic substances of the invention do make it possible to stabilise a dispersion of this type.
The cosmetic composition according to the invention can be prepared in two stages; in a first stage, an aqueous dispersion of small spheres is prepared from non-ionic amphiphilic lipids using either the process described in French Patent 2,31 5,991 or the procedures described in French Patent 2,221,122, the disclosures of which are hereby incorporated by reference. In a second stage, once the aqueous dispersion of small spheres has been produced, the oil is added thereto. The oil is then dispersed in the external aqueous phase by agitation.
Preferably, the cosmetic composition according to the invention contains from 2 to 10% of nonionic amphiphilic lipid(s) which form the walls of the small spheres, and from 2 to 40% of dispersed oil(s), these percentages being expressed by weight, relative to the total weight of the composition.
Advantageously, the ratio by weight of non-ionic amphiphilic lipid(s), relative to the dispersed oil (or oils), is from 0.2:1 to 1:1.
The oils which are incorporated into the composition according to the invention are fatty acid esters of polyols, in particular liquid triglycerides, and fatty acid esters of branched alcohols, of the formula: R-C00-R', in which formula R represents the radical of a higher fatty acid containing from 8 to 20 carbon atoms and R7 represents a branched hydrocarbon chain containing from 3 to 20 carbon atoms. Suitable fatty acid esters of polyols include sunflower oil, maize oil, soya oil, gourd oil, grapeseed oil, jojoba oil and glycerol tricaprocaprylate. Purcellin oil may be mentioned specifically as a higher fatty acid ester of a branched alcohol.
The cosmetic active substances of the composition according to the invention can be encapsulated inside or outside the small spheres. Thus, in a preferred embodiment, the oily phase of the composition contains one or more liposoluble cosmetic substances. In the preparation of the composition according to the invention, these substances are dissolved beforehand in the oil which is to be added to the dispersion of small lipid spheres. Amongst these liposoluble active cosmetic substances, there may be mentioned, in particular, anti-sunburn filters such as 2-ethylhexyl paradimethylaminobenzoate, or substances for improving the condition of dry or old skin, in particular unsaponifiable substances such as those derived from soya and from avocado, tocopherols, vitamins E and F and antioxidants.
The oil-in-water dispersion which constitutes the external medium of the dispersion of small spheres can contain at least one additive, in particular a gelling agent or a perfume. The additive can be added to the dispersion at the same time as the oil. The gelling agent can be introduced at a concentration of, say, 0.1 to 2%, these percentages being expressed by weight, relative to the total weight of the composition. Amongst the gelling agents which can be used, there may be mentioned cellulose derivatives such as hydroxyethylcellulose, synthetic polymers, algae derivatives such as satiagum, and natural gums such as tragacanth. Hydroxyethylcellulose, a mixture of carboxyvinylic acids commercially available under the name "Carbopol 940" satiagum and tragacanth are preferably used as gelling agents.
The non-ionic amphiphilic lipids which are to constitute the concentric laminae of the small spheres in the cosmetic composition according to the invention are typically:
linear or branched polyglycerol ethers or esters of the formulae respectively: R~(OCH2CHOH~CH2)n OH and
in which formulae n is a number from 2 to 6 and R represents a linear or branched saturated aliphatic chain containing from 16 to 20 carbon atoms or the hydrocarbon radical of a lanolin alcohol; and
polyoxyethyleneated sterols.
At the moment of formation of the plane lamellar phase obtained by bringing the non-ionic amphiphilic lipids into contact with the aqueous phase to be encapsulated, various auxiliary agents can be associated with the said lipids in order to modify, for example, the permeability or the surface charge of the small spheres.For this purpose, there may be mentioned the optional addition of long chain alcohols and diols, sterols, in particular cholesterol and s-sitosterol, long-chain amines and their quaternary ammonium derivatives, in particular didodecyldimethylammonium bromide, hydroxyalkylamines, polyoxyethyleneated fatty amines, long-chain aminoalcohol esters and their salts and quaternary ammonium derivatives, phosphoric acid esters of fatty alcohols, in particular dicetyl phosphate, alkyl-sulphates, for example sodium cetyl-sulphate, and certain polymers such as polypeptides and proteins.
Apart from the auxiliary agents listed above, it is possible to add a preservative such as methyl parahydroxybenzoate.
The aqueous phase whether internal or external, can contain a water-soluble cosmetic substance normally used for the care of the face, the hands or the body. Amongst these substances, there may be mentioned humectants such a glycerol, sorbitol, pentaerythritol, inositol and pyrrolidonecarboxylic acid and its salts, artificial tanning agents such as dihydroxyacetone, erythruiose, glyceraldehyde and ydialdehydes such as tartaraldehyde, skin-colouring agents, sun filters, anti-perspirants, deodorants, astringents, freshening-up products, tonics, cicatrising agents, keratolytic agents, depilatories, perfumed waters, extracts from animal or plant tissues, such as proteins, amniotic liquid and polysaccharides, and antiseborrheic agents.
The following Examples further illustrate the present invention.
The cosmetic formulations given in the Examples below are prepared in two stages. In a first stage, an aqueous dispersion is produced in accordance with the process described in French Patent 2,31 5,991.The aqueous dispersion of small lipid spheres is prepared from:
a non-ionic amphiphilic lipid;
sterols such as cholesterol or #-sitosternl; optionally, dicetyl phosphate;
optionally, active cosmetic substances of a water-soluble nature; and
demineralised water which can contain a preservative.
In a second stage, oil is added and dispersed by intense mechanical agitation at ambient temperature and preferably at a temperature of about 400C. It is during this second stage that liposoluble cosmetic substances, perfumes and/or gelling agents can optionally be incorporated.
Example 1
Experiments for comparing a cosmetic composition according to the invention with a cosmetic composition of a known type.
Two compositions (A) and (B) are prepared; they are strictly identical, the only difference being that the preparation of composition (B) does not comprise a second stage for the addition of oil.
Composition (A) contains the following ingredients: 1 st stage Non-ionic amphiphilic lipid of the formula:
in which R is a hexadecyl radical and has an average statistical value of 3 3.8 g p-Sitosterol 3.8 g
Diceyl phosphate 0.4g Methyl para-hydroxybenzoate 0.3 g
Demineralised water 66.7 g 2nd stage
25 g of sunflower oil are added to the above dispersion; the whole is subjected to mechanical agitation in order to obtain the final dispersion.
Cosmetic composition (B) is prepared in the same manner, but without a second stage for the addition of sunflower oil, the 25 g of oil being replaced in this case by an identical amount of demineralised water.
Cosmetic composition (A) consequently differs from cosmetic composition (B) in that it contains 25% of sunflower oil.
1) Measurements of the Coefficient of Friction of the Skin During the Spreading of Cosmetic
Compositions (A) and (B)
The coefficient of friction of the skin during the spreading of cosmetic compositions (A) or (B) is measured on the forearm of a subject with the aid of a sensor driven with a rotational movement; the change in the opposing couple in the region of the sensor, during its rotation about itself, is recorded; the sensor is applied with a constant force (20 or 50 g).
The following results are obtained:
Variation in the coefficient of friction of the skin, measured 15minutes after application ; Under å force | Under a force of 20 g l of 50 g Composition (B) +209 l +245 Composition according ~40 - 60 to the invention (containing 25% of sunflower oil) It is observed that composition (B), that is to say the aqueous dispersion of small lipid spheres which does not contain oil, substantially increases the coefficient of friction of the skin, whereas composition (A) according to the invention, that is to say a dispersion of small spheres which does contain oil, produces the opposite effect.This significant lowering of the coefficient of friction of the skin results, in cosmetic terms, in the softness effect provided by formulation (A) according to the invention.
2) Measurement of the Modulus of Elasticity of Human Stratum Corneum, Carried out in Vitro
Before and After Application of Cosmetic Compositions (A) and (B) Above
These measurements were carried out on a laboratory apparatus for measuring the modulus of
elasticity of the skin. A laboratory apparatus of this type is described in British Specification No.
2029018.
The experimental conditions are as follows:
relative humidity: 72%+2 temperature: 300C+0.2 amount of product applied: 5 mg/cm2
The following results are obtained:
Average % reduction in the modulus of elasticity 1 1 hour30 minutes after Products Tested \ application Composition (B) | 0 Composition (A) according to the invention j +15 The above results show clearly the difference in suppleness of the cornea, according to whether a dispersion of small spheres without an oily phase or a dispersion of small spheres with an oily phase is applied thereto.
Example 2
Body-care Fluid 1 st stage As indicated above, an aqueous dispersion of small lipid spheres is produced from the following
substances:
Non-ionic amphiphilic lipid of the general formula
in which R is a hexadecyl radical and has an average statistical value of 3 4.5 g #-Sitosternl 4.5 g
Dicetyl phosphate 1.0 g
Methyl para-hydroxybenzoate 0.3 g
Sodium salt of pyrrolidonecarboxylic acid 2.0 g
Dimineralised water 56.5 g 2nd stage
The following substances are added to the dispersion of small spheres obtained in the 1 st stage::
Perfume 0.4 g Sunflower oil 10.0 g f Mixture of carboxyvinylic acids marketed under the name "Carbopol 940" 0.4 g Triethanolamine 0.4g Demineralised water 20.0 g Example 3
Face-care Fluid
1 st stage
As indicated above, an aqueous dispersion of small lipid spheres is produced from the following I substances:: Non-ionic amphiphilic lipid of the general formula
in which R is a hexadecyl radical and n has a value of 2 6.0 g
Cholesterol 1.6 g Dicetyl phosphate 0.4 g
Methyl para-hydroxybenzoate 0.3 g
Demineralised water 61.1 g 2nd stage
The following substances are added to the dispersion of small spheres obtained in the 1 st stage::
Perfume 0.2 g Grapeseed oil 20.0 g Mixture of carboxyvinylic acids marketed under the name "Carbopol 940" 0.2 g Triethanolamine 0.2 g Demineralised water 10.0 g Example 4
Hand-care Fluid 1 sot stage
As indicated above, an aqueous dispersion of small lipid spheres is produced from the following substances:
Polyoxyethyleneated phytosterols (statistical average value of 5 for the
oxyethylene units) 6.0 g
Cholesterol 2.0 g
Methyl para-hydroxybenzoate 0.3 g
Demineralised water 45.7 g 2nd stage
The following substances are added to the dispersion of small spheres obtained in the 1 st stage::
Perfume 0.2 g Jojoba oil 25.0 g Mixture of carboxyvinylic acids marketed under the name "Carbopol 940" 0.4 g Triethanolamine 0.4g Demineralised water 20.0 g Example 5
Body-care Fluid 1 st stage As indicated above, an aqueous dispersion of small lipid spheres is produced from the following
substances:
Non-ionic amphiphilic lipid of the general formula
in which R is a hexadecyl radical and ri has an average statistical value of 3 4.0 g
Cholesterol 4.0 g
Methyl para-hydroxybenzoate 0.3 g
Demineralised water 45.5 g 2nd stage
The following substances are added to the dispersion of small spheres obtained in the 1 st stage::
Perfume 0.4 o4 g Maize oil 25.0g Mixture of carboxyvinylic acids marketed under the name "Carbopol 940" 0.4 g Triethanolamine 0.4 g Demineralised water 20.0 g Example 6
Face-care Fluid Iststage As indicated above, an aqueous dispersion of small lipid spheres is produced from the following substances::
Non-ionic amphiphilic lipid of the general formula
in which R is a hexadecyl radical and ri has an average statistical value of 3 0.95 g ,B-Sitosterol 0.95 g
Dicetyl phosphate 0.10g
Methyl para-hydroxybenzoate 0.30 g
Demineralised water 64.80 g 2nd stage
The following substances are added to the dispersion of small spheres obtained in the 1 st stage::
Perfume 0.4g Soya oil 10.0 g U nsaponifiable substances derived from soya 2.0 g Hydrnxyethylcellulose marketed under the name "Natrosol 250 HHR" 0.5 g Demineralised water 20.0 g Example 7
Anti-sunburn Fluid 1 st stage
As indicated above, an aqueous dispersion of small lipid spheres is produced from the following substances::
Non-ionic amphiphilic lipid of the general formula
in which R is a hexadecyl radical and ri has an average statistical value of 3 3.6 g /3-Sitosterol 3.6 g
Didodecyldimethylammonium bromide 0.8 g
Methyl para-hydroxybenzoate 0.3 g
Demineralised water 45.9 g 2nd stage
The following substances are added to the dispersion of small spheres obtained in the 1 st stage::
Perfume 0.4 g Gourd oil 22.0g 2-Ethylhexyl para-dimethylaminobenzoate 3.0 g Gumtragacanth 0.4g Demineralised water 20.0 g Example 8
Hand-care Fluid 1 st stage
As indicated above, an aqueous dispersion of small lipid spheres is produced from the following substances::
Non-ionic amphiphilic lipid of the general formula
in which R is a hexadecyl radical and ri has an average statistical value of 3 3.8 g /3-Sitosterol 3.8 g
Dicetyl phosphate 0.4 g
Methyl para-hydroxybenzoate 0.3 g
Glycerol 3.0 g
Demineralised water 42.5 g 2nd stage
The following substances are added to the dispersion of small spheres obtained in the 1 st stage:
Perfume Purcellin oil 25.0 g Satiagum 1.0 g Demineralised water 20.0 g Example 9
Body-care Fluid 1 sot stage
As indicated above, an aqueous dispersion of small lipid spheres is produced from the following substances::
Non-ionic amphiphilic lipid of the general formula
in which R is a hexadecyl radical and ri has an average statistical value of 3 3.8 g /3-Sitosterol 3.8 g
Dicetyl phosphate 0.4g Methyl para-hydroxybenzoate 0.3 g
Demineralised water 60.5 g 2nd stage
The following substances are added to the dispersion of small spheres obtained in the 1 st stage: :
Perfume 0.4g Glycerol tricaprocaprylate 10.0 g Mixture of carboxylvinylic acids marketed under the name "Carbopol 940" 0.4 g Triethanolamine 0.4 g Demineralised water 20.0 g Example 10
Face-care Cream 1 sot stage
As indicated above, an aqueous dispersion of small lipid spheres is produced from the following substances: :
Non-ionic amphiphilic lipid of the general formula
in which R is a hexadecyl radical and ri has an average statistical value of 3 3.8 g #Sitosternl 3.8 g Dicetyl phosphate
Preservative 0.3 g
Demineralised water 47.6 g 2nd stage
The following substances are added to the dispersion of small spheres obtained in the 1 st stage:
Sunflower oil 35.0 g
Perfume 0.6 g
Mixture of carboxyvinylic acids marketed under the name "Carbopol 940" 0.2 g
Triethanolamine 0.2 g
Demineralised water 8.1 g
Claims (15)
1. A composition suitable for use in cosmetics which is in the form of an aqueous dispersion of small spheres composed of organised molecular layers between which an internal aqueous phase is encapsulated, these layers comprising at least one non-ionic amphiphilic lipid, the external aqueous phase containing at least one oil which is a fatty acid ester of a polyol, or a fatty acid ester of a branched alcohol, of the formula R--COOR', in which formula R represents the radical of a fatty acid containing from 8 to 20 carbon atoms and R' represents a branched hydrocarbon chain containing from 3 to 20 carbon atoms.
2. A composition according to claim 1 in which the fatty acid ester of a polyol is sunflower oil, maize oil, soya oil, gourd oil, grapeseed oil, jojoba oil or glycerol tricaprocaprylate.
3. A composition according to claim 1 in which the fatty acid ester of a branched alcohol is purcellin oil.
4. A composition according to any one of claims 1 to 3 which contains from 2 to 10% of nonionic amphiphilic lipid constituting the walls of the small spheres, and from 2 to 40% of dispersed oil, by weight, relative to the total weight of the composition, the ratio by weight of non-ionic amphiphilic lipid, relative to the dispersed oil, being from 0.2:1 to 1:1.
5. A composition according to any one of claims 1 to 4 in which the external phase contains from 0.1 to 2% by weight of gelling agent, relative to the total weight of the composition.
6. A composition according to claim 5 in which the gelling agent is a cellulose derivative, synthetic polymer, algae derivative~or a natural gum.
7. A composition according to any one of claims 1 to 6 in which the external phase contains at least one perfume and/or one or more liposoluble cosmetic substances.
8. A composition according to claim 7 in which the liposoluble cosmetic substance is an antisunburn filter, a substance for improving the condition of dry or old skin, or an antioxidant.
9. A composition according to any one of claims 1 to 8 in which the non-ionic amphiphilic lipid is linear or branched polyglycerol ether or ester of the formulae respectively: R~(OCH2CHOHCH2)n~OH or
in which formulae n is a number from 2 to 6 and R represents a linear or branched saturated aliphatic radical containing from 1 6 to 20 carbon atoms or a hydrocarbon radical of a lanolin alcohol; or
a polyoxyethyleneated sterol.
10. A composition according to claim 9 in which the non-ionic amphiphilic lipid is mixed with at least one of a long-chain alcohol or diol, a sterol, a long-chain amine or a quaternary ammonium derivative thereof, a hydroxyalkylamine, a polyoxyethyleneated fatty amine, a long-chain aminoalcohol ester or a salt or quaternary ammonium derivative thereof, a polymer or a phosphoric acid ester of a fatty alcohol.
1 A composition according to claim 10 in which the non-ionic amphiphilic lipid is mixed with at least one of cholesterol, '3-sitosterol and dicetyl phosphate.
12. A composition according to any one of claims 1 to 11 in which the internal aqueous phase or the external phase contains at least one water-soluble cosmetic substance.
13. A composition according to claim 12 in which the water-soluble cosmetic substance is a humectant, an artificial tanning agent, a skin-colouring agent, sun filter, antiperspirant, deodorant, astringent, freshening-up product, tonic, cicatrising agent, keratolytic agent, depilatory, perfumed water, an animal or plant tissue extract or an antiseborrheic agent.
14. A composition according to claim 13 in which the water-soluble substance is glycerol, sorbitol, pentaerythritol, inositol, pyrrolidone carboxylic acid or a salt thereof, dihydroxyacetone, erythrulose, glyceraldehyde, tartaraldehyde, a protein, polysaccharide or aminiotic liquid.
15. A composition according to claim 1 substantially as described in any one of Examples 1 to 10. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8014657A FR2485921A1 (en) | 1980-07-01 | 1980-07-01 | COSMETIC COMPOSITION BASED ON AN AQUEOUS DISPERSION OF LIPID SPHERULES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2079179A true GB2079179A (en) | 1982-01-20 |
| GB2079179B GB2079179B (en) | 1984-03-07 |
Family
ID=9243726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8120182A Expired GB2079179B (en) | 1980-07-01 | 1981-06-30 | Cosmetic composition based on an aqueous dispersion of small lipid spheres |
Country Status (8)
| Country | Link |
|---|---|
| JP (2) | JPS5794326A (en) |
| BE (2) | BE889452A (en) |
| CA (1) | CA1168158A (en) |
| CH (1) | CH649915A5 (en) |
| DE (1) | DE3125710A1 (en) |
| FR (1) | FR2485921A1 (en) |
| GB (1) | GB2079179B (en) |
| IT (1) | IT1144739B (en) |
Cited By (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2102290A (en) * | 1981-07-23 | 1983-02-02 | Oreal | Jojoba oil containing cosmetic compositions |
| US4777035A (en) * | 1985-11-15 | 1988-10-11 | Bristol-Myers Company | Antiperspirant composition and process |
| US4830857A (en) * | 1984-10-24 | 1989-05-16 | L'oreal | Cosmetic and pharmaceutical compositions containing niosomes and a water-soluble polyamide, and a process for preparing these compositions |
| US4855090A (en) * | 1987-03-13 | 1989-08-08 | Micro-Pak, Inc. | Method of producing high aqueous volume multilamellar vesicles |
| US4911928A (en) * | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
| US4917951A (en) * | 1987-07-28 | 1990-04-17 | Micro-Pak, Inc. | Lipid vesicles formed of surfactants and steroids |
| US5000960A (en) * | 1987-03-13 | 1991-03-19 | Micro-Pak, Inc. | Protein coupling to lipid vesicles |
| WO1991004731A1 (en) * | 1989-09-21 | 1991-04-18 | Micro Vesicular Systems, Inc. | Liposomal cleaner |
| US5019392A (en) * | 1988-03-03 | 1991-05-28 | Micro-Pak, Inc. | Encapsulation of parasiticides |
| US5023086A (en) * | 1987-03-13 | 1991-06-11 | Micro-Pak, Inc. | Encapsulated ionophore growth factors |
| US5032457A (en) * | 1988-03-03 | 1991-07-16 | Micro Vesicular Systems, Inc. | Paucilamellar lipid vesicles using charge-localized, single chain, nonphospholipid surfactants |
| US5160669A (en) * | 1988-03-03 | 1992-11-03 | Micro Vesicular Systems, Inc. | Method of making oil filled paucilamellar lipid vesicles |
| US5213805A (en) * | 1991-07-25 | 1993-05-25 | Micro Vesicular Systems, Inc. | Lipid vesicles having n,n-dimethylamide derivatives as their primary lipid |
| US5234767A (en) * | 1987-03-13 | 1993-08-10 | Micro-Pak, Inc. | Hybrid paucilamellar lipid vesicles |
| US5256422A (en) * | 1991-03-28 | 1993-10-26 | Micro Vesicular Systems, Inc. | Lipid vesicle containing water-in-oil emulsions |
| US5260065A (en) * | 1991-09-17 | 1993-11-09 | Micro Vesicular Systems, Inc. | Blended lipid vesicles |
| US5405615A (en) * | 1991-09-17 | 1995-04-11 | Micro Vesicular Systems, Inc. | Sucrose distearate lipid vesicles |
| US5628936A (en) * | 1987-03-13 | 1997-05-13 | Micro-Pak, Inc. | Hybrid paucilamellar lipid vesicles |
| US6051250A (en) * | 1993-02-12 | 2000-04-18 | L'oreal | Process for the stabilization of vesicles of amphiphilic lipid(s) and composition for topical application containing the said stabilized vesicles |
| US6110492A (en) * | 1997-05-28 | 2000-08-29 | Jenner Biotherapies, Inc. | Immunogenic compositions |
| US6132763A (en) * | 1988-10-20 | 2000-10-17 | Polymasc Pharmaceuticals Plc | Liposomes |
| US6844009B1 (en) * | 1999-03-16 | 2005-01-18 | Capsulis | Media in the form of complex dispersions, method for preparing same and uses |
| US9139850B2 (en) | 2005-05-19 | 2015-09-22 | L'oreal | Vectorization of dsRNA by cationic particles and topical use |
| US9549891B2 (en) | 2012-03-19 | 2017-01-24 | The Procter & Gamble Company | Superabsorbent polymers and sunscreen actives for use in skin care compositions |
| US10285926B2 (en) | 2015-06-29 | 2019-05-14 | The Procter & Gamble Company | Superabsorbent polymers and starch powders for use in skin care compositions |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2569561B1 (en) * | 1984-08-30 | 1990-05-18 | Oreal | STABLE ANTHRALIN COMPOSITION IN SATURATED FATTY ACID TRIGLYCERIDES OF PLANT ORIGIN WITH 6 TO 12 CARBON ATOMS |
| JPH0676308B2 (en) * | 1985-06-18 | 1994-09-28 | ポーラ化成工業株式会社 | External skin preparation |
| MY101125A (en) * | 1985-12-23 | 1991-07-31 | Kao Corp | Gel-like emulsion and o/w emulsions obtained from gel-like emulsion |
| DE3836971C1 (en) | 1988-10-31 | 1990-05-17 | Weck, Wolfgang, Dr.Med., 6990 Bad Mergentheim, De | |
| FR2648462B1 (en) * | 1989-06-15 | 1994-01-28 | Oreal | PROCESS FOR IMPROVING THE THERAPEUTIC EFFICIENCY OF LIPOSOLUBLE CORTICOSTEROIDS AND COMPOSITION FOR CARRYING OUT SAID METHOD |
| FR2655542B1 (en) * | 1989-12-13 | 1994-02-11 | Oreal | COSMETIC COMPOSITION FOR TOPICAL APPLICATION CONTAINING ESSENTIAL OILS. |
| FR2655540B1 (en) * | 1989-12-13 | 1994-02-11 | Oreal | COSMETIC COMPOSITION FOR HAIR CARE AND USE OF THE SAME. |
| FR2657607B1 (en) * | 1990-01-30 | 1992-04-30 | Durand Muriel | METHOD FOR PROTECTING DIHYDROXYACETONE, DIHYDROXYACETONE PROTECTED BY THIS PROCESS AND COSMETIC PRODUCT CONTAINING SUCH PROTECTED DIHYDROXYACETONE. |
| FR2722102B1 (en) | 1994-07-11 | 1996-08-23 | Cird Galderma | USE OF DEFORMABLE HOLLOW PARTICLES IN A COSMETIC AND / OR DERMATOLOGICAL COMPOSITION CONTAINING FAT MATERIALS |
| FR2723848B1 (en) | 1994-08-31 | 1997-06-20 | Oreal | COSMETIC OR DERMATOLOGICAL COMPOSITION CONTAINING ENCAPSULATED PLANT EXTRACTS |
| FR2730928B1 (en) * | 1995-02-23 | 1997-04-04 | Oreal | COMPOSITION BASED ON LIPIDIC VESICLES WITH ACIDIC PH AND USE THEREOF IN TOPICAL APPLICATION |
| FR2742674B1 (en) | 1995-12-21 | 1998-02-06 | Oreal | STABLE DISPERSION OF A PHASE NOT MISCIBLE IN WATER, IN AN AQUEOUS PHASE BY MEANS OF VESICLES BASED ON SILICONE SURFACTANT |
| DE19703368C1 (en) * | 1997-01-30 | 1998-10-01 | Klaus Dr Goebel | Rapid production of homogeneous stable cream from storage-stable powder without mechanical work |
| PL353643A1 (en) * | 1999-07-13 | 2003-12-01 | Pharmasol Gmbhpharmasol Gmbh | Uv radiation reflecting or absorbing agents, protecting against harmful uv radiation and reinforcing the natural skin barrier |
| CA2708437C (en) | 2004-04-05 | 2013-05-14 | Kanagawa University | Emulsification dispersants, a method for emulsification and dispersion using the emulsification dispersants, emulsions, and emulsion fuels |
| FR2885808B1 (en) * | 2005-05-19 | 2007-07-06 | Oreal | VECTORIZATION OF DSRNA BY CATIONIC PARTICLES AND TOPICAL USE. |
| JP6274477B2 (en) * | 2010-12-21 | 2018-02-07 | 学校法人神奈川大学 | Manufacturing method of emulsifier manufacturing material, emulsifying material, and manufacturing method of emulsifier |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3161962D1 (en) * | 1980-07-01 | 1984-02-23 | Oreal | Process for obtaining stable dispersions in an aqueous phase of at least a water immiscible liquid phase, and corresponding dispersions |
-
1980
- 1980-07-01 FR FR8014657A patent/FR2485921A1/en active Granted
-
1981
- 1981-06-30 BE BE0/205269A patent/BE889452A/en not_active IP Right Cessation
- 1981-06-30 GB GB8120182A patent/GB2079179B/en not_active Expired
- 1981-06-30 DE DE19813125710 patent/DE3125710A1/en active Granted
- 1981-06-30 IT IT67906/81A patent/IT1144739B/en active
- 1981-06-30 BE BE0/205268A patent/BE889451A/en not_active IP Right Cessation
- 1981-06-30 CA CA000380902A patent/CA1168158A/en not_active Expired
- 1981-07-01 JP JP56101398A patent/JPS5794326A/en active Granted
- 1981-07-01 JP JP56101397A patent/JPS5777613A/en active Granted
- 1981-07-01 CH CH4357/81A patent/CH649915A5/en not_active IP Right Cessation
Cited By (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2102290A (en) * | 1981-07-23 | 1983-02-02 | Oreal | Jojoba oil containing cosmetic compositions |
| US4830857A (en) * | 1984-10-24 | 1989-05-16 | L'oreal | Cosmetic and pharmaceutical compositions containing niosomes and a water-soluble polyamide, and a process for preparing these compositions |
| US4777035A (en) * | 1985-11-15 | 1988-10-11 | Bristol-Myers Company | Antiperspirant composition and process |
| US5628936A (en) * | 1987-03-13 | 1997-05-13 | Micro-Pak, Inc. | Hybrid paucilamellar lipid vesicles |
| US5023086A (en) * | 1987-03-13 | 1991-06-11 | Micro-Pak, Inc. | Encapsulated ionophore growth factors |
| US5000960A (en) * | 1987-03-13 | 1991-03-19 | Micro-Pak, Inc. | Protein coupling to lipid vesicles |
| US4855090A (en) * | 1987-03-13 | 1989-08-08 | Micro-Pak, Inc. | Method of producing high aqueous volume multilamellar vesicles |
| US5234767A (en) * | 1987-03-13 | 1993-08-10 | Micro-Pak, Inc. | Hybrid paucilamellar lipid vesicles |
| US4911928A (en) * | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
| US4917951A (en) * | 1987-07-28 | 1990-04-17 | Micro-Pak, Inc. | Lipid vesicles formed of surfactants and steroids |
| US5019392A (en) * | 1988-03-03 | 1991-05-28 | Micro-Pak, Inc. | Encapsulation of parasiticides |
| US5160669A (en) * | 1988-03-03 | 1992-11-03 | Micro Vesicular Systems, Inc. | Method of making oil filled paucilamellar lipid vesicles |
| US5019174A (en) * | 1988-03-03 | 1991-05-28 | Micro Vesicular Systems, Inc. | Removing oil from surfaces with liposomal cleaner |
| US5032457A (en) * | 1988-03-03 | 1991-07-16 | Micro Vesicular Systems, Inc. | Paucilamellar lipid vesicles using charge-localized, single chain, nonphospholipid surfactants |
| US6132763A (en) * | 1988-10-20 | 2000-10-17 | Polymasc Pharmaceuticals Plc | Liposomes |
| WO1991004731A1 (en) * | 1989-09-21 | 1991-04-18 | Micro Vesicular Systems, Inc. | Liposomal cleaner |
| US5256422A (en) * | 1991-03-28 | 1993-10-26 | Micro Vesicular Systems, Inc. | Lipid vesicle containing water-in-oil emulsions |
| US5213805A (en) * | 1991-07-25 | 1993-05-25 | Micro Vesicular Systems, Inc. | Lipid vesicles having n,n-dimethylamide derivatives as their primary lipid |
| US5260065A (en) * | 1991-09-17 | 1993-11-09 | Micro Vesicular Systems, Inc. | Blended lipid vesicles |
| US5405615A (en) * | 1991-09-17 | 1995-04-11 | Micro Vesicular Systems, Inc. | Sucrose distearate lipid vesicles |
| US6051250A (en) * | 1993-02-12 | 2000-04-18 | L'oreal | Process for the stabilization of vesicles of amphiphilic lipid(s) and composition for topical application containing the said stabilized vesicles |
| US6110492A (en) * | 1997-05-28 | 2000-08-29 | Jenner Biotherapies, Inc. | Immunogenic compositions |
| US6844009B1 (en) * | 1999-03-16 | 2005-01-18 | Capsulis | Media in the form of complex dispersions, method for preparing same and uses |
| US9139850B2 (en) | 2005-05-19 | 2015-09-22 | L'oreal | Vectorization of dsRNA by cationic particles and topical use |
| US9549891B2 (en) | 2012-03-19 | 2017-01-24 | The Procter & Gamble Company | Superabsorbent polymers and sunscreen actives for use in skin care compositions |
| US9839598B2 (en) | 2012-03-19 | 2017-12-12 | The Procter & Gamble Company | Superabsorbent polymers and sunscreen actives for use in skin care compositions |
| US10285926B2 (en) | 2015-06-29 | 2019-05-14 | The Procter & Gamble Company | Superabsorbent polymers and starch powders for use in skin care compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2485921B1 (en) | 1983-07-22 |
| DE3125710A1 (en) | 1982-03-25 |
| IT8167906A0 (en) | 1981-06-30 |
| IT1144739B (en) | 1986-10-29 |
| CH649915A5 (en) | 1985-06-28 |
| FR2485921A1 (en) | 1982-01-08 |
| JPH0210803B2 (en) | 1990-03-09 |
| BE889451A (en) | 1981-12-30 |
| BE889452A (en) | 1981-12-30 |
| JPS5777613A (en) | 1982-05-15 |
| DE3125710C2 (en) | 1988-09-22 |
| CA1168158A (en) | 1984-05-29 |
| JPS6333414B2 (en) | 1988-07-05 |
| JPS5794326A (en) | 1982-06-11 |
| GB2079179B (en) | 1984-03-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB2079179A (en) | Cosmetic Composition Based On an Aqueous Dispersion of Small Lipid Spheres | |
| US5439672A (en) | Cosmetic composition based on an aqueous dispersion of small lipid spheres | |
| US4897308A (en) | Compositions comprising aqueous dispersions of lipid spheres | |
| US4772471A (en) | Aqueous dispersions of lipid spheres and compositions containing the same | |
| RU2121340C1 (en) | Composition for lose weight for local using containing two types of liposomes and a method for decrease and/or elimination of obesity and/or weight excess | |
| JP2544198B2 (en) | Composition based on a hydratable lamellar phase or liposome consisting of an extract of mulberry and a pharmaceutical composition, in particular a dermatological composition with skin lightening or anti-inflammatory activity, or a cosmetic composition Stuff | |
| JP2595479B2 (en) | Moisturizing composition that acts simultaneously on the surface layer and deep layer of skin and cosmetic method using the same | |
| DE69400337T2 (en) | Anti-aging agent that acts on the skin's upper and lower layers at the same time | |
| DE3713493C2 (en) | ||
| JP2736312B2 (en) | Use of spin trap in cosmetic or dermatological composition, its composition and cosmetic treatment method using the same | |
| US5728392A (en) | Cosmetic and/or dermatological composition for the treatment of aging, containing ceramides, and the use thereof | |
| JPH08511013A (en) | Skin protection composition containing emulsified petrolatum | |
| JP2001055308A (en) | Organogel and use thereof in cosmetic field | |
| DE3713492C2 (en) | ||
| CN110934763A (en) | Skin care composition for moisturizing | |
| JP3383496B2 (en) | Method for producing liquid crystal emulsion and liquid crystal emulsion composition obtained by the method | |
| JP2897973B2 (en) | Cosmetic or dermatological composition | |
| US6066326A (en) | Use of a polydimethylsiloxane containing glucoside groups as a moisturizing agent in a cosmetic or dermatological composition | |
| US5489426A (en) | Cosmetic composition based on an aqueous dispersion of small lipid spheres | |
| JPH0686373B2 (en) | Cosmetics | |
| JP2845466B2 (en) | Liposomes containing hydroquinone and kojic acid, and pharmaceutical compositions, especially dermatological compositions having skin lightening activity and anti-inflammatory activity, or cosmetics containing liposomes containing kojic acid and hydroquinone The active ingredient composition used for preparing a pharmaceutical composition or a cosmetic composition characterized by comprising: | |
| FR2532191A1 (en) | Process for the preparation of stable dispersions of an oily phase in an aqueous phase. | |
| JPH0616536A (en) | Composition for make-up or dermatological drug containing vesicle consisting of mixture of phospholipid/glycolipid | |
| JP2962670B2 (en) | Cosmetic or dermatological composition containing at least one ceramide 6 | |
| KR20050078283A (en) | Cosmetic compositions comprising marine organism-derived extract for skin caring |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PE20 | Patent expired after termination of 20 years |
Effective date: 20010629 |