DE3125710A1 - "COSMETIC AGENTS" - Google Patents
"COSMETIC AGENTS"Info
- Publication number
- DE3125710A1 DE3125710A1 DE19813125710 DE3125710A DE3125710A1 DE 3125710 A1 DE3125710 A1 DE 3125710A1 DE 19813125710 DE19813125710 DE 19813125710 DE 3125710 A DE3125710 A DE 3125710A DE 3125710 A1 DE3125710 A1 DE 3125710A1
- Authority
- DE
- Germany
- Prior art keywords
- agent
- beads
- lipid
- ionic
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002537 cosmetic Substances 0.000 title claims description 26
- 150000002632 lipids Chemical class 0.000 claims description 48
- 239000006185 dispersion Substances 0.000 claims description 46
- 239000011324 bead Substances 0.000 claims description 36
- 239000003795 chemical substances by application Substances 0.000 claims description 31
- 239000003921 oil Substances 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- -1 polyoxyethylene Polymers 0.000 claims description 25
- 150000002148 esters Chemical class 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 15
- 239000012071 phase Substances 0.000 claims description 15
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 13
- 239000000194 fatty acid Substances 0.000 claims description 13
- 229930195729 fatty acid Natural products 0.000 claims description 13
- 150000004665 fatty acids Chemical class 0.000 claims description 13
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 12
- 239000002304 perfume Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- 239000008346 aqueous phase Substances 0.000 claims description 10
- 229940076810 beta sitosterol Drugs 0.000 claims description 9
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 claims description 9
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 claims description 9
- 125000004432 carbon atom Chemical group C* 0.000 claims description 9
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 claims description 9
- 229950005143 sitosterol Drugs 0.000 claims description 9
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 7
- 150000001298 alcohols Chemical class 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 7
- 235000012000 cholesterol Nutrition 0.000 claims description 6
- 229920005862 polyol Polymers 0.000 claims description 6
- 150000003077 polyols Chemical class 0.000 claims description 6
- 229930182558 Sterol Natural products 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 235000003702 sterols Nutrition 0.000 claims description 5
- 235000010469 Glycine max Nutrition 0.000 claims description 4
- 150000001412 amines Chemical class 0.000 claims description 4
- RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 claims description 4
- 229940093541 dicetylphosphate Drugs 0.000 claims description 4
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 claims description 4
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 150000003432 sterols Chemical class 0.000 claims description 4
- 235000000832 Ayote Nutrition 0.000 claims description 3
- 239000004215 Carbon black (E152) Substances 0.000 claims description 3
- 235000009854 Cucurbita moschata Nutrition 0.000 claims description 3
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 229940124091 Keratolytic Drugs 0.000 claims description 3
- 125000001931 aliphatic group Chemical group 0.000 claims description 3
- 230000001166 anti-perspirative effect Effects 0.000 claims description 3
- 239000003213 antiperspirant Substances 0.000 claims description 3
- 239000003212 astringent agent Substances 0.000 claims description 3
- 239000008406 cosmetic ingredient Substances 0.000 claims description 3
- 239000002781 deodorant agent Substances 0.000 claims description 3
- 150000002191 fatty alcohols Chemical class 0.000 claims description 3
- 239000003349 gelling agent Substances 0.000 claims description 3
- 230000035876 healing Effects 0.000 claims description 3
- 229930195733 hydrocarbon Natural products 0.000 claims description 3
- 230000001530 keratinolytic effect Effects 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 230000003020 moisturizing effect Effects 0.000 claims description 3
- 229920000223 polyglycerol Polymers 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 235000015136 pumpkin Nutrition 0.000 claims description 3
- 150000003626 triacylglycerols Chemical class 0.000 claims description 3
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims description 2
- 241000195493 Cryptophyta Species 0.000 claims description 2
- 240000004244 Cucurbita moschata Species 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- MNQZXJOMYWMBOU-VKHMYHEASA-N D-glyceraldehyde Chemical compound OC[C@@H](O)C=O MNQZXJOMYWMBOU-VKHMYHEASA-N 0.000 claims description 2
- 235000003222 Helianthus annuus Nutrition 0.000 claims description 2
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims description 2
- 239000004166 Lanolin Substances 0.000 claims description 2
- 244000044822 Simmondsia californica Species 0.000 claims description 2
- 235000004433 Simmondsia californica Nutrition 0.000 claims description 2
- 240000008042 Zea mays Species 0.000 claims description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 2
- 150000001299 aldehydes Chemical class 0.000 claims description 2
- 150000001414 amino alcohols Chemical class 0.000 claims description 2
- 210000004381 amniotic fluid Anatomy 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims description 2
- 235000005822 corn Nutrition 0.000 claims description 2
- 230000002951 depilatory effect Effects 0.000 claims description 2
- 229940120503 dihydroxyacetone Drugs 0.000 claims description 2
- 150000002009 diols Chemical class 0.000 claims description 2
- UQPHVQVXLPRNCX-UHFFFAOYSA-N erythrulose Chemical compound OCC(O)C(=O)CO UQPHVQVXLPRNCX-UHFFFAOYSA-N 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- 229940087559 grape seed Drugs 0.000 claims description 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims description 2
- 229960000367 inositol Drugs 0.000 claims description 2
- 229940039717 lanolin Drugs 0.000 claims description 2
- 235000019388 lanolin Nutrition 0.000 claims description 2
- 229940059574 pentaerithrityl Drugs 0.000 claims description 2
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 claims description 2
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 229960002920 sorbitol Drugs 0.000 claims description 2
- 229920001059 synthetic polymer Polymers 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 240000007124 Brassica oleracea Species 0.000 claims 1
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 claims 1
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 claims 1
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 claims 1
- 244000020551 Helianthus annuus Species 0.000 claims 1
- 244000043261 Hevea brasiliensis Species 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 150000002430 hydrocarbons Chemical group 0.000 claims 1
- 229920003052 natural elastomer Polymers 0.000 claims 1
- 229920001194 natural rubber Polymers 0.000 claims 1
- 239000000419 plant extract Substances 0.000 claims 1
- 235000019198 oils Nutrition 0.000 description 25
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 12
- 210000003491 skin Anatomy 0.000 description 12
- 239000012530 fluid Substances 0.000 description 7
- 235000019486 Sunflower oil Nutrition 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 6
- 239000002600 sunflower oil Substances 0.000 description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 5
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 4
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 4
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 3
- 229920001615 Tragacanth Polymers 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 241000416162 Astragalus gummifer Species 0.000 description 2
- WYWZRNAHINYAEF-UHFFFAOYSA-N Padimate O Chemical compound CCCCC(CC)COC(=O)C1=CC=C(N(C)C)C=C1 WYWZRNAHINYAEF-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 239000000196 tragacanth Substances 0.000 description 2
- 235000010487 tragacanth Nutrition 0.000 description 2
- 229940116362 tragacanth Drugs 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 240000001980 Cucurbita pepo Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 241000208818 Helianthus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 244000025272 Persea americana Species 0.000 description 1
- 235000008673 Persea americana Nutrition 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229930183167 cerebroside Natural products 0.000 description 1
- 150000001784 cerebrosides Chemical class 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 239000008278 cosmetic cream Substances 0.000 description 1
- 239000008341 cosmetic lotion Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- XRWMGCFJVKDVMD-UHFFFAOYSA-M didodecyl(dimethyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCC XRWMGCFJVKDVMD-UHFFFAOYSA-M 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000008169 grapeseed oil Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 229940099367 lanolin alcohols Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- AYMRGURZBPZMQC-UHFFFAOYSA-N methyl 4-hydroxybenzoate phosphoric acid Chemical compound COC(=O)C1=CC=C(O)C=C1.P(=O)(O)(O)O AYMRGURZBPZMQC-UHFFFAOYSA-N 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
- 125000006353 oxyethylene group Chemical group 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 229940068065 phytosterols Drugs 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 229940080236 sodium cetyl sulfate Drugs 0.000 description 1
- GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0084—Antioxidants; Free-radical scavengers
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/42—Ethers, e.g. polyglycol ethers of alcohols or phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D19/00—Degasification of liquids
- B01D19/02—Foam dispersion or prevention
- B01D19/04—Foam dispersion or prevention by addition of chemical substances
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
- C11D17/0026—Structured liquid compositions, e.g. liquid crystalline phases or network containing non-Newtonian phase
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M7/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made of other substances with subsequent freeing of the treated goods from the treating medium, e.g. swelling, e.g. polyolefins
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2201/00—Inorganic compounds or elements as ingredients in lubricant compositions
- C10M2201/02—Water
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2203/00—Organic non-macromolecular hydrocarbon compounds and hydrocarbon fractions as ingredients in lubricant compositions
- C10M2203/02—Well-defined aliphatic compounds
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2203/00—Organic non-macromolecular hydrocarbon compounds and hydrocarbon fractions as ingredients in lubricant compositions
- C10M2203/02—Well-defined aliphatic compounds
- C10M2203/022—Well-defined aliphatic compounds saturated
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2203/00—Organic non-macromolecular hydrocarbon compounds and hydrocarbon fractions as ingredients in lubricant compositions
- C10M2203/02—Well-defined aliphatic compounds
- C10M2203/024—Well-defined aliphatic compounds unsaturated
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2203/00—Organic non-macromolecular hydrocarbon compounds and hydrocarbon fractions as ingredients in lubricant compositions
- C10M2203/04—Well-defined cycloaliphatic compounds
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2215/00—Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant compositions
- C10M2215/02—Amines, e.g. polyalkylene polyamines; Quaternary amines
- C10M2215/04—Amines, e.g. polyalkylene polyamines; Quaternary amines having amino groups bound to acyclic or cycloaliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2215/00—Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant compositions
- C10M2215/26—Amines
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2223/00—Organic non-macromolecular compounds containing phosphorus as ingredients in lubricant compositions
- C10M2223/10—Phosphatides, e.g. lecithin, cephalin
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
- C10N2040/00—Specified use or application for which the lubricating composition is intended
- C10N2040/46—Textile oils
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2200/00—Functionality of the treatment composition and/or properties imparted to the textile material
- D06M2200/40—Reduced friction resistance, lubricant properties; Sizing compositions
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Description
PATENTANWÄL'J'E
J. RBITSTÖTTER W. KINZEBACHPATENT AGENCIES'J'E
J. RBITSTÖTTER W. KINZEBACH
W. BUNTE (ΐ958-ΐ97β) K. P. HÖLLERW. BUNTE (ΐ958-ΐ97β) K. P. HÖLLER
TBLEFONi (08B) 37 0BB3 TELEXl 52IB208 ISAR D TBLEFONi (08B) 37 0BB3 TELEXl 52IB208 ISAR D
BAUERSTRASSB 22, 8000 MÜNCHEN BAUERSTRASSB 22, 8000 MUNICH
München, den3Q. Juni 1980 M/ 22 160Munich, the 3Q. June 1980 M / 22 160
L 1OREAL
14, rue RoyaleL 1 OREAL
14, rue Royale
F-75008 Paris (Frankreich)F-75008 Paris (France)
Kosmetische MittelCosmetic means
M/22 160M / 22 160
Die vorliegende Erfindung betrifft ein kosmetisches Mittel, bestehend aus einer Dispersion von Lipidkügelchen. Wässrige Dispersionen dieser Art sind bereits in der FR-PS 2 315 991 beschrieben.The present invention relates to a cosmetic agent consisting of a dispersion of lipid spheres. Aqueous dispersions of this type have already been described in FR-PS 2,315,991.
Die Lipidkügelchen dieser Dispersionen sind durch ihre Schichtstruktur gekennzeichnet, welche aus zwei oder mehreren Lipidschichten bestehen, die durch Schichten einer wäßrigen Phase voneinander getrennt sind. Sie können somit zum Verkapseln von wasserlöslichen Wirkstoffen in den zwischen den Lipidschichten bestehenden wäßrigen Abteilen, wie beispielsweise pharmazeutischen oder kosmetischen Wirkstoffen, dienen und diese nach außen abschirmen.The lipid spheres of these dispersions are characterized by their layer structure, which consists of two or consist of several lipid layers which are separated from one another by layers of an aqueous phase. So you can for encapsulating water-soluble active ingredients in the aqueous compartments between the lipid layers, such as pharmaceutical or cosmetic active ingredients, and shield them from the outside.
Das vorgenannte französische Patent beschreibt auch ein Verfahren zur Herstellung einer wäßrigen Dispersion von Lipidkügelchen, bei dem man in einer ersten Stufe die Lipide, welche die konzentrischen Schichten der Kügelchen bilden sollen, mit der wäßrigen, einzukapselnden Lösung in Kontakt bringt, wobei das Verhältnis lipophiler/hydrophiler Lipide so ausgewählt ist, daß die letzteren in Wasser oder in der einzukapselnden wäßrigen Phase aufquellen und eine ebene Lamellenphase bilden; in einer zweiten Stufe gibt man zu der Lamellenphase eine wäßrige Lösung, welche die externe kontinuierliche Phase der Dispersion bilden soll, und drittens rührt man dann das Ganze kräftig, wobeiThe aforementioned French patent also describes a process for the preparation of an aqueous dispersion of Lipid spheres, in which in a first stage the lipids, which are the concentric layers of the spheres should form, with the aqueous, encapsulated solution in contact, the ratio of lipophilic / hydrophilic Lipids is selected so that the latter swell in water or in the aqueous phase to be encapsulated and form a flat lamellar phase; in a second stage, an aqueous solution is added to the lamellar phase, which to form the external continuous phase of the dispersion, and thirdly, the whole is then vigorously stirred, whereby
Μ/22 160Μ / 22 160
man eine Dispersion von Kügelchen erhält, zwischen deren konzentrischen Schichten ^ie einzukapselnde wäßrige Phase eingeschlossen ist.a dispersion of spheres is obtained, between them concentric Layers ^ ie the aqueous phase to be encapsulated is included.
Zur Bildung der konzentrischen Schichten der Kügelchen kann man nach der Lehre dieser französischen Patentschrift sowohl amphiphile, oder ionische oder nicht-ionische Lipide verwenden. Von den nicht-ionischen amphiphilen Lipiden bevorzugt man:To form the concentric layers of the spheres, one can use the teaching of this French patent specification use both amphiphilic, or ionic or non-ionic lipids. Of the non-ionic amphiphilic lipids one prefers:
- die geradkettigen oder verzweigten Polyglycerinäther der folgenden Formeln:- the straight-chain or branched polyglycerol ethers of the following formulas:
R (-OCH0-CHOH-CH0-) OHR (-OCH 0 -CHOH-CH 0 -) OH
2 2 η2 2 η
undand
R- (-O-CH-CHI OHR- (-O-CH-CHI OH
CH-OHCH-OH
worinwherein
η eine ganze Zahl von 1 bis 6 bedeutet,η is an integer from 1 to 6,
R eine geradkettige oder verzweigte, gesättigte oder ungesättigte aliphatische Kette mit 12 bis 30 Kohlenstoffatomen ist, Kohlenwasserstoffreste von Lanolinalkoholen oder 2-Hydroxy-alkylreste von langkettigen a-Diolen;R is a straight or branched, saturated or unsaturated aliphatic chain with 12 to 30 carbon atoms is, hydrocarbon radicals of lanolin alcohols or 2-hydroxy-alkyl radicals of long-chain α-diols;
- die polyoxyäthylenierten Fettalkohole;- the polyoxyethylene fatty alcohols;
- die Ester von Polyolen, welche gegebenenfalls oxyäthyleniert sind, und insbesondere die polyoxyäthylenierten Sorbitester; - the esters of polyols, which may be oxyethylene are, and especially the polyoxyethylene sorbitol esters;
- die Glycolipide natürlichen oder synthetischen Ursprungs, beispielsweise die Cerebroside.the glycolipids of natural or synthetic origin, for example the cerebrosides.
^ ILLi -:->·- ·:■·:··: 3ΐ25^ ILLi - : -> · - ·: ■ ·: ··: 3ΐ25
Μ/22 160Μ / 22 160
Von den kosmetischen Wirkstoffen, die in die Lipidkügelchen eingekapselt werden können, zählt die französische Patentschrift beispielsweise auf: Substanzen, die zur Pflege der Hautoberfläche bestimmt sind, wie befeuchtende Mittel, künstliche Bräunungsmittel, Färbemittel für die Haut, wasserlösliche Sonnenfilter, Antiperspirantien, Deodorantien, Adstringentien, erfrischende, tonisierende, heilende, keratolytische, enthaarende Produkte, parfümierte Wasser und Extrakte tierischer oder pflanzlicher Gewebe.The French patent is one of the cosmetic active ingredients that can be encapsulated in the lipid spheres for example on: substances that are intended to care for the surface of the skin, such as moisturizing agents, artificial tanning agents, dyes for the skin, water-soluble sun filters, antiperspirants, deodorants, Astringents, refreshing, toning, healing, keratolytic, depilatory products, perfumed waters and extracts of animal or vegetable tissues.
Es wurde beobachtet, daß die obigen kosmetischen Mittel in Form einer wäßrigen Dispersion von Lipidkügelchen gegenüber klassischen Präparaten in Form von öl und Wasseremulsionen den Vorteil haben, daß sie weniger agressiv sind und somit weniger reizen, wenn sie auf die Hautoberfläche ! aufgetragen werden.It has been observed that the above cosmetic agents are in the form of an aqueous dispersion of lipid beads classic preparations in the form of oil and water emulsions have the advantage that they are less aggressive and therefore less irritating when they hit the surface of the skin! be applied.
Die vorliegende Erfindung beschreibt ein kosmetischesThe present invention describes a cosmetic
Mittel auf der Basis einer wäßrigen Dispersion von Lipid- ; kügelchen, mit dem man gleichzeitig die Vorteile der ! Dispersion von Kügelchen mit den Vorteilen, welche sich aus der Anwesenheit kosmetischer öle ergeben, vereinen kann.Agent based on an aqueous dispersion of lipid; globules, with which one can take advantage of the ! Dispersion of beads can combine with the advantages that result from the presence of cosmetic oils.
Die vorliegende Erfindung betrifft somit ein kosmetisches Mittel, bestehend aus einer wäßrigen Dispersion von Kügelchen, bestehend aus geordneten molekularen Schichten, zwischen denen eine innere wäßrige Phase eingeschlossen ist, wobei diese Schichten aus mindestens einem nicht-ionischen, amphiphilen Lipid bestehen. Die Erfindung ist gekennzeichnet durch mindestens ein öl, das in der wäßrigen, externen Phase, die die Kügelchen umgibt, dispergiert ist.The present invention thus relates to a cosmetic agent consisting of an aqueous dispersion of beads, consisting of ordered molecular layers between which an internal aqueous phase is enclosed, these layers consisting of at least one non-ionic, amphiphilic lipid. The invention is characterized by at least one oil dispersed in the aqueous external phase surrounding the beads.
_ .. ... -.> :.Λr..".,ir.Wj;. 1 312571_ .. ... -.> : .Λ r .. "., Ir.Wj ;. 1 312571
Μ/22 160 -Μ / 22 160 -
Dieses öl ist ausgewählt unter Estern von Fettsäuren und Polyolen, insbesondere flüssigen Triglyceriden, und Estern von Fettsäuren und verzweigten Alkoholen der Formel:This oil is chosen among esters of fatty acids and Polyols, especially liquid triglycerides, and esters of fatty acids and branched alcohols of the formula:
R-COOR'R-COOR '
R für den Rest einer höheren Fettsäure mit 8 bis 20 Kohlenstoffatomen stehtR stands for the residue of a higher fatty acid having 8 to 20 carbon atoms
und
R' eine verzweigte Kohlenwasserstoffkette mit 3 bis 2 0 Kohlenstoffatomenand
R 'is a branched hydrocarbon chain with 3 to 2 carbon atoms
darstellt.represents.
Es wurde nun überraschenderweise gefunden, daß man mit den nicht-ionischen amphiphilen Kügelchen die öl in Wasser Dispersion stabilisieren kann, ohne daß ein herkömmliches Emulgiermittel zugesetzt werden muß, noch daß Kügelchen zerstört werden. Es ist jedoch bekannt, daß die Stabilität einer Emulsion im wesentlichen von der Anwesenheit eines Emulgiermittels abhängt, dessen Moleküle an der Oberfläche der öltröpfchen absorbiert werden und eine Art ununterbrochene Membran bilden, die den direkten Kontakt zwischen zwei benachbarten Tröpfchen, beispeilsweise bei einer Erschütterung, verhindert. Im vorliegenden Fall hätte der Fachmann daher annehmen können, daß die nicht-ionischen amphphilen Lipide der Kügelchen die Rolle eines Emulgiermittels spielen könnten und an der Oberfläche der öltröpfchen absorbiert werden könntent wobeidiese Stabilisierung aber auch bewirken würde, daß die konzentrischen Schichten der Kügelchen zerstört würden. Dies ist jedoch nicht der Fall und man stellt überraschend fest, daß die nicht-ionischen amphiphilen Kügelchen gemäß der vorliegenden Erfindung eine Dispersion mindestens eines Pflanzenöles, wie oben definiert ; It has now surprisingly been found that the nonionic amphiphilic beads can be used to stabilize the oil-in-water dispersion without a conventional emulsifying agent having to be added or the beads being destroyed. It is known, however, that the stability of an emulsion depends essentially on the presence of an emulsifying agent, the molecules of which are absorbed on the surface of the oil droplets and form a kind of uninterrupted membrane which prevents direct contact between two adjacent droplets, for example in the event of a shock . In the present case, the skilled person could therefore be assumed that the non-ionic amphphilen lipids of the beads could play the role of an emulsifying agent and could be absorbed at the surface of the oil droplets t wobeidiese stabilization but would also cause the concentric layers of the beads would be destroyed . However, this is not the case and it is surprisingly found that the nonionic amphiphilic beads according to the present invention are a dispersion of at least one vegetable oil as defined above ;
M/22 160M / 22 160
in einer äußeren wäßrigen Phase stabilisieren können, indem sie sich um die öltröpfchen dispergieren und 'somit deren Form erhalten.can stabilize in an external aqueous phase by dispersing around the oil droplets and 'thus their Maintain shape.
In der US-PS 3 957 971 sind Dispersionen von Kügelchen ionischer Amphiphiler oder Liposomen beschrieben, welche in kosmetische Lotionen oder Cremes aufgenommen werden, d.h. Wasser-in-öl oder öl-in-Wasser Emulsionen. Gemäß der vorliegenden Erfindung bestehen die Kügelchen nicht aus ionischen Amphiphilen sondern aus nicht-ionischen Amphiphilen. Darüber hinaus wurde gefunden, daß man mit den Liposomen keine Dispersion eines der oben aufgeführten Pflanzenöle in Wasser stabilisieren kann, während völlig überraschend die Kügelchen nicht-ionischer Amphiphiler gemäß der vorliegenden Erfindung eine derartige Dispersion stabilisieren können.U.S. Patent 3,957,971 discloses dispersions of beads Ionic amphiphiles or liposomes described, which are included in cosmetic lotions or creams, i.e. water-in-oil or oil-in-water emulsions. According to According to the present invention, the beads are not composed of ionic amphiphiles but of non-ionic ones Amphiphiles. In addition, it has been found that the liposomes are not used to disperse any of the abovementioned Vegetable oils can stabilize in water, while completely surprisingly the spheres of non-ionic amphiphiles can stabilize such a dispersion according to the present invention.
Die Herstellung des erfindungsgemaßen kosmetischen Mittels erfolgt daher in zwei Stufen: In einer ersten Stufe stellt man aus nicht-ionischen amphiphilen Lipiden eine wäßrige Dispersion von Kügelchen her, indem man wie in der FR-PS 2 315 991 oder in der FR-PS 2 221 122 beschrieben arbeitet. In einer zweiten Stufe gibt man, wenn die wäßrige Dispersion der Kügelchen hergestellt ist, insbesondere ein Öl zu, das man dann durch Rühren in der externen, wäßrigen Phase dispergiert.The production of the cosmetic agent according to the invention therefore takes place in two stages: In a first stage, an aqueous one is made from non-ionic amphiphilic lipids Dispersion of spheres, as described in FR-PS 2 315 991 or in FR-PS 2 221 122 is working. In a second stage, when the aqueous dispersion of the beads is prepared, in particular an oil is added, which is then dispersed in the external, aqueous phase by stirring.
Vorzugsweise enthält das erfindungsgemäße kosmetische Mittel 2 bis 10 Gew.-% nicht-ionische, amphiphile Lipide, welche die Wände der Kügelchen bilden, und 2 bis 4 0 Gew.-% dispergierte(s) öl (e), bezogen auf das Gesamtgewicht des Mittels. Vorteilhafterweise liegt des Gewichtsverhältnis der nichtionischen amphiphilen Lipide zu den (oder dem) dispergierten öl (en) zwischen 0,2/1 und 1/1.The cosmetic agent according to the invention preferably contains 2 to 10% by weight of non-ionic, amphiphilic lipids, which form the walls of the beads, and 2 to 40% by weight of dispersed (s) oil (s), based on the total weight of the agent. The weight ratio of the nonionic amphiphilic lipids to the (or the) dispersed ones is advantageously oil (s) between 0.2 / 1 and 1/1.
Μ/22 160 -Μ / 22 160 -
4f4f
Die öle, welche in die erfindungsgemäßen Mittel aufgenommen werden können, sind ausgewählt unter Estern von Fettsäuren und Polyolen, insbesondere flüssigen Triglyceriden und den Estern von Fettsäuren und verzweigten Alkoholen der Formel:The oils which are included in the agents according to the invention are selected from esters of fatty acids and polyols, in particular liquid triglycerides and the esters of fatty acids and branched alcohols of the formula:
R - COO-R1,
worinR - COO-R 1 ,
wherein
R für den Best einer höheren Fettsäuremit 8 bis 20 Kohlenstoffatomen stehtR for the best of a higher fatty acid with 8 to 20 carbon atoms stands
R' eine verzweigte Kohlenwasserstoffkette mit 3 bis 20 Kohlenstoffatomen darstellt.R 'is a branched hydrocarbon chain with 3 to 20 Represents carbon atoms.
Zu den Estern von Fettsäuren und Polyolen gehören insbesondere Sonnenblumen-, Mais-, Soja-, Kürbis-, Traubenkern-, Jojoba-ölen und Glycerin-tri-capro-caprylat. Zu den Estern höherer Fettsäuren und verzweigten Alkoholen gehört Purcellinöl.The esters of fatty acids and polyols include in particular Sunflower, corn, soy, pumpkin, grape seed, jojoba oils and glycerine tri-capro-caprylate. Higher to the esters Purcellin oil is one of the fatty acids and branched alcohols.
Die kosmetisch aktiven Wirkstoffe des erfindungsgemäßen Mittels können innerhalb oder außerhalb der Kugelchen eingekapselt sein. Nach einer bevorzugten Ausführungsform enthält die ölphase des Mittels eine oder mehrere lipidlösliche kosmetische Substanzen. Bei der Herstellung des erfindungsgemäßen Mittels werden die letzteren zuvor in dem öl gelöst, welches der Dispersion der Lipidkügelchen zugesetzt werden soll. Zu den lipidlöslichen kosmetischen Wirkstoffen gehören insbesondere Sonnenfilter, wie 2-Äthyl-hexyl-p-dimethylaminobenzoat oder Verbindungen, die den Zustand trockener oder alternder Haut verbessern sollen, insbesondere nicht verseifbare als auch verseifbare Bestandteile von Soja, Avocado, Tocopherole, Vitamine E, F, und Antioxidantien.The cosmetically active ingredients of the invention Means can be encapsulated inside or outside of the spheres be. According to a preferred embodiment contains the oil phase of the agent is one or more lipid-soluble cosmetic substances. In the preparation of the agent according to the invention, the latter are previously dissolved in the oil, which to add to the lipid bead dispersion. The lipid-soluble cosmetic active ingredients include in particular solar filters, such as 2-ethyl-hexyl-p-dimethylaminobenzoate or compounds intended to improve the condition of dry or aging skin, especially unsaponifiable ones as well as saponifiable components of soy, avocado, tocopherols, vitamins E, F, and antioxidants.
Die öl-in-Wasser Dispersion, welche das äußere Milieu der Dispersion vojn Kügelchen darstellt, kann mindestens einen Zusatz, insbesondere ein gelbildedes Mittel oder ein Parfüm, enthalten. Der Zusatz wird zusammen mit dem öl der Dispersion zugesetzt.The oil-in-water dispersion, which vojn the external environment of the dispersion Is beads, can contain at least one additive, in particular a gel-forming agent or a perfume. The addition is added to the dispersion together with the oil.
M/22 160M / 22 160
IZIZ
Dasgelbildede1· Mittel kann in Konzentrationen von 0,1 bis 2 Gew.-%f bezogen auf das Gesamtgewicht des Mittels, eingesetzt werden. Zu den verwendbaren gelbildenden Mitteln gehören die Cellulosederivate, wie Hydroxyäthylcellulose; synthetische Polymere; Derivate von Algen, wie Satiagum, oder auch natürliche Gummi, wie Traganth. Bevorzugt verwendet man als gelierende Mittel Hydroxyäthylcellulose, eine Mischung von Carboxyvinylsäuren, die im Handel unter der Bezeichnung "CARBOPOL 940" erhältlich ist, Satiagum oder auch Traganth.Dasgelbildede 1 · agent may be obtained at concentrations of 0.1 to 2 wt .-% f based on the total weight of the agent used. The gelling agents which can be used include the cellulose derivatives, such as hydroxyethyl cellulose; synthetic polymers; Derivatives of algae, such as satiagum, or natural gums, such as tragacanth. The gelling agent used is preferably hydroxyethyl cellulose, a mixture of carboxyvinyl acids which is commercially available under the name "CARBOPOL 940", satiagum or tragacanth.
Die nicht-ionischen amphiphilen Lipide, welche die konzentrischen schichten der Kügelchen des erfindungsgemäßen Mittels bilden sollen, sind:The non-ionic amphiphilic lipids, which are the concentric layers of the beads of the agent according to the invention are to form:
- Äther oder Ester geradkettiger oder verzweigter PoIyglycerine der Formeln:- Ethers or esters of straight-chain or branched polyglycerols of the formulas:
R R.
bzw.
R respectively.
R.
och „choh-choch "choh-ch
OCH9 - CHOCH 9 - CH
worinwherein
η für eine ganze Zahl zwischen 2 und 6 stehtη stands for an integer between 2 and 6
und
R eine geradkettige oder verzweigte, gesättigte aliphatische Kette mit 16 bis 20 Kohlenstoffatomen
oder den Kohlenwasserstoffrest eines Lanolinalkohols darstellt;and
R represents a straight or branched, saturated aliphatic chain having 16 to 20 carbon atoms or the hydrocarbon radical of a lanolin alcohol;
- polyoxyäthylenierte Sterine.- polyoxyethylene sterols.
M/22 160 - Uf - M / 22 160 - Uf -
Bei. der Bildung der ebenen Lamellenphase, welche erhalten wird, wenn man die nicht-ionischen, amphiphilen Lipide mit der wäßrigen, einzukapselnden Phase in Kontakt bringt, kann man den Lipiden verschiedene Hilfsmittel zusetzen, um beispielsweise die Permeabilität oder die Oberflächenladung der Kügelchen zu variieren. Dabei kann man gegebenenfalls Alkohole und Diole mit langer Kette, Sterine, insbesondere Cholesterin und ß-Sitosterin, langkettige Amine und deren guaternäre Ammoniumderivate, insbesondere Didodecyl-dimethylammoniumbromid, Hydroxyalkylamine, polyoxyäthylenierte Fettamine, Ester von langkettigen Amino-alkoholen,. deren Salze und quaternären Ammoniumderivate, Phophorsäureester von Fettalkoholen, insbesondere Dicetylphosphat, Alkylsulfate, beispielsweise Natrium-cetyl-sulfat, bestimmte Polymere, wie Polypeptide und Proteine, zugeben.At. the formation of the flat lamellar phase that is obtained, when the non-ionic, amphiphilic lipids are brought into contact with the aqueous phase to be encapsulated various auxiliaries are added to the lipids, for example the permeability or the surface charge of the beads to vary. Here you can optionally alcohols and diols with a long chain, sterols, in particular Cholesterol and ß-sitosterol, long-chain amines and their quaternary ammonium derivatives, in particular didodecyl-dimethylammonium bromide, Hydroxyalkylamines, polyoxyethylene fatty amines, esters of long-chain amino alcohols. their salts and quaternary ammonium derivatives, phosphoric acid esters of fatty alcohols, in particular dicetyl phosphate, Certain alkyl sulfates, for example sodium cetyl sulfate Add polymers such as polypeptides and proteins.
Außer den oben aufgeführten Hilfsmitteln kann man auch ein Konservierungsmittel, wie Methyl-p-hydroxybenzoat, zugeben.In addition to the auxiliaries listed above, a preservative such as methyl p-hydroxybenzoate can also be added.
Die wäßrige Phase, sei sie intern oder extern, kann ein wasserlösliches kosmetisches Mittel enthalten, das üblicherweise zur Pflege des Gesichts, der Hände oder des Körpers verwendet wird. Zu diesen Substanzen gehören feucht machende Mittel, wie Glycerin, Sorbit, Pentaerythrit, Inosit, Pyrrolidoncarbonsäure und deren Salze; künstliche Bräunungsmittel, wie Dihydroxyaceton, Erythrulose, Glycerinaldehyd, γ-Dialdehyde, wie Weinsäurealdehyd; Färbemittel für die Haut; Sonnenfilter, Antiperspirants, Deodorants, Adstringentien, erfrischende, tonisierende, heilende, keratolytiscne^rodukte, parfümierte Wässer, Extrakte tierischer oder pflanzlicher Gewebe, wie Proteine, Amnionflüssigkeit, Polysaccharide und Antiseborrhoe-Mittel.The aqueous phase, be it internal or external, can be a Contain water-soluble cosmetic agent, usually for the care of the face, hands or body is used. These substances include moisturizing agents such as glycerine, sorbitol, pentaerythritol, inositol, Pyrrolidonecarboxylic acid and its salts; artificial tanning agents such as dihydroxyacetone, erythrulose, glyceraldehyde, γ-dialdehydes such as tartaric aldehyde; Colorants for the skin; Sun filters, antiperspirants, deodorants, astringents, refreshing, toning, healing, keratolytic products, perfumed waters, animal or vegetable extracts Tissues such as proteins, amniotic fluid, polysaccharides, and antiseborrhea agents.
Μ/22 160Μ / 22 160
■«■■ «■
Um die Erfindung näher zu beschreiben, werden nachstehend rein illustrativ einige Ausführungsformen aufgeführt.In order to describe the invention in more detail, some embodiments are given below, purely by way of illustration.
Die Herstellung der in den nachfolgenden Beispielen beschriebenen kosmetischen Mittel erfolgt in zwei Stufen. In einer ersten Stufe stellt man nach dem Verfahren der FR-PS 2 315 991 eine wäßrige Dispersion her. Die wäßrige Dispersion der Lipidkügelchen wird hergestellt aus:The cosmetic agents described in the examples below are produced in two stages. In a first stage, an aqueous dispersion is prepared using the process described in French Pat. No. 2,315,991. The watery one Dispersion of lipid spheres is made from:
- einem nicht-ionischen, amphiphilen Lipid,- a non-ionic, amphiphilic lipid,
- Sterinen, wie Cholesterin oder ß-Sitosterin; gegebenenfalls Dicetylphosphat;- sterols such as cholesterol or ß-sitosterol; optionally dicetyl phosphate;
- gegebenenfalls wasserlöslichen kosmetischen Wirstoffen und- optionally water-soluble cosmetic ingredients and
entmineralisiertem Wasser, das ein Konservierungsmittel enthalten kann.demineralized water, which may contain a preservative.
In einer zweiten Stufe gibt man das öl zu, das man durch intensives, mechanisches Rühren bei Raumtemperatur, vorzugsweise bei etwa 40 C, dispergiert. Während dieser zweiten Stufe kann man gegebenenfalls lipidlösliche kosmetische Wirkstoffe, Parfüms und/oder gelbildende Mittel zusetzen.In a second stage you add the oil that you put through intensive, mechanical stirring at room temperature, preferably at about 40 C, dispersed. During this second Stage one can optionally add lipid-soluble cosmetic active ingredients, perfumes and / or gel-forming agents.
M/22 160M / 22 160
Vergleichsversuche zwischen einem erfindungsgemäßen kosmetischen Mittel und einem bekannten MittelComparative tests between an inventive cosmetic agent and a known agent
Man stellt zwei Mittel (A) und (B) her, die im wesentlichen gleich sind, mit dem Unterschied, daß man dem Mittel (B) in der zweiten Phase kein öl zusetzt.Two remedies (A) and (B) are produced, which are essentially the same, with the difference that the remedy (B) no oil added in the second phase.
Das Mittel (A) enthält die folgenden Bestandteile:The agent (A) contains the following components:
1. Stufe1st stage
nicht-ionisches, amphiphiles Lipid der Formel:non-ionic, amphiphilic lipid of the formula:
OCH2 -OCH 2 -
OHOH
CH2OHCH 2 OH
worin R für einen Hexadecylrest steht und η einen statistischen Mittelwert von 3 hat 3,8gwhere R stands for a hexadecyl radical and η has a statistical mean of 3 3.8g
ß-Sitosterin 3,8 gß-sitosterol 3.8 g
Dicetylphosphat 0,4gDicetyl phosphate 0.4g
Methyl-p-hydroxybenzoat 0,3 gMethyl p-hydroxybenzoate 0.3 g
entmineralisiertes Wasser 66,7 gdemineralized water 66.7 g
2. Stufe2nd stage
Man setzt der obigen Dispersion 25 g Sonnenblumenöl zu und rührt das ganze kräftig, um die endgültige Dispersion zu erhalten.25 g of sunflower oil are added to the above dispersion and stir vigorously to get the final dispersion.
Auf gleiche Weise stellt man das kosmetische Mittel (B) her, jedoch ohne daß man in einer zweiten Phase Sonnenblumenöl zugibt, sondern die 25 g öl durch eine gleiche Menge entmineralisiertes Wasser ersetzt.Cosmetic agent (B) is produced in the same way, but without adding sunflower oil in a second phase, but rather the 25 g of oil with an equal amount Replaces demineralized water.
M/22 160M / 22 160
Das kosmetische Mittel (A) unterscheidet sich somit vom kosmetischen Mittel (B) nur dadurch, daß es 25 g Sonnenblumenöl enthält.The cosmetic agent (A) thus differs from the cosmetic agent (B) only in that it contains 25 g of sunflower oil contains.
1) Messungen des Reibungskoeffizienten der Haut beim Verteilen der kosmetischen Mittel (A) und (B)1) Measurements of the coefficient of friction of the skin at Distribution of cosmetic products (A) and (B)
Der Reibungskoeffizient der Haut wird beim Verteilen der kosmetischen Mittel (A) und (B) auf dem Unterarm einer Versuchsperson mit einem rotierenden Taster gemessen; dazu mißt man den Widerstand des Tasters bei seiner Drehung. Der Taster wird mit einer konstanten Kraft ( 20 oder 50 g) aufgedrückt.The coefficient of friction of the skin is increased when spreading of the cosmetic products (A) and (B) on the forearm of a test person with a rotating button measured; this is done by measuring the resistance of the button as it rotates. The push button is with a constant Force (20 or 50 g) pressed on.
Man erhält folgende Ergebnisse:The following results are obtained:
Äiderung des Reibungskoeffizienten der Haut, gemessen 15 Minuten nach dem AuftragenCorrection of the coefficient of friction of the skin, measured for 15 minutes after application
mit einer Kraft von 20 gwith a force of 20 g
mit einer Kraft von 50 gwith a force of 50 g
Mittel (B)Medium (B)
+ 209+ 209
+ 245+ 245
Mittel (A) erfindungsgemäß, enthaltend 25 % Sonnenblumenöl Agent (A) according to the invention containing 25% sunflower oil
- 40- 40
- 60- 60
Man stellt fest, daß das Mittel (B), d.h. die wäßrige Dispersion der Lipidkügelchen, die kein öl enthält, den Reibungskoeffizienten der Haut wesentlich erhöht, während das erfindungsgemäße Mittel (A), d.h.· eine Dispersion von Kügelchen, welche ein öl enthält, die gegenteilige Wirkung hat. Dieses bedeutende Absenken des Reibungskoeffizienten der Haut bedeutet in der Kosmetik, daß mit dem erfindungsgemäßen Mittel (A) die Haut viel It is found that the agent (B), i.e. the aqueous dispersion of lipid spheres which does not contain oil, significantly increases the coefficient of friction of the skin, while the agent (A) according to the invention, i.e. a Dispersion of beads, which contains an oil, has the opposite effect. This significant lowering of the In cosmetics, the coefficient of friction of the skin means that the skin with the agent (A) according to the invention does a lot
M/22 160 ·M / 22 160
2) Messung des Elastizitätsmoduls des menschlichen Stratum corneum, durchgeführt in vitro vor und nach Auftragen der oben beschriebenen kosmetischen MIttel A und B 2) Measurement of the modulus of elasticity of the human stratum corneum, carried out in vitro before and after application of the cosmetic agents A and B described above
Diese Messungen werden mit einem Laboratoriumsgerät durchgeführt, das zur Messung des Elastizität der Haut bestimmt ist. Ein derartige Gerät wird in der FR-PS 78.25149 beschrieben.These measurements are made with a laboratory device designed to measure the elasticity of the skin is. Such a device is described in FR-PS 78.25149.
Die Versuchsbedingungen sind wie folgt:The experimental conditions are as follows:
relative Feuchtigkeit: 72 % _+ 2relative humidity: 72% _ + 2
Temperatur: 30 0C + 0,2Temperature: 30 0 C + 0.2
Menge des aufgetragenen Produkts: 5 mg/cm* Man erhält folgende Ergebnisse:Amount of product applied: 5 mg / cm * The following results are obtained:
getestete Produkte % mittlere Reduktion des ElastizitätsmodulsProducts tested% mean reduction in the modulus of elasticity
1 h 30 Min. nach dem Auftragen1 hour 30 minutes after application
Produkt (B) 0Product (B) 0
Produkt (A)Product (A)
erfindungsgemäß + 15according to the invention + 15
Die obigen Ergebnisse zeigen deutlich den Unterschied in der Plastizität der Cornea, je nachdem ob man eine Dispersion von Kügelchen ohne ölphase oder mit ölphase aufträgt.The above results clearly show the difference in the plasticity of the cornea, depending on whether one has a dispersion of beads without an oil phase or with an oil phase.
M/22 160M / 22 160
Beispiel Pflegendes Fluid für den KörperExample nourishing fluid for the body
1. Stufe1st stage
Wie oben beschrieben stellt man eine wäßrige Dispersion von Lipidkügelchen ausgehend von folgenden Verbindungen her;As described above, an aqueous dispersion of lipid beads is prepared from the following compounds;
nicht-ionisches, amphiphiles Lipid der allgemeinen Formel:non-ionic, amphiphilic lipid of the general formula:
R {. OCH2 - CHR {. OCH 2 - CH
OHOH
CH2OHCH 2 OH
worinwherein
R für einen Hexadecylrest steht und η einen mittleren statistischen Wert von 3 darstelltR stands for a hexadecyl radical and η a mean statistical value of 3 represents
ß-Sitosterin Dicetylphosphat Methyl-p-hydroxybenzoat Pyrrolidoncarbonsäure-natriumsalz entmineralisiertes Wasserß-sitosterol dicetyl phosphate methyl p-hydroxybenzoate Pyrrolidoncarboxylic acid sodium salt demineralized water
2. Stufe2nd stage
Man gibt der nach der 1. Stufe erhaltenden Dispersion von Kügelchen folgende Verbindungen zu:The dispersion obtained after the 1st stage is added of spheres the following connections to:
Parfüm SonnenblumenölPerfume sunflower oil
Mischung von Vinylcarbonsäuren, unter der Handelsbezeichnung "CARBOPOL 940" vertriebenMixture of vinyl carboxylic acids sold under the trade name "CARBOPOL 940"
Triäthanolamin entmineralisiertes WasserTriethanolamine demineralized water
_. v:i;i jrw": Ί '. _ 312571 ο_. v: i; i jrw ": Ί '. _ 312571 ο
Μ/22 160 -Μ / 22 160 -
Beispiel 3Example 3
Pflegendes Fluid für das GesichtNourishing fluid for the face
1. Stufe1st stage
Wie oben beschrieben stellt man eine wäßrige Dispersion von Lipidkügfelchen aus folgenden Substanzen her:An aqueous dispersion is prepared as described above of lipid globules from the following substances:
nicht-ionisches amphiphiles Lipid der allgemeinen Formel:non-ionic amphiphilic lipid of the general formula:
R --(-0CH0-CH-) OHR - (- 0CH 0 -CH-) OH
2 , η2, η
CH2OHCH 2 OH
worin R für einen Hexadecylrest steht und η gleich 2 ist
Cholesterin
Dicety!phosphat
Methyl-p-hydroxybenzoat entmineralisiertes Wasserwhere R stands for a hexadecyl radical and η is 2
cholesterol
Dicety! Phosphate
Methyl p-hydroxybenzoate demineralized water
2. Stufe2nd stage
Man setzt der aus der 1. Stufe erhaltenen Dispersion von Kügelchen noch folgende Verbindungen zu:The following compounds are added to the dispersion of beads obtained from the 1st stage:
Parfüm TraubenkernölPerfume grapeseed oil
■Mischung von viny!carbonsäuren. unte^ der Handelsbezeichnung "CARBOPOL 940" vertrieben■ Mixture of vinyl carboxylic acids. under the trade name "CARBOPOL 940"
Tr i ä thano1amiη ■entmineralisiertes WasserTria thano1amiη ■ demineralized water
M/22 160M / 22 160
- ΨΓ- - ΨΓ-
Beispiel 4Example 4
Pflegendes Fluid für die HändeCaring fluid for the hands
1. Stufe1st stage
Wie oben beschrieben stellt man eine wäßrige Dispersion von Lipidkügelchen aus folgenden Verbindungen her:As described above, an aqueous dispersion of lipid beads is prepared from the following compounds:
polyoxyäthylenierte Phytosterine (statistische
Verteilung des Mittelwerts gleich 5) 6,0 gpolyoxyethylene phytosterols (statistical
Distribution of the mean equal to 5) 6.0 g
Cholesterin 2,0 gCholesterol 2.0 g
Methyl-p-hydroxybenzoat 0,3 gMethyl p-hydroxybenzoate 0.3 g
entmineralisiertes Wasser 45,7 gdemineralized water 45.7 g
2. Stufe2nd stage
Man setzt der aus der ersten Stufe erhaltenden Dispersion von Kügelchen nocht folgende Substanzen zu:The following substances are added to the dispersion of beads obtained from the first stage:
Parfüm Jojoba-ÖlPerfume jojoba oil
Mischung von Viny!carbonsäuren, unter der
Handelsbezeichnung 11CARBOPOL 940" vertriebenMixture of vinyl carboxylic acids, among which
Trade name 11 CARBOPOL 940 "
Triäthanolamin ■entmineralisiertes WasserTriethanolamine ■ demineralized water
20,0 g20.0 g
Beispiel 5
Fluid zur KörperpflegeExample 5
Body care fluid
1. Stufe1st stage
Wie oben beschrieben stellt man eine wäßrige Dispersion von Lipidkügelchen aus folgenden Verbindungen her:As described above, an aqueous dispersion of lipid beads is prepared from the following compounds:
nicht-ionisches, amphiphiles Lipid der allgemeinen Formel:non-ionic, amphiphilic lipid of the general formula:
OCH„-CHOCH "-CH
£· ι £ · ι
OHOH
CH0OHCH 0 OH
M/22 160M / 22 160
- ψ- - ψ-
worin R für einen Hexadecylrest steht undwherein R stands for a hexadecyl radical and
η einen mittleren statistischen Wert von 3 hat 4,0 gη has a mean statistical value of 3 4.0 g
Cholesterin 4,0 gCholesterol 4.0 g
Methyl-p-hydroxybenzoat 0,3 gMethyl p-hydroxybenzoate 0.3 g
entmineralisiertes Wasser 4 5,5 gdemineralized water 4 5.5 g
2. Stufe2nd stage
Man setzt der in der ersten Stufe erhaltenen Dispersion von Kügelchen noch folgende Verbindungen zu:The following compounds are added to the dispersion of beads obtained in the first stage:
Parfüm MaisölPerfume corn oil
Mischung von Viny!carbonsäuren, unter der Handelsbezeichnung "CARBOPOL 940" vertriebenMixture of vinyl carboxylic acids, among which Marketed under the trade name "CARBOPOL 940"
Triäthanolamin L entmineralisiertes WasserTriethanolamine L demineralized water
Fluid zur GesichtspflegeFacial care fluid
1. Stufe1st stage
Wie oben beschrieben stellt man eine wäßrige Dispersion von Lipidkügelchen aus folgenden Verbindungen her:An aqueous dispersion is prepared as described above of lipid spheres from the following compounds:
nicht-ionisches amphiphiles Lipid der allgemeinen Formelnon-ionic amphiphilic lipid of the general formula
OHOH
CH2OHCH 2 OH
worin R für einen Hexadecylrest steht und η einen statistischen Mittelwert von 3 hatwhere R stands for a hexadecyl radical and η has a statistical mean of 3
ß-Sitosterin Dicetylphosphat Methyl-p-hydroxybenzoat entmineralisiertes Wasserß-sitosterol dicetyl phosphate methyl p-hydroxybenzoate demineralized water
0,95 g0.95 g
0,95 g0.95 g
0,10 g0.10 g
0,30 g0.30 g
64,80 g64.80 g
■' *· —fr ■■ '* · —fr ■
M/22 160M / 22 160
2. Stufe2nd stage
Zu der Dispersion der in der ersten Phase erhaltenen Kügelchen gibt man folgende Mittel zu:To the dispersion of the beads obtained in the first phase one admits the following means:
Parfüm
Sojaöl
ρnicht-verseifbare Soja-BestandteilePerfume
Soybean oil
ρnon-saponifiable soy components
Hydroxyathylcellulose, unter der Handelsbezeichnung "Natrosol 250 HHR" vertriebenHydroxyethyl cellulose sold under the trade name "Natrosol 250 HHR"
- entmineralisiertes Wasser- demineralized water
Beispiel SonnenschutzmittelExample sunscreen
1. Stufe1st stage
Wie oben beschrieben, stellt man eine wäßrige Dispersion von Lipidkügelchen aus folgenden Verbindungen her:As described above, an aqueous dispersion of lipid beads is prepared from the following compounds:
nicht-ionisches amphiphiles Lipid der allgemeinen Formelnon-ionic amphiphilic lipid of the general formula
OCH0-CHOCH 0 -CH
-OH-OH
CH2OHCH 2 OH
worin R für einen Hexadecylrest steht und η einen statistischen Mittelwert von 3 hatwhere R stands for a hexadecyl radical and η has a statistical mean of 3
ß-Sitoserin Didodecyl-dimethyl-ammonium-bromid Methyl-p-hydroxybenzoat entmineralisiertes Wasserß-sitoserine didodecyl-dimethyl-ammonium-bromide Methyl p-hydroxybenzoate demineralized water
3,6 g3.6 g
3,6 g3.6 g
0,8 g0.8 g
0,3 g0.3 g
45,9 g45.9 g
M/22 160M / 22 160
2. Stufe2nd stage
2323
Der aus der ersten Stufe erhaltenen Dispersion von Kügelchen setzt man folgende Substanzen zu:The following substances are added to the dispersion of beads obtained from the first stage:
Parfüm KürbisÖl ■2-Äthylhexyl-p-dimethylamino-benzoat Traganth-Gummi -entmineralisiertes WasserPerfume Pumpkin Oil ■ 2-ethylhexyl-p-dimethylamino-benzoate Tragacanth gum demineralized water
0,4 g0.4 g
22,0 g22.0 g
3,0 g3.0 g
0,4 g0.4 g
20,0 g20.0 g
Pflegefluid für die HändeCare fluid for the hands
1. Stufe1st stage
Wie oben angegeben stellt man eine wäßrige Dispersion von Lipidkügelchen aus folgenden Verbindungen her:As indicated above, an aqueous dispersion of lipid beads is prepared from the following compounds:
nicht-ionisches, amphiphiles Lipid der allgemeinen Formelnon-ionic, amphiphilic lipid of the general formula
OCHOCH
OHOH
CH2OHCH 2 OH
worin R für einen Hexadecylrest steht und η einen statistischen Mittelwert von 3 hat ß-Sitosterin Dicetylphosphat Methyl-p-hydroxybenzoat Glycerin entmineralisiertes Wasserwhere R stands for a hexadecyl radical and η has a statistical mean of 3 ß-sitosterol dicetyl phosphate methyl p-hydroxybenzoate Glycerin demineralized water
M/22 160M / 22 160
.2. Stufe.2. step
Zu der aus der ersten Stufe erhaltenen Dispersion von Kugelchen gibt man folgende Verbindungen:The following compounds are added to the dispersion of spheres obtained from the first stage:
Parfüm Purcellinöl Satiagum entmineralisiertes WasserPerfume purcellin oil Satiagum demineralized water
0,2 g0.2 g
25,0 g25.0 g
1,0 g1.0 g
20,0 g20.0 g
Beispiel 9 Körperpflege-FluidExample 9 Personal Care Fluid
1. Stufe 1st stage
Wie oben angegeben stellt man eine wäßrige Dispersion von Lipidkügelchen aus folgenden Verbindungen her:As indicated above, an aqueous dispersion of lipid beads is prepared from the following compounds:
nicht-ionisches amphiphiles Lipid der allgemeinen Formelnon-ionic amphiphilic lipid of the general formula
CH2OHCH 2 OH
worin R für einen Hexadecylrest steht und η einen statistischen Mittelwert 3 hatwhere R stands for a hexadecyl radical and η has a statistical mean value of 3
ß-Sitosterin Dicetylphosphat Methyl-p-hydroxybenzoat entmineralisiertes Wasserß-sitosterol dicetyl phosphate methyl p-hydroxybenzoate demineralized water
2. Stufe2nd stage
3,8
3,8
0,4
0,3
60,53.8
3.8
0.4
0.3
60.5
g g g g gg g g g g
Zu der erhaltenen Dispersion von Kügelchen gibt man folgende Verbindungen zu:The following compounds are added to the resulting dispersion of beads:
Parfüm 0,4Perfume 0.4
Glycerin-tricapro-caprylat 10,0Glycerine tricapro caprylate 10.0
rMischung von Carboxyvinylsäuren, unter derrMixture of carboxyvinyl acids, under the
g gg g
Handelsbezeichnung "CARBOPOL 940" vertriebenMarketed under the trade name "CARBOPOL 940"
Triethanolamin L entmineralisiertes WasserTriethanolamine L demineralized water
0,4 g0.4 g
0,4 g
20,0 g0.4 g
20.0 g
3T257103T25710
M/22 160M / 22 160
Beispiel 10Example 10
Creme für die Gesichtspflege 1. StufeCream for facial care 1st stage
Wie oben angegeben stellt man eine wäßrige Dispersion von Lipidkügelchen aus folgenden Verbindungen her:As indicated above, an aqueous dispersion of lipid beads is prepared from the following compounds:
nicht-ionisches, amphiphiles Lipid der allgemeinen Formelnon-ionic, amphiphilic lipid of the general formula
- CH- CH
CH^OHCH ^ OH
OHOH
worin R für einen Hexadecylrest steht und η einen statistischen Mittelwert 3 hatwhere R stands for a hexadecyl radical and η has a statistical mean value of 3
ß-Sitosterin Dicety!phosphat Konservierungsmittel entmineralisiertes Wasserß-sitosterol Dicety! phosphate preservative demineralized water
3,
3,3,
3,
0,40.4
0,30.3
47,647.6
g g g g gg g g g g
Stufestep
Man gibt der aus der ersten Stufe erhaltenen Dispersion der Rügelchen folgende Verbindungen zu:The dispersion obtained from the first stage is added Rügelchen the following connections to:
Sonnenblumenöl ParfümSunflower oil perfume
Mischung von Vinylcarbonsauren, unter der Handelsbezeichnung "CARBOPOL 940" vertriebenMixture of vinyl carboxylic acids, among which Marketed under the trade name "CARBOPOL 940"
Triäthanolamin entmineralisiertes WasserTriethanolamine demineralized water
HchHh
Claims (12)
R1 eine verzweigte Kohlenwasserstoffkette mit 3 bisand
R 1 is a branched hydrocarbon chain with 3 to
darstellt.Carbon atoms
represents.
R eine gerade oder verzweigte, gesättigte aliphatisch© Kette mit 16 bis 20 Kohlenstoffatomen, oder den Kohlenwasserstoffrest eines Lanolinalkohls bedeutet; oderand
R is a straight or branched, saturated aliphatic © chain with 16 to 20 carbon atoms, or the hydrocarbon radical of a lanolin cabbage; or
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8014657A FR2485921A1 (en) | 1980-07-01 | 1980-07-01 | COSMETIC COMPOSITION BASED ON AN AQUEOUS DISPERSION OF LIPID SPHERULES |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3125710A1 true DE3125710A1 (en) | 1982-03-25 |
DE3125710C2 DE3125710C2 (en) | 1988-09-22 |
Family
ID=9243726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19813125710 Granted DE3125710A1 (en) | 1980-07-01 | 1981-06-30 | "COSMETIC AGENTS" |
Country Status (8)
Country | Link |
---|---|
JP (2) | JPS5794326A (en) |
BE (2) | BE889452A (en) |
CA (1) | CA1168158A (en) |
CH (1) | CH649915A5 (en) |
DE (1) | DE3125710A1 (en) |
FR (1) | FR2485921A1 (en) |
GB (1) | GB2079179B (en) |
IT (1) | IT1144739B (en) |
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EP0227012A1 (en) * | 1985-12-23 | 1987-07-01 | Kao Corporation | Gel-like emulsion and O/W emulsions obtained from the gel-like emulsion |
WO1990004967A2 (en) | 1988-10-31 | 1990-05-17 | Weck, Wolfgang | Topical ointment |
DE4018995A1 (en) * | 1989-06-15 | 1990-12-20 | Oreal | METHOD FOR IMPROVING THE THERAPEUTIC EFFICACY OF FATTYLIC CORTICOSTEROIDS AND AGENTS THEREOF FOR USING THIS METHOD |
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FR2509988B1 (en) * | 1981-07-23 | 1986-05-30 | Oreal | MIXTURE OF VEGETABLE OILS BASED ON JOJOBA OIL AS AN OXIDATION STABILIZING AGENT AND COSMETIC COMPOSITIONS CONTAINING THE SAME |
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US5256422A (en) * | 1991-03-28 | 1993-10-26 | Micro Vesicular Systems, Inc. | Lipid vesicle containing water-in-oil emulsions |
US5213805A (en) * | 1991-07-25 | 1993-05-25 | Micro Vesicular Systems, Inc. | Lipid vesicles having n,n-dimethylamide derivatives as their primary lipid |
US5260065A (en) * | 1991-09-17 | 1993-11-09 | Micro Vesicular Systems, Inc. | Blended lipid vesicles |
US5405615A (en) * | 1991-09-17 | 1995-04-11 | Micro Vesicular Systems, Inc. | Sucrose distearate lipid vesicles |
FR2701396B1 (en) * | 1993-02-12 | 1995-04-21 | Oreal | Method for stabilizing vesicles of amphiphilic lipid (s) and composition for topical application containing said stabilized vesicles. |
FR2722102B1 (en) | 1994-07-11 | 1996-08-23 | Cird Galderma | USE OF DEFORMABLE HOLLOW PARTICLES IN A COSMETIC AND / OR DERMATOLOGICAL COMPOSITION CONTAINING FAT MATERIALS |
FR2723848B1 (en) | 1994-08-31 | 1997-06-20 | Oreal | COSMETIC OR DERMATOLOGICAL COMPOSITION CONTAINING ENCAPSULATED PLANT EXTRACTS |
FR2730928B1 (en) * | 1995-02-23 | 1997-04-04 | Oreal | COMPOSITION BASED ON LIPIDIC VESICLES WITH ACIDIC PH AND USE THEREOF IN TOPICAL APPLICATION |
FR2742674B1 (en) | 1995-12-21 | 1998-02-06 | Oreal | STABLE DISPERSION OF A PHASE NOT MISCIBLE IN WATER, IN AN AQUEOUS PHASE BY MEANS OF VESICLES BASED ON SILICONE SURFACTANT |
DE19703368C1 (en) * | 1997-01-30 | 1998-10-01 | Klaus Dr Goebel | Rapid production of homogeneous stable cream from storage-stable powder without mechanical work |
US6110492A (en) * | 1997-05-28 | 2000-08-29 | Jenner Biotherapies, Inc. | Immunogenic compositions |
FR2790975B1 (en) * | 1999-03-16 | 2001-06-01 | Capsulis | MEDIA IN THE FORM OF COMPLEX DISPERSIONS, THEIR PREPARATION PROCESS AND THEIR USES |
ES2269166T3 (en) * | 1999-07-13 | 2007-04-01 | Clr Chemisches Laboratorium Dr. Kurt Richter Gmbh | AGENTS WITH ABSORBENT AND / OR REFLECTIVE UV RADIATION EFFECT FOR THE PROTECTION AGAINST HARMFUL UV RADIATION FOR HEALTH AND STRENGTHENING OF THE NATURAL CUTANEOUS BARRIER. |
EP1754532B1 (en) | 2004-04-05 | 2018-06-20 | Kanagawa University | Emulsifying dispersants, method for emusification and dispersion with the same, emulsions, and emulsion fuels |
US9139850B2 (en) | 2005-05-19 | 2015-09-22 | L'oreal | Vectorization of dsRNA by cationic particles and topical use |
FR2885808B1 (en) * | 2005-05-19 | 2007-07-06 | Oreal | VECTORIZATION OF DSRNA BY CATIONIC PARTICLES AND TOPICAL USE. |
JP6274477B2 (en) * | 2010-12-21 | 2018-02-07 | 学校法人神奈川大学 | Manufacturing method of emulsifier manufacturing material, emulsifying material, and manufacturing method of emulsifier |
US9549891B2 (en) | 2012-03-19 | 2017-01-24 | The Procter & Gamble Company | Superabsorbent polymers and sunscreen actives for use in skin care compositions |
CN107787222B (en) | 2015-06-29 | 2020-12-04 | 宝洁公司 | Superabsorbent polymers and starch powders for use in skin care compositions |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0043327A1 (en) * | 1980-07-01 | 1982-01-06 | L'oreal | Process for obtaining stable dispersions in an aqueous phase of at least a water immiscible liquid phase, and corresponding dispersions |
-
1980
- 1980-07-01 FR FR8014657A patent/FR2485921A1/en active Granted
-
1981
- 1981-06-30 IT IT67906/81A patent/IT1144739B/en active
- 1981-06-30 CA CA000380902A patent/CA1168158A/en not_active Expired
- 1981-06-30 BE BE0/205269A patent/BE889452A/en not_active IP Right Cessation
- 1981-06-30 DE DE19813125710 patent/DE3125710A1/en active Granted
- 1981-06-30 GB GB8120182A patent/GB2079179B/en not_active Expired
- 1981-06-30 BE BE0/205268A patent/BE889451A/en not_active IP Right Cessation
- 1981-07-01 JP JP56101398A patent/JPS5794326A/en active Granted
- 1981-07-01 CH CH4357/81A patent/CH649915A5/en not_active IP Right Cessation
- 1981-07-01 JP JP56101397A patent/JPS5777613A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0043327A1 (en) * | 1980-07-01 | 1982-01-06 | L'oreal | Process for obtaining stable dispersions in an aqueous phase of at least a water immiscible liquid phase, and corresponding dispersions |
GB2078543A (en) * | 1980-07-01 | 1982-01-13 | Oreal | Process for the preparation of stable dispersions of at least one water-immiscible liquid phase in an aqueous phase |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0227012A1 (en) * | 1985-12-23 | 1987-07-01 | Kao Corporation | Gel-like emulsion and O/W emulsions obtained from the gel-like emulsion |
WO1990004967A2 (en) | 1988-10-31 | 1990-05-17 | Weck, Wolfgang | Topical ointment |
DE3836971C1 (en) * | 1988-10-31 | 1990-05-17 | Weck, Wolfgang, Dr.Med., 6990 Bad Mergentheim, De | |
DE4018995A1 (en) * | 1989-06-15 | 1990-12-20 | Oreal | METHOD FOR IMPROVING THE THERAPEUTIC EFFICACY OF FATTYLIC CORTICOSTEROIDS AND AGENTS THEREOF FOR USING THIS METHOD |
Also Published As
Publication number | Publication date |
---|---|
CH649915A5 (en) | 1985-06-28 |
GB2079179A (en) | 1982-01-20 |
FR2485921B1 (en) | 1983-07-22 |
DE3125710C2 (en) | 1988-09-22 |
GB2079179B (en) | 1984-03-07 |
IT1144739B (en) | 1986-10-29 |
JPS5794326A (en) | 1982-06-11 |
BE889451A (en) | 1981-12-30 |
JPS5777613A (en) | 1982-05-15 |
BE889452A (en) | 1981-12-30 |
JPS6333414B2 (en) | 1988-07-05 |
CA1168158A (en) | 1984-05-29 |
FR2485921A1 (en) | 1982-01-08 |
JPH0210803B2 (en) | 1990-03-09 |
IT8167906A0 (en) | 1981-06-30 |
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