GB2072658B - 13-(1-oxyl-2,2,6,6-tertamethylpiperylidenyl-4) hydrazone rubomycin hydrochloride and a method of producing the same - Google Patents
13-(1-oxyl-2,2,6,6-tertamethylpiperylidenyl-4) hydrazone rubomycin hydrochloride and a method of producing the sameInfo
- Publication number
- GB2072658B GB2072658B GB8032334A GB8032334A GB2072658B GB 2072658 B GB2072658 B GB 2072658B GB 8032334 A GB8032334 A GB 8032334A GB 8032334 A GB8032334 A GB 8032334A GB 2072658 B GB2072658 B GB 2072658B
- Authority
- GB
- United Kingdom
- Prior art keywords
- tertamethylpiperylidenyl
- oxyl
- hydrazone
- producing
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GUGHGUXZJWAIAS-QQYBVWGSSA-N Daunorubicin hydrochloride Chemical compound Cl.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 GUGHGUXZJWAIAS-QQYBVWGSSA-N 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
- 229930191933 Rubomycin Natural products 0.000 title 1
- 150000007857 hydrazones Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU802893526A RU977462C (ru) | 1980-03-24 | 1980-03-24 | 13-(1-оксил-2,2,6,6-тетраметилпиперилиденил-4)гидразон рубомицина хлоргидрат с парамагнитным центром, проявляющий противоопухолевую активность, и способ его получения |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2072658A GB2072658A (en) | 1981-10-07 |
| GB2072658B true GB2072658B (en) | 1983-11-02 |
Family
ID=20882488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8032334A Expired GB2072658B (en) | 1980-03-24 | 1980-10-07 | 13-(1-oxyl-2,2,6,6-tertamethylpiperylidenyl-4) hydrazone rubomycin hydrochloride and a method of producing the same |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4332934A (enExample) |
| JP (1) | JPS56133298A (enExample) |
| DE (1) | DE3037884C2 (enExample) |
| FR (1) | FR2478633A1 (enExample) |
| GB (1) | GB2072658B (enExample) |
| IT (1) | IT1134110B (enExample) |
| NL (1) | NL182882C (enExample) |
| RU (1) | RU977462C (enExample) |
| SE (1) | SE449105B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050003008A1 (en) * | 1997-09-23 | 2005-01-06 | Natalya Rapoport | Method of in vivo drug targeting to solid tumors via acoustically triggered drug delivery in polymeric micelles |
| US7910607B2 (en) * | 2006-03-10 | 2011-03-22 | The Trustees Of California State University | Nitroxide free radical synergized antineoplastic agents |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2235103A1 (en) * | 1973-06-29 | 1975-01-24 | Commissariat Energie Atomique | Marked nitroxide derivatives of saccharides - by reaction of acid nitroxide with halogenated saccharides |
| GB1469430A (en) | 1974-12-24 | 1977-04-06 | Farmaceutici Italia | Daunomycin derivatives |
| US4112217A (en) * | 1977-09-02 | 1978-09-05 | Sri International | Bis-hydrazones of daunomycin and adriamycin |
-
1980
- 1980-03-24 RU SU802893526A patent/RU977462C/ru active
- 1980-10-02 SE SE8006901A patent/SE449105B/sv not_active IP Right Cessation
- 1980-10-02 US US06/192,964 patent/US4332934A/en not_active Expired - Lifetime
- 1980-10-07 DE DE3037884A patent/DE3037884C2/de not_active Expired
- 1980-10-07 GB GB8032334A patent/GB2072658B/en not_active Expired
- 1980-10-07 NL NLAANVRAGE8005543,A patent/NL182882C/xx not_active IP Right Cessation
- 1980-10-22 FR FR8022569A patent/FR2478633A1/fr active Granted
- 1980-10-30 IT IT25669/80A patent/IT1134110B/it active
-
1981
- 1981-01-08 JP JP158681A patent/JPS56133298A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| SE449105B (sv) | 1987-04-06 |
| RU977462C (ru) | 1995-06-27 |
| DE3037884C2 (de) | 1983-12-29 |
| NL182882B (nl) | 1988-01-04 |
| DE3037884A1 (de) | 1981-10-01 |
| JPS6334879B2 (enExample) | 1988-07-12 |
| IT8025669A0 (it) | 1980-10-30 |
| FR2478633A1 (fr) | 1981-09-25 |
| NL8005543A (nl) | 1981-10-16 |
| FR2478633B1 (enExample) | 1983-07-22 |
| GB2072658A (en) | 1981-10-07 |
| US4332934A (en) | 1982-06-01 |
| IT1134110B (it) | 1986-07-24 |
| NL182882C (nl) | 1988-06-01 |
| SE8006901L (sv) | 1981-09-25 |
| JPS56133298A (en) | 1981-10-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR900700420A (ko) | 2,3-디플루오로벤젠의 제조방법 | |
| GB2076041B (en) | Well drilling method | |
| NZ196039A (en) | 25-hydroxy-26,26,26,27,27,27-hexaflurocholecaciferol and related compounds | |
| YU180181A (en) | Process for producing 4,5-diaryl-alpha-polyfluoroalkyl-1h-imidazole-2-methane amide | |
| EP0125439A3 (en) | 3,6-disubstituted-1,8-naphthalimides and methods for their production and use | |
| PL232330A1 (en) | Method of obtaining new derivatives of oxazolidinodione-2,4 | |
| GB2089920B (en) | Locking mandrel | |
| DE3165316D1 (en) | 2-substituted-5-trifluoromethylpyridines and a process for producing the same | |
| ZA818847B (en) | New heterocyclic aminoalcoyl derivatives,the process for preparing same and the therapeutical use thereof | |
| DE3160780D1 (en) | 2,3-dichloro-2-trifluoromethyl-1,1,1,3,4,4,5,5,5-nonafluoropentane and process for its preparation | |
| GB2075089B (en) | Drilling method | |
| DE3161335D1 (en) | Cis-6-undecene-1-chloride and a method for the preparation thereof | |
| GB2072658B (en) | 13-(1-oxyl-2,2,6,6-tertamethylpiperylidenyl-4) hydrazone rubomycin hydrochloride and a method of producing the same | |
| PH16259A (en) | 2,9-dioxatricyclo(4,3,1,0 3,7)decane and a method of producing the same | |
| YU107183A (en) | Process for obtaining new 1,1,2-triphenyl-propane and 1,1,2-triphenyl-propene derivatives | |
| ZA828238B (en) | 1-(3,4,5-trimethoxycinnamoyl)-4-aminocarbonylethyl-substituted pirerazine derivatives and a process for preparation thereof | |
| DE3176577D1 (en) | Agglomerates, a process for producing thereof and use thereof | |
| GB2130200B (en) | New acylated 1,2,4-triazole derivatives and a process for the preparation thereof | |
| DE3165708D1 (en) | N-substituted phenyl-1-methylcyclopropanecarboxamides, their production and use | |
| IL63247A0 (en) | Process for the manufacture of 2,6-dichlorobenzoxazole and 2,6 dichlorobenzthiazole | |
| PL241602A1 (en) | Biocide and method of obtaining new derivatives of 1,2,4-triazol-1-ilopropionitriles | |
| ZA81902B (en) | Piperidinoquinazolines and a process for the preparation thereof | |
| EP0115811A3 (en) | 2,4-dichlor-5-thiazolecarboxaldehyd and a process for its preparation | |
| CS222448B1 (en) | Method of making the tetrakis /2-hydroxypropyl/ alkylendiamine | |
| CS509080A2 (en) | Process for making exploration wells and device for making this process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |