GB2070017B - Electrolytic dehydrogenation of steroidal 3,5enol ethers to 4,6-dien-3-ones - Google Patents

Electrolytic dehydrogenation of steroidal 3,5enol ethers to 4,6-dien-3-ones

Info

Publication number
GB2070017B
GB2070017B GB8105254A GB8105254A GB2070017B GB 2070017 B GB2070017 B GB 2070017B GB 8105254 A GB8105254 A GB 8105254A GB 8105254 A GB8105254 A GB 8105254A GB 2070017 B GB2070017 B GB 2070017B
Authority
GB
United Kingdom
Prior art keywords
5enol
dien
dehydrogenation
steroidal
electrolytic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8105254A
Other languages
English (en)
Other versions
GB2070017A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of GB2070017A publication Critical patent/GB2070017A/en
Application granted granted Critical
Publication of GB2070017B publication Critical patent/GB2070017B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/20—Processes
    • C25B3/23—Oxidation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
GB8105254A 1980-02-20 1981-02-19 Electrolytic dehydrogenation of steroidal 3,5enol ethers to 4,6-dien-3-ones Expired GB2070017B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/122,938 US4270994A (en) 1980-02-20 1980-02-20 Electrochemical dehydrogenation of steroidal Δ3,5 enol ethers under basic conditions to provide steroidal Δ4,6 dienones

Publications (2)

Publication Number Publication Date
GB2070017A GB2070017A (en) 1981-09-03
GB2070017B true GB2070017B (en) 1984-11-07

Family

ID=22405765

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8105254A Expired GB2070017B (en) 1980-02-20 1981-02-19 Electrolytic dehydrogenation of steroidal 3,5enol ethers to 4,6-dien-3-ones

Country Status (7)

Country Link
US (1) US4270994A (enExample)
JP (1) JPS56135499A (enExample)
AU (1) AU6745681A (enExample)
CA (1) CA1181717A (enExample)
DE (1) DE3106162A1 (enExample)
FR (1) FR2476094A1 (enExample)
GB (1) GB2070017B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5531908A (en) * 1993-08-20 1996-07-02 Suntory Limited Germ-free liquid dispenser
DE69637140T2 (de) * 1995-12-11 2008-04-10 G.D. Searle Llc, Chicago Verfahren zur herstellung einer epoxy-verbindung
US6887991B1 (en) * 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
BR9714510A (pt) 1996-12-11 2000-11-28 Searle & Co Processo e preparo de esteróides de 9,11-époxi e intermediários úteis dos mesmos
CA2474072A1 (en) * 2002-03-22 2003-10-09 Pharmacia & Upjohn Company Process to prepare eplerenone
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
CL2004000574A1 (es) * 2003-03-21 2005-02-11 Pharmacia Corp Sa Organizada B Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.
EP3922759A1 (en) * 2020-06-11 2021-12-15 Minakem Process of alpha,beta-desaturation of compounds containing a carbonyl moiety
CN114622228B (zh) * 2022-02-22 2024-04-26 浙江工业大学 一种电催化氧化制取甾体激素类羰基中间体的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL279866A (enExample) * 1961-08-08
US3485829A (en) * 1967-04-10 1969-12-23 Syntex Corp Cyclobutano- and cyclobuteno-(3',4':6,7) derivatives of the androstane and 19-nor-androstane series
US3491090A (en) * 1967-04-10 1970-01-20 Syntex Corp Cyclobutano- and cyclobuteno - (3',4':6,7) derivatives of the corticoid series
GB1360904A (en) * 1972-01-19 1974-07-24 Ici Ltd Oxidation of aromatic compounds
DD125838A1 (enExample) * 1974-06-28 1977-05-25
DD134769A1 (de) * 1978-01-20 1979-03-21 Helmut Kasch Verfahren zur herstellung von 3-oxo-oestra-4,9,11-trienen

Also Published As

Publication number Publication date
JPS56135499A (en) 1981-10-22
FR2476094A1 (fr) 1981-08-21
US4270994A (en) 1981-06-02
CA1181717A (en) 1985-01-29
GB2070017A (en) 1981-09-03
AU6745681A (en) 1981-08-27
DE3106162A1 (de) 1981-12-17
FR2476094B1 (enExample) 1983-07-29

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee