GB202105776D0 - Engineering of antigen-binding proteins - Google Patents

Engineering of antigen-binding proteins

Info

Publication number
GB202105776D0
GB202105776D0 GBGB2105776.5A GB202105776A GB202105776D0 GB 202105776 D0 GB202105776 D0 GB 202105776D0 GB 202105776 A GB202105776 A GB 202105776A GB 202105776 D0 GB202105776 D0 GB 202105776D0
Authority
GB
United Kingdom
Prior art keywords
antigen
engineering
binding proteins
proteins
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB2105776.5A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alchemab Therapeutics Ltd
Original Assignee
Alchemab Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alchemab Therapeutics Ltd filed Critical Alchemab Therapeutics Ltd
Priority to GBGB2105776.5A priority Critical patent/GB202105776D0/en
Publication of GB202105776D0 publication Critical patent/GB202105776D0/en
Priority to JP2023564230A priority patent/JP2024514691A/ja
Priority to CN202280036343.6A priority patent/CN117337470A/zh
Priority to US18/287,352 priority patent/US20240203523A1/en
Priority to EP22717415.8A priority patent/EP4327328A1/en
Priority to KR1020237039964A priority patent/KR20240011144A/ko
Priority to AU2022260043A priority patent/AU2022260043A1/en
Priority to IL307832A priority patent/IL307832A/en
Priority to PCT/EP2022/060073 priority patent/WO2022223451A1/en
Priority to CA3215778A priority patent/CA3215778A1/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30—Drug targeting using structural data; Docking or binding prediction
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/044—Recurrent networks, e.g. Hopfield networks
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/045—Combinations of networks
    • G06N3/0455—Auto-encoder networks; Encoder-decoder networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G16B35/10—Design of libraries
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Data Mining & Analysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Evolutionary Computation (AREA)
  • Molecular Biology (AREA)
  • Library & Information Science (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Computing Systems (AREA)
  • General Physics & Mathematics (AREA)
  • Computational Linguistics (AREA)
  • Mathematical Physics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
GBGB2105776.5A 2021-04-22 2021-04-22 Engineering of antigen-binding proteins Ceased GB202105776D0 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GBGB2105776.5A GB202105776D0 (en) 2021-04-22 2021-04-22 Engineering of antigen-binding proteins
CA3215778A CA3215778A1 (en) 2021-04-22 2022-04-14 Engineering of antigen-binding proteins
EP22717415.8A EP4327328A1 (en) 2021-04-22 2022-04-14 Engineering of antigen-binding proteins
CN202280036343.6A CN117337470A (zh) 2021-04-22 2022-04-14 抗原结合蛋白的工程化
US18/287,352 US20240203523A1 (en) 2021-04-22 2022-04-14 Engineering of antigen-binding proteins
JP2023564230A JP2024514691A (ja) 2021-04-22 2022-04-14 抗原結合タンパク質の遺伝子操作
KR1020237039964A KR20240011144A (ko) 2021-04-22 2022-04-14 항원-결합 단백질의 조작
AU2022260043A AU2022260043A1 (en) 2021-04-22 2022-04-14 Engineering of antigen-binding proteins
IL307832A IL307832A (en) 2021-04-22 2022-04-14 Engineering of antigen-binding proteins
PCT/EP2022/060073 WO2022223451A1 (en) 2021-04-22 2022-04-14 Engineering of antigen-binding proteins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB2105776.5A GB202105776D0 (en) 2021-04-22 2021-04-22 Engineering of antigen-binding proteins

Publications (1)

Publication Number Publication Date
GB202105776D0 true GB202105776D0 (en) 2021-06-09

Family

ID=76193388

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB2105776.5A Ceased GB202105776D0 (en) 2021-04-22 2021-04-22 Engineering of antigen-binding proteins

Country Status (10)

Country Link
US (1) US20240203523A1 (https=)
EP (1) EP4327328A1 (https=)
JP (1) JP2024514691A (https=)
KR (1) KR20240011144A (https=)
CN (1) CN117337470A (https=)
AU (1) AU2022260043A1 (https=)
CA (1) CA3215778A1 (https=)
GB (1) GB202105776D0 (https=)
IL (1) IL307832A (https=)
WO (1) WO2022223451A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113392929A (zh) * 2021-07-01 2021-09-14 中国科学院深圳先进技术研究院 一种基于词嵌入与自编码器融合的生物序列特征提取方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL321771A (en) 2023-01-09 2025-08-01 Lilly Co Eli Anti-unc5c antibodies
EP4688852A2 (en) 2023-04-03 2026-02-11 Alchemab Therapeutics Ltd. Anti-cd33 antibodies
WO2025022002A1 (en) 2023-07-26 2025-01-30 Alchemab Therapeutics Ltd Analysis of antigen-binding proteins
US20250079011A1 (en) * 2023-09-01 2025-03-06 Siemens Healthcare Diagnostics Inc. Clinical decision support using transformer-based networks by imputing biomarkers
WO2025125898A1 (en) 2023-12-15 2025-06-19 Alchemab Therapeutics Ltd Anti-unc5c antibodies and uses thereof
US12367329B1 (en) * 2024-06-06 2025-07-22 EvolutionaryScale, PBC Protein binder search

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7648099B2 (ja) * 2019-05-19 2025-03-18 ジャスト－エヴォテック バイオロジクス，インコーポレイテッド 機械学習法によるタンパク質配列の生成

Non-Patent Citations (48)

* Cited by examiner, † Cited by third party
Title
BAHDANAU ET AL.: "Neural machine translation by jointly learning to align and translate", ARXIV: 1409.0473, 2015
BASHFORD-ROGERS ET AL.: "Analysis of the B cell receptor repertoire in six immune-mediated diseases.", NATURE, vol. 574, 2019, pages 122 - 126, XP037070580, DOI: 10.1038/s41586-019-1595-3
CARTER JASON A.PREALL JONATHAN B.GRIGAITYTE KRISTINAGOLDFLESS STEPHEN J.JEFFERY ERICBRIGGS ADRIAN W.VIGNEAULT FRANCOISATWAL GURIND: "Single T Cell Sequencing Demonstrates the Functional Role of αβ TCR Pairing in Cell Lineage and Antigen Specificity", FRONTIERS IN IMMUNOLOGY, vol. 10, 2019, pages 1516
CHILD ET AL.: "Generating Long Sequences with Sparse Transformers", ARXIV: 1904.10509, 2019
CHO ET AL.: "Empirical Evaluation of Gated Recurrent Neural Networks on Sequence Modeling", ARXIV:1412.3555, 2014
DEKOSKY ET AL.: "High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire", NATURE BIOTECHNOLOGY, vol. 31, 2013, pages 166 - 169, XP055545134, DOI: 10.1038/nbt.2492
DEKOSKY ET AL.: "In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire", NATURE MEDICINE, vol. 21, 2015, pages 86 - 91, XP055217399, DOI: 10.1038/nm.3743
DEKOSKY ET AL.: "Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires", PNAS, vol. 113, no. 19, 10 May 2016 (2016-05-10), pages E2636 - E2645, XP055611478, DOI: 10.1073/pnas.1525510113
DEVLIN ET AL.: "BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding", ARXIV: 1810.04805, 2019
DUNBARDEANE: "ANARCI: antigen receptor numbering and receptor classification", BIOINFORMATICS, vol. 32, no. 2, 15 January 2016 (2016-01-15), pages 298 - 300
ECCLES ET AL.: "T-bet+ Memory B Cells Link to Local Cross-Reactive IgG upon Human Rhinovirus Infection", CELL REPORTS, vol. 30, 14 January 2020 (2020-01-14), pages 351 - 366
EVE RICHARDSONJACOB D. GALSONPAUL KELLAMDOMINIC F. KELLYSARAH E. SMITHANNE PALSERSIMON WATSONCHARLOTTE M. DEANE: "A computational method for immune repertoire mining that identifies novel binders from different clonotypes, demonstrated by identifying anti-pertussis toxoid antibodies", MABS, vol. 13, 2021, pages 1
FURCY, DAVIDKOENIG, SVEN: "Limited Discrepancy Beam Search", IJCAI'05: PROCEEDINGS OF THE 19TH INTERNATIONAL JOINT CONFERENCE ON ARTIFICIAL INTELLIGENCE, July 2005 (2005-07-01), pages 125 - 131
GALSON ET AL.: "Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures", FRONT. IMMUNOL., 15 December 2020 (2020-12-15)
GLANVILLE ET AL.: "Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire.", PNAS, vol. 106, no. 48, 1 December 2009 (2009-12-01), pages 20216 - 20221, XP055062648, DOI: 10.1073/pnas.0909775106
HOWIE BSHERWOOD AMBERKEBILE ADBERKA JEMERSON ROWILLIAMSON DW ET AL.: "High-throughput pairing of T cell receptor a and β sequences", SCI TRANSL MED, vol. 7, 2015, pages 301 - 131, XP055318674, DOI: 10.1126/scitranslmed.aac5624
JAYARAM ET AL.: "Germline VH/VL pairing in antibodies", PROTEIN ENGINEERING, DESIGN AND SELECTION, vol. 25, 10 October 2012 (2012-10-10), pages 523 - 530, XP055216142, DOI: 10.1093/protein/gzs043
KING ET AL.: "Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics.", SCIENCE IMMUNOLOGY, vol. 6, 12 February 2021 (2021-02-12), pages eabe6291
KOVALTSUK ET AL.: "Observed Antibody Space: A Resource for Data Mining Next-Generation Sequencing of Antibody Repertoires", J IMMUNOL, vol. 201, no. 8, 15 October 2018 (2018-10-15), pages 2502 - 2509
KRAWCZYK ET AL.: "Looking for therapeutic antibodies in next-generation sequencing repositories", MABS, vol. 11, 2019, pages 1197 - 1205
LEEM ET AL.: "ABodyBuilder: Automated antibody structure prediction with data-driven accuracy estimation", MABS, vol. 8, no. 7, October 2016 (2016-10-01), pages 1259 - 1268, XP055416058, DOI: 10.1080/19420862.2016.1205773
LING ET AL.: "Effect of VH-VL Families in Pertuzumab and Trastuzumab Recombinant Production, Her2 and FcyllA Binding", FRONT. IMMUNOL., 12 March 2018 (2018-03-12)
LIU ET AL.: "RoBERTa: A Robustly Optimized BERT Pretraining Approach", ARXIV: 1907.11692, 2019
MASON, D.M.FRIEDENSOHN, S.WEBER, C.R. ET AL.: "Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning", NAT BIOMED ENG, 2021
MORAWALCZAK: "How many different clonotypes do immune repertoires contain?", CURRENT OPINION IN SYSTEMS BIOLOGY, vol. 18, December 2019 (2019-12-01), pages 104 - 110
NIELSEN ET AL.: "Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2", BIORXIV, 9 July 2020 (2020-07-09)
RADFORD ET AL., LANGUAGE MODELS ARE UNSUPERVISED MULTITASK LEARNERS., 2019, Retrieved from the Internet <URL:https://openai.com/blog/better-language-models>
RAKOCEVIC ET AL.: "The landscape of high-affinity human antibodies against intratumoral antigens", BIORXIV, 8 February 2021 (2021-02-08)
RAYBOULD ET AL.: "Public Baseline and shared response structures support the theory of antibody repertoire functional commonality", PLOS COMPUT BIOL, vol. 17, no. 3, 2021, pages e1008781
REDDY ET AL.: "Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells", NATURE BIOTECHNOLOGY, vol. 28, 2010, pages 965 - 969, XP055617221, DOI: 10.1038/nbt.1673
REES: "Understanding the human antibody repertoire", MABS., vol. 12, no. 1, 2020, pages 1729683
ROTHE ET AL.: "Leveraging Pre-trained Checkpoints for Sequence Generation Tasks", ARXIV: 1907.12461, 2020
SEELIGER DSCHULZ PLITZENBURGER TSPITZ JHOERER SBLECH MENENKEL BSTUDTS JMGARIDEL PKAROW AR: "Boosting antibody developability through rational sequence optimization", MABS, vol. 7, no. 3, 2015, pages 505 - 15
SETLIFF ET AL.: "High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity", CELL VOLUME, vol. 179, 12 December 2019 (2019-12-12), pages 1636 - 1646
SIMONICH ET AL.: "Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage", NATURE COMMUNICATIONS, vol. 10, 2019
SUTSKEVER ET AL.: "Sequence to Sequence Learning with Neural Networks", ARXIV: 1409.3215, 2014
TEPLYAKOV ET AL.: "Structural diversity in a human antibody germline library", MABS, vol. 8, no. 6, August 2016 (2016-08-01), pages 1045 - 63, XP055697646, DOI: 10.1080/19420862.2016.1190060
TILLER ET AL.: "A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties", MABS, vol. 5, no. 3, 1 May 2013 (2013-05-01), pages 445 - 470, XP055377037, DOI: 10.4161/mabs.24218
VANDER HEIDEN ET AL.: "Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing", J IMMUNOL., vol. 198, no. 4, 15 February 2017 (2017-02-15), pages 1460 - 1473, XP055636836, DOI: 10.4049/jimmunol.1601415
VASWANI ET AL.: "Attention Is All You Need", ARXIV: 1706.03762, 2017
WARSZAWSKI SBORENSTEIN KATZ ALIPSH RKHMELNITSKY LBEN NISSAN GJAVITT G ET AL.: "Optimizing antibody affinity and stability by the automated design of the variable lightheavy chain interfaces", PLOS COMPUT BIOL, vol. 15, no. 8, 2019, pages e1007207, XP055680871, DOI: 10.1371/journal.pcbi.1007207
WOLF ET AL.: "HuggingFace's Transformers: State-of-the-art Natural Language Processing", ARXIV: 1910.03771, 2019
XIONG ET AL.: "On Layer Normalization in the Transformer Architecture", ARXIV:2002.04745, 2020
YE ET AL.: "IgBLAST: an immunoglobulin variable domain sequence analysis tool.", NUCLEIC ACIDS RES., vol. 41, July 2013 (2013-07-01), pages W34 - 40
YI-CHUN HSIAOYONGLEI SHANGDANIELLE M. DICARAANGIE YEEJOYCE LAISI HYUN KIMDIEGO ELLERMANRACQUEL CORPUZYONGMEI CHENSHARMILA RAJAN: "Immune repertoire mining for rapid affinity optimization of mouse monoclonal antibodies", MABS, vol. 11, no. 4, 2019, pages 735 - 746, XP055797539, DOI: 10.1080/19420862.2019.1584517
ZHENG GXYTERRY JMBELGRADER PRYVKIN PBENT ZWWILSON R ET AL.: "Massively parallel digital transcriptional profiling of single cells", NAT COMMUN, vol. 8, 2017, pages 14049, XP055503732, DOI: 10.1038/ncomms14049
ZHOU, RONG. HANSEN, ERIC: "Beam-Stack Search: Integrating Backtracking with Beam Search", CONFERENCE: PROCEEDINGS OF THE FIFTEENTH INTERNATIONAL CONFERENCE ON AUTOMATED PLANNING AND SCHEDULING (ICAPS 2005, 5 June 2005 (2005-06-05)
ZHU ET AL.: "Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains", PNAS, vol. 110, no. 16, 16 April 2013 (2013-04-16), pages 6470 - 5, XP055234665, DOI: 10.1073/pnas.1219320110

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113392929A (zh) * 2021-07-01 2021-09-14 中国科学院深圳先进技术研究院 一种基于词嵌入与自编码器融合的生物序列特征提取方法
CN113392929B (zh) * 2021-07-01 2024-05-14 中国科学院深圳先进技术研究院 一种基于词嵌入与自编码器融合的生物序列特征提取方法

Also Published As

Publication number Publication date
JP2024514691A (ja) 2024-04-02
CN117337470A (zh) 2024-01-02
CA3215778A1 (en) 2022-10-27
WO2022223451A1 (en) 2022-10-27
US20240203523A1 (en) 2024-06-20
EP4327328A1 (en) 2024-02-28
IL307832A (en) 2023-12-01
KR20240011144A (ko) 2024-01-25
AU2022260043A1 (en) 2023-11-16

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