CN117337470A - 抗原结合蛋白的工程化 - Google Patents

抗原结合蛋白的工程化 Download PDF

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Publication number
CN117337470A
CN117337470A CN202280036343.6A CN202280036343A CN117337470A CN 117337470 A CN117337470 A CN 117337470A CN 202280036343 A CN202280036343 A CN 202280036343A CN 117337470 A CN117337470 A CN 117337470A
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sequence
chain
sequences
query
training
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Pending
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Chinese (zh)
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林珍宇
雅各布·盖尔森
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Alekai Antibody Therapy Co ltd
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Alekai Antibody Therapy Co ltd
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Publication of CN117337470A publication Critical patent/CN117337470A/zh
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30—Drug targeting using structural data; Docking or binding prediction
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/044—Recurrent networks, e.g. Hopfield networks
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/045—Combinations of networks
    • G06N3/0455—Auto-encoder networks; Encoder-decoder networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G16B35/10—Design of libraries
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Data Mining & Analysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Evolutionary Computation (AREA)
  • Molecular Biology (AREA)
  • Library & Information Science (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Computing Systems (AREA)
  • General Physics & Mathematics (AREA)
  • Computational Linguistics (AREA)
  • Mathematical Physics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202280036343.6A 2021-04-22 2022-04-14 抗原结合蛋白的工程化 Pending CN117337470A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB2105776.5A GB202105776D0 (en) 2021-04-22 2021-04-22 Engineering of antigen-binding proteins
GB2105776.5 2021-04-22
PCT/EP2022/060073 WO2022223451A1 (en) 2021-04-22 2022-04-14 Engineering of antigen-binding proteins

Publications (1)

Publication Number Publication Date
CN117337470A true CN117337470A (zh) 2024-01-02

Family

ID=76193388

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280036343.6A Pending CN117337470A (zh) 2021-04-22 2022-04-14 抗原结合蛋白的工程化

Country Status (10)

Country Link
US (1) US20240203523A1 (https=)
EP (1) EP4327328A1 (https=)
JP (1) JP2024514691A (https=)
KR (1) KR20240011144A (https=)
CN (1) CN117337470A (https=)
AU (1) AU2022260043A1 (https=)
CA (1) CA3215778A1 (https=)
GB (1) GB202105776D0 (https=)
IL (1) IL307832A (https=)
WO (1) WO2022223451A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113392929B (zh) * 2021-07-01 2024-05-14 中国科学院深圳先进技术研究院 一种基于词嵌入与自编码器融合的生物序列特征提取方法
IL321771A (en) 2023-01-09 2025-08-01 Lilly Co Eli Anti-unc5c antibodies
EP4688852A2 (en) 2023-04-03 2026-02-11 Alchemab Therapeutics Ltd. Anti-cd33 antibodies
WO2025022002A1 (en) 2023-07-26 2025-01-30 Alchemab Therapeutics Ltd Analysis of antigen-binding proteins
US20250079011A1 (en) * 2023-09-01 2025-03-06 Siemens Healthcare Diagnostics Inc. Clinical decision support using transformer-based networks by imputing biomarkers
WO2025125898A1 (en) 2023-12-15 2025-06-19 Alchemab Therapeutics Ltd Anti-unc5c antibodies and uses thereof
US12367329B1 (en) * 2024-06-06 2025-07-22 EvolutionaryScale, PBC Protein binder search

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7648099B2 (ja) * 2019-05-19 2025-03-18 ジャスト－エヴォテック バイオロジクス，インコーポレイテッド 機械学習法によるタンパク質配列の生成

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Publication number Publication date
JP2024514691A (ja) 2024-04-02
CA3215778A1 (en) 2022-10-27
WO2022223451A1 (en) 2022-10-27
US20240203523A1 (en) 2024-06-20
EP4327328A1 (en) 2024-02-28
GB202105776D0 (en) 2021-06-09
IL307832A (en) 2023-12-01
KR20240011144A (ko) 2024-01-25
AU2022260043A1 (en) 2023-11-16

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