CA3215778A1 - Engineering of antigen-binding proteins - Google Patents

Engineering of antigen-binding proteins Download PDF

Info

Publication number
CA3215778A1
CA3215778A1 CA3215778A CA3215778A CA3215778A1 CA 3215778 A1 CA3215778 A1 CA 3215778A1 CA 3215778 A CA3215778 A CA 3215778A CA 3215778 A CA3215778 A CA 3215778A CA 3215778 A1 CA3215778 A1 CA 3215778A1
Authority
CA
Canada
Prior art keywords
sequence
chain
sequences
heavy
training
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3215778A
Other languages
English (en)
French (fr)
Inventor
Jinwoo LEEM
Jacob GALSON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alchemab Therapeutics Ltd
Original Assignee
Alchemab Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alchemab Therapeutics Ltd filed Critical Alchemab Therapeutics Ltd
Publication of CA3215778A1 publication Critical patent/CA3215778A1/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30—Drug targeting using structural data; Docking or binding prediction
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/044—Recurrent networks, e.g. Hopfield networks
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/045—Combinations of networks
    • G06N3/0455—Auto-encoder networks; Encoder-decoder networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G16B35/10—Design of libraries
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Data Mining & Analysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Evolutionary Computation (AREA)
  • Molecular Biology (AREA)
  • Library & Information Science (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Computing Systems (AREA)
  • General Physics & Mathematics (AREA)
  • Computational Linguistics (AREA)
  • Mathematical Physics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3215778A 2021-04-22 2022-04-14 Engineering of antigen-binding proteins Pending CA3215778A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB2105776.5A GB202105776D0 (en) 2021-04-22 2021-04-22 Engineering of antigen-binding proteins
GB2105776.5 2021-04-22
PCT/EP2022/060073 WO2022223451A1 (en) 2021-04-22 2022-04-14 Engineering of antigen-binding proteins

Publications (1)

Publication Number Publication Date
CA3215778A1 true CA3215778A1 (en) 2022-10-27

Family

ID=76193388

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3215778A Pending CA3215778A1 (en) 2021-04-22 2022-04-14 Engineering of antigen-binding proteins

Country Status (10)

Country Link
US (1) US20240203523A1 (https=)
EP (1) EP4327328A1 (https=)
JP (1) JP2024514691A (https=)
KR (1) KR20240011144A (https=)
CN (1) CN117337470A (https=)
AU (1) AU2022260043A1 (https=)
CA (1) CA3215778A1 (https=)
GB (1) GB202105776D0 (https=)
IL (1) IL307832A (https=)
WO (1) WO2022223451A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113392929B (zh) * 2021-07-01 2024-05-14 中国科学院深圳先进技术研究院 一种基于词嵌入与自编码器融合的生物序列特征提取方法
IL321771A (en) 2023-01-09 2025-08-01 Lilly Co Eli Anti-unc5c antibodies
EP4688852A2 (en) 2023-04-03 2026-02-11 Alchemab Therapeutics Ltd. Anti-cd33 antibodies
WO2025022002A1 (en) 2023-07-26 2025-01-30 Alchemab Therapeutics Ltd Analysis of antigen-binding proteins
US20250079011A1 (en) * 2023-09-01 2025-03-06 Siemens Healthcare Diagnostics Inc. Clinical decision support using transformer-based networks by imputing biomarkers
WO2025125898A1 (en) 2023-12-15 2025-06-19 Alchemab Therapeutics Ltd Anti-unc5c antibodies and uses thereof
US12367329B1 (en) * 2024-06-06 2025-07-22 EvolutionaryScale, PBC Protein binder search

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7648099B2 (ja) * 2019-05-19 2025-03-18 ジャスト－エヴォテック バイオロジクス，インコーポレイテッド 機械学習法によるタンパク質配列の生成

Also Published As

Publication number Publication date
JP2024514691A (ja) 2024-04-02
CN117337470A (zh) 2024-01-02
WO2022223451A1 (en) 2022-10-27
US20240203523A1 (en) 2024-06-20
EP4327328A1 (en) 2024-02-28
GB202105776D0 (en) 2021-06-09
IL307832A (en) 2023-12-01
KR20240011144A (ko) 2024-01-25
AU2022260043A1 (en) 2023-11-16

Similar Documents

Publication Publication Date Title
US20240203523A1 (en) Engineering of antigen-binding proteins
Kim et al. Germinal centre-driven maturation of B cell response to mRNA vaccination
Steichen et al. A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses
Wang et al. A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2
Wang et al. mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
Richardson et al. A computational method for immune repertoire mining that identifies novel binders from different clonotypes, demonstrated by identifying anti-pertussis toxoid antibodies
Ford et al. Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19
Prabakaran et al. Landscape of non-canonical cysteines in human VH repertoire revealed by immunogenetic analysis
Könitzer et al. Generation of a highly diverse panel of antagonistic chicken monoclonal antibodies against the GIP receptor
WO2025022002A1 (en) Analysis of antigen-binding proteins
Wang et al. Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques
Hsiao et al. Immune repertoire mining for rapid affinity optimization of mouse monoclonal antibodies
Swanson et al. Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations
Xu et al. Functional clustering of B cell receptors using sequence and structural features
Xu et al. Advances in antibody discovery from human BCR repertoires
Yan et al. Deep immunoglobulin repertoire sequencing depicts a comprehensive atlas of spike-specific antibody lineages shared among COVID-19 convalescents
Wasdin et al. Generation of antigen-specific paired-chain antibodies using large language models
Wu et al. De novo design of epitope-specific antibodies via a structure-driven computational workflow
AU2023361018A1 (en) Engineering of antigen-binding proteins
Campbell et al. Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody
Ramon et al. AbNatiV: VQ-VAE-based assessment of antibody and nanobody nativeness for hit selection, humanisation, and engineering
Thomas et al. High affinity mAb infusion can enhance maximum affinity maturation during HIV Env immunization
Zou et al. Antibody humanization via protein language model and neighbor retrieval
Zhao et al. Quantitative characterization of the B cell receptor repertoires of human immunized with commercial rabies virus vaccine
Rosenfeld et al. Efficient identification of monoclonal antibodies against Rift Valley fever virus using high-throughput single lymphocyte transcriptomics of immunized mice

Legal Events

Date Code Title Description
MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 3RD ANNIV.) - STANDARD

Year of fee payment: 3

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250410

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250410