GB2020975A - Compositions containing cyanine compounds - Google Patents

Compositions containing cyanine compounds

Info

Publication number
GB2020975A
GB2020975A GB7917270A GB7917270A GB2020975A GB 2020975 A GB2020975 A GB 2020975A GB 7917270 A GB7917270 A GB 7917270A GB 7917270 A GB7917270 A GB 7917270A GB 2020975 A GB2020975 A GB 2020975A
Authority
GB
United Kingdom
Prior art keywords
formula
same
different
group
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7917270A
Other versions
GB2020975B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP5927478A external-priority patent/JPS54151133A/en
Priority claimed from JP10354978A external-priority patent/JPS5531024A/en
Priority claimed from JP14385878A external-priority patent/JPS5569513A/en
Priority claimed from JP854479A external-priority patent/JPS55100318A/en
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Publication of GB2020975A publication Critical patent/GB2020975A/en
Application granted granted Critical
Publication of GB2020975B publication Critical patent/GB2020975B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/84—Naphthothiazoles

Abstract

There is provided a pharmaceutical use as antitumour agents of cyanine compounds having the formula A - Q = A' (I) wherein A is a group of the formula: <IMAGE> A' is a group of the formula: <IMAGE> Q is a group of the formula: <IMAGE> wherein Z is hydrogen, halogen, C1-3 alkyl or a group of the formula: <IMAGE> Y, Y' and Y'' in the above group formula being the same or different and being respectively S, O or -C(CH3)2-; X<->1 and X<->2 being the same or different anions; R, R' and R'' being the same or different, C1-18 alkyl groups; R1, R2, R'1, R'2, R''1 and R''2 being the same or different and being respectively hydrogen or C1-16 alkyl, or R1 together with R2, or R'1 together with R'2, or R''1 together with R''2 forming a benzene or naphthalene ring including the respectively adjacent carbon atoms or chains; and R3 and R'3 being the same or different and being respectively hydrogen, C1-4 alkyl, C1-4 alkoxy or di-C1-4 alkylamino.
GB7917270A 1978-05-17 1979-05-17 Compositions containg cyanine compounds Expired GB2020975B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP5927478A JPS54151133A (en) 1978-05-17 1978-05-17 Antitumorigenic agent
JP10354978A JPS5531024A (en) 1978-08-24 1978-08-24 Anti-tumor agent
JP14385878A JPS5569513A (en) 1978-11-20 1978-11-20 Anti-tumor agent
JP854479A JPS55100318A (en) 1979-01-26 1979-01-26 Antitumorigenic agent

Publications (2)

Publication Number Publication Date
GB2020975A true GB2020975A (en) 1979-11-28
GB2020975B GB2020975B (en) 1983-03-30

Family

ID=27454964

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7917270A Expired GB2020975B (en) 1978-05-17 1979-05-17 Compositions containg cyanine compounds

Country Status (3)

Country Link
DE (1) DE2919447A1 (en)
FR (1) FR2425857A1 (en)
GB (1) GB2020975B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2516793A1 (en) * 1981-11-24 1983-05-27 Yamamoto Itaru NOVEL IMMUNOMODULATORY MEDICAMENTS CONTAINING TRITHIAZOLEPENTAMETHYLIDENE-CYANINE DERIVATIVE
EP0198605A1 (en) * 1985-03-19 1986-10-22 Teijin Limited Prophylaxis of pharmacotherapy of liver disorders
EP0286252A2 (en) * 1987-03-17 1988-10-12 Dana Farber Cancer Institute Anti-cancer composition & method featuring cyanine dyes
EP0417941A2 (en) * 1989-08-30 1991-03-20 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Use of a cyanine dye in an antitumor agent
EP0527494A1 (en) * 1991-08-13 1993-02-17 Fuji Photo Film Co., Ltd. Compositon containing rhodacyanine dyes for treating cancer
WO1996003393A1 (en) * 1994-07-21 1996-02-08 Fuji Photo Film Co., Ltd. Water-soluble methine compound and pharmaceutical composition for treatment of cancer comprising the same
WO2007096618A2 (en) * 2006-02-21 2007-08-30 Cancer Research Technology Limited 2-[3h-thiazol-2-ylidinemethyl]pyridines and related compounds and their use

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19706161A1 (en) * 1997-02-17 1998-08-20 Oswald Hartmut Prof Dr Med Use of cyanines, isocyanines and pseudoisocyanines as diuretics
DE19841985A1 (en) * 1998-09-03 2000-03-09 Schering Ag New heterocyclic alkanesulfonic and alkane carboxylic acid derivatives are VEGF receptor blockers useful in treatment of e.g. psoriasis, rheumatoid arthritis, stroke, tumors and endometriosis
US6190641B1 (en) * 2000-01-18 2001-02-20 Mallinckrodt Inc. Indocyanine dyes
US6761878B2 (en) * 2001-10-17 2004-07-13 Mallinckrodt, Inc. Pathological tissue detection and treatment employing targeted benzoindole optical agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387658A1 (en) * 1977-03-25 1978-11-17 Ciba Geigy Ag PROCEDURE FOR FIGHTING MICROORGANISMS

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2516793A1 (en) * 1981-11-24 1983-05-27 Yamamoto Itaru NOVEL IMMUNOMODULATORY MEDICAMENTS CONTAINING TRITHIAZOLEPENTAMETHYLIDENE-CYANINE DERIVATIVE
GB2116422A (en) * 1981-11-24 1983-09-28 Itaru Yamamoto Immunomodulator containing trithiazole pentamethine cyanine derivative
EP0198605A1 (en) * 1985-03-19 1986-10-22 Teijin Limited Prophylaxis of pharmacotherapy of liver disorders
EP0286252A2 (en) * 1987-03-17 1988-10-12 Dana Farber Cancer Institute Anti-cancer composition & method featuring cyanine dyes
EP0286252A3 (en) * 1987-03-17 1990-10-31 Dana Farber Cancer Institute Anti-cancer composition & method featuring cyanine dyes
EP0417941A2 (en) * 1989-08-30 1991-03-20 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Use of a cyanine dye in an antitumor agent
EP0417941A3 (en) * 1989-08-30 1991-11-06 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Use of a cyanine dye in an antitumor agent
EP0527494A1 (en) * 1991-08-13 1993-02-17 Fuji Photo Film Co., Ltd. Compositon containing rhodacyanine dyes for treating cancer
US5360803A (en) * 1991-08-13 1994-11-01 Dan Farber Cancer Institute Composition and method for treating cancer
WO1996003393A1 (en) * 1994-07-21 1996-02-08 Fuji Photo Film Co., Ltd. Water-soluble methine compound and pharmaceutical composition for treatment of cancer comprising the same
WO2007096618A2 (en) * 2006-02-21 2007-08-30 Cancer Research Technology Limited 2-[3h-thiazol-2-ylidinemethyl]pyridines and related compounds and their use
WO2007096618A3 (en) * 2006-02-21 2008-12-11 Cancer Rec Tech Ltd 2-[3h-thiazol-2-ylidinemethyl]pyridines and related compounds and their use

Also Published As

Publication number Publication date
FR2425857A1 (en) 1979-12-14
DE2919447A1 (en) 1979-11-22
FR2425857B1 (en) 1982-12-03
GB2020975B (en) 1983-03-30

Similar Documents

Publication Publication Date Title
DE3262880D1 (en) Tricyclic ethers, process for their preparation and their use in pharmaceutical preparations
ES486990A1 (en) Pharmaceutically useful carbostyril derivatives
PT77410A (en) Process for the preparation of a fungicidal composition containing substituted 1-hydroxymethyltriazolyl derivatives
GB2020975A (en) Compositions containing cyanine compounds
ES8506635A1 (en) Morphinane derivatives, their preparation and pharmaceutical preparations containing them.
ES482472A1 (en) Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them.
HU900141D0 (en) Process for preparation of new 1,8 benzonapthridine-derivatives and for manufacturing of the pharmaceutical composition containing these compounds
ES8200108A1 (en) Xanthine derivatives, a process for their preparation and their use in pharmaceutical compositions.
ATE2432T1 (en) MAYTANSINOIDS, THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS CONTAINING THEM.
ZA858418B (en) 5-alkyl-1-phenyl-2-piperazinoalkylpyrazoline-3-one compounds and methods for the preparation thereof,intermediates for use in the preparation of said compounds and medicaments containing said compounds
MX170732B (en) COMPOSITION OF SUCCINIMIDE DERIVATIVES AND THEIR USE
CS713183A2 (en) Zpsob vyroby benzenovych derivatu
ES455909A1 (en) 1,4-Substituted piperazinyl derivatives useful as psychostimulants
IL80215A0 (en) 5,6,7,8-tetrahydro-beta-carboline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
ES8305359A1 (en) Bicyclo (3,2,1) octylbenzamides, a process for their preparation and pharmaceutical compositions containing them.
ES8105319A1 (en) Pyrazolo[1,5-c]quinazoline derivatives and analgesic compositions containing them
ZA835899B (en) 1,7-dihydro-pyrrolo(3,4-e)(1,4)diazepin-2(3h)-one derivatives,a process for preparing them and their use as anticonvulsant and antianxiety agents
GB2133012B (en) Quinazolines process for their preparation and pharmaceutical compositions containing them
GB2011455A (en) 4,9-Dihydronaphtho[2,3- b]thiophene-4,9-diones
IL76936A (en) 3-amino-2,3-dihydro-1-benzoxepine compounds,their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee