GB2011888A - Aminophenyl Ether Compounds - Google Patents

Aminophenyl Ether Compounds

Info

Publication number
GB2011888A
GB2011888A GB7848658A GB7848658A GB2011888A GB 2011888 A GB2011888 A GB 2011888A GB 7848658 A GB7848658 A GB 7848658A GB 7848658 A GB7848658 A GB 7848658A GB 2011888 A GB2011888 A GB 2011888A
Authority
GB
United Kingdom
Prior art keywords
group
alkyl group
lower alkyl
substituted
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7848658A
Other versions
GB2011888B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP15809977A external-priority patent/JPS5492926A/en
Priority claimed from JP3462478A external-priority patent/JPS54128535A/en
Priority claimed from JP9129278A external-priority patent/JPS5519217A/en
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of GB2011888A publication Critical patent/GB2011888A/en
Application granted granted Critical
Publication of GB2011888B publication Critical patent/GB2011888B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed are aminophenyl ether compounds having the formula <IMAGE> wherein R1 represents a hydrogen atom or a lower alkyl group; R2 represents a cyclohexyl group which may be substituted by lower alkyl group(s), an alkyl group containing from 1 to 20 carbon atoms, a phenyl group or a benzyl group; R3 represents a hydrogen atom, a lower alkyl group, or a cyclohexyl group which may be substituted by lower alkyl group(s); R4 represents a hydrogen atom, a lower alkyl group or a lower alkoxycarbonyl group; and R5 represents hydrogen atom, an aryl group or the group -COR6 or-CH2R6 (wherein R6 represents a hydrogen atom, an amino group, an alkyl group containing from 1 to 19 carbon atoms, a cyclohexyl group, an aryl group, an aralkyl group, an aralkenyl group, an amino group substituted by lower alkyl group(s) a heterocyclic group which may be substituted by lower alkyl group(s), or a bridged hydrocarbon group); and R2 and R3 may instead form together with the adjacent carbon atom a cyclohexane ring which may be substituted by lower alkyl group(s) and R4 and R5 may instead form together with the adjacent nitrogen atom a pyrrolidine ring or a piperidine ring; and pharmacologically acceptable salts thereof. The above compounds have hypolipemic activity, a cholesterol- and triglyceride-reducing effect on blood and the effect of increasing the high density lipoprotein (HDL) cholesterol level in blood.
GB7848658A 1977-12-29 1978-12-15 Aminophenyl ether compoungd Expired GB2011888B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP15809977A JPS5492926A (en) 1977-12-29 1977-12-29 Compound of aminophenyl ether and its preparation
JP3462478A JPS54128535A (en) 1978-03-25 1978-03-25 Aminophenyl ether compound and its preparation
JP9129278A JPS5519217A (en) 1978-07-26 1978-07-26 Aminophenyl ether derivative and its preparation

Publications (2)

Publication Number Publication Date
GB2011888A true GB2011888A (en) 1979-07-18
GB2011888B GB2011888B (en) 1982-09-22

Family

ID=27288474

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7848658A Expired GB2011888B (en) 1977-12-29 1978-12-15 Aminophenyl ether compoungd

Country Status (12)

Country Link
AT (1) AT367738B (en)
AU (1) AU4301778A (en)
CA (1) CA1110248A (en)
DE (1) DE2854595A1 (en)
DK (1) DK584978A (en)
ES (3) ES476458A1 (en)
FR (1) FR2413382A1 (en)
GB (1) GB2011888B (en)
IT (1) IT7869973A0 (en)
NL (1) NL7812574A (en)
NO (2) NO784394L (en)
SE (1) SE7813355L (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087743A (en) * 1989-02-10 1992-02-11 Basf Aktiengesellschaft Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261651A (en) * 1978-05-31 1981-04-14 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Liquid crystal compounds
DE2948056A1 (en) * 1979-11-29 1981-06-04 Boehringer Mannheim Gmbh, 6800 Mannheim NEW AMINOPROPANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US5527945A (en) * 1989-02-10 1996-06-18 Basf Aktiengesellschaft Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1793030A (en) * 1930-03-01 1931-02-17 Thorp Lambert Isopropyl ether of para-acetyl amino phenol
GB1093121A (en) * 1963-05-31 1967-11-29 Wellcome Found Etherified ªÐ-hydroxyanilines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087743A (en) * 1989-02-10 1992-02-11 Basf Aktiengesellschaft Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom

Also Published As

Publication number Publication date
NO784394L (en) 1979-07-02
GB2011888B (en) 1982-09-22
CA1110248A (en) 1981-10-06
ES481505A1 (en) 1980-04-01
FR2413382A1 (en) 1979-07-27
ES476458A1 (en) 1979-11-16
ES481504A1 (en) 1980-04-01
IT7869973A0 (en) 1978-12-28
NL7812574A (en) 1979-07-03
DE2854595A1 (en) 1979-07-12
AT367738B (en) 1982-07-26
NO820355L (en) 1979-07-02
AU4301778A (en) 1979-07-05
ATA935778A (en) 1981-12-15
SE7813355L (en) 1979-06-30
DK584978A (en) 1979-06-30

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee