GB201116106D0 - Compounds and methods for the treatment of replicative senescence - Google Patents

Compounds and methods for the treatment of replicative senescence

Info

Publication number
GB201116106D0
GB201116106D0 GB201116106A GB201116106A GB201116106D0 GB 201116106 D0 GB201116106 D0 GB 201116106D0 GB 201116106 A GB201116106 A GB 201116106A GB 201116106 A GB201116106 A GB 201116106A GB 201116106 D0 GB201116106 D0 GB 201116106D0
Authority
GB
United Kingdom
Prior art keywords
treatment
beta
integrin
replicative senescence
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GB201116106A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALJAMAL NAYLOR REHAB
Original Assignee
ALJAMAL NAYLOR REHAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALJAMAL NAYLOR REHAB filed Critical ALJAMAL NAYLOR REHAB
Priority to GB201116106A priority Critical patent/GB201116106D0/en
Publication of GB201116106D0 publication Critical patent/GB201116106D0/en
Priority to PCT/GB2012/052273 priority patent/WO2013038196A1/en
Ceased legal-status Critical Current

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A method for inhibiting and/or reversing replicative senescence is provided comprising a step of administering a therapeutically effective amount of a compound which mediates allosteric modulation of beta 1 integrin to a subject in need thereof. Typically the allosteric modulation of beta 1 integrin results in beta 1 integrin assuming an intermediate affinity state conformation. The method of the present invention may be used in the treatment and/or prevention of ageing and ageing-related conditions.
GB201116106A 2011-09-17 2011-09-17 Compounds and methods for the treatment of replicative senescence Ceased GB201116106D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB201116106A GB201116106D0 (en) 2011-09-17 2011-09-17 Compounds and methods for the treatment of replicative senescence
PCT/GB2012/052273 WO2013038196A1 (en) 2011-09-17 2012-09-14 Method for reversing or inhibiting replicative senescence

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB201116106A GB201116106D0 (en) 2011-09-17 2011-09-17 Compounds and methods for the treatment of replicative senescence

Publications (1)

Publication Number Publication Date
GB201116106D0 true GB201116106D0 (en) 2011-11-02

Family

ID=44937454

Family Applications (1)

Application Number Title Priority Date Filing Date
GB201116106A Ceased GB201116106D0 (en) 2011-09-17 2011-09-17 Compounds and methods for the treatment of replicative senescence

Country Status (2)

Country Link
GB (1) GB201116106D0 (en)
WO (1) WO2013038196A1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2912313B1 (en) 2007-02-13 2012-07-06 Rocher Yves Biolog Vegetale COMPOSITION OF WHEAT AND ESCULIN EXTRACT AND USE IN COSMETICS.
GB0703652D0 (en) * 2007-02-26 2007-04-04 Univ Bradford Method for the allosteric modulation of beta1 integrin
GB2478082B (en) * 2007-02-26 2011-11-30 Rehab Al-Jamal Compounds and methods for the modulation of beta-1 integrin function to mediate tissue repair
JP2010115131A (en) 2008-11-12 2010-05-27 Kao Corp Evaluation method and method for screening skin ageing improving agent and skin aging preventive
JP2011020951A (en) 2009-07-15 2011-02-03 Nagase & Co Ltd Agent for ameliorating skin flabbiness

Also Published As

Publication number Publication date
WO2013038196A1 (en) 2013-03-21

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)