GB2478082B - Compounds and methods for the modulation of beta-1 integrin function to mediate tissue repair - Google Patents

Compounds and methods for the modulation of beta-1 integrin function to mediate tissue repair

Info

Publication number
GB2478082B
GB2478082B GB1108815A GB201108815A GB2478082B GB 2478082 B GB2478082 B GB 2478082B GB 1108815 A GB1108815 A GB 1108815A GB 201108815 A GB201108815 A GB 201108815A GB 2478082 B GB2478082 B GB 2478082B
Authority
GB
United Kingdom
Prior art keywords
beta
modulation
compounds
methods
tissue repair
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1108815A
Other versions
GB201108815D0 (en
GB2478082A (en
Inventor
David Harrison
Rehab Al-Jamal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0703652.8A external-priority patent/GB0703652D0/en
Application filed by Individual filed Critical Individual
Publication of GB201108815D0 publication Critical patent/GB201108815D0/en
Publication of GB2478082A publication Critical patent/GB2478082A/en
Application granted granted Critical
Publication of GB2478082B publication Critical patent/GB2478082B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
GB1108815A 2007-02-26 2008-02-26 Compounds and methods for the modulation of beta-1 integrin function to mediate tissue repair Active GB2478082B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0703652.8A GB0703652D0 (en) 2007-02-26 2007-02-26 Method for the allosteric modulation of beta1 integrin
GB0916943A GB2460009B (en) 2007-02-26 2008-02-26 Compounds and methods for the modulation of beta-1 integrin function to mediatetissue repair

Publications (3)

Publication Number Publication Date
GB201108815D0 GB201108815D0 (en) 2011-07-06
GB2478082A GB2478082A (en) 2011-08-24
GB2478082B true GB2478082B (en) 2011-11-30

Family

ID=44315456

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1108815A Active GB2478082B (en) 2007-02-26 2008-02-26 Compounds and methods for the modulation of beta-1 integrin function to mediate tissue repair

Country Status (1)

Country Link
GB (1) GB2478082B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116106D0 (en) * 2011-09-17 2011-11-02 Aljamal Naylor Rehab Compounds and methods for the treatment of replicative senescence

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037313A2 (en) * 2003-10-17 2005-04-28 University Court Of The University Of Edinburgh Tissue repair by modulation of beta-1 integrin biological function

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037313A2 (en) * 2003-10-17 2005-04-28 University Court Of The University Of Edinburgh Tissue repair by modulation of beta-1 integrin biological function

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Chinese J. Pathol., Vol.35, 2006, Huang, J.-M., et al., "Effects of beta1 integrin...", pp.478-482 *

Also Published As

Publication number Publication date
GB201108815D0 (en) 2011-07-06
GB2478082A (en) 2011-08-24

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