EA201690753A1 - COMBINATION INHIBITORS OF HISTONDEACETYLASE AND IMMUNOMODULATING MEDICINES - Google Patents
COMBINATION INHIBITORS OF HISTONDEACETYLASE AND IMMUNOMODULATING MEDICINESInfo
- Publication number
- EA201690753A1 EA201690753A1 EA201690753A EA201690753A EA201690753A1 EA 201690753 A1 EA201690753 A1 EA 201690753A1 EA 201690753 A EA201690753 A EA 201690753A EA 201690753 A EA201690753 A EA 201690753A EA 201690753 A1 EA201690753 A1 EA 201690753A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- histondeacetylase
- immunomodulating
- medicines
- subject
- combinations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Настоящее изобретение относится к комбинациям, содержащим ингибитор ГДАЦ и иммуномодулирующее лекарственное средство, для лечения множественной миеломы у нуждающегося в этом субъекта. Указанные комбинации могут также содержать противовоспалительный агент, такой как дексаметазон. Также в настоящем изобретении предложены способы лечения множественной миеломы у нуждающегося в этом субъекта, включающие введение указанному субъекту эффективного количества одной из вышеуказанных комбинаций.The present invention relates to combinations comprising an HDAC inhibitor and an immunomodulatory drug for treating multiple myeloma in a subject in need thereof. These combinations may also contain an anti-inflammatory agent, such as dexamethasone. The present invention also provides methods for treating multiple myeloma in a subject in need thereof, comprising administering to said subject an effective amount of one of the above combinations.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361889640P | 2013-10-11 | 2013-10-11 | |
US201361911089P | 2013-12-03 | 2013-12-03 | |
PCT/US2014/059387 WO2015054175A1 (en) | 2013-10-11 | 2014-10-07 | Combinations of histone deactylase inhibitors and immunomodulatory drugs |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201690753A1 true EA201690753A1 (en) | 2016-07-29 |
Family
ID=52810182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201690753A EA201690753A1 (en) | 2013-10-11 | 2014-10-07 | COMBINATION INHIBITORS OF HISTONDEACETYLASE AND IMMUNOMODULATING MEDICINES |
Country Status (17)
Country | Link |
---|---|
US (2) | US20150105358A1 (en) |
EP (1) | EP3054939A4 (en) |
JP (4) | JP2016532667A (en) |
KR (1) | KR20160060143A (en) |
CN (1) | CN105722507A (en) |
AU (1) | AU2014332147A1 (en) |
CA (1) | CA2926808A1 (en) |
CL (1) | CL2016000838A1 (en) |
CR (1) | CR20160200A (en) |
EA (1) | EA201690753A1 (en) |
IL (1) | IL244923A0 (en) |
MX (1) | MX2016004604A (en) |
NI (1) | NI201600051A (en) |
PE (1) | PE20161342A1 (en) |
PH (1) | PH12016500649A1 (en) |
SG (1) | SG11201602791RA (en) |
WO (1) | WO2015054175A1 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011091213A2 (en) | 2010-01-22 | 2011-07-28 | Acetylon Pharmaceuticals | Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof |
CN107011270A (en) | 2010-11-16 | 2017-08-04 | 阿塞蒂隆制药公司 | It is used as the pyrimidine hydroxyamide compounds and its application method of protein deacetylase inhibitor |
JP2015515279A (en) | 2012-04-19 | 2015-05-28 | アセチロン ファーマシューティカルズ インコーポレイテッドAcetylon Pharmaceuticals,Inc. | Biomarkers identifying patients who respond to treatment and treatment of such patients |
US9145412B2 (en) | 2012-11-02 | 2015-09-29 | Acetylon Pharmaceuticals, Inc. | Selective HDAC1 and HDAC2 inhibitors |
EP3054952B1 (en) * | 2013-10-08 | 2022-10-26 | Acetylon Pharmaceuticals, Inc. | Combinations of histone deacetylase 6 inhibitors and the her2 inhibitor lapatinib for use in the treatment of breast cancer |
EP3055299B1 (en) * | 2013-10-10 | 2021-01-06 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors |
AU2014332147A1 (en) * | 2013-10-11 | 2016-05-05 | Acetylon Pharmaceuticals, Inc. | Combinations of histone deactylase inhibitors and immunomodulatory drugs |
US10660890B2 (en) | 2013-10-24 | 2020-05-26 | National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs), U.S. Government Nih Division Of Extramural Inventions And Technology Resources (Deitr) | Treatment of polycystic diseases with an HDAC6 inhibitor |
WO2015084905A1 (en) | 2013-12-03 | 2015-06-11 | Acetylon Pharmaceuticals, Inc. | Combinations of histone deacetylase inhibitors and immunomodulatory drugs |
US9464073B2 (en) | 2014-02-26 | 2016-10-11 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors |
CA2954522A1 (en) | 2014-07-07 | 2016-01-14 | Acetylon Pharmaceuticals, Inc. | Treatment of leukemia with histone deacetylase inhibitors |
CA2969790A1 (en) | 2014-12-05 | 2016-06-09 | University of Modena and Reggio Emilia | Combinations of histone deacetylase inhibitors and bendamustine |
CN107835810A (en) | 2014-12-12 | 2018-03-23 | 瑞格纳西制药有限公司 | Piperidine derivative as HDAC1/2 inhibitor |
JP6816036B2 (en) | 2015-06-08 | 2021-01-20 | アセチロン ファーマシューティカルズ インコーポレイテッドAcetylon Pharmaceuticals,Inc. | Crystalline morphology of histone deacetylase inhibitors |
AR105812A1 (en) | 2015-06-08 | 2017-11-15 | Acetylon Pharmaceuticals Inc | METHODS FOR THE PREPARATION OF PROTEIN DEACETILASE INHIBITORS |
WO2017143237A1 (en) * | 2016-02-17 | 2017-08-24 | Acetylon Pharmaceuticals, Inc. | Increasing expression of interferon regulated genes with combinatons of histone deacetylase inhibitors and immunomodulatory drugs |
EP3445364A4 (en) | 2016-04-19 | 2019-11-27 | Acetylon Pharmaceuticals, Inc. | Hdac inhibitors, alone or in combination with btk inhibitors, for treating chronic lymphocytic leukemia |
JP7233220B2 (en) | 2016-06-09 | 2023-03-06 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Methods of using HDAC inhibitors and BET inhibitors and pharmaceutical combinations thereof |
EP3496751B1 (en) | 2016-08-08 | 2022-10-19 | Acetylon Pharmaceuticals Inc. | Pharmaceutical combinations of histone deacetylase 6 inhibitors and cd20 inhibitory antibodies and uses thereof |
KR102002581B1 (en) * | 2016-10-04 | 2019-07-22 | 주식회사 종근당 | Pharmaceutical combinations of histone deacetylase inhibitor and proteasome inhibitor or immunomodulatory drug for the treatment of hematological cancer |
WO2018098348A1 (en) | 2016-11-23 | 2018-05-31 | Acetylon Pharmaceuticals, Inc. | Pharmaceutical combinations comprising a histone deacetylase inhibitor and a cd38 inhibitor and methods of use thereof |
JP7090611B2 (en) * | 2016-11-23 | 2022-06-24 | アセチロン ファーマシューティカルズ インコーポレイテッド | A pharmaceutical combination containing a histone deacetylase inhibitor and a programmed cell death ligand 1 (PD-L1) inhibitor and a method for using the same. |
KR20240013098A (en) | 2021-04-23 | 2024-01-30 | 테나야 테라퓨틱스, 인코포레이티드 | HDAC6 inhibitors for use in the treatment of dilated cardiomyopathy |
AU2022270657A1 (en) | 2021-05-04 | 2023-11-16 | Tenaya Therapeutics, Inc. | 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7323479B2 (en) * | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
US7968569B2 (en) * | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
CA2627923C (en) * | 2005-11-10 | 2016-01-12 | Topotarget Uk Limited | Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer |
WO2011091213A2 (en) * | 2010-01-22 | 2011-07-28 | Acetylon Pharmaceuticals | Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof |
CN107011270A (en) * | 2010-11-16 | 2017-08-04 | 阿塞蒂隆制药公司 | It is used as the pyrimidine hydroxyamide compounds and its application method of protein deacetylase inhibitor |
WO2013013113A2 (en) * | 2011-07-20 | 2013-01-24 | The General Hospital Corporation | Histone deacetylase 6 selective inhibitors for the treatment of bone disease |
AU2014332147A1 (en) * | 2013-10-11 | 2016-05-05 | Acetylon Pharmaceuticals, Inc. | Combinations of histone deactylase inhibitors and immunomodulatory drugs |
-
2014
- 2014-10-07 AU AU2014332147A patent/AU2014332147A1/en not_active Abandoned
- 2014-10-07 CN CN201480062094.3A patent/CN105722507A/en active Pending
- 2014-10-07 MX MX2016004604A patent/MX2016004604A/en unknown
- 2014-10-07 PE PE2016000490A patent/PE20161342A1/en not_active Application Discontinuation
- 2014-10-07 EA EA201690753A patent/EA201690753A1/en unknown
- 2014-10-07 CA CA2926808A patent/CA2926808A1/en not_active Abandoned
- 2014-10-07 CR CR20160200A patent/CR20160200A/en unknown
- 2014-10-07 EP EP14851888.9A patent/EP3054939A4/en active Pending
- 2014-10-07 US US14/508,072 patent/US20150105358A1/en not_active Abandoned
- 2014-10-07 KR KR1020167011860A patent/KR20160060143A/en not_active Application Discontinuation
- 2014-10-07 JP JP2016521758A patent/JP2016532667A/en active Pending
- 2014-10-07 SG SG11201602791RA patent/SG11201602791RA/en unknown
- 2014-10-07 WO PCT/US2014/059387 patent/WO2015054175A1/en active Application Filing
-
2016
- 2016-04-05 IL IL244923A patent/IL244923A0/en unknown
- 2016-04-08 PH PH12016500649A patent/PH12016500649A1/en unknown
- 2016-04-11 CL CL2016000838A patent/CL2016000838A1/en unknown
- 2016-04-11 NI NI201600051A patent/NI201600051A/en unknown
-
2018
- 2018-11-30 JP JP2018225287A patent/JP7403950B2/en active Active
-
2019
- 2019-11-15 US US16/684,809 patent/US20200323849A1/en active Pending
-
2021
- 2021-02-12 JP JP2021020680A patent/JP2021073314A/en active Pending
-
2023
- 2023-10-26 JP JP2023184173A patent/JP2024010118A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
PH12016500649A1 (en) | 2016-05-30 |
JP2021073314A (en) | 2021-05-13 |
JP2019052171A (en) | 2019-04-04 |
IL244923A0 (en) | 2016-05-31 |
CL2016000838A1 (en) | 2016-11-25 |
US20200323849A1 (en) | 2020-10-15 |
EP3054939A1 (en) | 2016-08-17 |
SG11201602791RA (en) | 2016-05-30 |
JP2016532667A (en) | 2016-10-20 |
PE20161342A1 (en) | 2016-12-31 |
MX2016004604A (en) | 2016-08-01 |
US20150105358A1 (en) | 2015-04-16 |
NI201600051A (en) | 2017-07-11 |
KR20160060143A (en) | 2016-05-27 |
CR20160200A (en) | 2016-08-29 |
CA2926808A1 (en) | 2015-04-16 |
CN105722507A (en) | 2016-06-29 |
EP3054939A4 (en) | 2017-12-13 |
JP2024010118A (en) | 2024-01-23 |
WO2015054175A1 (en) | 2015-04-16 |
AU2014332147A1 (en) | 2016-05-05 |
JP7403950B2 (en) | 2023-12-25 |
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