GB2008121A - Tetrapeptides - Google Patents
TetrapeptidesInfo
- Publication number
- GB2008121A GB2008121A GB7841534A GB7841534A GB2008121A GB 2008121 A GB2008121 A GB 2008121A GB 7841534 A GB7841534 A GB 7841534A GB 7841534 A GB7841534 A GB 7841534A GB 2008121 A GB2008121 A GB 2008121A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- hydrogen
- alkyl
- leu
- ala
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
Abstract
Tetrapeptides of formula: <IMAGE> wherein R<1> is hydrogen or C1-C6 alkyl; R<2> is hydrogen, C1-C6 alkyl or when R<1> is hydrogen, R<2> is allyl or cyclopropylmethyl; X<2> is D-Ala, D-Met, D-Nle, D-Leu, D-Pgl, D-Ser, S-methyl-D-Cys or C. Me-Ala; X<4> is N-methyl-Trp, N-methyl-Leu, N- methyl-Phe or N-methyl-His; and Y is -OM, wherein M is hydrogen, pharmaceutically acceptable cation, C1- C5 alkyl or Y is <IMAGE> wherein R<3> and R<4> are independently hydrogen or C1-C6 alkyl, or a pharmaceutically acceptable salt thereof, which produce an analgesic effect in warm blooded animals.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84552377A | 1977-10-26 | 1977-10-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2008121A true GB2008121A (en) | 1979-05-31 |
| GB2008121B GB2008121B (en) | 1982-03-17 |
Family
ID=25295420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7841534A Expired GB2008121B (en) | 1977-10-26 | 1978-10-23 | Tetrapeptides |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2008121B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4254107A (en) * | 1979-11-27 | 1981-03-03 | Merck & Co., Inc. | Long-lasting agonists of enkephalin |
| EP0030845A2 (en) * | 1979-12-17 | 1981-06-24 | Eli Lilly And Company | Pharmacologically active peptides, their preparation and pharmaceutical compositions containing them |
-
1978
- 1978-10-23 GB GB7841534A patent/GB2008121B/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4254107A (en) * | 1979-11-27 | 1981-03-03 | Merck & Co., Inc. | Long-lasting agonists of enkephalin |
| EP0030845A2 (en) * | 1979-12-17 | 1981-06-24 | Eli Lilly And Company | Pharmacologically active peptides, their preparation and pharmaceutical compositions containing them |
| EP0030845A3 (en) * | 1979-12-17 | 1981-11-04 | Eli Lilly And Company | Pharmacologically active peptides, their preparation and pharmaceutical compositions containing them |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2008121B (en) | 1982-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |