GB2007656A - 4-amino-2-(piperazin-1-yl or homopiperazin-1-yl) quinazoline derivatives - Google Patents

4-amino-2-(piperazin-1-yl or homopiperazin-1-yl) quinazoline derivatives

Info

Publication number
GB2007656A
GB2007656A GB7842814A GB7842814A GB2007656A GB 2007656 A GB2007656 A GB 2007656A GB 7842814 A GB7842814 A GB 7842814A GB 7842814 A GB7842814 A GB 7842814A GB 2007656 A GB2007656 A GB 2007656A
Authority
GB
United Kingdom
Prior art keywords
different
same
homopiperazin
piperazin
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7842814A
Other versions
GB2007656B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Priority to GB7842814A priority Critical patent/GB2007656B/en
Publication of GB2007656A publication Critical patent/GB2007656A/en
Application granted granted Critical
Publication of GB2007656B publication Critical patent/GB2007656B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Quinazoline antihypertensives of the formula: <IMAGE> wherein (R)n represents 6,7-di(lower alkoxy) or 6,7,8-tri(lower alkoxy); m is 1 or 2; X represents -CHR<1>- or -CH2CH2-; each R<1>, which may be the same or different, represents hydrogen or lower alkyl; and R<2> and R<3>, which may be the same or different, each represent hydrogen, lower alkyl, lower alkoxy, halogen, lower alkanoyl, lower alkoxycarbonyl or a group of the formula -CONR<4>R<5> or -SO<2>NR<4>R<5> wherein R<4> and R<5>, which may be the same or different, each represent hydrogen or lower alkyl; and the pharmaceutically acceptable acid addition salts thereof; pharmaceutical compositions containing them, and processes for their preparation.
GB7842814A 1977-11-05 1978-11-01 Therapeutic agents Expired GB2007656B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7842814A GB2007656B (en) 1977-11-05 1978-11-01 Therapeutic agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4612877 1977-11-05
GB7842814A GB2007656B (en) 1977-11-05 1978-11-01 Therapeutic agents

Publications (2)

Publication Number Publication Date
GB2007656A true GB2007656A (en) 1979-05-23
GB2007656B GB2007656B (en) 1982-05-19

Family

ID=26265739

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7842814A Expired GB2007656B (en) 1977-11-05 1978-11-01 Therapeutic agents

Country Status (1)

Country Link
GB (1) GB2007656B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2468595A2 (en) * 1979-10-30 1981-05-08 Synthelabo N1-4-amino-6,7-di:methoxy-2-quinazolinyl N2-cinnamoyl alkylene di:amin - and N2-benzopyranyl and benzo-dioxanyl cpds., antihypertensive with low toxicity
US4279910A (en) * 1979-04-25 1981-07-21 Pfizer Inc. Quinazoline therapeutic agents
EP0037495A1 (en) * 1980-03-27 1981-10-14 CASSELLA Aktiengesellschaft Pyrimidyl quinazolines, process for their preparation and pharmaceutical compositions containing them
FR2704857A1 (en) * 1993-05-07 1994-11-10 Adir Novel substituted benzodioxins, process for their preparation and pharmaceutical compositions containing them
US5753641A (en) * 1991-03-20 1998-05-19 Merck & Co., Inc. Method of treatment for benign prostatic hyperplasia
US6248888B1 (en) 1997-11-14 2001-06-19 Teva Pharmaceutical Industries Ltd. Process for the preparation of terazosin hydrochloride dihydrate
WO2004058746A1 (en) * 2002-12-20 2004-07-15 Merck Patent Gmbh Substituted benzodioxepins

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4625637B2 (en) 2002-02-22 2011-02-02 シャイア エルエルシー Active substance delivery system and method for protecting and administering an active substance

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4279910A (en) * 1979-04-25 1981-07-21 Pfizer Inc. Quinazoline therapeutic agents
FR2468595A2 (en) * 1979-10-30 1981-05-08 Synthelabo N1-4-amino-6,7-di:methoxy-2-quinazolinyl N2-cinnamoyl alkylene di:amin - and N2-benzopyranyl and benzo-dioxanyl cpds., antihypertensive with low toxicity
EP0037495A1 (en) * 1980-03-27 1981-10-14 CASSELLA Aktiengesellschaft Pyrimidyl quinazolines, process for their preparation and pharmaceutical compositions containing them
US5753641A (en) * 1991-03-20 1998-05-19 Merck & Co., Inc. Method of treatment for benign prostatic hyperplasia
US6046183A (en) * 1991-03-20 2000-04-04 Merck & Co., Inc. Method of synergistic treatment for benign prostatic hyperplasia
FR2704857A1 (en) * 1993-05-07 1994-11-10 Adir Novel substituted benzodioxins, process for their preparation and pharmaceutical compositions containing them
EP0624582A1 (en) * 1993-05-07 1994-11-17 Adir Et Compagnie Substituted benzodioxine, process for their preparation and pharmaceutical compositions containing them
AU675699B2 (en) * 1993-05-07 1997-02-13 Adir Et Compagnie New substituted benzodioxins, a process for their preparation and pharmaceutical compositions containing them
US6248888B1 (en) 1997-11-14 2001-06-19 Teva Pharmaceutical Industries Ltd. Process for the preparation of terazosin hydrochloride dihydrate
WO2004058746A1 (en) * 2002-12-20 2004-07-15 Merck Patent Gmbh Substituted benzodioxepins
US7253202B2 (en) 2002-12-20 2007-08-07 Merck Patent Gmbh Substituted benzodioxepines

Also Published As

Publication number Publication date
GB2007656B (en) 1982-05-19

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Legal Events

Date Code Title Description
CTFF Certificate filed

Free format text: SPC/GB93/045, 930525

CTFA Application for certificate granted

Free format text: SPC/GB93/045, 931005, EXPIRES:20020401

CTFE Certificate entered into force

Free format text: SPC/GB93/045, 19981101, EXPIRES: 20020401

PE20 Patent expired after termination of 20 years

Effective date: 19981031