GB2001636A - Prostaglandin amides - Google Patents

Prostaglandin amides

Info

Publication number
GB2001636A
GB2001636A GB787830629A GB7830629A GB2001636A GB 2001636 A GB2001636 A GB 2001636A GB 787830629 A GB787830629 A GB 787830629A GB 7830629 A GB7830629 A GB 7830629A GB 2001636 A GB2001636 A GB 2001636A
Authority
GB
United Kingdom
Prior art keywords
lactones
hydroxy
prostaglandin amides
prostaglandin
amides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB787830629A
Other versions
GB2001636B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/819,940 external-priority patent/US4499293A/en
Priority claimed from US05/819,857 external-priority patent/US4158667A/en
Priority claimed from US05/819,856 external-priority patent/US4123441A/en
Priority claimed from US05/819,941 external-priority patent/US4124599A/en
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB2001636A publication Critical patent/GB2001636A/en
Application granted granted Critical
Publication of GB2001636B publication Critical patent/GB2001636B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Abstract

Pharmaceutically useful compounds are amido derivatives of known prostaglandins having a 6- oxo and a 9 alpha -hydroxy or hydroxymethyl group, and 6,9-lactones thereof, and a 6-hydroxy, 5-halo and 5,6-didehydro analogues of the lactones.
GB787830629A 1977-07-28 1978-07-21 Prostaglandin amides Expired GB2001636B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US05/819,940 US4499293A (en) 1976-09-22 1977-07-28 PGI2 Salts
US05/819,857 US4158667A (en) 1976-02-04 1977-07-28 6-Keto PGF analogs
US05/819,856 US4123441A (en) 1976-09-22 1977-07-28 Enlarged-hetero-ring prostacyclin analogs
US05/819,941 US4124599A (en) 1976-09-22 1977-07-28 Enlarged-hetero-ring prostacyclin analogs

Publications (2)

Publication Number Publication Date
GB2001636A true GB2001636A (en) 1979-02-07
GB2001636B GB2001636B (en) 1982-03-17

Family

ID=27505860

Family Applications (1)

Application Number Title Priority Date Filing Date
GB787830629A Expired GB2001636B (en) 1977-07-28 1978-07-21 Prostaglandin amides

Country Status (11)

Country Link
JP (1) JPS5427545A (en)
AU (1) AU527238B2 (en)
CH (1) CH639378A5 (en)
DE (1) DE2832372A1 (en)
FR (4) FR2408588A1 (en)
GB (1) GB2001636B (en)
IE (1) IE47284B1 (en)
IL (1) IL55097A0 (en)
IT (1) IT1098350B (en)
NL (1) NL7807543A (en)
SE (3) SE7808040L (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004335A2 (en) * 1978-03-18 1979-10-03 Hoechst Aktiengesellschaft Prostacyclin analogs, process and intermediates for their preparation and their use as medicines
US5185374A (en) * 1988-05-11 1993-02-09 K.K. Ueno Seiyaku Oyo Kenkyujo Use of 15-ketoprostaglandin E or F compounds for uterine contraction

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU524786B2 (en) * 1977-03-07 1982-10-07 The Upjohn Company Prostacyclins
IT1098350B (en) * 1977-07-28 1985-09-07 Upjohn Co PROSTAGLANDINIC DERIVATIVES
BR0212233A (en) * 2001-08-31 2004-10-05 Sucampo Ag Chloride Channel Opener

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351112A1 (en) * 1975-10-21 1977-12-09 Wellcome Found Prostaglandin derivs.
US4035642A (en) * 1976-08-20 1977-07-12 Rohm And Haas Company Gamma counter apparatus
AU511711B2 (en) * 1976-12-30 1980-09-04 Upjohn Company, The 6-Oxo and 5, 6-Dihalo prostaglandin analogues
AU524786B2 (en) * 1977-03-07 1982-10-07 The Upjohn Company Prostacyclins
IT1098350B (en) * 1977-07-28 1985-09-07 Upjohn Co PROSTAGLANDINIC DERIVATIVES
IT1088036B (en) * 1977-11-25 1985-06-04 Erba Carlo Spa 15-EPI-PROSTACYCLINE AND ANALOG PROSTACYCLINE

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004335A2 (en) * 1978-03-18 1979-10-03 Hoechst Aktiengesellschaft Prostacyclin analogs, process and intermediates for their preparation and their use as medicines
EP0004335A3 (en) * 1978-03-18 1979-11-28 Hoechst Aktiengesellschaft Prostacyclin analogs, process and intermediates for their preparation and their use as medicines
US5185374A (en) * 1988-05-11 1993-02-09 K.K. Ueno Seiyaku Oyo Kenkyujo Use of 15-ketoprostaglandin E or F compounds for uterine contraction

Also Published As

Publication number Publication date
FR2408588A1 (en) 1979-06-08
IT1098350B (en) 1985-09-07
SE8304218D0 (en) 1983-08-01
SE8304219L (en) 1983-08-01
IT7825225A0 (en) 1978-06-30
NL7807543A (en) 1979-01-30
IE47284B1 (en) 1984-02-08
FR2401921A1 (en) 1979-03-30
SE8304219D0 (en) 1983-08-01
FR2401919B1 (en) 1982-10-22
IE781522L (en) 1979-01-28
IL55097A0 (en) 1978-09-29
SE7808040L (en) 1979-01-29
JPS5427545A (en) 1979-03-01
AU527238B2 (en) 1983-02-24
CH639378A5 (en) 1983-11-15
AU3788278A (en) 1980-01-17
FR2401921B1 (en) 1982-10-22
GB2001636B (en) 1982-03-17
DE2832372A1 (en) 1979-02-08
FR2401920A1 (en) 1979-03-30
FR2401919A1 (en) 1979-03-30
FR2401920B1 (en) 1982-11-19
SE8304218L (en) 1983-08-01

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee