GB2000151A - Polypeptides - Google Patents

Polypeptides

Info

Publication number
GB2000151A
GB2000151A GB7827104A GB7827104A GB2000151A GB 2000151 A GB2000151 A GB 2000151A GB 7827104 A GB7827104 A GB 7827104A GB 7827104 A GB7827104 A GB 7827104A GB 2000151 A GB2000151 A GB 2000151A
Authority
GB
United Kingdom
Prior art keywords
chiral
polypeptides
carbon atoms
fragment
lipotropin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7827104A
Other versions
GB2000151B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB2000151A publication Critical patent/GB2000151A/en
Application granted granted Critical
Publication of GB2000151B publication Critical patent/GB2000151B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/675—Beta-endorphins
    • C07K14/6755—Beta-endorphins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Polypeptides having the general formula: H-Tyr-X-Z-Y in which: X represents a chiral residue of a D-amino acid selected from D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-histidine, D-proline, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-aspartic acid, D-asparagine, D-lysine, and D-arginine; Y represents a hydroxy, amino, lower alkylamino, dilower alkylamino in which the lower alkyl groups contain 1 to 6 carbon atoms or a lower alkoxy group containing 1 to 6 carbon atoms; Z represents a segment of a mammalian beta lipotropin chain, beginning at chiral fragment 63 and containing 1 to 29 chiral fragments with the proviso that Z is not beta -lipotropin fragment 63 to 65; pharmaceutically acceptable salts thereof, their preparation and pharmaceutical compositions containing said polypeptides.
GB7827104A 1977-06-16 1978-06-16 Polypeptides Expired GB2000151B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80712777A 1977-06-16 1977-06-16

Publications (2)

Publication Number Publication Date
GB2000151A true GB2000151A (en) 1979-01-04
GB2000151B GB2000151B (en) 1982-03-17

Family

ID=25195641

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7827104A Expired GB2000151B (en) 1977-06-16 1978-06-16 Polypeptides

Country Status (11)

Country Link
JP (1) JPS5470216A (en)
AU (1) AU3710778A (en)
BE (1) BE868218A (en)
DE (1) DE2826533A1 (en)
FR (1) FR2394521A1 (en)
GB (1) GB2000151B (en)
IL (1) IL54920A0 (en)
IT (1) IT1099555B (en)
MX (1) MX5770E (en)
NL (1) NL7806540A (en)
ZA (1) ZA783287B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004394A2 (en) * 1978-03-02 1979-10-03 Akzo N.V. Psychopharmacological peptides, process for their preparation and their pharmaceutical formulations

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4330465A (en) * 1978-03-02 1982-05-18 Hoffmann-La Roche Inc. Novel β-endorphin analogs
AU530062B2 (en) * 1979-02-21 1983-06-30 Akzo N.V. Psycho-pharmacological peptides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038222A (en) * 1976-03-17 1977-07-26 Hoffman-La Roche Inc. Untriakontapeptide with opiate activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004394A2 (en) * 1978-03-02 1979-10-03 Akzo N.V. Psychopharmacological peptides, process for their preparation and their pharmaceutical formulations
EP0004394A3 (en) * 1978-03-02 1979-10-31 Akzo N.V. Psychopharmacological peptides, process for their preparation and their pharmaceutical formulations

Also Published As

Publication number Publication date
AU3710778A (en) 1979-12-20
DE2826533A1 (en) 1979-01-11
IL54920A0 (en) 1978-08-31
GB2000151B (en) 1982-03-17
JPS5470216A (en) 1979-06-05
NL7806540A (en) 1978-12-19
BE868218A (en) 1978-10-16
MX5770E (en) 1984-07-06
ZA783287B (en) 1980-01-30
IT1099555B (en) 1985-09-18
IT7824664A0 (en) 1978-06-16
FR2394521A1 (en) 1979-01-12

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee