GB191210352A - Manufacture of New Derivatives of Phenyl-cinchoninic Acid and of Homologues and Derivatives thereof. - Google Patents

Manufacture of New Derivatives of Phenyl-cinchoninic Acid and of Homologues and Derivatives thereof.

Info

Publication number
GB191210352A
GB191210352A GB191210352DA GB191210352A GB 191210352 A GB191210352 A GB 191210352A GB 191210352D A GB191210352D A GB 191210352DA GB 191210352 A GB191210352 A GB 191210352A
Authority
GB
United Kingdom
Prior art keywords
derivatives
acid
homologues
alpha
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of GB191210352A publication Critical patent/GB191210352A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

10,352. Farbwerke vorm. Meister, Lucius, & Br³ning. Jan. 16, [Convention date]. Amides of arylcinchoninic acids are produced by the action of ammonia or of a primary or secondary aliphatic amine upon alpha - phenylcinchoninic acid chloride or homologues or derivatives thereof. In an example diethylamine is used. The products are useful in medicine. Arylcinchoninic acids and chlorides thereof.- Arylcinchoninic acids are prepared by treating aniline or its homologues or derivatives with pyroracemic acid and benzaldehyde or its derivatives, such as salicylaldehyde, or pmethoxy-, or m - ethoxy-benzaldehyde. They may also he prepared by treating isatin with aromatic ketones. The chloride of alpha-phenylcinchoninic acid is prepared by the action of thionyl chloride upon the acid. The chlorides of alpha-p-methoxyphenyl- and alpha-m-ethoxyphenylcinchoninic acids are stated to melt at 230‹ C. and 248‹ C. respectively.
GB191210352D 1912-01-16 1912-05-01 Manufacture of New Derivatives of Phenyl-cinchoninic Acid and of Homologues and Derivatives thereof. Expired GB191210352A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE191210352X 1912-01-16

Publications (1)

Publication Number Publication Date
GB191210352A true GB191210352A (en) 1913-05-01

Family

ID=32798588

Family Applications (2)

Application Number Title Priority Date Filing Date
GB191210352D Expired GB191210352A (en) 1912-01-16 1912-05-01 Manufacture of New Derivatives of Phenyl-cinchoninic Acid and of Homologues and Derivatives thereof.
GB191210443D Expired GB191210443A (en) 1912-01-16 1912-05-02 Manufacture of New Derivatives of Phenyl-Cinchoninic Acid and of Homologues and Derivatives thereof.

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB191210443D Expired GB191210443A (en) 1912-01-16 1912-05-02 Manufacture of New Derivatives of Phenyl-Cinchoninic Acid and of Homologues and Derivatives thereof.

Country Status (1)

Country Link
GB (2) GB191210352A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388A1 (en) * 1982-12-24 1984-06-29 Pharmuka Lab NOVEL NAPHTHALENE OR AZANAPHTALENECARBOXAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388A1 (en) * 1982-12-24 1984-06-29 Pharmuka Lab NOVEL NAPHTHALENE OR AZANAPHTALENECARBOXAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
EP0112776A2 (en) * 1982-12-24 1984-07-04 Rhone-Poulenc Sante Medicaments based on naphthalene or azanaphthalene carboxamides, naphtalene or azanaphthalene carboxamide derivatives and processes for their preparation
EP0112776A3 (en) * 1982-12-24 1984-09-12 Rhone-Poulenc Sante Medicaments based on naphthalene or azanaphthalene carboxamides, naphtalene or azanaphthalene carboxamide derivatives and processes for their preparation

Also Published As

Publication number Publication date
GB191210443A (en) 1913-05-02

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