GB1600280A - Control of lepidoptera and colorado beetle - Google Patents

Description

(54) CONTROL OF LEPIDOPTERA AND COLORADO BEETLE (71) We, SANDOZ LTD., of 35 Lichtstrasse, 4002 Basle, Switzerland, a Swiss Body Corporate, do hereby declare the invention, for which we pray that a patent may be granted to us, and the method by which it is to be performed, to be particularly described in and by the following statement: The present invention relates to a new pesticidal use of 5-dimethylamino-1,2,3trithiane.

Accordingly, the present invention provides a method of combating Colorado beetle (Leptinotarsa decemlineata) or lepidopterous pests in a locus which comprises treating said locus in the period between egg deposition and larval hatching with an ovicidally effective amount of 5dimethylamino-1,2,3-trithiane, in free base or agriculturally acceptable acid addition salt form.

By "agriculturally acceptable acid addition salt form" is meant those addition salts which are sufficiently stable and sufficiently non-toxic to mammals or plants to enable their agricultural use. Examples of such salts are the hydrogen oxalate, hydrochloride and p-toluene sulphonate. The preferred form is the hydrogen oxalate.

The method of the invention is particularly applicable to the combating of Colorado beetle in potato crops.

The method of the invention is also applicable to a wide variety of crops susceptible to infestation by lepidopterous pests.

The following is a list of crops with important lepidopterous pests in which the present method may be advantageously employed.

Cotton: Alabama argillacea, cotton leaf worm (N.

and S. America) Laphygma (Spodoptera) spp. army worms (America, Asia) Spodoptera littoralis, cotton leaf worm (Africa, Mediterranean regions) Prodenia ornithogalli, yellow striped army worm (U.S.A., Australia) Trichoplusia ni, cabbage looper (America) Diparopsis castanea, red bollworm (Africa) Earias insulana, Egyptian (spiny) bollworm (Africa) Heliothis armigera, cotton bollworm (Africa, Asia, Europe) Heliothis zea. cotton bollworm (N. and S.

America) virescens, tobacco bud worm (N.

Heliothis virescens, and S. America) Agrotis, Felthia, etc., cutworms (U.S.A.) Rice:- Tryporyza incertulas, paddy borer (Asia) Cello suppressalis, Rice stem borer (Asia) Cnaphalocrocis medinalis, paddy leaf roller (Asia) Fruit Trees: Apples: Leaf miners, e.g. Lyonetia clerkella (Europe, Japan) and Stigmella mallella (Europe, Japan) Laspeyresia pomonella, codling moth (worldwide) Peaches: Grapholitha molesta, oriental fruit moth (worldwide) Vegetables: Plutella xylostella, diamond-back moth (worldwide) Trichoplusia ni, cabbage looper (America) Pieris rapae, P. brassicae, imported cabbage worm Mamestra brassicae, cabbage moth Preferably, the locus is treated or first treated in the period between the first sign of egg deposition and the first sign of newly hatched eggs. The treatment may be repeated as long as egg deposition occurs, the frequency of treatment depending on the crop and the target pest, and may vary from 5 to 20 days between treatments.

If necessary, the treatment may be followed by larvicide and/or insecticide treatments after the hatching stage has elapsed, employing the same or other active agents.

The amount of active agent applied to the locus will vary, depending on such factors as the type of crop (when used for crop protection), the degree of infestation of the target pest and climatic conditions. In field treatment, however, in general, satisfactory results are obtained when employed at an active agent dosage of from 0.5 to 2 kg/ha, preferably, however, at about 1 kg/ha.

The active agent may be formulated in conventional manner and applied by means of conventional applicator equipment. For example, the active agent may be employed in the form of dusting powders of spraying liquors incorporating solid (e.g. talc, diatomaceous earth, bentonite or pumice) or liquid (e.g. water, alcohol or petroleum or tar distillates) carriers, as well as emulsifiers, wetting agents and other such additives.

Concentrate formulations may generally contain between 5 and 90% by weight of active agent and application forms between 0.1 and 20% by weight active agent.

Examples of formulations are as follows: a) 25 parts by weight of the active agent, 5 parts by weight of a condensation product from formaldehyde and naphthalene sulphonate, 2 parts by weight of ammonium caseinate and 62 parts by weight of diatomaceous earth are mixed until a homogenous mixture is obtained, then this is subsequently ground until the particles are considerably smaller than 45 microns as an average. Before application the powder is diluted with water to the desired concentration.

b) 25 parts by weight of an active agent of the invention are mixed with 25 parts by weight of an alkylphenolethylene oxide adduct (with approximately 10 moles of ethylene oxide) and 50 parts by weight of acetone. Before application the concentrate is diluted with water to the desired concentration.

The invention is illustrated by the following Examples.

Example 1 A cotton culture subject to severe infestation from the cotton bollworm (Heliothis zea) was sprayed with 5-dimethylamino1,2,3,-trithiane hydrogen oxalate at an approximate application rate of 1 kg of active agent per hectare. The active agent was formulated in accordance with example a) above and diluted before use with water to a concentration of 0.05% by weight active agent. The cotton was treated at the first sign of egg deposition, the treatment being repeated at 7 day intervals until egg deposition had substantially terminated. Comparison with an untreated cotton culture at cotton harvesting showed a significantly greater cotton yield in the treated crop.

Example 2 A potato culture subject to severe infestation from the Colorado beetle was sprayed with 5-dimethylamino-1 ,2,3-trithiane hydrogen oxalate at an approximate application rate of 1 kg of active agent per hectare. The active agent was formulated in accordance with Example a) above and diluted before use with water to a concentration of 0.05% by weight active agent. The culture was treated at the first sign of egg deposition, the treatment being repeated at 7 day intervals until egg deposition had substantially terminated. Comparison with an untreated potato culture at harvesting showed a significantly greater potato yield in the treated crop.

WHAT WE CLAIM IS: 1. A method of combating Colorado beetle (Leptinotarsa decemlineata) or lepidopterous pests in a locus which comprises treating said locus in the period between egg deposition and larval hatching with an ovi cm dally effective amount of 5 dimethylamino-1 ,2 ,3-triathiane, in free base or agriculturally acceptable acid addition salt form.

2. A method according to Claim 1 for the combating of Colorado beetle wherein the locus is a potato locus.

3. A method according to Claim 4 for the combating of lepidopterous pests wherein the locus is a cotton, rice, vegetable or fruit tree locus.

4. A method according to Claim 3 wherein the locus is a cotton locus.

5. A method according to Claim 1 substantially as described herein with reference to either of the Examples.

**WARNING** end of DESC field may overlap start of CLMS **.

Claims (5)

**WARNING** start of CLMS field may overlap end of DESC **. treated in the period between the first sign of egg deposition and the first sign of newly hatched eggs. The treatment may be repeated as long as egg deposition occurs, the frequency of treatment depending on the crop and the target pest, and may vary from 5 to 20 days between treatments. If necessary, the treatment may be followed by larvicide and/or insecticide treatments after the hatching stage has elapsed, employing the same or other active agents. The amount of active agent applied to the locus will vary, depending on such factors as the type of crop (when used for crop protection), the degree of infestation of the target pest and climatic conditions. In field treatment, however, in general, satisfactory results are obtained when employed at an active agent dosage of from 0.5 to 2 kg/ha, preferably, however, at about 1 kg/ha. The active agent may be formulated in conventional manner and applied by means of conventional applicator equipment. For example, the active agent may be employed in the form of dusting powders of spraying liquors incorporating solid (e.g. talc, diatomaceous earth, bentonite or pumice) or liquid (e.g. water, alcohol or petroleum or tar distillates) carriers, as well as emulsifiers, wetting agents and other such additives. Concentrate formulations may generally contain between 5 and 90% by weight of active agent and application forms between 0.1 and 20% by weight active agent. Examples of formulations are as follows: a) 25 parts by weight of the active agent, 5 parts by weight of a condensation product from formaldehyde and naphthalene sulphonate, 2 parts by weight of ammonium caseinate and 62 parts by weight of diatomaceous earth are mixed until a homogenous mixture is obtained, then this is subsequently ground until the particles are considerably smaller than 45 microns as an average. Before application the powder is diluted with water to the desired concentration. b) 25 parts by weight of an active agent of the invention are mixed with 25 parts by weight of an alkylphenolethylene oxide adduct (with approximately 10 moles of ethylene oxide) and 50 parts by weight of acetone. Before application the concentrate is diluted with water to the desired concentration. The invention is illustrated by the following Examples. Example 1 A cotton culture subject to severe infestation from the cotton bollworm (Heliothis zea) was sprayed with 5-dimethylamino1,2,3,-trithiane hydrogen oxalate at an approximate application rate of 1 kg of active agent per hectare. The active agent was formulated in accordance with example a) above and diluted before use with water to a concentration of 0.05% by weight active agent. The cotton was treated at the first sign of egg deposition, the treatment being repeated at 7 day intervals until egg deposition had substantially terminated. Comparison with an untreated cotton culture at cotton harvesting showed a significantly greater cotton yield in the treated crop. Example 2 A potato culture subject to severe infestation from the Colorado beetle was sprayed with 5-dimethylamino-1 ,2,3-trithiane hydrogen oxalate at an approximate application rate of 1 kg of active agent per hectare. The active agent was formulated in accordance with Example a) above and diluted before use with water to a concentration of 0.05% by weight active agent. The culture was treated at the first sign of egg deposition, the treatment being repeated at 7 day intervals until egg deposition had substantially terminated. Comparison with an untreated potato culture at harvesting showed a significantly greater potato yield in the treated crop. WHAT WE CLAIM IS:

1. A method of combating Colorado beetle (Leptinotarsa decemlineata) or lepidopterous pests in a locus which comprises treating said locus in the period between egg deposition and larval hatching with an ovi cm dally effective amount of 5 dimethylamino-1 ,2 ,3-triathiane, in free base or agriculturally acceptable acid addition salt form.

2. A method according to Claim 1 for the combating of Colorado beetle wherein the locus is a potato locus.

3. A method according to Claim 4 for the combating of lepidopterous pests wherein the locus is a cotton, rice, vegetable or fruit tree locus.

4. A method according to Claim 3 wherein the locus is a cotton locus.

5. A method according to Claim 1 substantially as described herein with reference to either of the Examples.