GB1589585A - 12a-halocorticoids - Google Patents

12a-halocorticoids Download PDF

Info

Publication number
GB1589585A
GB1589585A GB28994/77A GB2899477A GB1589585A GB 1589585 A GB1589585 A GB 1589585A GB 28994/77 A GB28994/77 A GB 28994/77A GB 2899477 A GB2899477 A GB 2899477A GB 1589585 A GB1589585 A GB 1589585A
Authority
GB
United Kingdom
Prior art keywords
compound
methyl
dione
general formula
pregnadiene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28994/77A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of GB1589585A publication Critical patent/GB1589585A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0023—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
    • C07J5/003—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
    • C07J5/0038—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes by an alkyl group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
GB28994/77A 1976-07-16 1977-07-11 12a-halocorticoids Expired GB1589585A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2632678A DE2632678C2 (de) 1976-07-16 1976-07-16 6α-Fluor-12α-Halogen-Kortikoide und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
GB1589585A true GB1589585A (en) 1981-05-13

Family

ID=5983515

Family Applications (1)

Application Number Title Priority Date Filing Date
GB28994/77A Expired GB1589585A (en) 1976-07-16 1977-07-11 12a-halocorticoids

Country Status (11)

Country Link
JP (1) JPS5315361A (enExample)
AT (1) AT355743B (enExample)
BE (1) BE856862A (enExample)
CH (1) CH627191A5 (enExample)
DE (1) DE2632678C2 (enExample)
DK (1) DK323877A (enExample)
FR (1) FR2358421A1 (enExample)
GB (1) GB1589585A (enExample)
IT (1) IT1125789B (enExample)
LU (1) LU77768A1 (enExample)
NL (1) NL7707920A (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2244000A (en) * 1990-05-18 1991-11-20 Teasdale S Mattress
US9744168B2 (en) 2011-10-19 2017-08-29 Galderma Laboratories, Inc. Method of reducing facial flushing associated with systemic use of phosphodiesterase type 5 inhibitors
US9861632B2 (en) 2010-03-26 2018-01-09 Galderma Laboratories, L.P. Methods and compositions for safe and effective treatment of erythema

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3053837A (en) * 1958-10-01 1962-09-11 Olin Mathieson 16, 17-acetal and ketal derivatives of 6alpha, 12alpha-dihalo-16alpha, 17alpha-dihydroxy steroids of the pregnane series; and intermediates therefor
GB1179547A (en) * 1965-12-22 1970-01-28 Squibb & Sons Inc 01beta,12beta-Oxido-16alpha-Methyl-Pregnenes

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2244000A (en) * 1990-05-18 1991-11-20 Teasdale S Mattress
US9861632B2 (en) 2010-03-26 2018-01-09 Galderma Laboratories, L.P. Methods and compositions for safe and effective treatment of erythema
US9861631B2 (en) 2010-03-26 2018-01-09 Galderma Laboratories, L.P. Methods and compositions for safe and effective treatment of erythema
US9744168B2 (en) 2011-10-19 2017-08-29 Galderma Laboratories, Inc. Method of reducing facial flushing associated with systemic use of phosphodiesterase type 5 inhibitors

Also Published As

Publication number Publication date
ATA504777A (de) 1979-08-15
DE2632678A1 (de) 1978-01-26
LU77768A1 (enExample) 1977-10-17
NL7707920A (nl) 1978-01-18
FR2358421A1 (fr) 1978-02-10
JPS5315361A (en) 1978-02-13
BE856862A (fr) 1978-01-16
DK323877A (da) 1978-01-17
AT355743B (de) 1980-03-25
CH627191A5 (en) 1981-12-31
IT1125789B (it) 1986-05-14
FR2358421B1 (enExample) 1979-05-11
DE2632678C2 (de) 1986-02-27

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee