GB1567997A - Biologically active tetracyclic compounds and pharmaceutical compositions containing same - Google Patents

Biologically active tetracyclic compounds and pharmaceutical compositions containing same Download PDF

Info

Publication number
GB1567997A
GB1567997A GB38887/77A GB3888777A GB1567997A GB 1567997 A GB1567997 A GB 1567997A GB 38887/77 A GB38887/77 A GB 38887/77A GB 3888777 A GB3888777 A GB 3888777A GB 1567997 A GB1567997 A GB 1567997A
Authority
GB
United Kingdom
Prior art keywords
acid
methyl
hexahydro
compound
melting point
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB38887/77A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of GB1567997A publication Critical patent/GB1567997A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GB38887/77A 1976-10-02 1977-09-19 Biologically active tetracyclic compounds and pharmaceutical compositions containing same Expired GB1567997A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7610942A NL7610942A (nl) 1976-10-02 1976-10-02 Werkwijze voor het bereiden van 1,4-diazepine derivaten.

Publications (1)

Publication Number Publication Date
GB1567997A true GB1567997A (en) 1980-05-21

Family

ID=19826997

Family Applications (1)

Application Number Title Priority Date Filing Date
GB38887/77A Expired GB1567997A (en) 1976-10-02 1977-09-19 Biologically active tetracyclic compounds and pharmaceutical compositions containing same

Country Status (17)

Country Link
US (1) US4224321A (enExample)
JP (1) JPS5359697A (enExample)
AU (1) AU511572B2 (enExample)
BE (1) BE859279A (enExample)
CA (1) CA1082183A (enExample)
DE (1) DE2744179A1 (enExample)
DK (1) DK142582B (enExample)
ES (1) ES462838A1 (enExample)
FI (1) FI772872A7 (enExample)
FR (1) FR2366292A1 (enExample)
GB (1) GB1567997A (enExample)
HU (1) HU177404B (enExample)
IE (1) IE45587B1 (enExample)
LU (1) LU78208A1 (enExample)
NL (1) NL7610942A (enExample)
SE (1) SE7710958L (enExample)
ZA (1) ZA775472B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008125577A1 (en) * 2007-04-11 2008-10-23 N.V. Organon A method for the preparation of an enantiomerically pure benzazepine
US7994314B2 (en) 2007-04-11 2011-08-09 N.V. Organon Method for the preparation of an enantiomerically pure benzazepine

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0618643A2 (pt) 2005-11-09 2011-09-06 Combinatorx Inc composição compreendendo um par de fármacos, composição compreendendo um corticosteróide e um imunossupressor dependente de imunofilina não-esteróide, kits e uso

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL129434C (enExample) * 1966-03-12
NL6806701A (enExample) * 1967-05-19 1968-11-20
US3465042A (en) * 1967-07-26 1969-09-02 Sandoz Ag Substituted 2-nitrobenzophenones
NL176458C (nl) * 1972-09-23 1985-04-16 Akzo Nv Werkwijze ter bereiding van een farmaceutisch preparaat en werkwijze voor de bereiding van daartoe geschikte actieve stoffen.

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008125577A1 (en) * 2007-04-11 2008-10-23 N.V. Organon A method for the preparation of an enantiomerically pure benzazepine
US7994314B2 (en) 2007-04-11 2011-08-09 N.V. Organon Method for the preparation of an enantiomerically pure benzazepine
EP2133350A3 (en) * 2007-04-11 2013-09-04 Merck Sharp & Dohme B.V. A method for the preparation of an enantiomerically pure benzazepine
CN101679420B (zh) * 2007-04-11 2014-05-14 默沙东有限责任公司 一种制备对映体纯的苯并氮杂*的方法

Also Published As

Publication number Publication date
HU177404B (en) 1981-10-28
DK142582B (da) 1980-11-24
CA1082183A (en) 1980-07-22
FR2366292B1 (enExample) 1980-04-11
NL7610942A (nl) 1978-04-04
US4224321A (en) 1980-09-23
FI772872A7 (fi) 1978-04-03
AU511572B2 (en) 1980-08-28
ES462838A1 (es) 1978-06-01
AU2883877A (en) 1979-03-22
FR2366292A1 (fr) 1978-04-28
BE859279A (fr) 1978-03-30
DK424277A (enExample) 1978-04-03
LU78208A1 (enExample) 1978-01-23
JPS5359697A (en) 1978-05-29
IE45587L (en) 1978-04-02
SE7710958L (sv) 1978-04-03
DK142582C (enExample) 1981-07-27
DE2744179A1 (de) 1978-04-06
IE45587B1 (en) 1982-10-06
ZA775472B (en) 1978-07-26

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee