GB1567561A - Amino-spiro(oxa-(orthia)cycloalkane-penam) - carboxylic acids - Google Patents

Amino-spiro(oxa-(orthia)cycloalkane-penam) - carboxylic acids Download PDF

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Publication number
GB1567561A
GB1567561A GB1905/77A GB190577A GB1567561A GB 1567561 A GB1567561 A GB 1567561A GB 1905/77 A GB1905/77 A GB 1905/77A GB 190577 A GB190577 A GB 190577A GB 1567561 A GB1567561 A GB 1567561A
Authority
GB
United Kingdom
Prior art keywords
amino
general formula
thia
benzyl
oxa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1905/77A
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English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Priority to GB1905/77A priority Critical patent/GB1567561A/en
Priority to NO780110A priority patent/NO780110L/no
Priority to SE7800367A priority patent/SE7800367L/xx
Priority to NL7800397A priority patent/NL7800397A/xx
Priority to DK15678A priority patent/DK15678A/da
Priority to FI780088A priority patent/FI780088A/fi
Priority to US05/869,859 priority patent/US4137236A/en
Priority to IT47658/78A priority patent/IT1103123B/it
Priority to IL53825A priority patent/IL53825A/xx
Priority to ZA00780304A priority patent/ZA78304B/xx
Priority to AT32078A priority patent/AT355721B/de
Priority to ES466053A priority patent/ES466053A1/es
Priority to FR7801578A priority patent/FR2377408A1/fr
Priority to AU32495/78A priority patent/AU512338B2/en
Priority to PT67537A priority patent/PT67537B/pt
Priority to CA295,109A priority patent/CA1101411A/en
Priority to BE1008646A priority patent/BE862972A/xx
Priority to HU78UE86A priority patent/HU173788B/hu
Priority to CH44878A priority patent/CH634324A5/fr
Priority to YU00085/78A priority patent/YU8578A/xx
Priority to DE19782801849 priority patent/DE2801849A1/de
Priority to LU78885A priority patent/LU78885A1/xx
Priority to JP366678A priority patent/JPS5390290A/ja
Priority to DD78203268A priority patent/DD135284A5/xx
Priority to PL20406678A priority patent/PL204066A1/xx
Priority to SU782566653A priority patent/SU786902A3/ru
Publication of GB1567561A publication Critical patent/GB1567561A/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D305/08—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/20—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hydrogen atoms and substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D331/00—Heterocyclic compounds containing rings of less than five members, having one sulfur atom as the only ring hetero atom
    • C07D331/04—Four-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
GB1905/77A 1977-01-18 1977-01-18 Amino-spiro(oxa-(orthia)cycloalkane-penam) - carboxylic acids Expired GB1567561A (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
GB1905/77A GB1567561A (en) 1977-01-18 1977-01-18 Amino-spiro(oxa-(orthia)cycloalkane-penam) - carboxylic acids
NO780110A NO780110L (no) 1977-01-18 1978-01-12 Amino-spiro(oxa(eller thia)cycloalkan-penam)-carboxylsyrer for anvendelse som utgangsmaterialer ved fremstilling av antibiotika
SE7800367A SE7800367L (sv) 1977-01-18 1978-01-12 Amino-spiro-(oxa(eller tia)-cykloalkan-penam)-karboxylsyror till anvendning som mellanprodukter for framstellning av nya antibiotika samt sett for framstellning av mellanprodukterna
NL7800397A NL7800397A (nl) 1977-01-18 1978-01-12 Amino-spiro (oxa(of thia)cycloalkaanpenam)-car- bonzuren en werkwijze voor de bereiding daarvan.
DK15678A DK15678A (da) 1977-01-18 1978-01-12 Fremgangsmaade til fremstilling af amino-spiro(oxa (eller thia) cycloalkan-penam)-carboxylsyrer eller salte eller estere deraf
FI780088A FI780088A (fi) 1977-01-18 1978-01-12 Aminospiro(oxa (eller thia) cykloalkanpenam)-karboxylsyror
US05/869,859 US4137236A (en) 1977-01-18 1978-01-16 Amino-spiro[oxa(or thia)cycloalkane-penam]-carboxylic
IT47658/78A IT1103123B (it) 1977-01-18 1978-01-17 Acidi ammino-spiro(ossa o tia cicloalcan-penam)-carbossilici e procedimento per la loro produzione ed applicazione
IL53825A IL53825A (en) 1977-01-18 1978-01-17 Amino-spiro(oxa(or thia)cycloalkane-penam)-carboxylic acids and their preparation
ZA00780304A ZA78304B (en) 1977-01-18 1978-01-17 Amino-spiro(oxa(or thia)cyclo-alkanepenam)-carboxylic acides
AT32078A AT355721B (de) 1977-01-18 1978-01-17 Verfahren zur herstellung von neuen amino-spiro (oxa(oder thia)-cycloalkan-penam)- carbonsaeuren sowie von deren salzen und estern
ES466053A ES466053A1 (es) 1977-01-18 1978-01-17 Un procedimiento de preparacion de acidos amino-espiro(oxa- (0 tia)cicloalcanopenam)-carboxilicos.
FR7801578A FR2377408A1 (fr) 1977-01-18 1978-01-17 Acides amino-spiro(oxa (ou thia)cycloalcane-penam)-carboxylique
AU32495/78A AU512338B2 (en) 1977-01-18 1978-01-17 Amino-spiro( oxa (or thia) cycloalkane-penam)- carboxylic acids
PT67537A PT67537B (fr) 1977-01-18 1978-01-17 Acides amino-spiro /oxa (ou tia)cicloalcane-penam/-carboxyliques
CA295,109A CA1101411A (en) 1977-01-18 1978-01-17 Amino-spiro ¬oxa(or thia) cycloalkane-penam|- carboxylic acids
BE1008646A BE862972A (fr) 1977-01-18 1978-01-17 Acides amino-spiro(oxa(ou thia)cycloalcane-penam)-carboxyliques
HU78UE86A HU173788B (hu) 1977-01-18 1978-01-17 Sposob poluchenija proizvodnykh 6-amino-2-spiro/oksa-/ ili/tia/ - cikloalkil-penam-3-karbonovoj kisloty
CH44878A CH634324A5 (fr) 1977-01-18 1978-01-17 Acides amino-spiro(oxa(ou thia)cycloalcane-penam)-carboxyliques.
YU00085/78A YU8578A (en) 1977-01-18 1978-01-17 Process for obtaining new amino-spiro-(oxa(or thia)cycloalkane-penam)carboxylic acids and esters thereof
DE19782801849 DE2801849A1 (de) 1977-01-18 1978-01-17 Amino-spiro eckige klammer auf oxa- (oder thia-)-cycloalkan-penam eckige klammer zu -carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung
LU78885A LU78885A1 (fr) 1977-01-18 1978-01-17 Procede de preparation d'acides amino-spiro(oxa(ou thia)cycloalcane-penam)-carboxylique
JP366678A JPS5390290A (en) 1977-01-18 1978-01-17 Aminoospiro*oxa or thia*cycloalkanee penum*carboxylates
DD78203268A DD135284A5 (de) 1977-01-18 1978-01-17 Verfahren zur herstellung von amino-spiro eckige klammer auf oxa(oder thia)zykloalkan-penam eckige klammer zu-karboxylsaeuren
PL20406678A PL204066A1 (pl) 1977-01-18 1978-01-18 Sposob wytwarzania kwasow amino-spiro(oksa/lub tia/cykloalkanopenamo)karboksylowych
SU782566653A SU786902A3 (ru) 1977-01-18 1978-01-18 Способ получени 6-амино-2,3,5,6-тетрагидро-спиро /пенам-2,4-(4н)(тио)пиран/-3карбоновой кислоты или ее сложного эфира

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1905/77A GB1567561A (en) 1977-01-18 1977-01-18 Amino-spiro(oxa-(orthia)cycloalkane-penam) - carboxylic acids

Publications (1)

Publication Number Publication Date
GB1567561A true GB1567561A (en) 1980-05-14

Family

ID=9730099

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1905/77A Expired GB1567561A (en) 1977-01-18 1977-01-18 Amino-spiro(oxa-(orthia)cycloalkane-penam) - carboxylic acids

Country Status (26)

Country Link
US (1) US4137236A (US20100223739A1-20100909-C00005.png)
JP (1) JPS5390290A (US20100223739A1-20100909-C00005.png)
AT (1) AT355721B (US20100223739A1-20100909-C00005.png)
AU (1) AU512338B2 (US20100223739A1-20100909-C00005.png)
BE (1) BE862972A (US20100223739A1-20100909-C00005.png)
CA (1) CA1101411A (US20100223739A1-20100909-C00005.png)
CH (1) CH634324A5 (US20100223739A1-20100909-C00005.png)
DD (1) DD135284A5 (US20100223739A1-20100909-C00005.png)
DE (1) DE2801849A1 (US20100223739A1-20100909-C00005.png)
DK (1) DK15678A (US20100223739A1-20100909-C00005.png)
ES (1) ES466053A1 (US20100223739A1-20100909-C00005.png)
FI (1) FI780088A (US20100223739A1-20100909-C00005.png)
FR (1) FR2377408A1 (US20100223739A1-20100909-C00005.png)
GB (1) GB1567561A (US20100223739A1-20100909-C00005.png)
HU (1) HU173788B (US20100223739A1-20100909-C00005.png)
IL (1) IL53825A (US20100223739A1-20100909-C00005.png)
IT (1) IT1103123B (US20100223739A1-20100909-C00005.png)
LU (1) LU78885A1 (US20100223739A1-20100909-C00005.png)
NL (1) NL7800397A (US20100223739A1-20100909-C00005.png)
NO (1) NO780110L (US20100223739A1-20100909-C00005.png)
PL (1) PL204066A1 (US20100223739A1-20100909-C00005.png)
PT (1) PT67537B (US20100223739A1-20100909-C00005.png)
SE (1) SE7800367L (US20100223739A1-20100909-C00005.png)
SU (1) SU786902A3 (US20100223739A1-20100909-C00005.png)
YU (1) YU8578A (US20100223739A1-20100909-C00005.png)
ZA (1) ZA78304B (US20100223739A1-20100909-C00005.png)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2052496B (en) * 1979-06-25 1983-06-29 Ucb Sa 6 - amino - spiro - (penam - 2,4' - piperidine) - 3 - carboxylic acid derivatives
GB2052497B (en) * 1979-06-25 1983-06-29 Ucb Sa 6 - amino - spiro - (penam - 2,4' - piperidine) - 3 - carboxylic acid derivatives
ES2147162B1 (es) 1999-01-27 2001-03-16 Lacer Sa "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias".
EP1939179A1 (en) 2006-12-28 2008-07-02 Lacer, S.A. Stable S-nitrosothiols, method of synthesis and use
EP2601940A1 (en) 2011-12-05 2013-06-12 Lacer, S.A. (4-mercapto-piperidin-4-yl)-aminoacetic acid derivatives, pharmaceutical compositions and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3047467A (en) * 1957-08-02 1962-07-31 Beecham Res Lab Process for the preparation of penicillins
US3129217A (en) * 1959-08-19 1964-04-14 Beecham Group Ltd Derivatives of 6-(9-anthramido) penicillanic acid
US3134767A (en) * 1960-04-20 1964-05-26 Beecham Group Ltd Synthetic penicillin
US3210337A (en) * 1962-09-21 1965-10-05 Smith Kline French Lab 6-(benzofurylcarboxamido)- and 6-(thianaphthenylcarboxamido)-penicillanic acid derivatives

Also Published As

Publication number Publication date
IL53825A (en) 1981-01-30
YU8578A (en) 1983-04-30
DE2801849A1 (de) 1978-07-20
AT355721B (de) 1980-03-25
PT67537A (fr) 1978-02-01
JPS5390290A (en) 1978-08-08
LU78885A1 (fr) 1978-09-18
SU786902A3 (ru) 1980-12-07
NO780110L (no) 1978-07-19
PL204066A1 (pl) 1979-04-09
PT67537B (fr) 1979-06-15
CA1101411A (en) 1981-05-19
IT1103123B (it) 1985-10-14
ES466053A1 (es) 1978-10-01
US4137236A (en) 1979-01-30
HU173788B (hu) 1979-08-28
AU3249578A (en) 1979-07-26
AU512338B2 (en) 1980-10-02
ATA32078A (de) 1979-08-15
DK15678A (da) 1978-07-19
IL53825A0 (en) 1978-04-30
FR2377408B1 (US20100223739A1-20100909-C00005.png) 1980-04-18
BE862972A (fr) 1978-07-17
DD135284A5 (de) 1979-04-25
FR2377408A1 (fr) 1978-08-11
ZA78304B (en) 1978-12-27
SE7800367L (sv) 1978-07-19
NL7800397A (nl) 1978-07-20
FI780088A (fi) 1978-07-19
CH634324A5 (fr) 1983-01-31
IT7847658A0 (it) 1978-01-17

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee