GB1552498A - Intermediates in the preparation of 13,14-didehydro - 16 fluoroprostaglandins - Google Patents

Intermediates in the preparation of 13,14-didehydro - 16 fluoroprostaglandins

Info

Publication number
GB1552498A
GB1552498A GB289/78A GB28978A GB1552498A GB 1552498 A GB1552498 A GB 1552498A GB 289/78 A GB289/78 A GB 289/78A GB 28978 A GB28978 A GB 28978A GB 1552498 A GB1552498 A GB 1552498A
Authority
GB
United Kingdom
Prior art keywords
fluoroprostaglandins
didehydro
intermediates
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB289/78A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Chicago
Original Assignee
University of Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Chicago filed Critical University of Chicago
Publication of GB1552498A publication Critical patent/GB1552498A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/42—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing triple carbon-to-carbon bonds, e.g. with metal-alkynes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB289/78A 1975-09-10 1976-09-03 Intermediates in the preparation of 13,14-didehydro - 16 fluoroprostaglandins Expired GB1552498A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61185575A 1975-09-10 1975-09-10

Publications (1)

Publication Number Publication Date
GB1552498A true GB1552498A (en) 1979-09-12

Family

ID=24450658

Family Applications (4)

Application Number Title Priority Date Filing Date
GB36570/76A Expired GB1552497A (en) 1975-09-10 1976-09-03 1314 - didehydro 16-fluoroprostaglandis
GB289/78A Expired GB1552498A (en) 1975-09-10 1976-09-03 Intermediates in the preparation of 13,14-didehydro - 16 fluoroprostaglandins
GB291/78A Expired GB1552500A (en) 1975-09-10 1976-09-03 Aluminium acetylides
GB290/78A Expired GB1552499A (en) 1975-09-10 1976-09-03 Intermediates in the preparation of 1314-didehydro - 16 -fluoroprostaglandins

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB36570/76A Expired GB1552497A (en) 1975-09-10 1976-09-03 1314 - didehydro 16-fluoroprostaglandis

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB291/78A Expired GB1552500A (en) 1975-09-10 1976-09-03 Aluminium acetylides
GB290/78A Expired GB1552499A (en) 1975-09-10 1976-09-03 Intermediates in the preparation of 1314-didehydro - 16 -fluoroprostaglandins

Country Status (8)

Country Link
JP (1) JPS5248643A (en)
AU (1) AU1722176A (en)
BE (1) BE846080A (en)
DE (1) DE2640487A1 (en)
ES (1) ES451093A1 (en)
FR (1) FR2323379A1 (en)
GB (4) GB1552497A (en)
ZA (1) ZA765031B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA77160B (en) * 1976-02-13 1977-11-30 Upjohn Co Prostaglandin analogs
IL51877A (en) * 1976-06-01 1981-09-13 Carlo Erba Sa -nor-16-benzyl or phenoxy-13,14-dehydro-prostaglandins and process for their preparation

Also Published As

Publication number Publication date
BE846080A (en) 1977-03-10
GB1552497A (en) 1979-09-12
AU1722176A (en) 1978-03-02
GB1552500A (en) 1979-09-12
ZA765031B (en) 1977-10-26
JPS5248643A (en) 1977-04-18
GB1552499A (en) 1979-09-12
FR2323379A1 (en) 1977-04-08
DE2640487A1 (en) 1977-04-14
ES451093A1 (en) 1977-09-01

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