GB1548741A - Heterogenous specific binding assay method and test systemfor use therein - Google Patents

Heterogenous specific binding assay method and test systemfor use therein

Info

Publication number
GB1548741A
GB1548741A GB16609/76A GB1660976A GB1548741A GB 1548741 A GB1548741 A GB 1548741A GB 16609/76 A GB16609/76 A GB 16609/76A GB 1660976 A GB1660976 A GB 1660976A GB 1548741 A GB1548741 A GB 1548741A
Authority
GB
United Kingdom
Prior art keywords
specific binding
bound
labelling
liquid medium
conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB16609/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of GB1548741A publication Critical patent/GB1548741A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

A test process operating using a specific bond for the investigation of a liquid medium on a ligand is described. The test process comprises the following steps: (a) the liquid medium is brought into contact with a reagent which contains a conjugate of a labelling substance which has a predetermined characteristic and a specific binding substance, the reagent and the ligand forming a binding reaction system which (i) forms a bound phase of the labelling conjugate, in which the specific binding fraction is bound thereto by a specific binding component, and (ii) forms a free phase of the labelling conjugate, in which the specific binding fraction is not bound thereto by a specific binding component, (b) determination of the said characteristics either in the bound phase or in the free phase as a measure of the said ligands in the said liquid medium. The said characteristic of the labelling substance proves to be active in the following reaction systems: (1) as a substrate in an enzyme-catalysed reaction, (2) as a reactant in a cyclic reaction system, (3) as a reactant in a chemiluminescent reaction system, or (4) as a coenzyme in an enzyme-catalysed reaction.
GB16609/76A 1975-04-28 1976-04-23 Heterogenous specific binding assay method and test systemfor use therein Expired GB1548741A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57200875A 1975-04-28 1975-04-28

Publications (1)

Publication Number Publication Date
GB1548741A true GB1548741A (en) 1979-07-18

Family

ID=24285954

Family Applications (2)

Application Number Title Priority Date Filing Date
GB16610/76A Expired GB1552607A (en) 1975-04-28 1976-04-23 Homogenous specific binding assay method and test system for use therein
GB16609/76A Expired GB1548741A (en) 1975-04-28 1976-04-23 Heterogenous specific binding assay method and test systemfor use therein

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB16610/76A Expired GB1552607A (en) 1975-04-28 1976-04-23 Homogenous specific binding assay method and test system for use therein

Country Status (23)

Country Link
JP (6) JPS604939B2 (en)
AT (1) AT357685B (en)
AU (2) AU502726B2 (en)
BE (1) BE841179A (en)
BR (1) BR7602561A (en)
CA (2) CA1078712A (en)
CH (1) CH635438A5 (en)
DD (1) DD125231A5 (en)
DE (3) DE2660548C2 (en)
DK (3) DK149969C (en)
ES (1) ES447378A1 (en)
FI (1) FI68324C (en)
FR (1) FR2332533A1 (en)
GB (2) GB1552607A (en)
HU (1) HU179542B (en)
IE (1) IE42544B1 (en)
IL (1) IL49354A (en)
IN (1) IN142734B (en)
IT (1) IT1064132B (en)
LU (1) LU74834A1 (en)
NL (1) NL181281C (en)
SE (3) SE440280B (en)
ZA (1) ZA762030B (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4259232A (en) * 1979-10-23 1981-03-31 Miles Laboratories, Inc. Flavin adenine dinucleotide-labeled protein and polypeptide conjugates
EP0027036A1 (en) * 1979-10-03 1981-04-15 Colin Henry Self Assay method using enzymes as labeling substances
EP0049606A1 (en) * 1980-10-02 1982-04-14 Colin Henry Self Detection method, use and diagnostic aid
US4446231A (en) * 1979-10-03 1984-05-01 Self Colin H Immunoassay using an amplified cyclic detection system
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4946958A (en) * 1981-12-11 1990-08-07 The Welsh National School Of Medicine Chemiluminescent acridinium labelling compounds
US5783696A (en) * 1988-02-20 1998-07-21 Hoechst Aktiengesellschaft Special chemiluminescent acridine derivatives
US6380377B1 (en) 2000-07-14 2002-04-30 Applied Gene Technologies, Inc. Nucleic acid hairpin probes and uses thereof
US6596490B2 (en) 2000-07-14 2003-07-22 Applied Gene Technologies, Inc. Nucleic acid hairpin probes and uses thereof
US7064197B1 (en) 1983-01-27 2006-06-20 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. System, array and non-porous solid support comprising fixed or immobilized nucleic acids
US7718362B2 (en) 2003-06-30 2010-05-18 Capitalbio Corporation DNA chip based genetic typing

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51668A (en) 1977-03-16 1981-12-31 Israel State Analytical method for the quantitative determination of immunogens and antibodies and a kit therefor
SE7811630L (en) * 1977-11-17 1979-05-18 Welsh Nat School Med METHOD OF DETECTION OR QUANTITATION OF SUBSTANCES USING LABELING TECHNIQUES
USRE34394E (en) * 1978-01-23 1993-09-28 Baxter Diagnostics Inc. Method and composition for double receptor, specific binding assays
AU531777B2 (en) * 1978-04-05 1983-09-08 Syva Co. Label/solid conjugate immunoassay system
US4233402A (en) * 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
FR2422956A1 (en) * 1978-04-13 1979-11-09 Pasteur Institut METHOD OF DETECTION AND CHARACTERIZATION OF A NUCLEIC ACID OR OF A SEQUENCE OF THE SAME, AND ENZYMATIC REAGENT FOR THE IMPLEMENTATION OF THIS PROCESS
US5605800A (en) * 1978-04-13 1997-02-25 Institut Pasteur Method of detecting and characterizing a nucleic acid or a sequence of the latter, and enzymatic reactant for the application of this method
IL57570A (en) * 1978-06-22 1982-07-30 Miles Lab Method and reagent for specific binding assay with a prosthetic group as a label component
IL57571A (en) * 1978-06-22 1983-03-31 Miles Lab Flavin adenine dinucleotide-labeled conjugates and their use in a homogeneous immunoassay method for determining haptens
US4334069A (en) * 1978-07-24 1982-06-08 Miles Laboratories, Inc. Chemiluminescent phthalhydrazide-labeled hapten conjugates
US4225485A (en) * 1978-07-24 1980-09-30 Miles Laboratories, Inc. Chemiluminescent naphthalene-1,2-dicarboxylic acid hydrazide-labeled polypeptides and proteins
US4228237A (en) * 1978-09-21 1980-10-14 Calbiochem-Behring Corp. Methods for the detection and determination of ligands
US4288538A (en) 1979-01-31 1981-09-08 Baxter Travenol Laboratories, Inc. Test method and composition therefor
US4273866A (en) * 1979-02-05 1981-06-16 Abbott Laboratories Ligand analog-irreversible enzyme inhibitor conjugates and methods for use
AT367796B (en) * 1979-10-29 1982-07-26 List Hans METHOD FOR DETERMINING A SUBSTANCE CONCENTRATION IN A SOLUTION
EP0040224A4 (en) * 1979-11-19 1982-09-09 Prince Charles Hospital Dev Ct An improved method of non homogenous enzyme immunoassay.
US4299916A (en) * 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
DK256581A (en) * 1980-06-13 1981-12-14 Nat Res Dev BINDING ASSAY
CA1183450A (en) * 1980-10-30 1985-03-05 Alfred C. Greenquist Homogeneous specific binding assay device and method
US4404278A (en) * 1980-11-24 1983-09-13 Syva Company Methods and compositions for assaying for the production of 1,4-dihydropyridyl
US4378458A (en) * 1981-03-30 1983-03-29 Baker Instruments Corporation Novel chromogenic and/or fluorogenic substrates for monitoring catalytic or enzymatic activity
US4366243A (en) 1981-04-17 1982-12-28 Miles Laboratories, Inc. Stabilization of glucose oxidase apoenzyme
ATE48140T1 (en) * 1981-04-17 1989-12-15 Univ Yale MODIFIED NUCLEOTIDES AND PROCESSES FOR THEIR PRODUCTION AND USE.
CA1219824A (en) * 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
JPS5818167A (en) * 1981-07-24 1983-02-02 Fuji Photo Film Co Ltd Analyzing film and analysis using said film
JPS5877843U (en) * 1981-11-20 1983-05-26 株式会社三協精機製作所 tape recorder
FR2519005B1 (en) * 1981-12-29 1985-10-25 Pasteur Institut DNA FRAGMENTS MARKED WITH AT LEAST ONE OF THEIR ENDS ENDANGERED BY MODIFIED RIBONUCLEOTIDES RECOGNIZABLE BY AFFINOUS MOLECULES AND METHOD FOR CARRYING OUT ANALYSIS OF SUCH DNA FRAGMENTS
FR2519004B1 (en) * 1981-12-29 1985-09-27 Pasteur Institut MODIFIED ADENOSINE 5'-TRIPHOSPHORIC ACID AND METHOD FOR DETERMINING BIOLOGICAL SUBSTANCES LIKELY TO FIX ADENOSINE 5'-TRIPHOSPHORIC ACID DEGRADATION PRODUCTS
US5650270A (en) * 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
US4709016A (en) * 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
IL67289A (en) * 1982-03-18 1985-12-31 Miles Lab Homogeneous immunoassay with labeled monoclonal anti-analyte
CA1223831A (en) * 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4495281A (en) * 1982-10-21 1985-01-22 Miles Laboratories, Inc. Tricyclic antidepressant drug immunogens, antibodies, labeled conjugates, and related derivatives
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
EP0201211A1 (en) * 1985-04-10 1986-11-12 Whittaker Corporation Method and compositions for visual solid phase immunoassays based on luminescent microspheric particles
JPS61271457A (en) * 1985-05-28 1986-12-01 Olympus Optical Co Ltd Immunological analysis
JPH06100599B2 (en) * 1985-06-27 1994-12-12 東亜医用電子株式会社 How to measure body fluid components
JPS6321559A (en) * 1986-07-16 1988-01-29 Matsushita Electric Ind Co Ltd Enzyme immunoassay for hapten
DE3844954C2 (en) * 1988-02-20 1998-07-16 Hoechst Ag Special chemiluminescent acridine derivatives and their use in luminescent immunoassays
JP2525678B2 (en) * 1989-10-03 1996-08-21 富士写真フイルム株式会社 Immunoassay device
US7732153B2 (en) 2006-05-09 2010-06-08 Beckman Coulter, Inc. Nonseparation assay methods
US7799534B2 (en) 2006-05-09 2010-09-21 Beckman Coulter, Inc. Nonseparation assay methods
JP6214449B2 (en) * 2014-03-31 2017-10-18 シスメックス株式会社 Method for measuring kinase activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (en) * 1971-02-10 1977-09-15 Organon Nv METHOD FOR THE DETERMINATION AND DETERMINATION OF SPECIFIC BINDING PROTEINS AND THEIR CORRESPONDING BINDABLE SUBSTANCES.
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3880934A (en) * 1972-02-10 1975-04-29 Syntex Inc Nitrophenyloxy-butanediols
JPS5147347A (en) * 1974-10-21 1976-04-22 Nippon Electric Co JOHOSHORISOCHI
JPS5147348A (en) * 1974-10-21 1976-04-22 Nippon Electric Co JOHOSHORISOCHI

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769321A (en) * 1979-10-03 1988-09-06 Self Colin H Assay method and reagent therefor
EP0027036A1 (en) * 1979-10-03 1981-04-15 Colin Henry Self Assay method using enzymes as labeling substances
WO1981001057A1 (en) * 1979-10-03 1981-04-16 C Self Assay method using enzymes as labelling substances
US4446231A (en) * 1979-10-03 1984-05-01 Self Colin H Immunoassay using an amplified cyclic detection system
US4595655A (en) * 1979-10-03 1986-06-17 Self Colin H Assay method and reagent therefor
US4598042A (en) * 1979-10-03 1986-07-01 Self Colin H Immunoassay with an increasing cyclic detection system
US4259232A (en) * 1979-10-23 1981-03-31 Miles Laboratories, Inc. Flavin adenine dinucleotide-labeled protein and polypeptide conjugates
EP0049606A1 (en) * 1980-10-02 1982-04-14 Colin Henry Self Detection method, use and diagnostic aid
US5328824A (en) * 1981-04-17 1994-07-12 Yale University Methods of using labeled nucleotides
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US5449767A (en) * 1981-04-17 1995-09-12 Yale University Modified polynucleotides and methods of preparing same
US5476928A (en) * 1981-04-17 1995-12-19 Yale University Modified nucleotides and polynucleotides and complexes form therefrom
US4946958A (en) * 1981-12-11 1990-08-07 The Welsh National School Of Medicine Chemiluminescent acridinium labelling compounds
US7064197B1 (en) 1983-01-27 2006-06-20 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. System, array and non-porous solid support comprising fixed or immobilized nucleic acids
US5783696A (en) * 1988-02-20 1998-07-21 Hoechst Aktiengesellschaft Special chemiluminescent acridine derivatives
US6002007A (en) * 1988-02-20 1999-12-14 Dade Behring Marburg Gmbh Special chemiluminescent acridine derivatives and the use thereof in luminescence immunoassays
US6380377B1 (en) 2000-07-14 2002-04-30 Applied Gene Technologies, Inc. Nucleic acid hairpin probes and uses thereof
US6596490B2 (en) 2000-07-14 2003-07-22 Applied Gene Technologies, Inc. Nucleic acid hairpin probes and uses thereof
US6696255B2 (en) 2000-07-14 2004-02-24 Applied Gene Technologies, Inc. Nucleic acid hairpin probes and uses thereof
US7718362B2 (en) 2003-06-30 2010-05-18 Capitalbio Corporation DNA chip based genetic typing

Also Published As

Publication number Publication date
AU1335276A (en) 1977-11-03
DK189176A (en) 1976-10-29
DK576181A (en) 1981-12-23
JPH0137693B2 (en) 1989-08-09
DK158366C (en) 1990-10-01
DK158366B (en) 1990-05-07
AT357685B (en) 1980-07-25
LU74834A1 (en) 1977-01-12
CA1082577A (en) 1980-07-29
NL181281C (en) 1987-07-16
JPH0137694B2 (en) 1989-08-09
JPS51146295A (en) 1976-12-15
AU1335376A (en) 1977-11-03
NL181281B (en) 1987-02-16
DE2660548C2 (en) 1984-04-12
IN142734B (en) 1977-08-20
IE42544L (en) 1976-10-28
SE447510B (en) 1986-11-17
DE2618511C3 (en) 1981-05-07
DE2618419C2 (en) 1983-02-10
DK150808C (en) 1988-02-15
JPS5951354A (en) 1984-03-24
SE7604841L (en) 1976-10-29
DD125231A5 (en) 1977-04-06
GB1552607A (en) 1979-09-19
FR2332533A1 (en) 1977-06-17
AU502726B2 (en) 1979-08-09
ZA762030B (en) 1977-08-31
JPS5942454A (en) 1984-03-09
CA1078712A (en) 1980-06-03
NL7604420A (en) 1976-11-01
SE451895B (en) 1987-11-02
DK149969B (en) 1986-11-03
JPS5951353A (en) 1984-03-24
DE2618511B2 (en) 1980-08-14
IE42544B1 (en) 1980-08-27
BR7602561A (en) 1976-11-23
FR2332533B1 (en) 1981-12-18
BE841179A (en) 1976-08-16
FI761148A (en) 1976-10-29
SE8007396L (en) 1980-10-21
DE2618419A1 (en) 1976-11-04
DK576281A (en) 1981-12-23
SE440280B (en) 1985-07-22
JPS5942453A (en) 1984-03-09
DK150808B (en) 1987-06-22
CH635438A5 (en) 1983-03-31
JPH0145026B2 (en) 1989-10-02
SE8007397L (en) 1980-10-21
IL49354A0 (en) 1976-06-30
IT1064132B (en) 1985-02-18
ES447378A1 (en) 1977-11-01
JPS5267388A (en) 1977-06-03
AU509182B2 (en) 1980-04-24
IL49354A (en) 1979-03-12
HU179542B (en) 1982-11-29
FI68324B (en) 1985-04-30
JPH0145027B2 (en) 1989-10-02
ATA309376A (en) 1979-12-15
DK149969C (en) 1988-08-01
JPS604939B2 (en) 1985-02-07
DE2618511A1 (en) 1976-11-04
FI68324C (en) 1985-08-12
JPS6052378B2 (en) 1985-11-19

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee