GB1542749A - N,n-dimethyl-aminoalkyl-3',4'-dihalo-anilides methods for their preparation and compositions containing them - Google Patents

N,n-dimethyl-aminoalkyl-3',4'-dihalo-anilides methods for their preparation and compositions containing them

Info

Publication number
GB1542749A
GB1542749A GB7746751A GB4675177A GB1542749A GB 1542749 A GB1542749 A GB 1542749A GB 7746751 A GB7746751 A GB 7746751A GB 4675177 A GB4675177 A GB 4675177A GB 1542749 A GB1542749 A GB 1542749A
Authority
GB
United Kingdom
Prior art keywords
formula
anilides
groups
image
chain consisting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7746751A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1542749A publication Critical patent/GB1542749A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel halogen-substituted anilides of the formula III <IMAGE> and salts thereof, are prepared by acylating a corresponding aniline of the formula II <IMAGE> In the anilides of the formula III, A denotes a straight chain consisting of 2-5 CH2 groups or a group of the formula <IMAGE> X is bromine or chlorine, and R denotes ethyl, vinyl or cyclopropyl. The starting materials of the formula II in which A possesses another meaning than a chain consisting of 4 or 5 CH2 groups are prepared by an appropriate N-alkylation of a dihaloaniline, and those starting materials of the formula II in which A represents a chain consisting of 4 or 5 CH2 groups are produced by reducing an appropriate acid dimethylamide. The compounds of the formula III and their salts may be employed as active compounds in agents possessing antidepressant activity.
GB7746751A 1976-12-02 1977-11-10 N,n-dimethyl-aminoalkyl-3',4'-dihalo-anilides methods for their preparation and compositions containing them Expired GB1542749A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74686376A 1976-12-02 1976-12-02

Publications (1)

Publication Number Publication Date
GB1542749A true GB1542749A (en) 1979-03-21

Family

ID=25002691

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7746751A Expired GB1542749A (en) 1976-12-02 1977-11-10 N,n-dimethyl-aminoalkyl-3',4'-dihalo-anilides methods for their preparation and compositions containing them

Country Status (9)

Country Link
JP (1) JPS5371024A (en)
AU (1) AU509345B2 (en)
BE (1) BE861455A (en)
CH (1) CH636596A5 (en)
DE (1) DE2751905A1 (en)
FR (1) FR2372796A1 (en)
GB (1) GB1542749A (en)
NL (1) NL7713204A (en)
SE (2) SE441445B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0345733Y2 (en) * 1987-12-04 1991-09-26
JPH0345734Y2 (en) * 1987-12-04 1991-09-26

Also Published As

Publication number Publication date
DE2751905A1 (en) 1978-06-08
BE861455A (en) 1978-06-02
SE8304187L (en) 1983-07-28
DE2751905C2 (en) 1987-06-11
CH636596A5 (en) 1983-06-15
FR2372796B1 (en) 1980-08-22
NL7713204A (en) 1978-06-06
FR2372796A1 (en) 1978-06-30
AU509345B2 (en) 1980-05-08
AU3037677A (en) 1979-05-17
JPS6220182B2 (en) 1987-05-06
SE7713442L (en) 1978-06-03
SE8304187D0 (en) 1983-07-28
SE441445B (en) 1985-10-07
JPS5371024A (en) 1978-06-24

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee