GB1541100A - Preparation and use of a protein-bound polyurethane foam - Google Patents

Preparation and use of a protein-bound polyurethane foam

Info

Publication number
GB1541100A
GB1541100A GB15115/76A GB1511576A GB1541100A GB 1541100 A GB1541100 A GB 1541100A GB 15115/76 A GB15115/76 A GB 15115/76A GB 1511576 A GB1511576 A GB 1511576A GB 1541100 A GB1541100 A GB 1541100A
Authority
GB
United Kingdom
Prior art keywords
protein
foam
antibody
water
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB15115/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WR Grace and Co
Original Assignee
WR Grace and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WR Grace and Co filed Critical WR Grace and Co
Publication of GB1541100A publication Critical patent/GB1541100A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/093—Polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/64—Macromolecular compounds not provided for by groups C08G18/42 - C08G18/63
    • C08G18/6415—Macromolecular compounds not provided for by groups C08G18/42 - C08G18/63 having nitrogen
    • C08G18/6446—Proteins and derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C13—SUGAR INDUSTRY
    • C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
    • C13K1/00—Glucose; Glucose-containing syrups
    • C13K1/06—Glucose; Glucose-containing syrups obtained by saccharification of starch or raw materials containing starch
    • C—CHEMISTRY; METALLURGY
    • C13—SUGAR INDUSTRY
    • C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
    • C13K11/00—Fructose

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

In order to prepare the foam containing bonded protein, first, in the absence of water, a solution of the protein in liquid polyurethane prepolymer containing terminal isocyanate groups is prepared, and the resultant solution is then foamed by admixing water. The resultant foam contains from 0.1 to 50% by weight of the added, active protein preparation on a water-free (anhydrous) basis. It has a hydrophillic poly(urea-urethane) foam matrix. The protein employed can be an enzyme, an antibody or an antigen. The foam with the immobilised protein can be used for carrying out various biological reactions. For example, the foam can contain, as antibody, the bonded hepatitis antibody and can be used to separate the hepatitis antigen from human blood. By correspondingly immobilising the immunoglobulin G, the rheumatic arthritis factor can also be removed from human blood.
GB15115/76A 1975-06-10 1976-04-13 Preparation and use of a protein-bound polyurethane foam Expired GB1541100A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58567475A 1975-06-10 1975-06-10
US66098276A 1976-02-24 1976-02-24

Publications (1)

Publication Number Publication Date
GB1541100A true GB1541100A (en) 1979-02-21

Family

ID=27079467

Family Applications (1)

Application Number Title Priority Date Filing Date
GB15115/76A Expired GB1541100A (en) 1975-06-10 1976-04-13 Preparation and use of a protein-bound polyurethane foam

Country Status (9)

Country Link
JP (1) JPS5917733B2 (en)
AT (1) AT347028B (en)
CA (1) CA1076027A (en)
CH (1) CH639673A5 (en)
DE (1) DE2612138C2 (en)
FR (1) FR2314194B1 (en)
GB (1) GB1541100A (en)
MX (1) MX4074E (en)
NL (1) NL7603951A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393166A (en) 1979-05-21 1983-07-12 Bayer Aktiengesellschaft Process for the preparation of polyaddition products of isocyanates and denatured biomasses, their use as reactive fillers and as plant nutrients and a process for the production of sheets or shaped articles using the polyaddition products
US4764467A (en) * 1982-06-18 1988-08-16 Basf Aktiengeselschaft, Preparation of an insoluble biocatalyst

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226935A (en) * 1978-08-07 1980-10-07 W. R. Grace & Co. Enzymatic diagnostic composition
CA1178909A (en) * 1980-09-17 1984-12-04 Murray C. Fusee Process for production of l-alanine using immobilized microorganisms
US4732851A (en) * 1982-03-16 1988-03-22 Purification Engineering, Inc. Immobilization of cells with a polyazetidine prepolymer
JPS61198235U (en) * 1985-05-27 1986-12-11
US5549891A (en) * 1994-04-05 1996-08-27 Allergan Method for disinfecting contact lens with catalase compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1227855B (en) * 1960-07-12 1966-11-03 Ichthyol Ges Process for the production of enzyme bodies for the implementation of enzymatic reactions
US3672955A (en) * 1970-05-20 1972-06-27 Us Agriculture Preparation of an insoluble active enzyme
CA1042600A (en) * 1972-05-03 1978-11-14 Louis L. Wood Crosslinked hydrophilic polyurethane foams
DE2413137A1 (en) * 1974-03-19 1975-10-16 Boehringer Mannheim Gmbh Enzymatically active polyurethane foam - produced by adding conc. enzyme soln. to mix before forming, giving high activity

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393166A (en) 1979-05-21 1983-07-12 Bayer Aktiengesellschaft Process for the preparation of polyaddition products of isocyanates and denatured biomasses, their use as reactive fillers and as plant nutrients and a process for the production of sheets or shaped articles using the polyaddition products
US4454259A (en) * 1979-05-21 1984-06-12 Bayer Aktiengesellschaft Process for the preparation of polyaddition products of isocyanates and denatured biomasses, their use as reactive fillers and as plant nutrients and a process for the production of sheets or shaped articles using the polyaddition products
US4764467A (en) * 1982-06-18 1988-08-16 Basf Aktiengeselschaft, Preparation of an insoluble biocatalyst

Also Published As

Publication number Publication date
ATA280376A (en) 1978-04-15
DE2612138A1 (en) 1976-12-30
CA1076027A (en) 1980-04-22
NL7603951A (en) 1976-12-14
JPS5917733B2 (en) 1984-04-23
FR2314194B1 (en) 1981-09-25
CH639673A5 (en) 1983-11-30
AT347028B (en) 1978-12-11
FR2314194A1 (en) 1977-01-07
DE2612138C2 (en) 1986-09-11
JPS51150600A (en) 1976-12-24
MX4074E (en) 1981-12-02

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19940413