GB1538097A - Substituted phenyl-amidines - Google Patents

Substituted phenyl-amidines

Info

Publication number
GB1538097A
GB1538097A GB2895/76A GB289576A GB1538097A GB 1538097 A GB1538097 A GB 1538097A GB 2895/76 A GB2895/76 A GB 2895/76A GB 289576 A GB289576 A GB 289576A GB 1538097 A GB1538097 A GB 1538097A
Authority
GB
United Kingdom
Prior art keywords
amidines
substituted phenyl
phenyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2895/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Priority to GB2895/76A priority Critical patent/GB1538097A/en
Priority to CH27377A priority patent/CH620901A5/fr
Priority to IE110/77A priority patent/IE44416B1/en
Priority to DE2702119A priority patent/DE2702119C2/de
Priority to FR7701595A priority patent/FR2338927A1/fr
Priority to ES455294A priority patent/ES455294A1/es
Priority to CA270,277A priority patent/CA1074797A/en
Priority to DK30277A priority patent/DK30277A/da
Priority to US05/762,774 priority patent/US4146647A/en
Priority to BE174356A priority patent/BE850723A/xx
Priority to SE7700777A priority patent/SE440501B/xx
Priority to LU76641A priority patent/LU76641A1/xx
Priority to NLAANVRAGE7700806,A priority patent/NL188573C/xx
Priority to JP52007602A priority patent/JPS5953895B2/ja
Priority to FR7804019A priority patent/FR2380256A2/fr
Publication of GB1538097A publication Critical patent/GB1538097A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30Oxygen or sulfur atoms
    • C07D233/42Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB2895/76A 1976-01-26 1976-01-26 Substituted phenyl-amidines Expired GB1538097A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
GB2895/76A GB1538097A (en) 1976-01-26 1976-01-26 Substituted phenyl-amidines
CH27377A CH620901A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-01-26 1977-01-11
IE110/77A IE44416B1 (en) 1976-01-26 1977-01-20 Substituted phenyl amidines
DE2702119A DE2702119C2 (de) 1976-01-26 1977-01-20 Substituierte Anilinoacetamidoxim-Derivate und diese enthaltende Arzneimittel
FR7701595A FR2338927A1 (fr) 1976-01-26 1977-01-20 Phenyl-amidines substituees
ES455294A ES455294A1 (es) 1976-01-26 1977-01-24 Un procedimiento de preparacion de una fenilamidina sustituida.
CA270,277A CA1074797A (en) 1976-01-26 1977-01-24 Process for the preparation of substituted phenyl-amidines
DK30277A DK30277A (da) 1976-01-26 1977-01-25 Fremgangsmade til fremstilling af substituerede phenylamidiner
US05/762,774 US4146647A (en) 1976-01-26 1977-01-25 Substituted phenyl-amidines
BE174356A BE850723A (fr) 1976-01-26 1977-01-25 Phenyl-amidines substituees
SE7700777A SE440501B (sv) 1976-01-26 1977-01-25 Forfarande for framstellning av substituerade fenylamidoximer
LU76641A LU76641A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-01-26 1977-01-25
NLAANVRAGE7700806,A NL188573C (nl) 1976-01-26 1977-01-26 Werkwijze voor de bereiding van een farmaceutisch preparaat met hypotensieve werking en werkwijze voor de bereiding van gesubstitueerde anilinoaceetamidoximen.
JP52007602A JPS5953895B2 (ja) 1976-01-26 1977-01-26 置換アニリノ−アセトアミドオキシム誘導体
FR7804019A FR2380256A2 (fr) 1976-01-26 1978-02-13 Derives de phenyl-amidines utiles notamment en therapeutique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2895/76A GB1538097A (en) 1976-01-26 1976-01-26 Substituted phenyl-amidines

Publications (1)

Publication Number Publication Date
GB1538097A true GB1538097A (en) 1979-01-10

Family

ID=9748048

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2895/76A Expired GB1538097A (en) 1976-01-26 1976-01-26 Substituted phenyl-amidines

Country Status (14)

Country Link
US (1) US4146647A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5953895B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE850723A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1074797A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH620901A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2702119C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK30277A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES455294A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2338927A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1538097A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE44416B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU76641A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL188573C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE440501B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2804576A1 (de) * 1977-02-15 1978-08-17 Lafon Labor Phenylamidin-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE2961710D1 (en) * 1978-10-09 1982-02-18 Ciba Geigy Ag 2-(alpha-phenoxy-alkyl)-imidazolines and their salts, their preparation and use, and agents against phytoparasitic and zooparasitic mites containing them
DE2961996D1 (en) * 1978-11-03 1982-03-11 Bayer Ag N-alkyl-haloacetanilides substituted by an oxime group, processes for their preparation, herbicidal compositions containing them, a process for combating weeds, a process for preparing herbicidal compositions.
US4260626A (en) * 1979-03-26 1981-04-07 Richardson-Merrell Inc. Tetrahydro and imidazoline antisecretory compounds
US4616085A (en) * 1980-06-19 1986-10-07 Petrolite Corporation Thioethers of imidazolines
FR2506764A1 (fr) * 1981-05-26 1982-12-03 Synthelabo Derives d'amidoximes, leur preparation et leur application en therapeutique
US5227484A (en) * 1982-01-14 1993-07-13 Merck Patent Gmbh Anisotropic compounds having nematic phase and liquid crystal mixtures
FR2549049B1 (fr) * 1983-07-13 1986-06-20 Chauvin Blache Lab Nouvelles amidines, leur procede de preparation et leur application therapeutique
US4659363A (en) * 1983-07-25 1987-04-21 Ciba-Geigy Corporation N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof
GB9509930D0 (en) * 1995-05-17 1995-07-12 Smithkline Beecham Corp Method for preparing certain acetonitriles
KR20080080410A (ko) * 2006-01-27 2008-09-03 에프. 호프만-라 로슈 아게 이미다졸린 유도체의 치환된 2-이미다졸의 용도
RU2009112495A (ru) * 2006-10-19 2010-11-27 Ф. Хоффманн-Ля Рош Аг (Ch) Аминометил-2-имидазолы со сродством к рецепторам, ассоциированным со следовыми аминами
EP2076497B1 (en) * 2006-10-19 2012-02-22 F. Hoffmann-La Roche AG Aminomethyl-4-imidazoles
ATE533755T1 (de) * 2006-11-02 2011-12-15 Hoffmann La Roche Substituierte 2-imidazole als modulatoren der mit spurenaminen assoziierten rezeptoren
AU2007321376A1 (en) * 2006-11-16 2008-05-22 F. Hoffmann-La Roche Ag Substituted 4-imidazoles
BRPI0720047A2 (pt) * 2006-12-13 2013-12-24 Hoffmann La Roche 2-imidazóis como ligantes para receptores associados a aminas de traço (taar)
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
CN101600700B (zh) * 2007-02-02 2013-08-21 弗·哈夫曼-拉罗切有限公司 作为taar1配体用于cns病症的新的2-氨基噁唑啉
EP2121641B1 (en) * 2007-02-15 2014-09-24 F. Hoffmann-La Roche AG 2-aminooxazolines as taar1 ligands
JP2010531837A (ja) 2007-07-02 2010-09-30 エフ.ホフマン−ラ ロシュ アーゲー 微量アミン関連レセプター(taar)に対して良好な親和性を有する2−イミダゾリン
CA2691704A1 (en) * 2007-07-03 2009-01-08 F. Hoffmann-La Roche Ag 4-imidazolines and their use as antidepressants
AU2008281918A1 (en) * 2007-07-27 2009-02-05 F. Hoffmann-La Roche Ag 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as TAAR-ligands
AU2008281877A1 (en) * 2007-08-02 2009-02-05 F. Hoffmann-La Roche Ag The use of benzamide derivatives for the treatment of CNS disorders
CA2695331A1 (en) * 2007-08-03 2009-02-12 F. Hoffmann-La Roche Ag Pyridinecarboxamide and benzamide derivatives as taar1 ligands
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
KR101307007B1 (ko) * 2008-07-24 2013-09-11 에프. 호프만-라 로슈 아게 4,5-다이하이드로-옥사졸-2-일 유도체
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) * 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
JPWO2013137371A1 (ja) * 2012-03-15 2015-08-03 興和株式会社 新規ピリミジン化合物及びそれらを含有する医薬
PE20181446A1 (es) 2016-03-17 2018-09-12 Hoffmann La Roche Derivados de 5-etil-4-metil-pirazol-3-carboxamida con actividad como de taar

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE598730A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1960-01-01
US3115525A (en) * 1960-04-21 1963-12-24 Wassermann S P A Soc It Per Sp Halogen-substituted amidoximes
US3394181A (en) * 1964-06-29 1968-07-23 Sterling Drug Inc Phenoxy-lower-alkyl-amidoximes and phenylamino-lower-alkyl-amidoximes
US3445517A (en) * 1966-06-03 1969-05-20 Lilly Co Eli Aryl acetamidines
FR2036958A6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1969-04-23 1970-12-31 Orsymonde
FR2149264B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1971-08-13 1974-09-06 Orsymonde
US3775478A (en) * 1972-05-30 1973-11-27 Dow Chemical Co Substituted phenylthioamidines
FR2207706B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1972-11-24 1975-11-28 Orsymonde
US3939912A (en) * 1975-03-21 1976-02-24 Continental Oil Company Method for reducing the production of water from oil wells

Also Published As

Publication number Publication date
JPS52105131A (en) 1977-09-03
CA1074797A (en) 1980-04-01
IE44416L (en) 1977-07-26
FR2338927A1 (fr) 1977-08-19
IE44416B1 (en) 1981-11-18
US4146647A (en) 1979-03-27
FR2338927B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-10-10
ES455294A1 (es) 1978-01-01
NL188573C (nl) 1992-08-03
BE850723A (fr) 1977-05-16
DE2702119A1 (de) 1977-07-28
SE7700777L (sv) 1977-07-27
CH620901A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-12-31
LU76641A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1977-06-24
NL7700806A (nl) 1977-07-28
DE2702119C2 (de) 1986-07-10
SE440501B (sv) 1985-08-05
DK30277A (da) 1977-07-27
JPS5953895B2 (ja) 1984-12-27

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
746 Register noted 'licences of right' (sect. 46/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930126