GB1536153A - Alkylated derivatives of antibiotic bm123 - Google Patents
Alkylated derivatives of antibiotic bm123Info
- Publication number
- GB1536153A GB1536153A GB50093/75A GB5009375A GB1536153A GB 1536153 A GB1536153 A GB 1536153A GB 50093/75 A GB50093/75 A GB 50093/75A GB 5009375 A GB5009375 A GB 5009375A GB 1536153 A GB1536153 A GB 1536153A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino group
- alkylation
- aldehydes
- ketones
- gamma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Reductive alkylation with aldehydes R1-CHO or ketones R2-CO-R3 results in alkylation of the antibiotics BM 123 gamma 1, gamma 2 or mixtures thereof at the terminal primary amino group. With ketones there is single N-alkylation, while with aldehydes the primary amino group is substituted once or twice, depending on the amount of reagents, and the proximal secondary amino group on the side chain can likewise be alkylated. The meanings of R1, R2 and R3 are to be found in Claim 1. The resulting derivatives have a potent antibacterial action; they can be used for the treatment of infectious diseases.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52986274A | 1974-12-05 | 1974-12-05 | |
| US61297575A | 1975-09-12 | 1975-09-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1536153A true GB1536153A (en) | 1978-12-20 |
Family
ID=27063126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB50093/75A Expired GB1536153A (en) | 1974-12-05 | 1975-12-05 | Alkylated derivatives of antibiotic bm123 |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS51125279A (en) |
| AR (1) | AR215581A1 (en) |
| BG (1) | BG26404A3 (en) |
| CA (1) | CA1072547A (en) |
| CH (1) | CH626895A5 (en) |
| DD (1) | DD124602A5 (en) |
| DE (1) | DE2553927C3 (en) |
| DK (1) | DK547975A (en) |
| EG (1) | EG12248A (en) |
| FI (1) | FI753415A (en) |
| FR (1) | FR2293212A1 (en) |
| GB (1) | GB1536153A (en) |
| GR (1) | GR58534B (en) |
| HK (1) | HK80779A (en) |
| HU (1) | HU177070B (en) |
| IE (2) | IE42455B1 (en) |
| IL (1) | IL48476A (en) |
| LU (1) | LU73930A1 (en) |
| NL (1) | NL165469C (en) |
| NO (1) | NO754011L (en) |
| NZ (1) | NZ179276A (en) |
| RO (1) | RO74426B (en) |
| SE (1) | SE7513707L (en) |
| YU (1) | YU304975A (en) |
| ZM (1) | ZM16475A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1087537A (en) * | 1975-08-21 | 1980-10-14 | John H. E. J. Martin | Antibiotic bm123 and production thereof |
| US4112219A (en) * | 1977-07-13 | 1978-09-05 | American Cyanamid Company | Acyl derivatives of antibiotic BM123γ |
-
1975
- 1975-11-14 IL IL48476A patent/IL48476A/en unknown
- 1975-11-18 NZ NZ179276A patent/NZ179276A/en unknown
- 1975-11-25 GR GR49451A patent/GR58534B/en unknown
- 1975-11-26 CA CA240,497A patent/CA1072547A/en not_active Expired
- 1975-11-27 AR AR261375A patent/AR215581A1/en active
- 1975-11-27 NO NO754011A patent/NO754011L/no unknown
- 1975-11-27 ZM ZM164/75A patent/ZM16475A1/en unknown
- 1975-12-01 DE DE2553927A patent/DE2553927C3/en not_active Expired
- 1975-12-03 LU LU73930A patent/LU73930A1/xx unknown
- 1975-12-03 RO RO84081A patent/RO74426B/en unknown
- 1975-12-03 YU YU03049/75A patent/YU304975A/en unknown
- 1975-12-04 DK DK547975A patent/DK547975A/en not_active Application Discontinuation
- 1975-12-04 HU HU75AE456A patent/HU177070B/en unknown
- 1975-12-04 SE SE7513707A patent/SE7513707L/en not_active Application Discontinuation
- 1975-12-04 FR FR7537174A patent/FR2293212A1/en active Granted
- 1975-12-04 CH CH1581275A patent/CH626895A5/en not_active IP Right Cessation
- 1975-12-04 FI FI753415A patent/FI753415A/fi not_active Application Discontinuation
- 1975-12-05 JP JP50144097A patent/JPS51125279A/en active Pending
- 1975-12-05 NL NL7514234.A patent/NL165469C/en not_active IP Right Cessation
- 1975-12-05 BG BG7531708A patent/BG26404A3/xx unknown
- 1975-12-05 IE IE2651/75A patent/IE42455B1/en unknown
- 1975-12-05 GB GB50093/75A patent/GB1536153A/en not_active Expired
- 1975-12-05 DD DD189912A patent/DD124602A5/xx unknown
- 1975-12-05 IE IE1836/76A patent/IE44567B1/en unknown
- 1975-12-06 EG EG75719A patent/EG12248A/en active
-
1979
- 1979-11-22 HK HK807/79A patent/HK80779A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO74426B (en) | 1983-04-30 |
| NL165469B (en) | 1980-11-17 |
| AU8659675A (en) | 1977-06-02 |
| IL48476A0 (en) | 1976-01-30 |
| DE2553927A1 (en) | 1976-06-16 |
| CH626895A5 (en) | 1981-12-15 |
| IL48476A (en) | 1980-12-31 |
| GR58534B (en) | 1977-10-31 |
| IE44567B1 (en) | 1982-01-13 |
| ZM16475A1 (en) | 1977-03-21 |
| AR215581A1 (en) | 1979-10-31 |
| DE2553927B2 (en) | 1979-10-18 |
| DD124602A5 (en) | 1977-03-02 |
| DK547975A (en) | 1976-06-06 |
| NL7514234A (en) | 1976-06-09 |
| FR2293212A1 (en) | 1976-07-02 |
| FR2293212B1 (en) | 1980-06-27 |
| CA1072547A (en) | 1980-02-26 |
| IE42455B1 (en) | 1980-08-13 |
| JPS51125279A (en) | 1976-11-01 |
| DE2553927C3 (en) | 1980-07-03 |
| NZ179276A (en) | 1978-06-20 |
| SE7513707L (en) | 1976-06-08 |
| BG26404A3 (en) | 1979-03-15 |
| EG12248A (en) | 1978-12-31 |
| NO754011L (en) | 1976-06-09 |
| NL165469C (en) | 1981-04-15 |
| RO74426A (en) | 1983-04-29 |
| HK80779A (en) | 1979-11-30 |
| LU73930A1 (en) | 1976-07-01 |
| HU177070B (en) | 1981-07-28 |
| IE42455L (en) | 1976-06-05 |
| YU304975A (en) | 1982-05-31 |
| FI753415A (en) | 1976-06-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |