GB1525434A - Anti-inflammatory thiophene derivatives - Google Patents
Anti-inflammatory thiophene derivativesInfo
- Publication number
- GB1525434A GB1525434A GB31852/76A GB3185276A GB1525434A GB 1525434 A GB1525434 A GB 1525434A GB 31852/76 A GB31852/76 A GB 31852/76A GB 3185276 A GB3185276 A GB 3185276A GB 1525434 A GB1525434 A GB 1525434A
- Authority
- GB
- United Kingdom
- Prior art keywords
- inflammatory
- formula
- thiophene derivatives
- compounds
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Rheumatology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
The compounds of the formula I are obtained by reacting a compound of the formula VI with an acylating derivative of a thienylcarboxylic acid or by reacting thiophene with an acylating derivative of an acid of the formula VII. The compounds which are obtained exhibit an antiinflammatory effect and, in contrast to the acidic antiinflammatory agents, exhibit less tendency to cause gastrointestinal irritations. <IMAGE>
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA283,755A CA1078400A (en) | 1976-07-30 | 1976-07-29 | Anti-inflammatory compounds |
GB31852/76A GB1525434A (en) | 1976-07-30 | 1976-07-30 | Anti-inflammatory thiophene derivatives |
IL52503A IL52503A (en) | 1976-07-30 | 1977-07-11 | 4-(thienoyl)phenyl alkanone derivatives,their preparation and pharmaceutical compositions containing them |
ZA00774222A ZA774222B (en) | 1976-07-30 | 1977-07-14 | Anti-inflammatory compounds |
NL7708062A NL7708062A (en) | 1976-07-30 | 1977-07-20 | METHOD FOR PREPARING NEW THIOPHENE DERIVATIVES WITH ANTI-INFLAMMATORY ACTION, AND DOSED PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS. |
BE179615A BE857128A (en) | 1976-07-30 | 1977-07-25 | NEW THIOPHENE DERIVATIVES |
FR7722739A FR2359837A1 (en) | 1976-07-30 | 1977-07-25 | NEW THIOPHENE DERIVATIVES WITH ANTI-INFLAMMATORY ACTIVITY |
CH919577A CH636613A5 (en) | 1976-07-30 | 1977-07-25 | Process for preparing thiophene derivatives |
ES461037A ES461037A1 (en) | 1976-07-30 | 1977-07-26 | Anti-inflammatory thiophene derivatives |
SE7708591A SE7708591L (en) | 1976-07-30 | 1977-07-26 | ASSOCIATIONS WITH ANTI-INFLAMMATORY EFFECT |
DE19772733683 DE2733683A1 (en) | 1976-07-30 | 1977-07-26 | THIOPHENE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICAL PREPARATIONS CONTAINING THESE COMPOUNDS |
DK339877A DK339877A (en) | 1976-07-30 | 1977-07-27 | PROCEDURE FOR PREPARATION OF ANTI-INFLAMMATORY EFFECTIVE CONDITIONS |
AU27471/77A AU507121B2 (en) | 1976-07-30 | 1977-07-29 | Thiophenes |
JP9053877A JPS5318558A (en) | 1976-07-30 | 1977-07-29 | Thiophene derivatives* their preparation and medical composition containing same |
AT560477A AT361466B (en) | 1976-07-30 | 1977-07-29 | METHOD FOR PRODUCING NEW TIOPHENE DERIVATIVES |
IE1585/77A IE45325B1 (en) | 1976-07-30 | 1977-07-29 | Anti-inflammatory thiophene derivatives |
US05/927,394 US4153718A (en) | 1976-07-30 | 1978-07-24 | Anti-inflammatory compounds |
US05/952,390 US4198519A (en) | 1976-07-30 | 1978-10-18 | Anti-inflammatory compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB31852/76A GB1525434A (en) | 1976-07-30 | 1976-07-30 | Anti-inflammatory thiophene derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1525434A true GB1525434A (en) | 1978-09-20 |
Family
ID=10329363
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB31852/76A Expired GB1525434A (en) | 1976-07-30 | 1976-07-30 | Anti-inflammatory thiophene derivatives |
Country Status (16)
Country | Link |
---|---|
JP (1) | JPS5318558A (en) |
AT (1) | AT361466B (en) |
AU (1) | AU507121B2 (en) |
BE (1) | BE857128A (en) |
CA (1) | CA1078400A (en) |
CH (1) | CH636613A5 (en) |
DE (1) | DE2733683A1 (en) |
DK (1) | DK339877A (en) |
ES (1) | ES461037A1 (en) |
FR (1) | FR2359837A1 (en) |
GB (1) | GB1525434A (en) |
IE (1) | IE45325B1 (en) |
IL (1) | IL52503A (en) |
NL (1) | NL7708062A (en) |
SE (1) | SE7708591L (en) |
ZA (1) | ZA774222B (en) |
-
1976
- 1976-07-29 CA CA283,755A patent/CA1078400A/en not_active Expired
- 1976-07-30 GB GB31852/76A patent/GB1525434A/en not_active Expired
-
1977
- 1977-07-11 IL IL52503A patent/IL52503A/en unknown
- 1977-07-14 ZA ZA00774222A patent/ZA774222B/en unknown
- 1977-07-20 NL NL7708062A patent/NL7708062A/en not_active Application Discontinuation
- 1977-07-25 CH CH919577A patent/CH636613A5/en not_active IP Right Cessation
- 1977-07-25 FR FR7722739A patent/FR2359837A1/en active Granted
- 1977-07-25 BE BE179615A patent/BE857128A/en unknown
- 1977-07-26 DE DE19772733683 patent/DE2733683A1/en not_active Withdrawn
- 1977-07-26 SE SE7708591A patent/SE7708591L/en not_active Application Discontinuation
- 1977-07-26 ES ES461037A patent/ES461037A1/en not_active Expired
- 1977-07-27 DK DK339877A patent/DK339877A/en not_active Application Discontinuation
- 1977-07-29 IE IE1585/77A patent/IE45325B1/en unknown
- 1977-07-29 JP JP9053877A patent/JPS5318558A/en active Pending
- 1977-07-29 AU AU27471/77A patent/AU507121B2/en not_active Expired
- 1977-07-29 AT AT560477A patent/AT361466B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CH636613A5 (en) | 1983-06-15 |
DK339877A (en) | 1978-01-31 |
AU2747177A (en) | 1979-02-01 |
CA1078400A (en) | 1980-05-27 |
IL52503A (en) | 1981-06-29 |
AU507121B2 (en) | 1980-02-07 |
ATA560477A (en) | 1980-08-15 |
JPS5318558A (en) | 1978-02-20 |
ZA774222B (en) | 1978-06-28 |
ES461037A1 (en) | 1978-12-01 |
IE45325L (en) | 1978-01-30 |
NL7708062A (en) | 1978-02-01 |
AT361466B (en) | 1981-03-10 |
IE45325B1 (en) | 1982-07-28 |
FR2359837B1 (en) | 1980-04-04 |
IL52503A0 (en) | 1977-10-31 |
SE7708591L (en) | 1978-01-31 |
BE857128A (en) | 1978-01-25 |
DE2733683A1 (en) | 1978-02-02 |
FR2359837A1 (en) | 1978-02-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |