GB1506518A - Preparation of penam derivatives - Google Patents
Preparation of penam derivativesInfo
- Publication number
- GB1506518A GB1506518A GB48886/75A GB4888675A GB1506518A GB 1506518 A GB1506518 A GB 1506518A GB 48886/75 A GB48886/75 A GB 48886/75A GB 4888675 A GB4888675 A GB 4888675A GB 1506518 A GB1506518 A GB 1506518A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- substituted
- penam
- tetrazolyl
- imine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1506518 Tetrazolylpenam derivatives PFIZER Inc 27 Nov 1975 [29 Nov 1974] 48886/75 Heading C2C [Also in Division C3] Novel penam compounds of the formula wherein R is a hydrogen atom, C 1-12 alkyl, C 3-7 cycloalkyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, furyl, thienyl or pyridyl, or C 2-12 alkenyl, each substituted group containing one or two substituents, each of which is a Cl, Br, I, OH, NO 2 , C 1-4 alkoxy or C 1-4 alkyl ; Y is a group of the formula wherein R 1 is R 2 or a tetrazolylpenam nitrogen protecting group, R 2 is H, C 3-8 alkanoyloxymethyl, C 4-9 alkanyloxyethyl, silyl, phthalidyl or a group of the formula wherein each of R 4 , R 5 and R 6 is H, Cl, Br, F, C 1-4 alkyl, C 1-4 alkoxy, or phenyl, and salts of those compounds wherein R 1 and R 2 are H atoms may be prepared by reacting an optionally R 1 or R 2 substituted 6-amino-2,2-dimethyl- 3-(5-tetrazolyl)penam with an aldehyde of the formula RCHO. A 6-acylamino-2,2-dimethyl-3(5-tetrazolyl)- penam is obtained by acylating an imine of Formula III with a compound of Formula R 3 COX to form an imine of Formula (IV) and hydrolysing the imine to form the product of Formula (V) Detailed preparations of intermediates (I) via the corresponding 6 - triphenylamino - 2,2- dimethyl - 3(5 - tetrazolyl)penams is also described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52814874A | 1974-11-29 | 1974-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1506518A true GB1506518A (en) | 1978-04-05 |
Family
ID=24104442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB48886/75A Expired GB1506518A (en) | 1974-11-29 | 1975-11-27 | Preparation of penam derivatives |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5176289A (en) |
| AR (1) | AR213080A1 (en) |
| BE (1) | BE836054A (en) |
| CA (1) | CA1060887A (en) |
| DE (1) | DE2552423A1 (en) |
| DK (1) | DK539175A (en) |
| ES (1) | ES443063A1 (en) |
| FR (1) | FR2296637A1 (en) |
| GB (1) | GB1506518A (en) |
| IE (1) | IE42492B1 (en) |
| LU (1) | LU73889A1 (en) |
| NL (1) | NL7513787A (en) |
| SE (1) | SE7513456L (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3843641A (en) * | 1971-11-29 | 1974-10-22 | Merck & Co Inc | Process for preparing penicillin and cephalosporin compounds |
-
1975
- 1975-11-17 IE IE2496/75A patent/IE42492B1/en unknown
- 1975-11-22 DE DE19752552423 patent/DE2552423A1/en active Pending
- 1975-11-26 NL NL7513787A patent/NL7513787A/en not_active Application Discontinuation
- 1975-11-27 SE SE7513456A patent/SE7513456L/en unknown
- 1975-11-27 BE BE1007040A patent/BE836054A/en unknown
- 1975-11-27 GB GB48886/75A patent/GB1506518A/en not_active Expired
- 1975-11-28 FR FR7536539A patent/FR2296637A1/en active Granted
- 1975-11-28 CA CA240,740A patent/CA1060887A/en not_active Expired
- 1975-11-28 DK DK539175A patent/DK539175A/en unknown
- 1975-11-28 ES ES443063A patent/ES443063A1/en not_active Expired
- 1975-11-28 AR AR261384A patent/AR213080A1/en active
- 1975-11-28 LU LU73889A patent/LU73889A1/xx unknown
- 1975-11-29 JP JP50142813A patent/JPS5176289A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR2296637A1 (en) | 1976-07-30 |
| AR213080A1 (en) | 1978-12-15 |
| DK539175A (en) | 1976-05-30 |
| LU73889A1 (en) | 1976-09-06 |
| AU8707675A (en) | 1977-01-06 |
| ES443063A1 (en) | 1977-08-16 |
| JPS5176289A (en) | 1976-07-01 |
| CA1060887A (en) | 1979-08-21 |
| DE2552423A1 (en) | 1976-06-10 |
| IE42492L (en) | 1976-05-29 |
| NL7513787A (en) | 1976-06-01 |
| FR2296637B1 (en) | 1978-08-18 |
| SE7513456L (en) | 1976-05-31 |
| BE836054A (en) | 1976-05-28 |
| IE42492B1 (en) | 1980-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |