GB1504424A - Isoquinoline-derived aminoethers - Google Patents

Isoquinoline-derived aminoethers

Info

Publication number
GB1504424A
GB1504424A GB33283/75A GB3328375A GB1504424A GB 1504424 A GB1504424 A GB 1504424A GB 33283/75 A GB33283/75 A GB 33283/75A GB 3328375 A GB3328375 A GB 3328375A GB 1504424 A GB1504424 A GB 1504424A
Authority
GB
United Kingdom
Prior art keywords
group
alkyl
hydrogen atom
phenyl
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB33283/75A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB33283/75A priority Critical patent/GB1504424A/en
Priority to IE1668/76A priority patent/IE43506B1/en
Priority to ZA764555A priority patent/ZA764555B/xx
Priority to NZ181619A priority patent/NZ181619A/xx
Priority to SE7608641A priority patent/SE7608641L/xx
Priority to IL50176A priority patent/IL50176A/xx
Priority to BE169475A priority patent/BE844783A/xx
Priority to US05/710,446 priority patent/US4113869A/en
Priority to CH1002076A priority patent/CH622780A5/de
Priority to DE19762635276 priority patent/DE2635276A1/de
Priority to ES450550A priority patent/ES450550A1/es
Priority to CA258,633A priority patent/CA1076119A/en
Priority to AT586876A priority patent/AT354448B/de
Priority to DK357976A priority patent/DK357976A/da
Priority to AU16702/76A priority patent/AU498422B2/en
Priority to JP51094721A priority patent/JPS5223083A/ja
Priority to NL7608856A priority patent/NL7608856A/xx
Priority to HU76BE1265A priority patent/HU173560B/hu
Priority to FR7624258A priority patent/FR2320755A1/fr
Priority to ES462058A priority patent/ES462058A1/es
Priority to ES462061A priority patent/ES462061A1/es
Priority to ES462060A priority patent/ES462060A1/es
Priority to ES77462062A priority patent/ES462062A1/es
Priority to ES462059A priority patent/ES462059A1/es
Publication of GB1504424A publication Critical patent/GB1504424A/en
Priority to AT717378A priority patent/AT353793B/de
Priority to CH52281A priority patent/CH626611A5/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
GB33283/75A 1975-08-09 1975-08-09 Isoquinoline-derived aminoethers Expired GB1504424A (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
GB33283/75A GB1504424A (en) 1975-08-09 1975-08-09 Isoquinoline-derived aminoethers
IE1668/76A IE43506B1 (en) 1975-08-09 1976-07-28 Isoquinoline-derived aminoethers
ZA764555A ZA764555B (en) 1975-08-09 1976-07-29 Polycyclic compounds
NZ181619A NZ181619A (en) 1975-08-09 1976-07-29 1-aminoalkoxy-4-substituted-1 2, 3, 4-tetrahydroiso-quinolines
SE7608641A SE7608641L (sv) 1975-08-09 1976-07-30 Tetrahydroisokinolinderivat
IL50176A IL50176A (en) 1975-08-09 1976-07-30 7-aminoalkoxy-tetrahydroisoquinoline derivatives,their preparation and pharmceutical compositions containing them
BE169475A BE844783A (fr) 1975-08-09 1976-07-30 Composes polycycliques
US05/710,446 US4113869A (en) 1975-08-09 1976-08-02 Tetrahydroisoquinoline basic ethers and pharmaceutical compositions and methods employing them
CH1002076A CH622780A5 (US07732459-20100608-C00012.png) 1975-08-09 1976-08-05
DE19762635276 DE2635276A1 (de) 1975-08-09 1976-08-05 Tetrahydroisochinolin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate
DK357976A DK357976A (da) 1975-08-09 1976-08-06 Fremgangsmade til fremstilling af tetrahydroisoquinolinderivater
CA258,633A CA1076119A (en) 1975-08-09 1976-08-06 Basic ethers of aryl-oxy-tetrahydroisoquinoline
AT586876A AT354448B (de) 1975-08-09 1976-08-06 Verfahren zur herstellung von neuen tetrahydro- isochinolinderivaten in form der reinen stereo- isomeren und ihrer gemische und ihren salzen
ES450550A ES450550A1 (es) 1975-08-09 1976-08-06 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
AU16702/76A AU498422B2 (en) 1975-08-09 1976-08-09 Tetrahydro-isoquinolines
JP51094721A JPS5223083A (en) 1975-08-09 1976-08-09 New 1*2*3*44tetrahydraquinoline derivatives preparation method thereof and medical composite containing these
NL7608856A NL7608856A (nl) 1975-08-09 1976-08-09 Werkwijze ter bereiding van nieuwe tetrahydro- isochinoline derivaten alsmede deze verbindingen bevattende farmaceutische preparaten.
HU76BE1265A HU173560B (hu) 1975-08-09 1976-08-09 Sposob poluchenija proizvodnykh tetragidroizokhinolina
FR7624258A FR2320755A1 (fr) 1975-08-09 1976-08-09 Composes polycycliques
ES462058A ES462058A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462061A ES462061A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462060A ES462060A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES77462062A ES462062A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462059A ES462059A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
AT717378A AT353793B (de) 1975-08-09 1978-10-05 Verfahren zur herstellung von neuen tetrahydro- isochinolinderivaten in form der reinen stereo- isomeren und ihrer gemische und ihren salzen
CH52281A CH626611A5 (US07732459-20100608-C00012.png) 1975-08-09 1981-01-27

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB33283/75A GB1504424A (en) 1975-08-09 1975-08-09 Isoquinoline-derived aminoethers

Publications (1)

Publication Number Publication Date
GB1504424A true GB1504424A (en) 1978-03-22

Family

ID=10350917

Family Applications (1)

Application Number Title Priority Date Filing Date
GB33283/75A Expired GB1504424A (en) 1975-08-09 1975-08-09 Isoquinoline-derived aminoethers

Country Status (19)

Country Link
US (1) US4113869A (US07732459-20100608-C00012.png)
JP (1) JPS5223083A (US07732459-20100608-C00012.png)
AT (2) AT354448B (US07732459-20100608-C00012.png)
AU (1) AU498422B2 (US07732459-20100608-C00012.png)
BE (1) BE844783A (US07732459-20100608-C00012.png)
CA (1) CA1076119A (US07732459-20100608-C00012.png)
CH (2) CH622780A5 (US07732459-20100608-C00012.png)
DE (1) DE2635276A1 (US07732459-20100608-C00012.png)
DK (1) DK357976A (US07732459-20100608-C00012.png)
ES (6) ES450550A1 (US07732459-20100608-C00012.png)
FR (1) FR2320755A1 (US07732459-20100608-C00012.png)
GB (1) GB1504424A (US07732459-20100608-C00012.png)
HU (1) HU173560B (US07732459-20100608-C00012.png)
IE (1) IE43506B1 (US07732459-20100608-C00012.png)
IL (1) IL50176A (US07732459-20100608-C00012.png)
NL (1) NL7608856A (US07732459-20100608-C00012.png)
NZ (1) NZ181619A (US07732459-20100608-C00012.png)
SE (1) SE7608641L (US07732459-20100608-C00012.png)
ZA (1) ZA764555B (US07732459-20100608-C00012.png)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2711655A1 (de) * 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
US4340600A (en) 1980-05-22 1982-07-20 Smithkline Corporation Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines
US4766131A (en) * 1980-10-17 1988-08-23 Pennwalt Corporation 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics
US4477670A (en) * 1981-02-19 1984-10-16 Hoechst-Roussel Pharmaceuticals Inc. 4-Aryloxy-1,2,3,4-tetrahydroisoquinolines
US4551474A (en) * 1981-02-19 1985-11-05 Hoechst-Roussel Pharmaceuticals Incorporated Methods of alleviating convulsions and pain employing 4-aryloxy-1,2,3,4 tetrahydroisoquinolines
US4375471A (en) * 1981-02-19 1983-03-01 Hoechst-Roussel Pharmaceuticals Inc. 4-Aryloxy-1,2,3,4-tetrahydroisoquinolines
US6562837B1 (en) * 1998-10-21 2003-05-13 Korea Institute Of Science & Technology Use of tetrahydroisoquinoline compounds for the treatment of septicemia
NZ519146A (en) * 1999-11-03 2004-02-27 Albany Molecular Res Inc 4-phenyl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
AU781179B2 (en) * 1999-11-03 2005-05-12 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
EP1113007A1 (en) 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisoquinoline compounds as estrogen agonists/antagonists
US7084152B2 (en) 2000-07-11 2006-08-01 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
US7314937B2 (en) * 2002-03-21 2008-01-01 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses
EP1778639B1 (en) * 2004-07-15 2015-09-02 Albany Molecular Research, Inc. Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US20060111393A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US20060111385A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
US20060111394A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
WO2006066197A1 (en) * 2004-12-17 2006-06-22 Janssen Pharmaceutica, N.V. Tetrahydroisoquinoline compounds for treatment of cns disorders
ES2314933T3 (es) 2005-06-17 2009-03-16 Janssen Pharmaceutica Nv Compuestos de naftiridina.
WO2006138604A1 (en) * 2005-06-17 2006-12-28 Janssen Pharmaceutica N.V. Hexahydro-pyrrolo-isoquinoline compounds for the treatment of cns disorders
KR20080044840A (ko) * 2005-07-15 2008-05-21 에이엠알 테크놀로지, 인크. 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기위한 용도
US7846930B2 (en) * 2007-05-18 2010-12-07 Janssen Pharmaceutica Nv Diaryl-substituted tetrahydroisoquinolines as histamine H3 receptor and serotonin transporter modulators
AR071997A1 (es) * 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
KR101881596B1 (ko) 2008-12-02 2018-07-24 웨이브 라이프 사이언시스 재팬 인코포레이티드 인 원자 변형된 핵산의 합성 방법
CN102638982B (zh) 2009-05-12 2015-07-08 百时美施贵宝公司 (S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途
KR101830447B1 (ko) 2009-05-12 2018-02-20 알바니 몰레큘라 리써치, 인크. 7-(［1,2,4］트리아졸로［1,5-α］피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린 및 이의 용도
MX2011011901A (es) 2009-05-12 2012-01-20 Albany Molecular Res Inc Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas.
CN102596204B (zh) 2009-07-06 2016-11-23 波涛生命科学有限公司 新的核酸前药及其使用方法
WO2012039448A1 (ja) * 2010-09-24 2012-03-29 株式会社キラルジェン 不斉補助基
ES2626488T3 (es) 2011-07-19 2017-07-25 Wave Life Sciences Pte. Ltd. Procedimientos para la síntesis de ácidos nucleicos funcionalizados
EP2873674B1 (en) 2012-07-13 2020-05-06 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant
AU2013288048A1 (en) 2012-07-13 2015-01-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
SG11201500232UA (en) 2012-07-13 2015-04-29 Wave Life Sciences Pte Ltd Chiral control
EP3095461A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
EP3095459A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
CN106068325B (zh) 2014-01-16 2021-07-09 波涛生命科学有限公司 手性设计

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1058822A (en) * 1963-07-30 1967-02-15 Ici Ltd 3-amino-2-hydroxypropoxy heterocyclic derivatives
US3479358A (en) * 1966-09-19 1969-11-18 Warner Lambert Pharmaceutical Hexahydro-9,4a - iminoethano-4a-h-xanthenes and process for their production
US3947456A (en) * 1970-01-06 1976-03-30 Hoffman-La Roche Inc. Substituted 4-phenyl isoquinolines
US3666763A (en) * 1970-01-06 1972-05-30 Hoffmann La Roche 4-phenyl isoquinolines and process for preparing same
US3878215A (en) * 1971-12-01 1975-04-15 Sandoz Ag 2-Alkyl-3-substituted-4-aryl isoquinolines
US3910924A (en) * 1972-04-13 1975-10-07 Otsuka Pharma Co Ltd 3,4-Dihydrocarbostyril derivatives and a process for preparing the same
US3855227A (en) * 1972-05-08 1974-12-17 C Hollander ({31 )-di-o-isopropylidene-2-keto-l-gulonates
JPS5239035B2 (US07732459-20100608-C00012.png) * 1972-12-14 1977-10-03
US3872125A (en) * 1973-03-03 1975-03-18 Sandoz Ag 3-substituted-4-aryl isoquinolines
US3870722A (en) * 1973-11-02 1975-03-11 Sandoz Ag 2-Methyl-3-substituted-4-aryl isoquinolines
AR206061A1 (es) * 1974-11-15 1976-06-23 Knoll Ag Procedimiento para la produccion de nuevas 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 7-, 6- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-isoquinolinas de 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 7- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-6-metoxi-isoquinolinas y de 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 6- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-7-metoxi-isoquinolinas eventualmente metiladas en la posicion 1

Also Published As

Publication number Publication date
AU498422B2 (en) 1979-03-15
JPS5223083A (en) 1977-02-21
ES462058A1 (es) 1978-06-16
NZ181619A (en) 1979-08-31
ES462062A1 (es) 1978-06-16
ES462061A1 (es) 1978-06-16
AT354448B (de) 1979-01-10
CA1076119A (en) 1980-04-22
IE43506B1 (en) 1981-03-11
HU173560B (hu) 1979-06-28
ATA717378A (de) 1979-05-15
ES462059A1 (es) 1978-06-16
AU1670276A (en) 1978-02-16
FR2320755B1 (US07732459-20100608-C00012.png) 1979-09-14
ES450550A1 (es) 1977-12-16
US4113869A (en) 1978-09-12
IL50176A0 (en) 1976-09-30
IL50176A (en) 1979-10-31
BE844783A (fr) 1977-01-31
CH622780A5 (US07732459-20100608-C00012.png) 1981-04-30
FR2320755A1 (fr) 1977-03-11
ZA764555B (en) 1977-07-27
CH626611A5 (US07732459-20100608-C00012.png) 1981-11-30
IE43506L (en) 1977-02-09
SE7608641L (sv) 1977-02-10
AT353793B (de) 1979-12-10
ES462060A1 (es) 1978-06-16
DE2635276A1 (de) 1977-02-17
ATA586876A (de) 1979-06-15
DK357976A (da) 1977-02-10
NL7608856A (nl) 1977-02-11

Similar Documents

Publication Publication Date Title
GB1504424A (en) Isoquinoline-derived aminoethers
ES8506677A1 (es) Un procedimiento para la preparacion de nuevos derivados de 8-cloro71,5-benzotiazepina.
ES8301925A1 (es) Un procedimiento para la obtencion de un derivado acilico sustituido del compuesto acido 1,2,3,4-tetrahidro-3-isoqui- nolein-carboxilico
MY100095A (en) 2-oxo-imidazolidine compounds, a process for preparing the same and a pharmaceutical composition.
ES431514A1 (es) Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos.
ES460678A1 (es) Un procedimiento para la preparacion de nuevos derivados delcromano.
GB1507717A (en) Benz(de)isoquinoline derivatives
ES8504682A1 (es) Un procedimiento para la preparacion de compuestos nitro alifaticos
DK318989A (da) Nye estere
GB1239553A (US07732459-20100608-C00012.png)
ES445661A1 (es) Procedimiento para la preparacion de derivados de acetileno.
GB1384035A (en) Amino alkyl esters of 2-anilino nicotinic acid and their preparation
GB1477302A (en) Triazolo-isoindole and triazolo-isoquinoline derivatives and their manufacture and uses
GB1478374A (en) Piperidyl-methylenedioxybenzene derivatives
GB1473971A (en) 3-hydroxy-5,6-benzomorphinan derivatives
ES8301888A1 (es) "procedimiento para la preparacion de derivados de fenoxi-aminopropanol substituidos" como divisional de la patente de invencion n 502.649 del 1 junio 1981.
GB1144935A (en) Anthrol derivatives and the preparation thereof
ES8405020A1 (es) Un procedimiento para la preparacion de derivados de fosfolipidos.
GB1178187A (en) Bis(tetrahydroisoquinolines) and compositions thereof
ES286809A1 (es) Un procedimiento para la preparacion de compuesto quinazolonicos
ES470462A1 (es) Procedimiento para producir imidazol-2-carbamatos
ES8800206A1 (es) Un procedimiento para preparar derivados de 2-aminopirimidinona
US4164502A (en) 2-Decarboxy-2-aminomethyl-trans-4,5,13,14-tetradehydro-PGI1 compounds
GB1449222A (en) N-hereroarylmethyl-desoxy-normorphines and-norcodeines
GB1418831A (en) Reserpine derivatives

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee