GB1501475A - Piperidinobutyrophenone derivatives - Google Patents

Piperidinobutyrophenone derivatives

Info

Publication number
GB1501475A
GB1501475A GB3147075A GB3147075A GB1501475A GB 1501475 A GB1501475 A GB 1501475A GB 3147075 A GB3147075 A GB 3147075A GB 3147075 A GB3147075 A GB 3147075A GB 1501475 A GB1501475 A GB 1501475A
Authority
GB
United Kingdom
Prior art keywords
pharmaceutically acceptable
salt
phenylpiperidino
butyrophenones
july
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3147075A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of GB1501475A publication Critical patent/GB1501475A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1501475 γ - (4 - Hydroxy - 4 - phenylpiperidino)-butyrophenones SUMITOMO CHEMICAL CO Ltd 28 July 1975 [29 July 1975] 31470/75 Heading C2C Novel γ - (4 - hydroxy - 4 - phenylpiperidino)- butyrophenones of the general Formula I wherein each of R 1 and R 3 is a halogen atom, R 2 is an amino or C 1-4 alkanoyl amino group and R 4 is a halogen atom or a C 1-4 alkyl or trifluoromethyl group, and non-toxic, pharmaceutically acceptable acid addition and quaternary ammonium salts thereof are prepared by oxidizing an indole of the general Formula II wherein R 5 is a hydrogen atom or C 1-3 alkyl group, or a salt thereof, and optionally hydrolysing the resulting compound I in which R 2 is -NHCOR 5 or salt thereof, followed optionally by salification of a resulting compound I. Indoles II are prepared by reacting an acid III, ethyl chloroformate and a piperidine X and reducing the resulting ketone IV with LiAlH 4 . Pharmaceutical compositions having psychotropic and analgesic activity comprise, as active ingredient, a compound I or non-toxic, pharmaceutically acceptable acid addition or quaternary ammonium salt thereof, together with a pharmaceutically acceptable carrier or diluent.
GB3147075A 1974-07-29 1975-07-28 Piperidinobutyrophenone derivatives Expired GB1501475A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8729574A JPS5116677A (en) 1974-07-29 1974-07-29 SHINKINABUCHIROFUENONJUDOTAI OYOBI SONOSANFUKAENNOSEIHO

Publications (1)

Publication Number Publication Date
GB1501475A true GB1501475A (en) 1978-02-15

Family

ID=13910811

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3147075A Expired GB1501475A (en) 1974-07-29 1975-07-28 Piperidinobutyrophenone derivatives

Country Status (7)

Country Link
JP (1) JPS5116677A (en)
BE (1) BE831818A (en)
CA (1) CA1038391A (en)
DE (1) DE2533865A1 (en)
FR (1) FR2280378A1 (en)
GB (1) GB1501475A (en)
NL (1) NL7508870A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003037863A2 (en) * 2001-10-29 2003-05-08 Grünenthal GmbH Substituted indoles, method for production and use thereof for the inhibition of pain

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04116411U (en) * 1991-03-28 1992-10-19 セントラル硝子株式会社 Glass antenna connection structure
JP2638715B2 (en) * 1992-07-31 1997-08-06 セントラル硝子株式会社 Glass antenna connection structure

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI52216C (en) * 1969-07-16 1977-07-11 Sumitomo Chemical Co Process for the preparation of gamma-piperidinobutyrophenone derivatives.
US3850935A (en) * 1971-10-16 1974-11-26 Sumitomo Chemical Co Process for producing piperidine derivatives by degrading quaternary piperidinium salts
BE792906A (en) * 1971-12-18 1973-06-18 Sumitomo Chemical Co ARYL-KETONES AND THEIR PREPARATION
CH599939A5 (en) * 1972-03-18 1978-06-15 Sumitomo Chemical Co

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003037863A2 (en) * 2001-10-29 2003-05-08 Grünenthal GmbH Substituted indoles, method for production and use thereof for the inhibition of pain
WO2003037863A3 (en) * 2001-10-29 2004-08-12 Gruenenthal Gmbh Substituted indoles, method for production and use thereof for the inhibition of pain
US7217729B2 (en) 2001-10-29 2007-05-15 Grunenthal Gmbh Substituted indoles, process for the production thereof and use thereof for combatting pain

Also Published As

Publication number Publication date
DE2533865A1 (en) 1976-02-19
CA1038391A (en) 1978-09-12
FR2280378A1 (en) 1976-02-27
FR2280378B1 (en) 1979-04-06
BE831818A (en) 1976-01-28
NL7508870A (en) 1976-02-02
JPS5116677A (en) 1976-02-10

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee