GB1499255A - Tetrazolo(a)quinazolone derivatives - Google Patents
Tetrazolo(a)quinazolone derivativesInfo
- Publication number
- GB1499255A GB1499255A GB27543/76A GB2754376A GB1499255A GB 1499255 A GB1499255 A GB 1499255A GB 27543/76 A GB27543/76 A GB 27543/76A GB 2754376 A GB2754376 A GB 2754376A GB 1499255 A GB1499255 A GB 1499255A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxy
- benzyloxy
- july
- chloro
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1499255 Tetrazolo[a]-quinazolone derivatives PFIZER Inc 1 July 1976 [10 July 1975 28 Jan 1976] 27543/76 Heading C2C Novel compounds of the Formula I wherein each of R 1 and R 2 is hydrogen, halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkanoyloxy, benzyloxy, hydroxy, trifluoromethyl, or sulphonamide, or R 1 and R 2 when attached to adjacent carbon atoms in the ring and taken together form a methylenedioxy or ethylenedioxy group, provided R 1 and R 2 are not both hydrogen, and pharmaceutically acceptable cationic salts thereof, may be prepared by reacting the appropriate 2-chloro-4(3H)quinazolinone with a metal azide to form the tetrazole ring, optionally followed by debenzylating when R 1 and/or R 2 is benzyloxy to form the corresponding compound in which R 1 and/or R 2 is hydroxy and esterification of a free hydroxy group at R 1 and/or R 2 . The 2-chloro-4(3H)quinazolinones are prepared by reacting the appropriate anthranilic acid with urea or alkali metal isocyanate followed by heating to form a 2,4-(lH,3H)quinazolinedione, which with phosphorus oxychloride forms a 2,4-dichloroquinazoline which with base yields the required compound.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59476575A | 1975-07-10 | 1975-07-10 | |
US65325076A | 1976-01-28 | 1976-01-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1499255A true GB1499255A (en) | 1978-01-25 |
Family
ID=27082077
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB27543/76A Expired GB1499255A (en) | 1975-07-10 | 1976-07-01 | Tetrazolo(a)quinazolone derivatives |
Country Status (20)
Country | Link |
---|---|
JP (1) | JPS5210297A (en) |
AR (1) | AR211272A1 (en) |
AU (1) | AU1515776A (en) |
DD (1) | DD126326A5 (en) |
DE (1) | DE2630053C3 (en) |
DK (1) | DK143704C (en) |
ES (1) | ES449570A1 (en) |
FI (1) | FI762013A (en) |
FR (1) | FR2316952A1 (en) |
GB (1) | GB1499255A (en) |
GR (1) | GR60543B (en) |
IE (1) | IE43466B1 (en) |
IL (1) | IL49850A0 (en) |
LU (1) | LU75342A1 (en) |
NL (1) | NL166024C (en) |
NO (1) | NO762170L (en) |
PH (1) | PH15280A (en) |
PT (1) | PT65337B (en) |
RO (1) | RO71662B (en) |
SE (1) | SE7606762L (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007261982A (en) * | 2006-03-28 | 2007-10-11 | Mitsubishi Gas Chem Co Inc | Method for producing quinazolin-2,4-dione derivative |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1519765A (en) * | 1974-09-05 | 1978-08-02 | Ici Ltd | Pesticidal dihydrotetrazolo(1,5a) quinazolines compositions and processes |
-
1976
- 1976-04-21 IE IE836/76A patent/IE43466B1/en unknown
- 1976-06-14 SE SE7606762A patent/SE7606762L/en unknown
- 1976-06-19 GR GR51048A patent/GR60543B/en unknown
- 1976-06-21 IL IL49850A patent/IL49850A0/en unknown
- 1976-06-23 AU AU15157/76A patent/AU1515776A/en not_active Expired
- 1976-06-23 NO NO762170A patent/NO762170L/no unknown
- 1976-06-28 PH PH18616A patent/PH15280A/en unknown
- 1976-07-01 GB GB27543/76A patent/GB1499255A/en not_active Expired
- 1976-07-02 NL NL7607315.A patent/NL166024C/en not_active IP Right Cessation
- 1976-07-03 DE DE2630053A patent/DE2630053C3/en not_active Expired
- 1976-07-05 ES ES449570A patent/ES449570A1/en not_active Expired
- 1976-07-08 AR AR263896A patent/AR211272A1/en active
- 1976-07-08 PT PT65337A patent/PT65337B/en unknown
- 1976-07-08 JP JP51081449A patent/JPS5210297A/en active Granted
- 1976-07-09 FR FR7621100A patent/FR2316952A1/en active Granted
- 1976-07-09 DK DK310876A patent/DK143704C/en not_active IP Right Cessation
- 1976-07-09 DD DD193778A patent/DD126326A5/xx unknown
- 1976-07-09 RO RO86909A patent/RO71662B/en unknown
- 1976-07-09 FI FI762013A patent/FI762013A/fi not_active Application Discontinuation
- 1976-07-09 LU LU75342A patent/LU75342A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE2630053C3 (en) | 1981-05-21 |
DK143704B (en) | 1981-09-28 |
FR2316952A1 (en) | 1977-02-04 |
FR2316952B1 (en) | 1979-07-20 |
FI762013A (en) | 1977-01-11 |
DD126326A5 (en) | 1977-07-06 |
IE43466B1 (en) | 1981-03-11 |
IL49850A0 (en) | 1976-08-31 |
GR60543B (en) | 1978-06-14 |
LU75342A1 (en) | 1977-04-01 |
DE2630053B2 (en) | 1980-09-11 |
PT65337B (en) | 1978-01-06 |
SE7606762L (en) | 1977-01-11 |
NL7607315A (en) | 1977-01-12 |
NL166024B (en) | 1981-01-15 |
RO71662B (en) | 1983-04-30 |
NL166024C (en) | 1981-06-15 |
PT65337A (en) | 1976-08-01 |
IE43466L (en) | 1977-01-10 |
AR211272A1 (en) | 1977-11-15 |
PH15280A (en) | 1982-11-02 |
JPS5210297A (en) | 1977-01-26 |
RO71662A (en) | 1983-04-29 |
DK310876A (en) | 1977-01-11 |
DE2630053A1 (en) | 1977-01-13 |
NO762170L (en) | 1977-01-11 |
AU1515776A (en) | 1978-01-05 |
ES449570A1 (en) | 1977-12-01 |
JPS5432798B2 (en) | 1979-10-16 |
DK143704C (en) | 1982-03-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
SP | Amendment (slips) printed | ||
PCNP | Patent ceased through non-payment of renewal fee |