GB1499047A - Pyrrolo(2,1-b)(3)benzazepines methods of preparing them pharmaceutical compositions containing them and their use for treatment of non-human animals - Google Patents
Pyrrolo(2,1-b)(3)benzazepines methods of preparing them pharmaceutical compositions containing them and their use for treatment of non-human animalsInfo
- Publication number
- GB1499047A GB1499047A GB27487/76A GB2748776A GB1499047A GB 1499047 A GB1499047 A GB 1499047A GB 27487/76 A GB27487/76 A GB 27487/76A GB 2748776 A GB2748776 A GB 2748776A GB 1499047 A GB1499047 A GB 1499047A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzazepines
- pyrrolo
- preparing
- treatment
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- SCHRRVXSPNLRMS-UHFFFAOYSA-N 3h-pyrrolo[2,1-b][3]benzazepine Chemical class C1=CN2CC=CC2=CC2=CC=CC=C21 SCHRRVXSPNLRMS-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 238000013375 chromatographic separation Methods 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 229940125706 skeletal muscle relaxant agent Drugs 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59243675A | 1975-07-02 | 1975-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1499047A true GB1499047A (en) | 1978-01-25 |
Family
ID=24370639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27487/76A Expired GB1499047A (en) | 1975-07-02 | 1976-07-01 | Pyrrolo(2,1-b)(3)benzazepines methods of preparing them pharmaceutical compositions containing them and their use for treatment of non-human animals |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS527996A (en:Method) |
| AU (1) | AU499122B2 (en:Method) |
| BE (1) | BE843678A (en:Method) |
| CA (1) | CA1092105A (en:Method) |
| CH (5) | CH626366A5 (en:Method) |
| CY (1) | CY1091A (en:Method) |
| DE (2) | DE2629877A1 (en:Method) |
| ES (1) | ES449432A1 (en:Method) |
| FR (1) | FR2315935A1 (en:Method) |
| GB (1) | GB1499047A (en:Method) |
| GR (1) | GR60851B (en:Method) |
| HK (1) | HK60580A (en:Method) |
| HU (1) | HU177866B (en:Method) |
| MY (1) | MY8100227A (en:Method) |
| NL (1) | NL188287C (en:Method) |
| PT (1) | PT65295B (en:Method) |
| SE (1) | SE424076B (en:Method) |
| ZA (1) | ZA763990B (en:Method) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4148903A (en) * | 1977-07-28 | 1979-04-10 | Merck & Co., Inc. | Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines |
| JPH0487401U (en:Method) * | 1990-12-06 | 1992-07-29 | ||
| US6271392B1 (en) | 1994-10-07 | 2001-08-07 | Rhone-Poulenc Inc. | Intermediates useful for the synthesis of 1-arylpyrrole pesticides |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3428677A (en) * | 1962-09-24 | 1969-02-18 | Merck & Co Inc | Chemical compounds and methods of preparing same |
| US3499037A (en) * | 1966-05-31 | 1970-03-03 | Merck & Co Inc | Preparation of trifluoromethyl substituted dibenzocycloheptenes |
-
1976
- 1976-06-30 PT PT65295A patent/PT65295B/pt unknown
- 1976-06-30 CA CA256,080A patent/CA1092105A/en not_active Expired
- 1976-06-30 FR FR7619897A patent/FR2315935A1/fr active Granted
- 1976-07-01 SE SE7607534A patent/SE424076B/xx not_active IP Right Cessation
- 1976-07-01 CH CH844376A patent/CH626366A5/de not_active IP Right Cessation
- 1976-07-01 ES ES449432A patent/ES449432A1/es not_active Expired
- 1976-07-01 GB GB27487/76A patent/GB1499047A/en not_active Expired
- 1976-07-01 AU AU15488/76A patent/AU499122B2/en not_active Expired
- 1976-07-01 BE BE168549A patent/BE843678A/xx not_active IP Right Cessation
- 1976-07-01 GR GR51162A patent/GR60851B/el unknown
- 1976-07-01 CY CY1091A patent/CY1091A/xx unknown
- 1976-07-02 ZA ZA00763990A patent/ZA763990B/xx unknown
- 1976-07-02 JP JP51077992A patent/JPS527996A/ja active Granted
- 1976-07-02 DE DE19762629877 patent/DE2629877A1/de active Granted
- 1976-07-02 HU HU76ME2001A patent/HU177866B/hu unknown
- 1976-07-02 DE DE2661014A patent/DE2661014C2/de not_active Expired
- 1976-07-02 NL NLAANVRAGE7607347,A patent/NL188287C/xx not_active IP Right Cessation
-
1980
- 1980-05-16 CH CH386280A patent/CH626618A5/de not_active IP Right Cessation
- 1980-05-16 CH CH386080A patent/CH626616A5/de not_active IP Right Cessation
- 1980-05-16 CH CH386180A patent/CH626617A5/de not_active IP Right Cessation
- 1980-05-16 CH CH385980A patent/CH626893A5/de not_active IP Right Cessation
- 1980-10-30 HK HK605/80A patent/HK60580A/xx unknown
-
1981
- 1981-12-30 MY MY227/81A patent/MY8100227A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1091A (en) | 1980-12-27 |
| SE7607534L (sv) | 1977-01-03 |
| JPS527996A (en) | 1977-01-21 |
| PT65295A (en) | 1976-07-01 |
| SE424076B (sv) | 1982-06-28 |
| NL188287C (nl) | 1992-05-18 |
| HU177866B (en) | 1982-01-28 |
| NL7607347A (nl) | 1977-01-04 |
| DE2661014A1 (en:Method) | 1985-07-04 |
| FR2315935B1 (en:Method) | 1978-11-17 |
| DE2629877C2 (en:Method) | 1989-01-05 |
| FR2315935A1 (fr) | 1977-01-28 |
| GR60851B (en) | 1978-08-31 |
| CA1092105A (en) | 1980-12-23 |
| ZA763990B (en) | 1978-02-22 |
| HK60580A (en) | 1980-11-07 |
| PT65295B (en) | 1978-05-10 |
| MY8100227A (en) | 1981-12-31 |
| DE2629877A1 (de) | 1977-01-20 |
| CH626893A5 (en) | 1981-12-15 |
| AU499122B2 (en) | 1979-04-05 |
| CH626616A5 (en) | 1981-11-30 |
| NL188287B (nl) | 1991-12-16 |
| AU1548876A (en) | 1978-01-05 |
| DE2661014C2 (en:Method) | 1989-01-05 |
| CH626618A5 (en) | 1981-11-30 |
| CH626617A5 (en) | 1981-11-30 |
| CH626366A5 (en) | 1981-11-13 |
| BE843678A (fr) | 1977-01-03 |
| JPH0132225B2 (en:Method) | 1989-06-29 |
| ES449432A1 (es) | 1977-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19930701 |