GB1496238A - Purification method for prolylleucylglycinamide - Google Patents
Purification method for prolylleucylglycinamideInfo
- Publication number
- GB1496238A GB1496238A GB40221/75A GB4022175A GB1496238A GB 1496238 A GB1496238 A GB 1496238A GB 40221/75 A GB40221/75 A GB 40221/75A GB 4022175 A GB4022175 A GB 4022175A GB 1496238 A GB1496238 A GB 1496238A
- Authority
- GB
- United Kingdom
- Prior art keywords
- volume
- diethyl ether
- parts
- prolylleucylglycinamide
- purification method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- 108010064699 MSH Release-Inhibiting Hormone Proteins 0.000 title 1
- BGHJSMSCPPBCBK-OFGSCBOVSA-N prolyl-leucyl-glycinamide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 BGHJSMSCPPBCBK-OFGSCBOVSA-N 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- NOOJLZTTWSNHOX-UWVGGRQHSA-N Melanostatin Chemical compound NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1 NOOJLZTTWSNHOX-UWVGGRQHSA-N 0.000 abstract 2
- 238000002425 crystallisation Methods 0.000 abstract 2
- 230000008025 crystallization Effects 0.000 abstract 2
- 238000004090 dissolution Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/519,463 US3931184A (en) | 1974-10-31 | 1974-10-31 | Purification method for prolyl-leucylglycinamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1496238A true GB1496238A (en) | 1977-12-30 |
Family
ID=24068408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB40221/75A Expired GB1496238A (en) | 1974-10-31 | 1975-10-01 | Purification method for prolylleucylglycinamide |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3931184A (enExample) |
| JP (1) | JPS5632307B2 (enExample) |
| CA (1) | CA1032935A (enExample) |
| FR (1) | FR2289490A1 (enExample) |
| GB (1) | GB1496238A (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4687841A (en) * | 1985-10-18 | 1987-08-18 | Monsanto Company | Peptide hydroxamic acid derivatives |
| US4720486A (en) * | 1985-10-18 | 1988-01-19 | Monsanto Company | Method of inhibiting vertebrate collagenase activity using peptide hydroxamic acid derivatives |
| US6767897B2 (en) * | 1994-05-04 | 2004-07-27 | Innapharma, Inc. | Therapeutic uses of tri-, tetra-, penta-, and polypeptides |
| US5767083A (en) * | 1994-05-04 | 1998-06-16 | Innapharma, Inc. | Tri-, tetra-, penta-, and polypeptides and their therapeutic use as an antidepressant agent |
| US5589460A (en) * | 1994-05-04 | 1996-12-31 | Innapharma, Inc. | Tri-, tetra-, penta-, and polypeptides and their therapeutic use as an antidepressant agent |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6707845A (enExample) * | 1966-06-11 | 1967-12-12 | ||
| US3708593A (en) * | 1971-08-24 | 1973-01-02 | Abbott Lab | Use of l-prolyl l-leucyl glycine amide as an anti-depressant |
| US3795738A (en) * | 1972-12-26 | 1974-03-05 | Abbott Lab | Use of l-propyl l-leucyl glycine amide to treat parkinson's disease |
| US3851055A (en) * | 1973-03-01 | 1974-11-26 | Abbott Lab | Method of treating tardive dyskinesia using l-prolyl l-leucyl glycine amide |
-
1974
- 1974-10-31 US US05/519,463 patent/US3931184A/en not_active Expired - Lifetime
-
1975
- 1975-09-29 CA CA236,621A patent/CA1032935A/en not_active Expired
- 1975-10-01 GB GB40221/75A patent/GB1496238A/en not_active Expired
- 1975-10-20 FR FR7532051A patent/FR2289490A1/fr active Granted
- 1975-10-22 JP JP12645575A patent/JPS5632307B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US3931184A (en) | 1976-01-06 |
| DE2548594B2 (de) | 1976-09-23 |
| JPS5632307B2 (enExample) | 1981-07-27 |
| FR2289490A1 (fr) | 1976-05-28 |
| FR2289490B1 (enExample) | 1978-12-01 |
| DE2548594A1 (de) | 1976-05-06 |
| CA1032935A (en) | 1978-06-13 |
| JPS5165756A (enExample) | 1976-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |