ES468333A1 - Un procedimiento para la preparacion de un derivado de tia- zolidin-azetidinona con la configuracion d. - Google Patents

Un procedimiento para la preparacion de un derivado de tia- zolidin-azetidinona con la configuracion d.

Info

Publication number
ES468333A1
ES468333A1 ES468333A ES468333A ES468333A1 ES 468333 A1 ES468333 A1 ES 468333A1 ES 468333 A ES468333 A ES 468333A ES 468333 A ES468333 A ES 468333A ES 468333 A1 ES468333 A1 ES 468333A1
Authority
ES
Spain
Prior art keywords
configuration
compound
epimerization process
epimerization
configurations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES468333A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES468333A1 publication Critical patent/ES468333A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

Un procedimiento para la preparación de un derivado de tiazolidin- azetidinona con la configuración D de fórmula: **(Fórmula)** cuyo procedimiento consiste en someter a reacción de epimerización un compuesto de fórmula I con la configuración L o dicho compuesto como mezcla de las configuraciones L y D por disolución en piridina, a una temperatura comprendida entre 20º y 30º C, hasta una concentración comprendida entre 50 mg/ml y 100 mg/ml; disminuir selectivamente la solubilidad del compuesto de configuración D por dilución de la solución anterior con agua en una cantidad correspondiente al 10-50% en solución y separar dicho compuesto de configuración D.
ES468333A 1977-03-31 1978-03-29 Un procedimiento para la preparacion de un derivado de tia- zolidin-azetidinona con la configuracion d. Expired ES468333A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/783,123 US4075219A (en) 1977-03-31 1977-03-31 Epimerization process

Publications (1)

Publication Number Publication Date
ES468333A1 true ES468333A1 (es) 1979-10-01

Family

ID=25128233

Family Applications (1)

Application Number Title Priority Date Filing Date
ES468333A Expired ES468333A1 (es) 1977-03-31 1978-03-29 Un procedimiento para la preparacion de un derivado de tia- zolidin-azetidinona con la configuracion d.

Country Status (11)

Country Link
US (1) US4075219A (es)
JP (1) JPS53130690A (es)
BE (1) BE865405A (es)
CA (1) CA1097652A (es)
DE (1) DE2813287A1 (es)
ES (1) ES468333A1 (es)
FR (1) FR2385723A1 (es)
GB (1) GB1598039A (es)
IE (1) IE46595B1 (es)
IL (1) IL54372A (es)
NL (1) NL7803363A (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148817A (en) * 1976-03-25 1979-04-10 Eli Lilly And Company Process and intermediates for preparing cephalosporin antibiotics
US4127568A (en) * 1977-03-07 1978-11-28 Eli Lilly And Company Process for 3β-aminoazetidin-2-ones
NL7806860A (nl) * 1977-07-05 1979-01-09 Farmaceutici Italia Werkwijze voor het bereiden van met nocardicine verwan- te azetidinonen.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2450784A (en) * 1944-06-19 1948-10-05 Therapeutic Res Corp Of Great Resolution of n-formylisopropylidenepenicillamine
BE786964A (fr) * 1971-07-30 1973-01-29 Degussa Procede pour l'obtention de d-penicillamine
US3966752A (en) * 1971-07-30 1976-06-29 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler Resolution of D,L-protected-penicillamine

Also Published As

Publication number Publication date
DE2813287A1 (de) 1978-10-19
BE865405A (fr) 1978-09-29
FR2385723B1 (es) 1981-05-29
JPS53130690A (en) 1978-11-14
IE46595B1 (en) 1983-07-27
NL7803363A (nl) 1978-10-03
CA1097652A (en) 1981-03-17
US4075219A (en) 1978-02-21
IL54372A (en) 1980-09-16
FR2385723A1 (fr) 1978-10-27
IE780627L (en) 1978-09-30
GB1598039A (en) 1981-09-16

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