GB1493684A - S-substituted-2-thiodenosines - Google Patents
S-substituted-2-thiodenosinesInfo
- Publication number
- GB1493684A GB1493684A GB15800/75A GB1580075A GB1493684A GB 1493684 A GB1493684 A GB 1493684A GB 15800/75 A GB15800/75 A GB 15800/75A GB 1580075 A GB1580075 A GB 1580075A GB 1493684 A GB1493684 A GB 1493684A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substituted
- april
- alkyl
- optionally substituted
- cooh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- BIXYYZIIJIXVFW-UUOKFMHZSA-N (2R,3R,4S,5R)-2-(6-amino-2-chloro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O BIXYYZIIJIXVFW-UUOKFMHZSA-N 0.000 abstract 1
- 125000004135 2-norbornyl group Chemical group [H]C1([H])C([H])([H])C2([H])C([H])([H])C1([H])C([H])([H])C2([H])* 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- LTESOZAUMTUKQX-UUOKFMHZSA-N 6-amino-9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1h-purine-2-thione Chemical compound C1=NC2=C(N)NC(=S)N=C2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O LTESOZAUMTUKQX-UUOKFMHZSA-N 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4271874A JPS5347117B2 (enExample) | 1974-04-18 | 1974-04-18 | |
| JP4343074A JPS55400B2 (enExample) | 1974-04-19 | 1974-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1493684A true GB1493684A (en) | 1977-11-30 |
Family
ID=26382448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB15800/75A Expired GB1493684A (en) | 1974-04-18 | 1975-04-17 | S-substituted-2-thiodenosines |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US3968102A (enExample) |
| DE (1) | DE2517277A1 (enExample) |
| FR (1) | FR2267789B1 (enExample) |
| GB (1) | GB1493684A (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4269839A (en) | 1979-09-13 | 1981-05-26 | Bristol-Myers Company | Alkylthio-adenines used as bronchodilators |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5277091A (en) * | 1975-12-24 | 1977-06-29 | Kohjin Co Ltd | Preparation of 2-substituted adenosines |
| US4683223A (en) * | 1985-09-09 | 1987-07-28 | Warner-Lambert Company | N6 -Benzopyrano-and benzothiopyrano adenosines and methods of use |
| US4954504A (en) * | 1986-11-14 | 1990-09-04 | Ciba-Geigy Corporation | N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity |
| US5063233A (en) * | 1986-11-14 | 1991-11-05 | Ciba-Geigy Corporation | N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists |
| US4968697A (en) * | 1987-02-04 | 1990-11-06 | Ciba-Geigy Corporation | 2-substituted adenosine 5'-carboxamides as antihypertensive agents |
| US20010051612A1 (en) * | 2000-02-23 | 2001-12-13 | Gloria Cristalli | 2-Thioether A2A receptor agonists |
| GB2372741A (en) | 2001-03-03 | 2002-09-04 | Univ Leiden | C2,8-Disubstituted adenosine derivatives and their different uses |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3752805A (en) * | 1969-06-05 | 1973-08-14 | Univ Sydney | 2-loweralkylthioadenosines |
| JPS4826038B1 (enExample) * | 1970-09-25 | 1973-08-03 |
-
1975
- 1975-04-16 US US05/568,491 patent/US3968102A/en not_active Expired - Lifetime
- 1975-04-17 GB GB15800/75A patent/GB1493684A/en not_active Expired
- 1975-04-18 DE DE19752517277 patent/DE2517277A1/de not_active Ceased
- 1975-04-18 FR FR7512224A patent/FR2267789B1/fr not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4269839A (en) | 1979-09-13 | 1981-05-26 | Bristol-Myers Company | Alkylthio-adenines used as bronchodilators |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2267789A1 (enExample) | 1975-11-14 |
| DE2517277A1 (de) | 1975-11-06 |
| FR2267789B1 (enExample) | 1978-07-28 |
| US3968102A (en) | 1976-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |